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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CRMP1
Full Name:
Dihydropyrimidinase-related protein 1
Alias:
Dihydropyrimidinase related protein-1; DPY1; DPYL1; DPYSL1; DRP-1
Type:
Enzyme, hydrolase
Mass (Da):
62184
Number AA:
572
UniProt ID:
Q14194
International Prot ID:
IPI00414123
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0005819
Uniprot
OncoNet
Molecular Function:
GO:0004157
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0006139
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Y
Q
G
K
K
S
I
Site 2
S8
M
S
Y
Q
G
K
K
S
I
P
H
I
T
S
D
Site 3
T13
K
K
S
I
P
H
I
T
S
D
R
L
L
I
K
Site 4
S14
K
S
I
P
H
I
T
S
D
R
L
L
I
K
G
Site 5
S30
R
I
I
N
D
D
Q
S
L
Y
A
D
V
Y
L
Site 6
Y32
I
N
D
D
Q
S
L
Y
A
D
V
Y
L
E
D
Site 7
Y36
Q
S
L
Y
A
D
V
Y
L
E
D
G
L
I
K
Site 8
T74
P
G
G
I
D
V
N
T
Y
L
Q
K
P
S
Q
Site 9
Y75
G
G
I
D
V
N
T
Y
L
Q
K
P
S
Q
G
Site 10
T84
Q
K
P
S
Q
G
M
T
A
A
D
D
F
F
Q
Site 11
T101
R
A
A
L
V
G
G
T
T
M
I
I
D
H
V
Site 12
T102
A
A
L
V
G
G
T
T
M
I
I
D
H
V
V
Site 13
S114
H
V
V
P
E
P
G
S
S
L
L
T
S
F
E
Site 14
S115
V
V
P
E
P
G
S
S
L
L
T
S
F
E
K
Site 15
T118
E
P
G
S
S
L
L
T
S
F
E
K
W
H
E
Site 16
S119
P
G
S
S
L
L
T
S
F
E
K
W
H
E
A
Site 17
Y135
D
T
K
S
C
C
D
Y
S
L
H
V
D
I
T
Site 18
S143
S
L
H
V
D
I
T
S
W
Y
D
G
V
R
E
Site 19
Y145
H
V
D
I
T
S
W
Y
D
G
V
R
E
E
L
Site 20
Y167
G
V
N
S
F
Q
V
Y
M
A
Y
K
D
V
Y
Site 21
Y170
S
F
Q
V
Y
M
A
Y
K
D
V
Y
Q
M
S
Site 22
Y174
Y
M
A
Y
K
D
V
Y
Q
M
S
D
S
Q
L
Site 23
S177
Y
K
D
V
Y
Q
M
S
D
S
Q
L
Y
E
A
Site 24
S179
D
V
Y
Q
M
S
D
S
Q
L
Y
E
A
F
T
Site 25
Y182
Q
M
S
D
S
Q
L
Y
E
A
F
T
F
L
K
Site 26
S226
G
P
E
G
H
A
L
S
R
P
E
E
L
E
A
Site 27
Y251
G
R
I
N
C
P
V
Y
I
T
K
V
M
S
K
Site 28
T253
I
N
C
P
V
Y
I
T
K
V
M
S
K
S
A
Site 29
S257
V
Y
I
T
K
V
M
S
K
S
A
A
D
I
I
Site 30
S259
I
T
K
V
M
S
K
S
A
A
D
I
I
A
L
Site 31
S282
F
G
E
P
I
A
A
S
L
G
T
D
G
T
H
Site 32
Y290
L
G
T
D
G
T
H
Y
W
S
K
N
W
A
K
Site 33
S304
K
A
A
A
F
V
T
S
P
P
L
S
P
D
P
Site 34
S308
F
V
T
S
P
P
L
S
P
D
P
T
T
P
D
Site 35
T312
P
P
L
S
P
D
P
T
T
P
D
Y
L
T
S
Site 36
T313
P
L
S
P
D
P
T
T
P
D
Y
L
T
S
L
Site 37
Y316
P
D
P
T
T
P
D
Y
L
T
S
L
L
A
C
Site 38
T318
P
T
T
P
D
Y
L
T
S
L
L
A
C
G
D
Site 39
S331
G
D
L
Q
V
T
G
S
G
H
C
P
Y
S
T
Site 40
Y336
T
G
S
G
H
C
P
Y
S
T
A
Q
K
A
V
Site 41
S337
G
S
G
H
C
P
Y
S
T
A
Q
K
A
V
G
Site 42
T338
S
G
H
C
P
Y
S
T
A
Q
K
A
V
G
K
Site 43
T349
A
V
G
K
D
N
F
T
L
I
P
E
G
V
N
Site 44
T363
N
G
I
E
E
R
M
T
V
V
W
D
K
A
V
Site 45
Y395
A
A
K
I
F
N
L
Y
P
R
K
G
R
I
A
Site 46
T419
W
D
P
D
K
L
K
T
I
T
A
K
S
H
K
Site 47
S424
L
K
T
I
T
A
K
S
H
K
S
A
V
E
Y
Site 48
S427
I
T
A
K
S
H
K
S
A
V
E
Y
N
I
F
Site 49
Y431
S
H
K
S
A
V
E
Y
N
I
F
E
G
M
E
Site 50
S442
E
G
M
E
C
H
G
S
P
L
V
V
I
S
Q
Site 51
Y479
K
A
F
P
E
H
L
Y
Q
R
V
K
I
R
N
Site 52
S495
V
F
G
L
Q
G
V
S
R
G
M
Y
D
G
P
Site 53
Y499
Q
G
V
S
R
G
M
Y
D
G
P
V
Y
E
V
Site 54
Y504
G
M
Y
D
G
P
V
Y
E
V
P
A
T
P
K
Site 55
T509
P
V
Y
E
V
P
A
T
P
K
Y
A
T
P
A
Site 56
Y512
E
V
P
A
T
P
K
Y
A
T
P
A
P
S
A
Site 57
T514
P
A
T
P
K
Y
A
T
P
A
P
S
A
K
S
Site 58
S518
K
Y
A
T
P
A
P
S
A
K
S
S
P
S
K
Site 59
S521
T
P
A
P
S
A
K
S
S
P
S
K
H
Q
P
Site 60
S522
P
A
P
S
A
K
S
S
P
S
K
H
Q
P
P
Site 61
S524
P
S
A
K
S
S
P
S
K
H
Q
P
P
P
I
Site 62
S537
P
I
R
N
L
H
Q
S
N
F
S
L
S
G
A
Site 63
S540
N
L
H
Q
S
N
F
S
L
S
G
A
Q
I
D
Site 64
S542
H
Q
S
N
F
S
L
S
G
A
Q
I
D
D
N
Site 65
T554
D
D
N
N
P
R
R
T
G
H
R
I
V
A
P
Site 66
S566
V
A
P
P
G
G
R
S
N
I
T
S
L
G
_
Site 67
S570
G
G
R
S
N
I
T
S
L
G
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation