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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX8
Full Name:
ATP-dependent RNA helicase DHX8
Alias:
DDX8; DEAH (Asp-Glu-Ala-His) box polypeptide 8; DEAH box protein 8; HRH1; PRP22; PRPF22
Type:
EC 3.6.1.-; RNA processing; RNA binding protein; Helicase
Mass (Da):
139315
Number AA:
1220
UniProt ID:
Q14562
International Prot ID:
IPI00031508
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005681
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004004
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
M
A
G
A
L
I
G
S
E
P
G
P
A
E
E
Site 2
T36
S
L
V
S
K
V
C
T
E
L
D
N
H
L
G
Site 3
T62
S
L
A
E
K
N
T
T
F
D
T
F
K
A
S
Site 4
T65
E
K
N
T
T
F
D
T
F
K
A
S
L
V
K
Site 5
S69
T
F
D
T
F
K
A
S
L
V
K
N
G
A
E
Site 6
S80
N
G
A
E
F
T
D
S
L
I
S
N
L
L
R
Site 7
T91
N
L
L
R
L
I
Q
T
M
R
P
P
A
K
P
Site 8
S99
M
R
P
P
A
K
P
S
T
S
K
D
P
V
V
Site 9
T110
D
P
V
V
K
P
K
T
E
K
E
K
L
K
E
Site 10
S129
L
C
Q
P
D
N
P
S
V
R
T
M
L
D
E
Site 11
T171
D
A
E
H
R
D
R
T
K
K
K
K
R
S
R
Site 12
S177
R
T
K
K
K
K
R
S
R
S
R
D
R
N
R
Site 13
S179
K
K
K
K
R
S
R
S
R
D
R
N
R
D
R
Site 14
S204
D
H
K
R
R
H
R
S
R
S
R
S
R
S
R
Site 15
S206
K
R
R
H
R
S
R
S
R
S
R
S
R
T
R
Site 16
S208
R
H
R
S
R
S
R
S
R
S
R
T
R
E
R
Site 17
S210
R
S
R
S
R
S
R
S
R
T
R
E
R
N
K
Site 18
T212
R
S
R
S
R
S
R
T
R
E
R
N
K
V
K
Site 19
S220
R
E
R
N
K
V
K
S
R
Y
R
S
R
S
R
Site 20
Y222
R
N
K
V
K
S
R
Y
R
S
R
S
R
S
Q
Site 21
S224
K
V
K
S
R
Y
R
S
R
S
R
S
Q
S
P
Site 22
S226
K
S
R
Y
R
S
R
S
R
S
Q
S
P
P
K
Site 23
S228
R
Y
R
S
R
S
R
S
Q
S
P
P
K
D
R
Site 24
S230
R
S
R
S
R
S
Q
S
P
P
K
D
R
K
D
Site 25
Y241
D
R
K
D
R
D
K
Y
G
E
R
N
L
D
R
Site 26
T263
R
P
P
P
E
E
P
T
I
G
D
I
Y
N
G
Site 27
Y268
E
P
T
I
G
D
I
Y
N
G
K
V
T
S
I
Site 28
T273
D
I
Y
N
G
K
V
T
S
I
M
Q
F
G
C
Site 29
S325
R
V
K
V
K
V
L
S
F
T
G
T
K
T
S
Site 30
T327
K
V
K
V
L
S
F
T
G
T
K
T
S
L
S
Site 31
T329
K
V
L
S
F
T
G
T
K
T
S
L
S
M
K
Site 32
S332
S
F
T
G
T
K
T
S
L
S
M
K
D
V
D
Site 33
S334
T
G
T
K
T
S
L
S
M
K
D
V
D
Q
E
Site 34
T362
V
G
E
T
N
E
E
T
S
M
R
N
P
D
R
Site 35
S363
G
E
T
N
E
E
T
S
M
R
N
P
D
R
P
Site 36
T371
M
R
N
P
D
R
P
T
H
L
S
L
V
S
A
Site 37
S374
P
D
R
P
T
H
L
S
L
V
S
A
P
E
V
Site 38
S377
P
T
H
L
S
L
V
S
A
P
E
V
E
D
D
Site 39
S385
A
P
E
V
E
D
D
S
L
E
R
K
R
L
T
Site 40
T392
S
L
E
R
K
R
L
T
R
I
S
D
P
E
K
Site 41
S395
R
K
R
L
T
R
I
S
D
P
E
K
W
E
I
Site 42
S412
M
I
A
A
N
V
L
S
K
E
E
F
P
D
F
Site 43
T453
P
P
F
L
R
G
H
T
K
Q
S
M
D
M
S
Site 44
S456
L
R
G
H
T
K
Q
S
M
D
M
S
P
I
K
Site 45
S460
T
K
Q
S
M
D
M
S
P
I
K
I
V
K
N
Site 46
S471
I
V
K
N
P
D
G
S
L
S
Q
A
A
M
M
Site 47
S473
K
N
P
D
G
S
L
S
Q
A
A
M
M
Q
S
Site 48
S500
Q
R
E
A
E
M
D
S
I
P
M
G
L
N
K
Site 49
S549
A
F
G
G
N
K
A
S
Y
G
K
K
T
Q
M
Site 50
Y550
F
G
G
N
K
A
S
Y
G
K
K
T
Q
M
S
Site 51
T554
K
A
S
Y
G
K
K
T
Q
M
S
I
L
E
Q
Site 52
S557
Y
G
K
K
T
Q
M
S
I
L
E
Q
R
E
S
Site 53
S564
S
I
L
E
Q
R
E
S
L
P
I
Y
K
L
K
Site 54
Y568
Q
R
E
S
L
P
I
Y
K
L
K
E
Q
L
V
Site 55
T596
E
T
G
S
G
K
T
T
Q
I
T
Q
Y
L
A
Site 56
Y601
K
T
T
Q
I
T
Q
Y
L
A
E
A
G
Y
T
Site 57
Y607
Q
Y
L
A
E
A
G
Y
T
S
R
G
K
I
G
Site 58
T608
Y
L
A
E
A
G
Y
T
S
R
G
K
I
G
C
Site 59
T616
S
R
G
K
I
G
C
T
Q
P
R
R
V
A
A
Site 60
S625
P
R
R
V
A
A
M
S
V
A
K
R
V
S
E
Site 61
Y644
C
L
G
Q
E
V
G
Y
T
I
R
F
E
D
C
Site 62
T645
L
G
Q
E
V
G
Y
T
I
R
F
E
D
C
T
Site 63
T652
T
I
R
F
E
D
C
T
S
P
E
T
V
I
K
Site 64
S653
I
R
F
E
D
C
T
S
P
E
T
V
I
K
Y
Site 65
T656
E
D
C
T
S
P
E
T
V
I
K
Y
M
T
D
Site 66
T694
A
H
E
R
T
I
H
T
D
V
L
F
G
L
L
Site 67
T704
L
F
G
L
L
K
K
T
V
Q
K
R
Q
D
M
Site 68
Y728
D
A
V
K
F
S
Q
Y
F
Y
E
A
P
I
F
Site 69
Y748
T
Y
P
V
E
I
L
Y
T
K
E
P
E
T
D
Site 70
T749
Y
P
V
E
I
L
Y
T
K
E
P
E
T
D
Y
Site 71
Y756
T
K
E
P
E
T
D
Y
L
D
A
S
L
I
T
Site 72
T788
T
G
Q
E
E
I
D
T
A
C
E
I
L
Y
E
Site 73
Y794
D
T
A
C
E
I
L
Y
E
R
M
K
S
L
G
Site 74
S799
I
L
Y
E
R
M
K
S
L
G
P
D
V
P
E
Site 75
S818
P
V
Y
S
A
L
P
S
E
M
Q
T
R
I
F
Site 76
T822
A
L
P
S
E
M
Q
T
R
I
F
D
P
A
P
Site 77
S832
F
D
P
A
P
P
G
S
R
K
V
V
I
A
T
Site 78
Y865
G
F
V
K
Q
K
V
Y
N
S
K
T
G
I
D
Site 79
S867
V
K
Q
K
V
Y
N
S
K
T
G
I
D
Q
L
Site 80
T869
Q
K
V
Y
N
S
K
T
G
I
D
Q
L
V
V
Site 81
S880
Q
L
V
V
T
P
I
S
Q
A
Q
A
K
Q
R
Site 82
Y903
P
G
K
C
Y
R
L
Y
T
E
R
A
Y
R
D
Site 83
T904
G
K
C
Y
R
L
Y
T
E
R
A
Y
R
D
E
Site 84
Y908
R
L
Y
T
E
R
A
Y
R
D
E
M
L
T
T
Site 85
T914
A
Y
R
D
E
M
L
T
T
N
V
P
E
I
Q
Site 86
T915
Y
R
D
E
M
L
T
T
N
V
P
E
I
Q
R
Site 87
T923
N
V
P
E
I
Q
R
T
N
L
A
S
T
V
L
Site 88
T963
T
A
M
E
Q
L
Y
T
L
G
A
L
D
D
E
Site 89
T974
L
D
D
E
G
L
L
T
R
L
G
R
R
M
A
Site 90
T1044
Q
T
E
G
D
H
L
T
L
L
A
V
Y
N
S
Site 91
Y1049
H
L
T
L
L
A
V
Y
N
S
W
K
N
N
K
Site 92
S1071
E
N
F
I
Q
A
R
S
L
R
R
A
Q
D
I
Site 93
S1095
R
H
K
L
D
V
V
S
C
G
K
S
T
V
R
Site 94
S1099
D
V
V
S
C
G
K
S
T
V
R
V
Q
K
A
Site 95
T1126
D
P
Q
E
G
Y
R
T
L
I
D
Q
Q
V
V
Site 96
S1138
Q
V
V
Y
I
H
P
S
S
A
L
F
N
R
Q
Site 97
S1139
V
V
Y
I
H
P
S
S
A
L
F
N
R
Q
P
Site 98
Y1151
R
Q
P
E
W
V
V
Y
H
E
L
V
L
T
T
Site 99
T1157
V
Y
H
E
L
V
L
T
T
K
E
Y
M
R
E
Site 100
T1166
K
E
Y
M
R
E
V
T
T
I
D
P
R
W
L
Site 101
S1190
V
S
D
P
T
K
L
S
K
Q
K
K
Q
Q
R
Site 102
Y1202
Q
Q
R
L
E
P
L
Y
N
R
Y
E
E
P
N
Site 103
Y1205
L
E
P
L
Y
N
R
Y
E
E
P
N
A
W
R
Site 104
S1214
E
P
N
A
W
R
I
S
R
A
F
R
R
R
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation