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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
mGluR2
Full Name:
Metabotropic glutamate receptor 2
Alias:
glutamate receptor, metabotropic 2; GPRC1B; GRM2; metabotropic glutamate receptor 2; mGlu2; MGLUR2; MGR2
Type:
G protein-coupled 7TM receptor, glutamate
Mass (Da):
95568
Number AA:
872
UniProt ID:
Q14416
International Prot ID:
IPI00030834
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008067
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007194
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S91
L
G
A
H
I
L
D
S
C
S
K
D
T
H
A
Site 2
S93
A
H
I
L
D
S
C
S
K
D
T
H
A
L
E
Site 3
S109
A
L
D
F
V
R
A
S
L
S
R
G
A
D
G
Site 4
S111
D
F
V
R
A
S
L
S
R
G
A
D
G
S
R
Site 5
S117
L
S
R
G
A
D
G
S
R
H
I
C
P
D
G
Site 6
Y126
H
I
C
P
D
G
S
Y
A
T
H
G
D
A
P
Site 7
S164
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
Site 8
S167
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
Site 9
T168
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
Site 10
S169
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
Site 11
S173
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
Site 12
S176
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
Site 13
Y180
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
Site 14
T184
R
Y
D
Y
F
A
R
T
V
P
P
D
F
F
Q
Site 15
T209
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
Site 16
S212
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
Site 17
Y216
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
Site 18
S238
R
N
I
C
V
A
T
S
E
K
V
G
R
A
M
Site 19
S246
E
K
V
G
R
A
M
S
R
A
A
F
E
G
V
Site 20
S282
A
R
E
L
L
A
A
S
Q
R
L
N
A
S
F
Site 21
S288
A
S
Q
R
L
N
A
S
F
T
W
V
A
S
D
Site 22
T290
Q
R
L
N
A
S
F
T
W
V
A
S
D
G
W
Site 23
S302
D
G
W
G
A
L
E
S
V
V
A
G
S
E
G
Site 24
S325
E
L
A
S
Y
P
I
S
D
F
A
S
Y
F
Q
Site 25
S329
Y
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
Site 26
Y330
P
I
S
D
F
A
S
Y
F
Q
S
L
D
P
W
Site 27
S366
Q
R
D
C
A
A
H
S
L
R
A
V
P
F
E
Site 28
Y419
P
V
N
G
R
R
L
Y
K
D
F
V
L
N
V
Site 29
Y453
F
G
D
G
I
G
R
Y
N
I
F
T
Y
L
R
Site 30
T457
I
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
Site 31
Y458
G
R
Y
N
I
F
T
Y
L
R
A
G
S
G
R
Site 32
S463
F
T
Y
L
R
A
G
S
G
R
Y
R
Y
Q
K
Site 33
Y468
A
G
S
G
R
Y
R
Y
Q
K
V
G
Y
W
A
Site 34
Y473
Y
R
Y
Q
K
V
G
Y
W
A
E
G
L
T
L
Site 35
S498
S
A
G
P
L
P
A
S
R
C
S
E
P
C
L
Site 36
S501
P
L
P
A
S
R
C
S
E
P
C
L
Q
N
E
Site 37
S511
C
L
Q
N
E
V
K
S
V
Q
P
G
E
V
C
Site 38
Y528
L
C
I
P
C
Q
P
Y
E
Y
R
L
D
E
F
Site 39
T551
Y
W
P
N
A
S
L
T
G
C
F
E
L
P
Q
Site 40
S675
A
Q
R
P
R
F
I
S
P
A
S
Q
V
A
I
Site 41
T705
L
V
V
E
A
P
G
T
G
K
E
T
A
P
E
Site 42
T718
P
E
R
R
E
V
V
T
L
R
C
N
H
R
D
Site 43
S727
R
C
N
H
R
D
A
S
M
L
G
S
L
A
Y
Site 44
S785
P
I
F
Y
V
T
S
S
D
Y
R
V
Q
T
T
Site 45
Y787
F
Y
V
T
S
S
D
Y
R
V
Q
T
T
T
M
Site 46
T791
S
S
D
Y
R
V
Q
T
T
T
M
C
V
S
V
Site 47
S827
Q
P
Q
K
N
V
V
S
H
R
A
P
T
S
R
Site 48
T832
V
V
S
H
R
A
P
T
S
R
F
G
S
A
A
Site 49
S833
V
S
H
R
A
P
T
S
R
F
G
S
A
A
A
Site 50
S837
A
P
T
S
R
F
G
S
A
A
A
R
A
S
S
Site 51
S843
G
S
A
A
A
R
A
S
S
S
L
G
Q
G
S
Site 52
S844
S
A
A
A
R
A
S
S
S
L
G
Q
G
S
G
Site 53
S845
A
A
A
R
A
S
S
S
L
G
Q
G
S
G
S
Site 54
S850
S
S
S
L
G
Q
G
S
G
S
Q
F
V
P
T
Site 55
T857
S
G
S
Q
F
V
P
T
V
C
N
G
R
E
V
Site 56
S867
N
G
R
E
V
V
D
S
T
T
S
S
L
_
_
Site 57
T868
G
R
E
V
V
D
S
T
T
S
S
L
_
_
_
Site 58
S871
V
V
D
S
T
T
S
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation