PhosphoNET

           
Protein Info 
   
Short Name:  HIC1
Full Name:  Hypermethylated in cancer 1 protein
Alias:  Hic-1; Hypermethylated in cancer 1; ZBTB29; Zinc finger and BTB domain-containing protein 29
Type:  Transcription factor
Mass (Da):  76468
Number AA:  733
UniProt ID:  Q14526
International Prot ID:  IPI00007993
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005634     Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0003700  GO:0008270 PhosphoSite+ KinaseNET
Biological Process:  GO:0007275  GO:0006355  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S12EADILLKSGECAGQT
Site 2T23AGQTMLDTMEAPGHS
Site 3Y155RLKRHGKYCHLRGGG
Site 4Y168GGGGGGGYAPYGRPG
Site 5Y171GGGGYAPYGRPGRGL
Site 6Y189TPVIQACYRSPVGPP
Site 7S191VIQACYRSPVGPPPP
Site 8S205PPAAEPPSGPEAAVN
Site 9Y219NTHCAELYASGPGPA
Site 10S232PAAALCASERRCSPL
Site 11S237CASERRCSPLCGLDL
Site 12S245PLCGLDLSKKSPPGS
Site 13S248GLDLSKKSPPGSAAP
Site 14S252SKKSPPGSAAPERPL
Site 15S270ELPPRPDSPPSAGPA
Site 16S273PRPDSPPSAGPAAYK
Site 17Y279PSAGPAAYKEPPLAL
Site 18S304LEEAAPPSDPFRGGS
Site 19S311SDPFRGGSGSPGPEP
Site 20S313PFRGGSGSPGPEPPG
Site 21S326PGRPDGPSLLYRWMK
Site 22Y329PDGPSLLYRWMKHEP
Site 23S340KHEPGLGSYGDELGR
Site 24S351ELGRERGSPSERCEE
Site 25S353GRERGSPSERCEERG
Site 26S366RGGDAAVSPGGPPLG
Site 27Y380GLAPPPRYPGSLDGP
Site 28S383PPPRYPGSLDGPGAG
Site 29Y396AGGDGDDYKSSSEET
Site 30S398GDGDDYKSSSEETGS
Site 31S399DGDDYKSSSEETGSS
Site 32S400GDDYKSSSEETGSSE
Site 33T403YKSSSEETGSSEDPS
Site 34S405SSSEETGSSEDPSPP
Site 35S406SSEETGSSEDPSPPG
Site 36S410TGSSEDPSPPGGHLE
Site 37Y419PGGHLEGYPCPHLAY
Site 38Y426YPCPHLAYGEPESFG
Site 39S431LAYGEPESFGDNLYV
Site 40S448PCGKGFPSSEQLNAH
Site 41S449CGKGFPSSEQLNAHV
Site 42Y467VEEEEALYGRAEAAE
Site 43Y507LGELLRPYRCASCDK
Site 44S511LRPYRCASCDKSYKD
Site 45S515RCASCDKSYKDPATL
Site 46Y516CASCDKSYKDPATLR
Site 47T521KSYKDPATLRQHEKT
Site 48T528TLRQHEKTHWLTRPY
Site 49T538LTRPYPCTICGKKFT
Site 50T545TICGKKFTQRGTMTR
Site 51T549KKFTQRGTMTRHMRS
Site 52S556TMTRHMRSHLGLKPF
Site 53Y576GMRFTRQYRLTEHMR
Site 54S586TEHMRIHSGEKPYEC
Site 55Y591IHSGEKPYECQVCGG
Site 56T726AAGPDGGTIDRFSPT
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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