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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BECN1
Full Name:
Beclin-1
Alias:
Coiled-coil myosin-like BCL2-interacting; Coiled-coil myosin-like BCL2-interacting protein; GT197; VPS30
Type:
Membrane protein, peripheral, Autophagy, Adaptor/scaffold
Mass (Da):
51896
Number AA:
450
UniProt ID:
Q14457
International Prot ID:
IPI00291235
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006968
GO:0009615
Phosida
TranscriptoNet
STRING
Kinexus Products
Beclin-1 pan-specific antibody AB-NN217-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN217-1#Beclin-1 pan-specific antibody AB-NN217-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN217-2
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
S
K
T
S
N
N
S
T
M
Q
V
S
F
V
Site 2
T11
S
K
T
S
N
N
S
T
M
Q
V
S
F
V
C
Site 3
S22
S
F
V
C
Q
R
C
S
Q
P
L
K
L
D
T
Site 4
T29
S
Q
P
L
K
L
D
T
S
F
K
I
L
D
R
Site 5
S30
Q
P
L
K
L
D
T
S
F
K
I
L
D
R
V
Site 6
T38
F
K
I
L
D
R
V
T
I
Q
E
L
T
A
P
Site 7
T57
A
Q
A
K
P
G
E
T
Q
E
E
E
T
N
S
Site 8
T62
G
E
T
Q
E
E
E
T
N
S
G
E
E
P
F
Site 9
S64
T
Q
E
E
E
T
N
S
G
E
E
P
F
I
E
Site 10
T72
G
E
E
P
F
I
E
T
P
R
Q
D
G
V
S
Site 11
S79
T
P
R
Q
D
G
V
S
R
R
F
I
P
P
A
Site 12
S90
I
P
P
A
R
M
M
S
T
E
S
A
N
S
F
Site 13
T91
P
P
A
R
M
M
S
T
E
S
A
N
S
F
T
Site 14
S93
A
R
M
M
S
T
E
S
A
N
S
F
T
L
I
Site 15
S96
M
S
T
E
S
A
N
S
F
T
L
I
G
E
A
Site 16
S104
F
T
L
I
G
E
A
S
D
G
G
T
M
E
N
Site 17
T108
G
E
A
S
D
G
G
T
M
E
N
L
S
R
R
Site 18
S113
G
G
T
M
E
N
L
S
R
R
L
K
V
T
G
Site 19
T119
L
S
R
R
L
K
V
T
G
D
L
F
D
I
M
Site 20
S127
G
D
L
F
D
I
M
S
G
Q
T
D
V
D
H
Site 21
T143
L
C
E
E
C
T
D
T
L
L
D
Q
L
D
T
Site 22
T150
T
L
L
D
Q
L
D
T
Q
L
N
V
T
E
N
Site 23
Y162
T
E
N
E
C
Q
N
Y
K
R
C
L
E
I
L
Site 24
S177
E
Q
M
N
E
D
D
S
E
Q
L
Q
M
E
L
Site 25
Y229
L
D
Q
E
E
A
Q
Y
Q
R
E
Y
S
E
F
Site 26
Y233
E
A
Q
Y
Q
R
E
Y
S
E
F
K
R
Q
Q
Site 27
S234
A
Q
Y
Q
R
E
Y
S
E
F
K
R
Q
Q
L
Site 28
S249
E
L
D
D
E
L
K
S
V
E
N
Q
M
R
Y
Site 29
Y256
S
V
E
N
Q
M
R
Y
A
Q
T
Q
L
D
K
Site 30
S295
F
R
L
G
R
L
P
S
V
P
V
E
W
N
E
Site 31
Y328
M
G
L
K
F
Q
R
Y
R
L
V
P
Y
G
N
Site 32
Y333
Q
R
Y
R
L
V
P
Y
G
N
H
S
Y
L
E
Site 33
S337
L
V
P
Y
G
N
H
S
Y
L
E
S
L
T
D
Site 34
Y338
V
P
Y
G
N
H
S
Y
L
E
S
L
T
D
K
Site 35
S341
G
N
H
S
Y
L
E
S
L
T
D
K
S
K
E
Site 36
S346
L
E
S
L
T
D
K
S
K
E
L
P
L
Y
C
Site 37
Y352
K
S
K
E
L
P
L
Y
C
S
G
G
L
R
F
Site 38
T388
E
E
V
E
K
G
E
T
R
F
C
L
P
Y
R
Site 39
Y394
E
T
R
F
C
L
P
Y
R
M
D
V
E
K
G
Site 40
T406
E
K
G
K
I
E
D
T
G
G
S
G
G
S
Y
Site 41
S412
D
T
G
G
S
G
G
S
Y
S
I
K
T
Q
F
Site 42
Y413
T
G
G
S
G
G
S
Y
S
I
K
T
Q
F
N
Site 43
S414
G
G
S
G
G
S
Y
S
I
K
T
Q
F
N
S
Site 44
T417
G
G
S
Y
S
I
K
T
Q
F
N
S
E
E
Q
Site 45
S444
K
W
G
L
A
W
V
S
S
Q
F
Y
N
K
_
Site 46
S445
W
G
L
A
W
V
S
S
Q
F
Y
N
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation