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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDIA5
Full Name:
Protein disulfide-isomerase A5
Alias:
EC 5.3.4.1; FLJ30401; PDIR; Protein disulfide isomerase family A, member 5; Protein disulfide isomerase-related protein
Type:
Oxidoreductase; EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Chaperone
Mass (Da):
59594
Number AA:
519
UniProt ID:
Q14554
International Prot ID:
IPI00031479
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
Uniprot
OncoNet
Molecular Function:
GO:0016491
GO:0003756
PhosphoSite+
KinaseNET
Biological Process:
GO:0045454
GO:0055114
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S28
L
S
S
A
K
V
S
S
L
I
E
R
I
S
D
Site 2
S34
S
S
L
I
E
R
I
S
D
P
K
D
L
K
K
Site 3
Y53
R
N
N
V
L
V
L
Y
S
K
S
E
V
A
A
Site 4
S68
E
N
H
L
R
L
L
S
T
V
A
Q
A
V
K
Site 5
S102
K
K
M
K
V
D
L
S
P
K
D
K
K
V
E
Site 6
Y113
K
K
V
E
L
F
H
Y
Q
D
G
A
F
H
T
Site 7
Y122
D
G
A
F
H
T
E
Y
N
R
A
V
T
F
K
Site 8
S158
K
D
V
V
H
L
D
S
E
K
D
F
R
R
L
Site 9
Y178
K
P
L
L
I
M
F
Y
A
P
W
C
S
M
C
Site 10
S223
E
N
I
K
E
E
Y
S
V
R
G
F
P
T
I
Site 11
T229
Y
S
V
R
G
F
P
T
I
C
Y
F
E
K
G
Site 12
Y232
R
G
F
P
T
I
C
Y
F
E
K
G
R
F
L
Site 13
Y242
K
G
R
F
L
F
Q
Y
D
N
Y
G
S
T
A
Site 14
Y245
F
L
F
Q
Y
D
N
Y
G
S
T
A
E
D
I
Site 15
T269
P
Q
P
Q
V
P
E
T
P
W
A
D
E
G
G
Site 16
T282
G
G
S
V
Y
H
L
T
D
E
D
F
D
Q
F
Site 17
S350
L
A
E
R
F
H
I
S
E
F
P
T
L
K
Y
Site 18
T354
F
H
I
S
E
F
P
T
L
K
Y
F
K
N
G
Site 19
Y357
S
E
F
P
T
L
K
Y
F
K
N
G
E
K
Y
Site 20
Y364
Y
F
K
N
G
E
K
Y
A
V
P
V
L
R
T
Site 21
T397
P
T
W
E
E
Q
Q
T
S
V
L
H
L
V
G
Site 22
S398
T
W
E
E
Q
Q
T
S
V
L
H
L
V
G
D
Site 23
T410
V
G
D
N
F
R
E
T
L
K
K
K
K
H
T
Site 24
Y473
Q
Q
E
A
V
K
G
Y
P
T
F
H
Y
Y
H
Site 25
Y478
K
G
Y
P
T
F
H
Y
Y
H
Y
G
K
F
A
Site 26
Y479
G
Y
P
T
F
H
Y
Y
H
Y
G
K
F
A
E
Site 27
Y481
P
T
F
H
Y
Y
H
Y
G
K
F
A
E
K
Y
Site 28
Y488
Y
G
K
F
A
E
K
Y
D
S
D
R
T
E
L
Site 29
S490
K
F
A
E
K
Y
D
S
D
R
T
E
L
G
F
Site 30
T493
E
K
Y
D
S
D
R
T
E
L
G
F
T
N
Y
Site 31
T498
D
R
T
E
L
G
F
T
N
Y
I
R
A
L
R
Site 32
Y500
T
E
L
G
F
T
N
Y
I
R
A
L
R
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation