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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MCM6
Full Name:
DNA replication licensing factor MCM6
Alias:
MCM6 minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae); Mis5; P105MCM
Type:
Cell cycle regulation
Mass (Da):
92889
Number AA:
821
UniProt ID:
Q14566
International Prot ID:
IPI00031517
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
GO:0005654
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006270
GO:0007049
GO:0045449
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
A
A
E
P
G
A
G
S
Q
H
L
E
V
R
D
Site 2
S39
D
F
L
E
E
F
Q
S
S
D
G
E
I
K
Y
Site 3
S40
F
L
E
E
F
Q
S
S
D
G
E
I
K
Y
L
Site 4
Y46
S
S
D
G
E
I
K
Y
L
Q
L
A
E
E
L
Site 5
Y87
Q
E
E
F
Y
R
V
Y
P
Y
L
C
R
A
L
Site 6
Y89
E
F
Y
R
V
Y
P
Y
L
C
R
A
L
K
T
Site 7
T96
Y
L
C
R
A
L
K
T
F
V
K
D
R
K
E
Site 8
T119
V
A
F
Q
D
L
P
T
R
H
K
I
R
E
L
Site 9
T127
R
H
K
I
R
E
L
T
S
S
R
I
G
L
L
Site 10
S128
H
K
I
R
E
L
T
S
S
R
I
G
L
L
T
Site 11
S129
K
I
R
E
L
T
S
S
R
I
G
L
L
T
R
Site 12
Y174
D
V
E
Q
Q
F
K
Y
T
Q
P
N
I
C
R
Site 13
T195
R
R
R
F
L
L
D
T
N
K
S
R
F
V
D
Site 14
S198
F
L
L
D
T
N
K
S
R
F
V
D
F
Q
K
Site 15
S219
Q
A
E
L
P
R
G
S
I
P
R
S
L
E
V
Site 16
S223
P
R
G
S
I
P
R
S
L
E
V
I
L
R
A
Site 17
S235
L
R
A
E
A
V
E
S
A
Q
A
G
D
K
C
Site 18
S258
V
P
D
V
S
K
L
S
T
P
G
A
R
A
E
Site 19
T259
P
D
V
S
K
L
S
T
P
G
A
R
A
E
T
Site 20
T266
T
P
G
A
R
A
E
T
N
S
R
V
S
G
V
Site 21
S268
G
A
R
A
E
T
N
S
R
V
S
G
V
D
G
Site 22
S271
A
E
T
N
S
R
V
S
G
V
D
G
Y
E
T
Site 23
Y276
R
V
S
G
V
D
G
Y
E
T
E
G
I
R
G
Site 24
T278
S
G
V
D
G
Y
E
T
E
G
I
R
G
L
R
Site 25
Y294
L
G
V
R
D
L
S
Y
R
L
V
F
L
A
C
Site 26
T321
E
L
R
D
E
E
Q
T
A
E
S
I
K
N
Q
Site 27
T330
E
S
I
K
N
Q
M
T
V
K
E
W
E
K
V
Site 28
Y347
M
S
Q
D
K
N
L
Y
H
N
L
C
T
S
L
Site 29
T379
L
F
G
G
V
P
K
T
T
G
E
G
T
S
L
Site 30
T380
F
G
G
V
P
K
T
T
G
E
G
T
S
L
R
Site 31
S385
K
T
T
G
E
G
T
S
L
R
G
D
I
N
V
Site 32
T400
C
I
V
G
D
P
S
T
A
K
S
Q
F
L
K
Site 33
S403
G
D
P
S
T
A
K
S
Q
F
L
K
H
V
E
Site 34
S413
L
K
H
V
E
E
F
S
P
R
A
V
Y
T
S
Site 35
Y418
E
F
S
P
R
A
V
Y
T
S
G
K
A
S
S
Site 36
S420
S
P
R
A
V
Y
T
S
G
K
A
S
S
A
A
Site 37
S424
V
Y
T
S
G
K
A
S
S
A
A
G
L
T
A
Site 38
S425
Y
T
S
G
K
A
S
S
A
A
G
L
T
A
A
Site 39
S483
A
M
E
Q
Q
T
I
S
I
T
K
A
G
V
K
Site 40
S498
A
T
L
N
A
R
T
S
I
L
A
A
A
N
P
Site 41
S507
L
A
A
A
N
P
I
S
G
H
Y
D
R
S
K
Site 42
Y510
A
N
P
I
S
G
H
Y
D
R
S
K
S
L
K
Site 43
S513
I
S
G
H
Y
D
R
S
K
S
L
K
Q
N
I
Site 44
S515
G
H
Y
D
R
S
K
S
L
K
Q
N
I
N
L
Site 45
S523
L
K
Q
N
I
N
L
S
A
P
I
M
S
R
F
Site 46
Y546
E
C
N
E
V
T
D
Y
A
I
A
R
R
I
V
Site 47
S557
R
R
I
V
D
L
H
S
R
I
E
E
S
I
D
Site 48
S562
L
H
S
R
I
E
E
S
I
D
R
V
Y
S
L
Site 49
Y567
E
E
S
I
D
R
V
Y
S
L
D
D
I
R
R
Site 50
S568
E
S
I
D
R
V
Y
S
L
D
D
I
R
R
Y
Site 51
Y575
S
L
D
D
I
R
R
Y
L
L
F
A
R
Q
F
Site 52
S587
R
Q
F
K
P
K
I
S
K
E
S
E
D
F
I
Site 53
S607
H
L
R
Q
R
D
G
S
G
V
T
K
S
S
W
Site 54
S612
D
G
S
G
V
T
K
S
S
W
R
I
T
V
R
Site 55
S613
G
S
G
V
T
K
S
S
W
R
I
T
V
R
Q
Site 56
T617
T
K
S
S
W
R
I
T
V
R
Q
L
E
S
M
Site 57
S628
L
E
S
M
I
R
L
S
E
A
M
A
R
M
H
Site 58
T661
K
S
I
I
R
V
E
T
P
D
V
N
L
D
Q
Site 59
S689
G
I
N
G
H
A
D
S
P
A
P
V
N
G
I
Site 60
Y699
P
V
N
G
I
N
G
Y
N
E
D
I
N
Q
E
Site 61
S712
Q
E
S
A
P
K
A
S
L
R
L
G
F
S
E
Site 62
S718
A
S
L
R
L
G
F
S
E
Y
C
R
I
S
N
Site 63
S741
V
E
E
E
E
D
E
S
A
L
K
R
S
E
L
Site 64
S746
D
E
S
A
L
K
R
S
E
L
V
N
W
Y
L
Site 65
Y752
R
S
E
L
V
N
W
Y
L
K
E
I
E
S
E
Site 66
S758
W
Y
L
K
E
I
E
S
E
I
D
S
E
E
E
Site 67
S762
E
I
E
S
E
I
D
S
E
E
E
L
I
N
K
Site 68
T781
E
K
V
I
H
R
L
T
H
Y
D
H
V
L
I
Site 69
T791
D
H
V
L
I
E
L
T
Q
A
G
L
K
G
S
Site 70
S798
T
Q
A
G
L
K
G
S
T
E
G
S
E
S
Y
Site 71
S802
L
K
G
S
T
E
G
S
E
S
Y
E
E
D
P
Site 72
S804
G
S
T
E
G
S
E
S
Y
E
E
D
P
Y
L
Site 73
Y810
E
S
Y
E
E
D
P
Y
L
V
V
N
P
N
Y
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation