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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SQLE
Full Name:
Squalene monooxygenase
Alias:
Squalene epoxidase
Type:
Mass (Da):
63923
Number AA:
574
UniProt ID:
Q14534
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
K
K
F
G
D
F
I
T
L
A
N
R
E
V
L
Site 2
S43
L
S
L
G
L
V
L
S
Y
R
C
R
H
R
N
Site 3
Y44
S
L
G
L
V
L
S
Y
R
C
R
H
R
N
G
Site 4
S59
G
L
L
G
R
Q
R
S
G
S
Q
F
A
L
F
Site 5
S61
L
G
R
Q
R
S
G
S
Q
F
A
L
F
S
D
Site 6
S83
I
G
F
F
W
A
K
S
P
P
E
S
E
N
K
Site 7
S87
W
A
K
S
P
P
E
S
E
N
K
E
Q
L
G
Site 8
T102
A
R
R
R
R
K
G
T
N
I
S
E
T
S
L
Site 9
S105
R
R
K
G
T
N
I
S
E
T
S
L
I
G
T
Site 10
T116
L
I
G
T
A
A
C
T
S
T
S
S
Q
N
D
Site 11
S117
I
G
T
A
A
C
T
S
T
S
S
Q
N
D
P
Site 12
T150
S
R
D
G
R
K
V
T
V
I
E
R
D
L
K
Site 13
Y172
E
F
L
Q
P
G
G
Y
H
V
L
K
D
L
G
Site 14
T183
K
D
L
G
L
G
D
T
V
E
G
L
D
A
Q
Site 15
S204
I
H
D
Q
E
S
K
S
E
V
Q
I
P
Y
P
Site 16
Y210
K
S
E
V
Q
I
P
Y
P
L
S
E
N
N
Q
Site 17
S213
V
Q
I
P
Y
P
L
S
E
N
N
Q
V
Q
S
Site 18
S220
S
E
N
N
Q
V
Q
S
G
R
A
F
H
H
G
Site 19
Y265
D
V
V
M
G
V
Q
Y
K
D
K
E
T
G
D
Site 20
S294
L
F
S
K
F
R
K
S
L
V
S
N
K
V
S
Site 21
S297
K
F
R
K
S
L
V
S
N
K
V
S
V
S
S
Site 22
Y335
N
P
S
P
V
L
I
Y
R
I
S
S
S
E
T
Site 23
T342
Y
R
I
S
S
S
E
T
R
V
L
V
D
I
R
Site 24
Y359
M
P
R
N
L
R
E
Y
M
V
E
K
I
Y
P
Site 25
Y365
E
Y
M
V
E
K
I
Y
P
Q
I
P
D
H
L
Site 26
S383
F
L
E
A
T
D
N
S
H
L
R
S
M
L
A
Site 27
S387
T
D
N
S
H
L
R
S
M
L
A
S
F
L
P
Site 28
S396
L
A
S
F
L
P
P
S
S
V
K
K
R
G
V
Site 29
S397
A
S
F
L
P
P
S
S
V
K
K
R
G
V
L
Site 30
T417
Y
N
M
R
H
P
L
T
G
G
G
M
T
V
A
Site 31
Y455
F
E
A
N
K
S
F
Y
W
A
R
K
T
S
H
Site 32
S478
Q
A
L
Y
E
L
F
S
A
T
D
D
S
L
H
Site 33
S483
L
F
S
A
T
D
D
S
L
H
Q
L
R
K
A
Site 34
T542
F
K
S
E
P
W
I
T
K
P
R
A
L
L
S
Site 35
S549
T
K
P
R
A
L
L
S
S
S
A
V
L
Y
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation