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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRB7
Full Name:
Growth factor receptor-bound protein 7
Alias:
B47; Epidermal growth factor receptor GRB-7; GRB7 adapter protein
Type:
Adapter/scaffold protein
Mass (Da):
59681
Number AA:
532
UniProt ID:
Q14451
International Prot ID:
IPI00448767
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005070
PhosphoSite+
KinaseNET
Biological Process:
GO:0007173
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
E
L
D
L
S
P
P
H
L
S
S
S
Site 2
S11
D
L
S
P
P
H
L
S
S
S
P
E
D
L
C
Site 3
S12
L
S
P
P
H
L
S
S
S
P
E
D
L
C
P
Site 4
S13
S
P
P
H
L
S
S
S
P
E
D
L
C
P
A
Site 5
T23
D
L
C
P
A
P
G
T
P
P
G
T
P
R
P
Site 6
T27
A
P
G
T
P
P
G
T
P
R
P
P
D
T
P
Site 7
T33
G
T
P
R
P
P
D
T
P
L
P
E
E
V
K
Site 8
S42
L
P
E
E
V
K
R
S
Q
P
L
L
I
P
T
Site 9
T49
S
Q
P
L
L
I
P
T
T
G
R
K
L
R
E
Site 10
T50
Q
P
L
L
I
P
T
T
G
R
K
L
R
E
E
Site 11
T62
R
E
E
E
R
R
A
T
S
L
P
S
I
P
N
Site 12
S63
E
E
E
R
R
A
T
S
L
P
S
I
P
N
P
Site 13
S76
N
P
F
P
E
L
C
S
P
P
S
Q
S
P
I
Site 14
S79
P
E
L
C
S
P
P
S
Q
S
P
I
L
G
G
Site 15
S81
L
C
S
P
P
S
Q
S
P
I
L
G
G
P
S
Site 16
S89
P
I
L
G
G
P
S
S
A
R
G
L
L
P
R
Site 17
S99
G
L
L
P
R
D
A
S
R
P
H
V
V
K
V
Site 18
Y107
R
P
H
V
V
K
V
Y
S
E
D
G
A
C
R
Site 19
S108
P
H
V
V
K
V
Y
S
E
D
G
A
C
R
S
Site 20
S115
S
E
D
G
A
C
R
S
V
E
V
A
A
G
A
Site 21
S139
V
Q
R
A
H
A
L
S
D
E
T
W
G
L
V
Site 22
S163
R
G
L
E
D
H
E
S
V
V
E
V
Q
A
A
Site 23
Y188
F
R
K
N
F
A
K
Y
E
L
F
K
S
S
P
Site 24
S193
A
K
Y
E
L
F
K
S
S
P
H
S
L
F
P
Site 25
S194
K
Y
E
L
F
K
S
S
P
H
S
L
F
P
E
Site 26
S197
L
F
K
S
S
P
H
S
L
F
P
E
K
M
V
Site 27
T212
S
S
C
L
D
A
H
T
G
I
S
H
E
D
L
Site 28
S228
Q
N
F
L
N
A
G
S
F
P
E
I
Q
G
F
Site 29
S241
G
F
L
Q
L
R
G
S
G
R
K
L
W
K
R
Site 30
Y259
F
L
R
R
S
G
L
Y
Y
S
T
K
G
T
S
Site 31
Y260
L
R
R
S
G
L
Y
Y
S
T
K
G
T
S
K
Site 32
S261
R
R
S
G
L
Y
Y
S
T
K
G
T
S
K
D
Site 33
Y274
K
D
P
R
H
L
Q
Y
V
A
D
V
N
E
S
Site 34
Y284
D
V
N
E
S
N
V
Y
V
V
T
Q
G
R
K
Site 35
T287
E
S
N
V
Y
V
V
T
Q
G
R
K
L
Y
G
Site 36
Y293
V
T
Q
G
R
K
L
Y
G
M
P
T
D
F
G
Site 37
T297
R
K
L
Y
G
M
P
T
D
F
G
F
C
V
K
Site 38
S320
K
G
L
R
I
F
C
S
E
D
E
Q
S
R
T
Site 39
T327
S
E
D
E
Q
S
R
T
C
W
L
A
A
F
R
Site 40
Y338
A
A
F
R
L
F
K
Y
G
V
Q
L
Y
K
N
Site 41
Y343
F
K
Y
G
V
Q
L
Y
K
N
Y
Q
Q
A
Q
Site 42
S357
Q
S
R
H
L
H
P
S
C
L
G
S
P
P
L
Site 43
S361
L
H
P
S
C
L
G
S
P
P
L
R
S
A
S
Site 44
S366
L
G
S
P
P
L
R
S
A
S
D
N
T
L
V
Site 45
S368
S
P
P
L
R
S
A
S
D
N
T
L
V
A
M
Site 46
T371
L
R
S
A
S
D
N
T
L
V
A
M
D
F
S
Site 47
S393
E
N
P
R
E
A
L
S
V
A
L
E
E
A
Q
Site 48
T406
A
Q
A
W
R
K
K
T
N
H
R
L
S
L
P
Site 49
S411
K
K
T
N
H
R
L
S
L
P
M
P
A
S
G
Site 50
S417
L
S
L
P
M
P
A
S
G
T
S
L
S
A
A
Site 51
S420
P
M
P
A
S
G
T
S
L
S
A
A
I
H
R
Site 52
S437
L
W
F
H
G
R
I
S
R
E
E
S
Q
R
L
Site 53
S441
G
R
I
S
R
E
E
S
Q
R
L
I
G
Q
Q
Site 54
S460
G
L
F
L
V
R
E
S
Q
R
N
P
Q
G
F
Site 55
S485
K
H
Y
L
I
L
P
S
E
E
E
G
R
L
Y
Site 56
Y492
S
E
E
E
G
R
L
Y
F
S
M
D
D
G
Q
Site 57
S494
E
E
G
R
L
Y
F
S
M
D
D
G
Q
T
R
Site 58
T503
D
D
G
Q
T
R
F
T
D
L
L
Q
L
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation