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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cas-L
Full Name:
Enhancer of filamentation 1
Alias:
Cas scaffolding protein family member 2; CASL; CAS-L; Cas-like; CASS2; CRK-associated substrate-related protein; Enhancer of filmentation 1; HEF1; MEF1; NEDD9; Neural precursor cell expressed developmentally downregulated 9; Neural precursor cell expressed developmentally down-regulated 9; Neural precursor cell expressed developmentally down-regulated protein 9; Neural precursor cell expressed, developmentally down-regulated 9; P105; PP105; Renal carcinoma antigen NY-REN-12
Type:
Adapter/scaffold protein
Mass (Da):
92861
Number AA:
834
UniProt ID:
Q14511
International Prot ID:
IPI00031407
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005938
GO:0005925
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051017
GO:0007155
GO:0051301
Phosida
TranscriptoNet
STRING
Kinexus Products
Enhancer of filamentation 1 Y166 phosphosite-specific antibody AB-PN505#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN505#Enhancer of filamentation 1 (G163-P169, human) pY166 phosphopeptide - Powder PE-04AFA99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFA99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y12
N
L
M
A
R
A
L
Y
D
N
V
P
E
C
A
Site 2
T31
F
R
K
G
D
I
L
T
V
I
E
Q
N
T
G
Site 3
S73
P
M
Q
E
T
A
S
S
H
E
Q
P
A
S
G
Site 4
S79
S
S
H
E
Q
P
A
S
G
L
M
Q
Q
T
F
Site 5
T85
A
S
G
L
M
Q
Q
T
F
G
Q
Q
K
L
Y
Site 6
Y92
T
F
G
Q
Q
K
L
Y
Q
V
P
N
P
Q
A
Site 7
T104
P
Q
A
A
P
R
D
T
I
Y
Q
V
P
P
S
Site 8
Y106
A
A
P
R
D
T
I
Y
Q
V
P
P
S
Y
Q
Site 9
Y112
I
Y
Q
V
P
P
S
Y
Q
N
Q
G
I
Y
Q
Site 10
Y118
S
Y
Q
N
Q
G
I
Y
Q
V
P
T
G
H
G
Site 11
T122
Q
G
I
Y
Q
V
P
T
G
H
G
T
Q
E
Q
Site 12
T126
Q
V
P
T
G
H
G
T
Q
E
Q
E
V
Y
Q
Site 13
Y132
G
T
Q
E
Q
E
V
Y
Q
V
P
P
S
V
Q
Site 14
S137
E
V
Y
Q
V
P
P
S
V
Q
R
S
I
G
G
Site 15
S141
V
P
P
S
V
Q
R
S
I
G
G
T
S
G
P
Site 16
T145
V
Q
R
S
I
G
G
T
S
G
P
H
V
G
K
Site 17
T156
H
V
G
K
K
V
I
T
P
V
R
T
G
H
G
Site 18
T160
K
V
I
T
P
V
R
T
G
H
G
Y
V
Y
E
Site 19
Y164
P
V
R
T
G
H
G
Y
V
Y
E
Y
P
S
R
Site 20
Y166
R
T
G
H
G
Y
V
Y
E
Y
P
S
R
Y
Q
Enhancer of filamentation 1 Y166 phosphosite-specific antibody AB-PN505#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN505#Enhancer of filamentation 1 (G163-P169, human) pY166 phosphopeptide - Powder PE-04AFA99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AFA99
Site 21
Y168
G
H
G
Y
V
Y
E
Y
P
S
R
Y
Q
K
D
Site 22
Y172
V
Y
E
Y
P
S
R
Y
Q
K
D
V
Y
D
I
Site 23
Y177
S
R
Y
Q
K
D
V
Y
D
I
P
P
S
H
T
Site 24
S182
D
V
Y
D
I
P
P
S
H
T
T
Q
G
V
Y
Site 25
T184
Y
D
I
P
P
S
H
T
T
Q
G
V
Y
D
I
Site 26
T185
D
I
P
P
S
H
T
T
Q
G
V
Y
D
I
P
Site 27
Y189
S
H
T
T
Q
G
V
Y
D
I
P
P
S
S
A
Site 28
S194
G
V
Y
D
I
P
P
S
S
A
K
G
P
V
F
Site 29
S195
V
Y
D
I
P
P
S
S
A
K
G
P
V
F
S
Site 30
Y214
E
I
K
P
Q
G
V
Y
D
I
P
P
T
K
G
Site 31
T219
G
V
Y
D
I
P
P
T
K
G
V
Y
A
I
P
Site 32
Y223
I
P
P
T
K
G
V
Y
A
I
P
P
S
A
C
Site 33
S228
G
V
Y
A
I
P
P
S
A
C
R
D
E
A
G
Site 34
Y241
A
G
L
R
E
K
D
Y
D
F
P
P
P
M
R
Site 35
Y261
D
L
R
P
E
G
V
Y
D
I
P
P
T
C
T
Site 36
T266
G
V
Y
D
I
P
P
T
C
T
K
P
A
G
K
Site 37
Y279
G
K
D
L
H
V
K
Y
N
C
D
I
P
G
A
Site 38
S296
P
V
A
R
R
H
Q
S
L
S
P
N
H
P
P
Site 39
S298
A
R
R
H
Q
S
L
S
P
N
H
P
P
P
Q
Site 40
S309
P
P
P
Q
L
G
Q
S
V
G
S
Q
N
D
A
Site 41
S312
Q
L
G
Q
S
V
G
S
Q
N
D
A
Y
D
V
Site 42
Y317
V
G
S
Q
N
D
A
Y
D
V
P
R
G
V
Q
Site 43
S333
L
E
P
P
A
E
T
S
E
K
A
N
P
Q
E
Site 44
Y345
P
Q
E
R
D
G
V
Y
D
V
P
L
H
N
P
Site 45
S369
V
D
G
I
N
R
L
S
F
S
S
T
G
S
T
Site 46
S371
G
I
N
R
L
S
F
S
S
T
G
S
T
R
S
Site 47
S372
I
N
R
L
S
F
S
S
T
G
S
T
R
S
N
Site 48
T373
N
R
L
S
F
S
S
T
G
S
T
R
S
N
M
Site 49
S375
L
S
F
S
S
T
G
S
T
R
S
N
M
S
T
Site 50
T376
S
F
S
S
T
G
S
T
R
S
N
M
S
T
S
Site 51
S378
S
S
T
G
S
T
R
S
N
M
S
T
S
S
T
Site 52
S381
G
S
T
R
S
N
M
S
T
S
S
T
S
S
K
Site 53
T382
S
T
R
S
N
M
S
T
S
S
T
S
S
K
E
Site 54
S383
T
R
S
N
M
S
T
S
S
T
S
S
K
E
S
Site 55
S384
R
S
N
M
S
T
S
S
T
S
S
K
E
S
S
Site 56
T385
S
N
M
S
T
S
S
T
S
S
K
E
S
S
L
Site 57
S386
N
M
S
T
S
S
T
S
S
K
E
S
S
L
S
Site 58
S387
M
S
T
S
S
T
S
S
K
E
S
S
L
S
A
Site 59
S390
S
S
T
S
S
K
E
S
S
L
S
A
S
P
A
Site 60
S391
S
T
S
S
K
E
S
S
L
S
A
S
P
A
Q
Site 61
S393
S
S
K
E
S
S
L
S
A
S
P
A
Q
D
K
Site 62
S395
K
E
S
S
L
S
A
S
P
A
Q
D
K
R
L
Site 63
T408
R
L
F
L
D
P
D
T
A
I
E
R
L
Q
R
Site 64
S495
E
L
Q
R
V
E
D
S
H
Q
I
L
S
Q
T
Site 65
S500
E
D
S
H
Q
I
L
S
Q
T
S
H
D
L
N
Site 66
T537
R
F
V
M
V
A
K
T
V
P
D
D
A
K
Q
Site 67
S563
L
F
R
P
G
P
G
S
L
H
L
K
N
G
P
Site 68
S572
H
L
K
N
G
P
E
S
I
M
N
S
T
E
Y
Site 69
S576
G
P
E
S
I
M
N
S
T
E
Y
P
H
G
G
Site 70
T577
P
E
S
I
M
N
S
T
E
Y
P
H
G
G
S
Site 71
Y579
S
I
M
N
S
T
E
Y
P
H
G
G
S
Q
G
Site 72
S584
T
E
Y
P
H
G
G
S
Q
G
Q
L
L
H
P
Site 73
S608
K
A
L
P
P
G
L
S
K
E
Q
A
P
D
C
Site 74
S616
K
E
Q
A
P
D
C
S
S
S
D
G
S
E
R
Site 75
S617
E
Q
A
P
D
C
S
S
S
D
G
S
E
R
S
Site 76
S618
Q
A
P
D
C
S
S
S
D
G
S
E
R
S
W
Site 77
S621
D
C
S
S
S
D
G
S
E
R
S
W
M
D
D
Site 78
S624
S
S
D
G
S
E
R
S
W
M
D
D
Y
D
Y
Site 79
Y629
E
R
S
W
M
D
D
Y
D
Y
V
H
L
Q
G
Site 80
Y631
S
W
M
D
D
Y
D
Y
V
H
L
Q
G
K
E
Site 81
S667
Q
L
E
H
H
Q
L
S
Q
F
Q
L
L
E
Q
Site 82
T677
Q
L
L
E
Q
E
I
T
K
P
V
E
N
D
I
Site 83
S685
K
P
V
E
N
D
I
S
K
W
K
P
S
Q
S
Site 84
S690
D
I
S
K
W
K
P
S
Q
S
L
P
T
T
N
Site 85
S692
S
K
W
K
P
S
Q
S
L
P
T
T
N
S
G
Site 86
T696
P
S
Q
S
L
P
T
T
N
S
G
V
S
A
Q
Site 87
S698
Q
S
L
P
T
T
N
S
G
V
S
A
Q
D
R
Site 88
Y711
D
R
Q
L
L
C
F
Y
Y
D
Q
C
E
T
H
Site 89
T764
V
F
I
G
D
T
L
T
R
Q
V
T
A
Q
D
Site 90
T768
D
T
L
T
R
Q
V
T
A
Q
D
I
R
N
K
Site 91
Y801
T
K
M
A
A
L
H
Y
P
S
T
T
A
L
Q
Site 92
S818
V
H
Q
V
T
D
L
S
R
N
A
Q
L
F
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation