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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIC1
Full Name:
Hypermethylated in cancer 1 protein
Alias:
Hic-1; Hypermethylated in cancer 1; ZBTB29; Zinc finger and BTB domain-containing protein 29
Type:
Transcription factor
Mass (Da):
76468
Number AA:
733
UniProt ID:
Q14526
International Prot ID:
IPI00007993
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
E
A
D
I
L
L
K
S
G
E
C
A
G
Q
T
Site 2
T23
A
G
Q
T
M
L
D
T
M
E
A
P
G
H
S
Site 3
Y155
R
L
K
R
H
G
K
Y
C
H
L
R
G
G
G
Site 4
Y168
G
G
G
G
G
G
G
Y
A
P
Y
G
R
P
G
Site 5
Y171
G
G
G
G
Y
A
P
Y
G
R
P
G
R
G
L
Site 6
Y189
T
P
V
I
Q
A
C
Y
R
S
P
V
G
P
P
Site 7
S191
V
I
Q
A
C
Y
R
S
P
V
G
P
P
P
P
Site 8
S205
P
P
A
A
E
P
P
S
G
P
E
A
A
V
N
Site 9
Y219
N
T
H
C
A
E
L
Y
A
S
G
P
G
P
A
Site 10
S232
P
A
A
A
L
C
A
S
E
R
R
C
S
P
L
Site 11
S237
C
A
S
E
R
R
C
S
P
L
C
G
L
D
L
Site 12
S245
P
L
C
G
L
D
L
S
K
K
S
P
P
G
S
Site 13
S248
G
L
D
L
S
K
K
S
P
P
G
S
A
A
P
Site 14
S252
S
K
K
S
P
P
G
S
A
A
P
E
R
P
L
Site 15
S270
E
L
P
P
R
P
D
S
P
P
S
A
G
P
A
Site 16
S273
P
R
P
D
S
P
P
S
A
G
P
A
A
Y
K
Site 17
Y279
P
S
A
G
P
A
A
Y
K
E
P
P
L
A
L
Site 18
S304
L
E
E
A
A
P
P
S
D
P
F
R
G
G
S
Site 19
S311
S
D
P
F
R
G
G
S
G
S
P
G
P
E
P
Site 20
S313
P
F
R
G
G
S
G
S
P
G
P
E
P
P
G
Site 21
S326
P
G
R
P
D
G
P
S
L
L
Y
R
W
M
K
Site 22
Y329
P
D
G
P
S
L
L
Y
R
W
M
K
H
E
P
Site 23
S340
K
H
E
P
G
L
G
S
Y
G
D
E
L
G
R
Site 24
S351
E
L
G
R
E
R
G
S
P
S
E
R
C
E
E
Site 25
S353
G
R
E
R
G
S
P
S
E
R
C
E
E
R
G
Site 26
S366
R
G
G
D
A
A
V
S
P
G
G
P
P
L
G
Site 27
Y380
G
L
A
P
P
P
R
Y
P
G
S
L
D
G
P
Site 28
S383
P
P
P
R
Y
P
G
S
L
D
G
P
G
A
G
Site 29
Y396
A
G
G
D
G
D
D
Y
K
S
S
S
E
E
T
Site 30
S398
G
D
G
D
D
Y
K
S
S
S
E
E
T
G
S
Site 31
S399
D
G
D
D
Y
K
S
S
S
E
E
T
G
S
S
Site 32
S400
G
D
D
Y
K
S
S
S
E
E
T
G
S
S
E
Site 33
T403
Y
K
S
S
S
E
E
T
G
S
S
E
D
P
S
Site 34
S405
S
S
S
E
E
T
G
S
S
E
D
P
S
P
P
Site 35
S406
S
S
E
E
T
G
S
S
E
D
P
S
P
P
G
Site 36
S410
T
G
S
S
E
D
P
S
P
P
G
G
H
L
E
Site 37
Y419
P
G
G
H
L
E
G
Y
P
C
P
H
L
A
Y
Site 38
Y426
Y
P
C
P
H
L
A
Y
G
E
P
E
S
F
G
Site 39
S431
L
A
Y
G
E
P
E
S
F
G
D
N
L
Y
V
Site 40
S448
P
C
G
K
G
F
P
S
S
E
Q
L
N
A
H
Site 41
S449
C
G
K
G
F
P
S
S
E
Q
L
N
A
H
V
Site 42
Y467
V
E
E
E
E
A
L
Y
G
R
A
E
A
A
E
Site 43
Y507
L
G
E
L
L
R
P
Y
R
C
A
S
C
D
K
Site 44
S511
L
R
P
Y
R
C
A
S
C
D
K
S
Y
K
D
Site 45
S515
R
C
A
S
C
D
K
S
Y
K
D
P
A
T
L
Site 46
Y516
C
A
S
C
D
K
S
Y
K
D
P
A
T
L
R
Site 47
T521
K
S
Y
K
D
P
A
T
L
R
Q
H
E
K
T
Site 48
T528
T
L
R
Q
H
E
K
T
H
W
L
T
R
P
Y
Site 49
T538
L
T
R
P
Y
P
C
T
I
C
G
K
K
F
T
Site 50
T545
T
I
C
G
K
K
F
T
Q
R
G
T
M
T
R
Site 51
T549
K
K
F
T
Q
R
G
T
M
T
R
H
M
R
S
Site 52
S556
T
M
T
R
H
M
R
S
H
L
G
L
K
P
F
Site 53
Y576
G
M
R
F
T
R
Q
Y
R
L
T
E
H
M
R
Site 54
S586
T
E
H
M
R
I
H
S
G
E
K
P
Y
E
C
Site 55
Y591
I
H
S
G
E
K
P
Y
E
C
Q
V
C
G
G
Site 56
T726
A
A
G
P
D
G
G
T
I
D
R
F
S
P
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation