KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Grb14
Full Name:
Growth factor receptor-bound protein 14
Alias:
GRB14 adapter protein
Type:
Adapter/scaffold protein
Mass (Da):
60988
Number AA:
540
UniProt ID:
Q14449
International Prot ID:
IPI00030917
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
T
S
L
Q
D
G
Q
S
A
A
S
R
A
A
A
Site 2
S20
S
R
A
A
A
R
D
S
P
L
A
A
Q
V
C
Site 3
S95
S
P
F
T
S
V
L
S
A
D
L
F
P
K
A
Site 4
Y113
K
K
Q
V
I
K
V
Y
S
E
D
E
T
S
R
Site 5
S114
K
Q
V
I
K
V
Y
S
E
D
E
T
S
R
A
Site 6
T118
K
V
Y
S
E
D
E
T
S
R
A
L
D
V
P
Site 7
Y143
L
L
I
L
K
N
H
Y
I
D
D
H
S
W
T
Site 8
Y186
I
E
E
E
N
K
L
Y
F
R
K
N
Y
A
K
Site 9
Y191
K
L
Y
F
R
K
N
Y
A
K
Y
E
F
F
K
Site 10
Y194
F
R
K
N
Y
A
K
Y
E
F
F
K
N
P
M
Site 11
S210
F
F
P
E
H
M
V
S
F
A
T
E
T
N
G
Site 12
S220
T
E
T
N
G
E
I
S
P
T
Q
I
L
Q
M
Site 13
S232
L
Q
M
F
L
S
S
S
T
Y
P
E
I
H
G
Site 14
Y255
K
K
S
W
K
K
I
Y
F
F
L
R
R
S
G
Site 15
Y264
F
L
R
R
S
G
L
Y
F
S
T
K
G
T
S
Site 16
S266
R
R
S
G
L
Y
F
S
T
K
G
T
S
K
E
Site 17
S281
P
R
H
L
Q
F
F
S
E
F
G
N
S
D
I
Site 18
Y289
E
F
G
N
S
D
I
Y
V
S
L
A
G
K
K
Site 19
S291
G
N
S
D
I
Y
V
S
L
A
G
K
K
K
H
Site 20
Y304
K
H
G
A
P
T
N
Y
G
F
C
F
K
P
N
Site 21
T331
A
E
E
E
Q
S
R
T
C
W
V
T
A
I
R
Site 22
T335
Q
S
R
T
C
W
V
T
A
I
R
L
L
K
Y
Site 23
Y342
T
A
I
R
L
L
K
Y
G
M
Q
L
Y
Q
N
Site 24
Y347
L
K
Y
G
M
Q
L
Y
Q
N
Y
M
H
P
Y
Site 25
Y350
G
M
Q
L
Y
Q
N
Y
M
H
P
Y
Q
G
R
Site 26
Y354
Y
Q
N
Y
M
H
P
Y
Q
G
R
S
G
C
S
Site 27
S358
M
H
P
Y
Q
G
R
S
G
C
S
S
Q
S
I
Site 28
S362
Q
G
R
S
G
C
S
S
Q
S
I
S
P
M
R
Site 29
S364
R
S
G
C
S
S
Q
S
I
S
P
M
R
S
I
Site 30
S366
G
C
S
S
Q
S
I
S
P
M
R
S
I
S
E
Site 31
S370
Q
S
I
S
P
M
R
S
I
S
E
N
S
L
V
Site 32
S372
I
S
P
M
R
S
I
S
E
N
S
L
V
A
M
Site 33
S375
M
R
S
I
S
E
N
S
L
V
A
M
D
F
S
Site 34
S386
M
D
F
S
G
Q
K
S
R
V
I
E
N
P
T
Site 35
S397
E
N
P
T
E
A
L
S
V
A
V
E
E
G
L
Site 36
T416
K
G
C
L
R
L
G
T
H
G
S
P
T
A
S
Site 37
S419
L
R
L
G
T
H
G
S
P
T
A
S
S
Q
S
Site 38
T421
L
G
T
H
G
S
P
T
A
S
S
Q
S
S
A
Site 39
S423
T
H
G
S
P
T
A
S
S
Q
S
S
A
T
N
Site 40
S424
H
G
S
P
T
A
S
S
Q
S
S
A
T
N
M
Site 41
S427
P
T
A
S
S
Q
S
S
A
T
N
M
A
I
H
Site 42
S468
G
V
F
L
V
R
D
S
Q
S
N
P
K
T
F
Site 43
S470
F
L
V
R
D
S
Q
S
N
P
K
T
F
V
L
Site 44
T474
D
S
Q
S
N
P
K
T
F
V
L
S
M
S
H
Site 45
S478
N
P
K
T
F
V
L
S
M
S
H
G
Q
K
I
Site 46
T502
D
D
G
E
M
F
H
T
L
D
D
G
H
T
R
Site 47
T511
D
D
G
H
T
R
F
T
D
L
I
Q
L
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation