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Updated November 2019
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Protein Info
Short Name:
DOCK1
Full Name:
Dedicator of cytokinesis protein 1
Alias:
180 kDa protein downstream of CRK; Ced5; Dedicator of cytokinesis 1; DOC1; DOCK180; DOwnstream of CrK
Type:
Adaptor/scaffold; Guanine nucleotide exchange factor, Rac/Rho; Cytoskeletal protein
Mass (Da):
215346
Number AA:
1865
UniProt ID:
Q14185
International Prot ID:
IPI00015286
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0017124
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0007229
GO:0006911
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
P
T
K
R
E
E
K
Y
G
V
A
F
Y
N
Y
Site 2
Y20
Y
G
V
A
F
Y
N
Y
D
A
R
G
A
D
E
Site 3
S29
A
R
G
A
D
E
L
S
L
Q
I
G
D
T
V
Site 4
Y42
T
V
H
I
L
E
T
Y
E
G
W
Y
R
G
Y
Site 5
Y49
Y
E
G
W
Y
R
G
Y
T
L
R
K
K
S
K
Site 6
T50
E
G
W
Y
R
G
Y
T
L
R
K
K
S
K
K
Site 7
S55
G
Y
T
L
R
K
K
S
K
K
G
I
F
P
A
Site 8
S63
K
K
G
I
F
P
A
S
Y
I
H
L
K
E
A
Site 9
T80
E
G
K
G
Q
H
E
T
V
I
P
G
D
L
P
Site 10
T95
L
I
Q
E
V
T
T
T
L
R
E
W
S
T
I
Site 11
S100
T
T
T
L
R
E
W
S
T
I
W
R
Q
L
Y
Site 12
T101
T
T
L
R
E
W
S
T
I
W
R
Q
L
Y
V
Site 13
Y107
S
T
I
W
R
Q
L
Y
V
Q
D
N
R
E
M
Site 14
Y123
R
S
V
R
H
M
I
Y
D
L
I
E
W
R
S
Site 15
S130
Y
D
L
I
E
W
R
S
Q
I
L
S
G
T
L
Site 16
S134
E
W
R
S
Q
I
L
S
G
T
L
P
Q
D
E
Site 17
Y155
K
V
T
A
K
I
D
Y
G
N
R
I
L
D
L
Site 18
T181
L
D
P
E
L
T
S
T
I
S
L
F
R
A
H
Site 19
S183
P
E
L
T
S
T
I
S
L
F
R
A
H
E
I
Site 20
S204
E
R
L
Q
E
E
K
S
Q
K
Q
N
I
D
I
Site 21
S245
E
D
A
E
V
L
M
S
L
Y
D
P
V
E
S
Site 22
S252
S
L
Y
D
P
V
E
S
K
F
I
S
E
N
Y
Site 23
S256
P
V
E
S
K
F
I
S
E
N
Y
L
V
R
W
Site 24
Y259
S
K
F
I
S
E
N
Y
L
V
R
W
S
S
S
Site 25
S264
E
N
Y
L
V
R
W
S
S
S
G
L
P
K
D
Site 26
S265
N
Y
L
V
R
W
S
S
S
G
L
P
K
D
I
Site 27
S266
Y
L
V
R
W
S
S
S
G
L
P
K
D
I
D
Site 28
T283
H
N
L
R
A
V
F
T
D
L
G
S
K
D
L
Site 29
S296
D
L
K
R
E
K
I
S
F
V
C
Q
I
V
R
Site 30
T314
M
E
L
R
D
N
N
T
R
K
L
T
S
G
L
Site 31
T318
D
N
N
T
R
K
L
T
S
G
L
R
R
P
F
Site 32
S319
N
N
T
R
K
L
T
S
G
L
R
R
P
F
G
Site 33
T384
K
G
Q
G
L
W
V
T
L
K
L
L
P
G
D
Site 34
T407
P
H
L
V
D
R
T
T
A
V
A
R
K
T
G
Site 35
Y429
G
D
V
R
N
D
I
Y
V
T
L
V
Q
G
D
Site 36
S441
Q
G
D
F
D
K
G
S
K
T
T
A
K
N
V
Site 37
T443
D
F
D
K
G
S
K
T
T
A
K
N
V
E
V
Site 38
S453
K
N
V
E
V
T
V
S
V
Y
D
E
D
G
K
Site 39
Y455
V
E
V
T
V
S
V
Y
D
E
D
G
K
R
L
Site 40
S476
G
A
G
D
E
A
I
S
E
Y
K
S
V
I
Y
Site 41
Y478
G
D
E
A
I
S
E
Y
K
S
V
I
Y
Y
Q
Site 42
S480
E
A
I
S
E
Y
K
S
V
I
Y
Y
Q
V
K
Site 43
Y483
S
E
Y
K
S
V
I
Y
Y
Q
V
K
Q
P
R
Site 44
Y484
E
Y
K
S
V
I
Y
Y
Q
V
K
Q
P
R
W
Site 45
T494
K
Q
P
R
W
F
E
T
V
K
V
A
I
P
I
Site 46
S507
P
I
E
D
V
N
R
S
H
L
R
F
T
F
R
Site 47
T512
N
R
S
H
L
R
F
T
F
R
H
R
S
S
Q
Site 48
S517
R
F
T
F
R
H
R
S
S
Q
D
S
K
D
K
Site 49
S518
F
T
F
R
H
R
S
S
Q
D
S
K
D
K
S
Site 50
S521
R
H
R
S
S
Q
D
S
K
D
K
S
E
K
I
Site 51
S525
S
Q
D
S
K
D
K
S
E
K
I
F
A
L
A
Site 52
Y539
A
F
V
K
L
M
R
Y
D
G
T
T
L
R
D
Site 53
T542
K
L
M
R
Y
D
G
T
T
L
R
D
G
E
H
Site 54
T543
L
M
R
Y
D
G
T
T
L
R
D
G
E
H
D
Site 55
T566
K
K
L
E
D
A
A
T
Y
L
S
L
P
S
T
Site 56
Y567
K
L
E
D
A
A
T
Y
L
S
L
P
S
T
K
Site 57
S569
E
D
A
A
T
Y
L
S
L
P
S
T
K
A
E
Site 58
T573
T
Y
L
S
L
P
S
T
K
A
E
L
E
E
K
Site 59
S583
E
L
E
E
K
G
H
S
A
T
G
K
S
M
Q
Site 60
S588
G
H
S
A
T
G
K
S
M
Q
S
L
G
S
C
Site 61
S591
A
T
G
K
S
M
Q
S
L
G
S
C
T
I
S
Site 62
S594
K
S
M
Q
S
L
G
S
C
T
I
S
K
D
S
Site 63
S598
S
L
G
S
C
T
I
S
K
D
S
F
Q
I
S
Site 64
S605
S
K
D
S
F
Q
I
S
T
L
V
C
S
T
K
Site 65
S627
L
G
L
L
K
W
R
S
N
T
S
L
L
Q
Q
Site 66
T629
L
L
K
W
R
S
N
T
S
L
L
Q
Q
N
L
Site 67
S668
I
M
M
E
N
S
E
S
E
T
F
D
T
L
V
Site 68
T670
M
E
N
S
E
S
E
T
F
D
T
L
V
F
D
Site 69
Y712
H
F
S
A
T
L
A
Y
T
K
L
T
K
V
L
Site 70
Y722
L
T
K
V
L
K
N
Y
V
D
G
A
E
K
P
Site 71
Y736
P
G
V
N
E
Q
L
Y
K
A
M
K
A
L
E
Site 72
Y760
R
I
L
F
N
Q
L
Y
E
N
K
G
E
A
D
Site 73
S784
R
S
I
N
D
M
M
S
S
M
S
D
Q
T
V
Site 74
S785
S
I
N
D
M
M
S
S
M
S
D
Q
T
V
R
Site 75
T790
M
S
S
M
S
D
Q
T
V
R
V
K
G
A
A
Site 76
T803
A
A
L
K
Y
L
P
T
I
V
N
D
V
K
L
Site 77
T851
I
V
H
S
D
L
F
T
Q
H
D
C
R
E
I
Site 78
Y892
S
H
I
L
E
V
L
Y
R
K
D
V
G
P
T
Site 79
T917
L
L
R
T
V
N
R
T
V
I
S
M
G
R
D
Site 80
S920
T
V
N
R
T
V
I
S
M
G
R
D
S
E
L
Site 81
Y945
I
L
R
Q
M
E
D
Y
H
Y
A
H
L
I
K
Site 82
Y947
R
Q
M
E
D
Y
H
Y
A
H
L
I
K
T
F
Site 83
T953
H
Y
A
H
L
I
K
T
F
G
K
M
R
T
D
Site 84
Y1003
F
L
R
A
I
N
Q
Y
A
D
M
L
N
K
K
Site 85
S1045
L
Q
L
E
N
F
S
S
A
K
R
A
K
I
L
Site 86
Y1055
R
A
K
I
L
N
K
Y
G
D
M
R
R
Q
I
Site 87
T1103
E
T
E
L
R
K
A
T
I
P
I
F
F
D
M
Site 88
Y1145
G
G
R
G
D
E
Q
Y
K
V
L
F
D
K
I
Site 89
Y1162
E
H
C
R
K
H
K
Y
L
A
K
T
G
E
T
Site 90
Y1184
L
M
E
R
L
L
D
Y
R
T
I
M
H
D
E
Site 91
T1186
E
R
L
L
D
Y
R
T
I
M
H
D
E
N
K
Site 92
Y1216
E
I
E
R
E
E
M
Y
I
R
Y
L
Y
K
L
Site 93
Y1219
R
E
E
M
Y
I
R
Y
L
Y
K
L
C
D
L
Site 94
Y1221
E
M
Y
I
R
Y
L
Y
K
L
C
D
L
H
K
Site 95
Y1233
L
H
K
E
C
D
N
Y
T
E
A
A
Y
T
L
Site 96
T1234
H
K
E
C
D
N
Y
T
E
A
A
Y
T
L
L
Site 97
T1259
D
V
C
V
A
H
L
T
Q
R
D
G
Y
Q
A
Site 98
Y1264
H
L
T
Q
R
D
G
Y
Q
A
T
T
Q
G
Q
Site 99
T1267
Q
R
D
G
Y
Q
A
T
T
Q
G
Q
L
K
E
Site 100
Y1277
G
Q
L
K
E
Q
L
Y
Q
E
I
I
H
Y
F
Site 101
Y1283
L
Y
Q
E
I
I
H
Y
F
D
K
G
K
M
W
Site 102
Y1311
Y
E
N
E
M
F
D
Y
E
Q
L
S
E
L
L
Site 103
Y1338
V
I
R
P
K
P
D
Y
F
A
V
G
Y
Y
G
Site 104
Y1343
P
D
Y
F
A
V
G
Y
Y
G
Q
G
F
P
T
Site 105
Y1344
D
Y
F
A
V
G
Y
Y
G
Q
G
F
P
T
F
Site 106
T1350
Y
Y
G
Q
G
F
P
T
F
L
R
G
K
V
F
Site 107
Y1364
F
I
Y
R
G
K
E
Y
E
R
R
E
D
F
E
Site 108
T1376
D
F
E
A
R
L
L
T
Q
F
P
N
A
E
K
Site 109
T1386
P
N
A
E
K
M
K
T
T
S
P
P
G
D
D
Site 110
S1388
A
E
K
M
K
T
T
S
P
P
G
D
D
I
K
Site 111
S1397
P
G
D
D
I
K
N
S
P
G
Q
Y
I
Q
C
Site 112
Y1401
I
K
N
S
P
G
Q
Y
I
Q
C
F
T
V
K
Site 113
T1406
G
Q
Y
I
Q
C
F
T
V
K
P
K
L
D
L
Site 114
S1422
P
K
F
H
R
P
V
S
E
Q
I
V
S
F
Y
Site 115
S1427
P
V
S
E
Q
I
V
S
F
Y
R
V
N
E
V
Site 116
Y1439
N
E
V
Q
R
F
E
Y
S
R
P
I
R
K
G
Site 117
Y1464
M
W
I
E
R
T
I
Y
T
T
A
Y
K
L
P
Site 118
T1466
I
E
R
T
I
Y
T
T
A
Y
K
L
P
G
I
Site 119
Y1468
R
T
I
Y
T
T
A
Y
K
L
P
G
I
L
R
Site 120
T1500
A
I
E
T
M
Q
L
T
N
D
K
I
N
S
M
Site 121
S1516
Q
Q
H
L
D
D
P
S
L
P
I
N
P
L
S
Site 122
Y1550
K
A
F
F
T
D
R
Y
L
Q
E
H
P
E
A
Site 123
T1587
R
I
H
G
D
K
V
T
E
A
L
R
P
F
H
Site 124
S1619
Y
G
V
R
I
M
P
S
S
L
D
D
R
R
G
Site 125
S1620
G
V
R
I
M
P
S
S
L
D
D
R
R
G
S
Site 126
S1627
S
L
D
D
R
R
G
S
R
P
R
S
M
V
R
Site 127
S1631
R
R
G
S
R
P
R
S
M
V
R
S
F
T
M
Site 128
S1635
R
P
R
S
M
V
R
S
F
T
M
P
S
S
S
Site 129
T1637
R
S
M
V
R
S
F
T
M
P
S
S
S
R
P
Site 130
S1640
V
R
S
F
T
M
P
S
S
S
R
P
L
S
V
Site 131
S1641
R
S
F
T
M
P
S
S
S
R
P
L
S
V
A
Site 132
S1642
S
F
T
M
P
S
S
S
R
P
L
S
V
A
S
Site 133
S1646
P
S
S
S
R
P
L
S
V
A
S
V
S
S
L
Site 134
S1649
S
R
P
L
S
V
A
S
V
S
S
L
S
S
D
Site 135
S1654
V
A
S
V
S
S
L
S
S
D
S
T
P
S
R
Site 136
S1655
A
S
V
S
S
L
S
S
D
S
T
P
S
R
P
Site 137
S1657
V
S
S
L
S
S
D
S
T
P
S
R
P
G
S
Site 138
T1658
S
S
L
S
S
D
S
T
P
S
R
P
G
S
D
Site 139
S1660
L
S
S
D
S
T
P
S
R
P
G
S
D
G
F
Site 140
S1664
S
T
P
S
R
P
G
S
D
G
F
A
L
E
P
Site 141
S1681
P
K
K
M
H
S
R
S
Q
D
K
L
D
K
D
Site 142
S1704
K
K
K
E
K
R
N
S
K
H
Q
E
I
F
E
Site 143
T1717
F
E
K
E
F
K
P
T
D
I
S
L
Q
Q
S
Site 144
S1720
E
F
K
P
T
D
I
S
L
Q
Q
S
E
A
V
Site 145
S1724
T
D
I
S
L
Q
Q
S
E
A
V
I
L
S
E
Site 146
S1730
Q
S
E
A
V
I
L
S
E
T
I
S
P
L
R
Site 147
T1732
E
A
V
I
L
S
E
T
I
S
P
L
R
P
Q
Site 148
S1734
V
I
L
S
E
T
I
S
P
L
R
P
Q
R
P
Site 149
S1743
L
R
P
Q
R
P
K
S
Q
V
M
N
V
I
G
Site 150
S1751
Q
V
M
N
V
I
G
S
E
R
R
F
S
V
S
Site 151
S1756
I
G
S
E
R
R
F
S
V
S
P
S
S
P
S
Site 152
S1758
S
E
R
R
F
S
V
S
P
S
S
P
S
S
Q
Site 153
S1760
R
R
F
S
V
S
P
S
S
P
S
S
Q
Q
T
Site 154
S1761
R
F
S
V
S
P
S
S
P
S
S
Q
Q
T
P
Site 155
S1763
S
V
S
P
S
S
P
S
S
Q
Q
T
P
P
P
Site 156
S1764
V
S
P
S
S
P
S
S
Q
Q
T
P
P
P
V
Site 157
T1767
S
S
P
S
S
Q
Q
T
P
P
P
V
T
P
R
Site 158
T1772
Q
Q
T
P
P
P
V
T
P
R
A
K
L
S
F
Site 159
S1778
V
T
P
R
A
K
L
S
F
S
M
Q
S
S
L
Site 160
S1780
P
R
A
K
L
S
F
S
M
Q
S
S
L
E
L
Site 161
S1783
K
L
S
F
S
M
Q
S
S
L
E
L
N
G
M
Site 162
S1784
L
S
F
S
M
Q
S
S
L
E
L
N
G
M
T
Site 163
S1807
P
P
L
P
L
K
G
S
V
A
D
Y
G
N
L
Site 164
Y1811
L
K
G
S
V
A
D
Y
G
N
L
M
E
N
Q
Site 165
S1823
E
N
Q
D
L
L
G
S
P
T
P
P
P
P
P
Site 166
T1825
Q
D
L
L
G
S
P
T
P
P
P
P
P
P
H
Site 167
S1842
H
L
P
P
P
L
P
S
K
T
P
P
P
P
P
Site 168
T1844
P
P
P
L
P
S
K
T
P
P
P
P
P
P
K
Site 169
T1852
P
P
P
P
P
P
K
T
T
R
K
Q
A
S
V
Site 170
S1858
K
T
T
R
K
Q
T
S
V
D
S
G
I
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation