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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HLTF
Full Name:
Helicase-like transcription factor
Alias:
DNA-binding protein/plasminogen activator inhibitor 1 regulator; EC=3.6.1.-; Helicase-like transcription factor; HIP116; HIP116A; HLTF1; RING finger protein 80; RNF80; SMARCA3; SNF2L3; Sucrose nonfermenting protein 2-like 3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3; ZBU1
Type:
Transcription protein
Mass (Da):
113929
Number AA:
1009
UniProt ID:
Q14527
International Prot ID:
IPI00339381
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003677
GO:0004386
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0019941
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
K
R
D
P
V
W
K
Y
L
Q
T
V
Q
Y
G
Site 2
Y19
K
Y
L
Q
T
V
Q
Y
G
V
H
G
N
F
P
Site 3
S29
H
G
N
F
P
R
L
S
Y
P
T
F
F
P
R
Site 4
Y30
G
N
F
P
R
L
S
Y
P
T
F
F
P
R
F
Site 5
T32
F
P
R
L
S
Y
P
T
F
F
P
R
F
E
F
Site 6
S51
P
P
D
D
F
L
T
S
D
E
E
V
D
S
V
Site 7
S57
T
S
D
E
E
V
D
S
V
L
F
G
S
L
R
Site 8
Y73
H
V
V
G
L
R
Y
Y
T
G
V
V
N
N
N
Site 9
T74
V
V
G
L
R
Y
Y
T
G
V
V
N
N
N
E
Site 10
Y93
Q
R
D
P
N
N
P
Y
D
K
N
A
I
K
V
Site 11
Y121
E
L
A
G
A
L
A
Y
I
M
D
N
K
L
A
Site 12
S161
E
E
N
R
K
A
V
S
D
Q
L
K
K
H
G
Site 13
T177
K
L
G
P
A
P
K
T
L
G
F
N
L
E
S
Site 14
S184
T
L
G
F
N
L
E
S
G
W
G
S
G
R
A
Site 15
S188
N
L
E
S
G
W
G
S
G
R
A
G
P
S
Y
Site 16
S194
G
S
G
R
A
G
P
S
Y
S
M
P
V
H
A
Site 17
Y195
S
G
R
A
G
P
S
Y
S
M
P
V
H
A
A
Site 18
S196
G
R
A
G
P
S
Y
S
M
P
V
H
A
A
V
Site 19
T212
M
T
T
E
Q
L
K
T
E
F
D
K
L
F
E
Site 20
T227
D
L
K
E
D
D
K
T
H
E
M
E
P
A
E
Site 21
T238
E
P
A
E
A
I
E
T
P
L
L
P
H
Q
K
Site 22
S253
Q
A
L
A
W
M
V
S
R
E
N
S
K
E
L
Site 23
S257
W
M
V
S
R
E
N
S
K
E
L
P
P
F
W
Site 24
Y271
W
E
Q
R
N
D
L
Y
Y
N
T
I
T
N
F
Site 25
Y272
E
Q
R
N
D
L
Y
Y
N
T
I
T
N
F
S
Site 26
Y332
K
N
L
L
K
K
E
Y
N
V
N
D
D
S
M
Site 27
S347
K
L
G
G
N
N
T
S
E
K
A
D
G
L
S
Site 28
S354
S
E
K
A
D
G
L
S
K
D
A
S
R
C
S
Site 29
S358
D
G
L
S
K
D
A
S
R
C
S
E
Q
P
S
Site 30
S361
S
K
D
A
S
R
C
S
E
Q
P
S
I
S
D
Site 31
S365
S
R
C
S
E
Q
P
S
I
S
D
I
K
E
K
Site 32
S367
C
S
E
Q
P
S
I
S
D
I
K
E
K
S
K
Site 33
S373
I
S
D
I
K
E
K
S
K
F
R
M
S
E
L
Site 34
S378
E
K
S
K
F
R
M
S
E
L
S
S
S
R
P
Site 35
S381
K
F
R
M
S
E
L
S
S
S
R
P
K
R
R
Site 36
S382
F
R
M
S
E
L
S
S
S
R
P
K
R
R
K
Site 37
S383
R
M
S
E
L
S
S
S
R
P
K
R
R
K
T
Site 38
T390
S
R
P
K
R
R
K
T
A
V
Q
Y
I
E
S
Site 39
Y394
R
R
K
T
A
V
Q
Y
I
E
S
S
D
S
E
Site 40
S397
T
A
V
Q
Y
I
E
S
S
D
S
E
E
I
E
Site 41
S398
A
V
Q
Y
I
E
S
S
D
S
E
E
I
E
T
Site 42
S400
Q
Y
I
E
S
S
D
S
E
E
I
E
T
S
E
Site 43
T405
S
D
S
E
E
I
E
T
S
E
L
P
Q
K
M
Site 44
S406
D
S
E
E
I
E
T
S
E
L
P
Q
K
M
K
Site 45
S421
G
K
L
K
N
V
Q
S
E
T
K
G
R
A
K
Site 46
S431
K
G
R
A
K
A
G
S
S
K
V
I
E
D
V
Site 47
S447
F
A
C
A
L
T
S
S
V
P
T
T
K
K
K
Site 48
T451
L
T
S
S
V
P
T
T
K
K
K
M
L
K
K
Site 49
T469
A
V
E
G
S
K
K
T
D
V
E
E
R
P
R
Site 50
T477
D
V
E
E
R
P
R
T
T
L
I
I
C
P
L
Site 51
Y507
S
D
V
H
L
N
F
Y
V
Y
Y
G
P
D
R
Site 52
Y509
V
H
L
N
F
Y
V
Y
Y
G
P
D
R
I
R
Site 53
T529
S
K
Q
D
I
V
L
T
T
Y
N
I
L
T
H
Site 54
Y531
Q
D
I
V
L
T
T
Y
N
I
L
T
H
D
Y
Site 55
Y538
Y
N
I
L
T
H
D
Y
G
T
K
G
D
S
P
Site 56
T540
I
L
T
H
D
Y
G
T
K
G
D
S
P
L
H
Site 57
S544
D
Y
G
T
K
G
D
S
P
L
H
S
I
R
W
Site 58
S548
K
G
D
S
P
L
H
S
I
R
W
L
R
V
I
Site 59
S578
K
A
V
L
D
L
E
S
E
R
R
W
V
L
T
Site 60
T585
S
E
R
R
W
V
L
T
G
T
P
I
Q
N
S
Site 61
T587
R
R
W
V
L
T
G
T
P
I
Q
N
S
L
K
Site 62
S592
T
G
T
P
I
Q
N
S
L
K
D
L
W
S
L
Site 63
T623
R
T
I
Q
R
P
V
T
M
G
D
E
G
G
L
Site 64
S635
G
G
L
R
R
L
Q
S
L
I
K
N
I
T
L
Site 65
T641
Q
S
L
I
K
N
I
T
L
R
R
T
K
T
S
Site 66
T645
K
N
I
T
L
R
R
T
K
T
S
K
I
K
G
Site 67
T647
I
T
L
R
R
T
K
T
S
K
I
K
G
K
P
Site 68
S648
T
L
R
R
T
K
T
S
K
I
K
G
K
P
V
Site 69
T669
K
V
F
I
Q
H
I
T
L
S
D
E
E
R
K
Site 70
S671
F
I
Q
H
I
T
L
S
D
E
E
R
K
I
Y
Site 71
Y678
S
D
E
E
R
K
I
Y
Q
S
V
K
N
E
G
Site 72
S680
E
E
R
K
I
Y
Q
S
V
K
N
E
G
R
A
Site 73
T688
V
K
N
E
G
R
A
T
I
G
R
Y
F
N
E
Site 74
Y692
G
R
A
T
I
G
R
Y
F
N
E
G
T
V
L
Site 75
T697
G
R
Y
F
N
E
G
T
V
L
A
H
Y
A
D
Site 76
S727
Y
L
L
T
N
A
V
S
S
N
G
P
S
G
N
Site 77
S728
L
L
T
N
A
V
S
S
N
G
P
S
G
N
D
Site 78
S732
A
V
S
S
N
G
P
S
G
N
D
T
P
E
E
Site 79
T736
N
G
P
S
G
N
D
T
P
E
E
L
R
K
K
Site 80
S753
R
K
M
K
L
I
L
S
S
G
S
D
E
E
C
Site 81
S754
K
M
K
L
I
L
S
S
G
S
D
E
E
C
A
Site 82
S821
P
E
E
L
A
R
D
S
E
K
K
S
D
M
E
Site 83
S825
A
R
D
S
E
K
K
S
D
M
E
W
T
S
S
Site 84
S831
K
S
D
M
E
W
T
S
S
S
K
I
N
A
L
Site 85
S832
S
D
M
E
W
T
S
S
S
K
I
N
A
L
M
Site 86
T843
N
A
L
M
H
A
L
T
D
L
R
K
K
N
P
Site 87
S854
K
K
N
P
N
I
K
S
L
V
V
S
Q
F
T
Site 88
S858
N
I
K
S
L
V
V
S
Q
F
T
T
F
L
S
Site 89
S884
V
F
T
R
L
D
G
S
M
A
Q
K
K
R
V
Site 90
S893
A
Q
K
K
R
V
E
S
I
Q
C
F
Q
N
T
Site 91
T900
S
I
Q
C
F
Q
N
T
E
A
G
S
P
T
I
Site 92
S965
T
K
F
I
V
K
D
S
V
E
E
N
M
L
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation