KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
TRIM25
Full Name:
E3 ubiquitin/ISG15 ligase TRIM25
Alias:
Efp; EFP; Estrogen responsive finger protein; TRI25; Tripartite motif protein 25; Zinc finger protein 147
Type:
Transcription protein
Mass (Da):
70989
Number AA:
630
UniProt ID:
Q14258
International Prot ID:
IPI00029629
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005925
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T25
E
P
F
K
E
P
V
T
T
P
C
G
H
N
F
Site 2
T26
P
F
K
E
P
V
T
T
P
C
G
H
N
F
C
Site 3
S46
E
T
W
A
V
Q
G
S
P
Y
L
C
P
Q
C
Site 4
Y48
W
A
V
Q
G
S
P
Y
L
C
P
Q
C
R
A
Site 5
Y57
C
P
Q
C
R
A
V
Y
Q
A
R
P
Q
L
H
Site 6
T91
E
P
P
A
D
V
W
T
P
P
A
R
A
S
A
Site 7
S97
W
T
P
P
A
R
A
S
A
P
S
P
N
A
Q
Site 8
S100
P
A
R
A
S
A
P
S
P
N
A
Q
V
A
C
Site 9
S137
H
L
Q
P
H
F
D
S
P
A
F
Q
D
H
P
Site 10
S158
D
L
L
R
R
K
C
S
Q
H
N
R
L
R
E
Site 11
S187
L
V
E
H
K
T
C
S
P
A
S
L
S
Q
A
Site 12
S190
H
K
T
C
S
P
A
S
L
S
Q
A
S
A
D
Site 13
S192
T
C
S
P
A
S
L
S
Q
A
S
A
D
L
E
Site 14
T201
A
S
A
D
L
E
A
T
L
R
H
K
L
T
V
Site 15
T207
A
T
L
R
H
K
L
T
V
M
Y
S
Q
I
N
Site 16
S211
H
K
L
T
V
M
Y
S
Q
I
N
G
A
S
R
Site 17
T233
R
Q
Q
D
V
R
M
T
A
N
R
K
V
E
Q
Site 18
Y245
V
E
Q
L
Q
Q
E
Y
T
E
M
K
A
L
L
Site 19
T246
E
Q
L
Q
Q
E
Y
T
E
M
K
A
L
L
D
Site 20
S255
M
K
A
L
L
D
A
S
E
T
T
S
T
R
K
Site 21
T258
L
L
D
A
S
E
T
T
S
T
R
K
I
K
E
Site 22
S259
L
D
A
S
E
T
T
S
T
R
K
I
K
E
E
Site 23
S272
E
E
E
K
R
V
N
S
K
F
D
T
I
Y
Q
Site 24
T276
R
V
N
S
K
F
D
T
I
Y
Q
I
L
L
K
Site 25
Y278
N
S
K
F
D
T
I
Y
Q
I
L
L
K
K
K
Site 26
S286
Q
I
L
L
K
K
K
S
E
I
Q
T
L
K
E
Site 27
T290
K
K
K
S
E
I
Q
T
L
K
E
E
I
E
Q
Site 28
S298
L
K
E
E
I
E
Q
S
L
T
K
R
D
E
F
Site 29
T300
E
E
I
E
Q
S
L
T
K
R
D
E
F
E
F
Site 30
S312
F
E
F
L
E
K
A
S
K
L
R
G
I
S
T
Site 31
S318
A
S
K
L
R
G
I
S
T
K
P
V
Y
I
P
Site 32
T319
S
K
L
R
G
I
S
T
K
P
V
Y
I
P
E
Site 33
Y323
G
I
S
T
K
P
V
Y
I
P
E
V
E
L
N
Site 34
S340
L
I
K
G
I
H
Q
S
T
I
D
L
K
N
E
Site 35
T359
I
G
R
L
Q
E
L
T
P
S
S
G
D
P
G
Site 36
S361
R
L
Q
E
L
T
P
S
S
G
D
P
G
E
H
Site 37
S362
L
Q
E
L
T
P
S
S
G
D
P
G
E
H
D
Site 38
S372
P
G
E
H
D
P
A
S
T
H
K
S
T
R
P
Site 39
S376
D
P
A
S
T
H
K
S
T
R
P
V
K
K
V
Site 40
S384
T
R
P
V
K
K
V
S
K
E
E
K
K
S
K
Site 41
S390
V
S
K
E
E
K
K
S
K
K
P
P
P
V
P
Site 42
T405
A
L
P
S
K
L
P
T
F
G
A
P
E
Q
L
Site 43
S429
A
A
A
K
A
T
S
S
H
P
N
S
T
S
L
Site 44
S433
A
T
S
S
H
P
N
S
T
S
L
K
A
K
V
Site 45
T434
T
S
S
H
P
N
S
T
S
L
K
A
K
V
L
Site 46
S435
S
S
H
P
N
S
T
S
L
K
A
K
V
L
E
Site 47
T443
L
K
A
K
V
L
E
T
F
L
A
K
S
R
P
Site 48
S448
L
E
T
F
L
A
K
S
R
P
E
L
L
E
Y
Site 49
Y455
S
R
P
E
L
L
E
Y
Y
I
K
V
I
L
D
Site 50
Y456
R
P
E
L
L
E
Y
Y
I
K
V
I
L
D
Y
Site 51
Y463
Y
I
K
V
I
L
D
Y
N
T
A
H
N
K
V
Site 52
T496
R
P
H
P
Q
R
F
T
Y
C
S
Q
V
L
G
Site 53
Y497
P
H
P
Q
R
F
T
Y
C
S
Q
V
L
G
L
Site 54
Y513
C
Y
K
K
G
I
H
Y
W
E
V
E
L
Q
K
Site 55
S540
M
N
R
Q
G
P
E
S
R
L
G
R
N
S
A
Site 56
S546
E
S
R
L
G
R
N
S
A
S
W
C
V
E
W
Site 57
T568
W
H
N
N
V
E
K
T
L
P
S
T
K
A
T
Site 58
T608
Y
K
F
R
V
D
F
T
E
A
L
Y
P
A
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation