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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NBR1
Full Name:
Next to BRCA1 gene 1 protein
Alias:
1A13B; 1A1-3B; CA125; KIAA0049; M17S2; Membrane component, chromosome 17, surface marker 2; Neighbor of BRCA1 gene 1; Neighbor of BRCA1 gene 1 protein
Type:
Unknown function
Mass (Da):
107432
Number AA:
966
UniProt ID:
Q14596
International Prot ID:
IPI00871941
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0008270
GO:0043167
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
P
Q
V
T
L
N
V
T
F
K
N
E
I
Q
S
Site 2
S17
T
F
K
N
E
I
Q
S
F
L
V
S
D
P
E
Site 3
S21
E
I
Q
S
F
L
V
S
D
P
E
N
T
T
W
Site 4
T43
K
V
S
F
D
L
N
T
I
Q
I
K
Y
L
D
Site 5
Y48
L
N
T
I
Q
I
K
Y
L
D
E
E
N
E
E
Site 6
Y64
S
I
N
S
Q
G
E
Y
E
E
A
L
K
M
A
Site 7
S116
K
P
L
A
H
Y
S
S
L
V
R
V
L
G
S
Site 8
S123
S
L
V
R
V
L
G
S
D
M
K
T
P
E
D
Site 9
T127
V
L
G
S
D
M
K
T
P
E
D
P
A
V
Q
Site 10
S135
P
E
D
P
A
V
Q
S
F
P
L
V
P
C
D
Site 11
T143
F
P
L
V
P
C
D
T
D
Q
P
Q
D
K
P
Site 12
T155
D
K
P
P
D
W
F
T
S
Y
L
E
T
F
R
Site 13
Y157
P
P
D
W
F
T
S
Y
L
E
T
F
R
E
Q
Site 14
T169
R
E
Q
V
V
N
E
T
V
E
K
L
E
Q
K
Site 15
S187
K
L
V
L
Q
N
P
S
L
G
S
C
P
S
E
Site 16
S190
L
Q
N
P
S
L
G
S
C
P
S
E
V
S
M
Site 17
S193
P
S
L
G
S
C
P
S
E
V
S
M
P
T
S
Site 18
S196
G
S
C
P
S
E
V
S
M
P
T
S
E
E
T
Site 19
T199
P
S
E
V
S
M
P
T
S
E
E
T
L
F
L
Site 20
S200
S
E
V
S
M
P
T
S
E
E
T
L
F
L
P
Site 21
Y229
R
R
I
V
G
V
R
Y
Q
C
S
L
C
P
S
Site 22
Y248
E
D
C
E
A
G
P
Y
G
H
D
T
N
H
V
Site 23
T252
A
G
P
Y
G
H
D
T
N
H
V
L
L
K
L
Site 24
S266
L
R
R
P
V
V
G
S
S
E
P
F
C
H
S
Site 25
S267
R
R
P
V
V
G
S
S
E
P
F
C
H
S
K
Site 26
S273
S
S
E
P
F
C
H
S
K
Y
S
T
P
R
L
Site 27
Y275
E
P
F
C
H
S
K
Y
S
T
P
R
L
P
A
Site 28
S276
P
F
C
H
S
K
Y
S
T
P
R
L
P
A
A
Site 29
T277
F
C
H
S
K
Y
S
T
P
R
L
P
A
A
L
Site 30
S334
R
K
I
H
L
W
N
S
I
H
G
L
Q
S
P
Site 31
S340
N
S
I
H
G
L
Q
S
P
K
S
P
L
G
R
Site 32
S343
H
G
L
Q
S
P
K
S
P
L
G
R
P
E
S
Site 33
S350
S
P
L
G
R
P
E
S
L
L
Q
S
N
T
L
Site 34
S354
R
P
E
S
L
L
Q
S
N
T
L
M
L
P
L
Site 35
T356
E
S
L
L
Q
S
N
T
L
M
L
P
L
Q
P
Site 36
T390
G
T
H
L
Q
P
G
T
K
F
I
K
H
W
R
Site 37
T420
K
F
M
W
G
N
L
T
L
A
S
T
E
K
K
Site 38
T456
P
A
L
E
G
T
Y
T
S
H
W
R
L
S
H
Site 39
S457
A
L
E
G
T
Y
T
S
H
W
R
L
S
H
K
Site 40
S483
I
I
V
D
P
F
P
S
E
E
S
P
D
N
I
Site 41
S486
D
P
F
P
S
E
E
S
P
D
N
I
E
K
G
Site 42
S498
E
K
G
M
I
S
S
S
K
T
D
D
L
T
C
Site 43
T500
G
M
I
S
S
S
K
T
D
D
L
T
C
Q
Q
Site 44
T504
S
S
K
T
D
D
L
T
C
Q
Q
E
E
T
F
Site 45
T530
V
T
E
Q
T
E
G
T
A
A
C
I
P
Q
K
Site 46
S543
Q
K
A
K
N
V
A
S
E
R
E
L
Y
I
P
Site 47
T581
L
E
R
V
P
H
N
T
P
V
D
V
T
P
C
Site 48
T586
H
N
T
P
V
D
V
T
P
C
M
S
P
L
P
Site 49
S590
V
D
V
T
P
C
M
S
P
L
P
H
D
S
P
Site 50
S596
M
S
P
L
P
H
D
S
P
L
I
E
K
P
G
Site 51
S622
G
F
K
A
L
P
D
S
M
V
S
V
K
R
K
Site 52
S635
R
K
A
E
N
I
A
S
V
E
E
A
E
E
D
Site 53
S644
E
E
A
E
E
D
L
S
G
T
Q
F
V
C
E
Site 54
S656
V
C
E
T
V
I
R
S
L
T
L
D
A
A
P
Site 55
T658
E
T
V
I
R
S
L
T
L
D
A
A
P
D
H
Site 56
S673
N
P
P
C
R
Q
K
S
L
Q
M
T
F
A
L
Site 57
T677
R
Q
K
S
L
Q
M
T
F
A
L
P
E
G
P
Site 58
S723
E
L
K
D
E
V
Q
S
Q
S
S
A
S
S
E
Site 59
S725
K
D
E
V
Q
S
Q
S
S
A
S
S
E
D
Y
Site 60
S726
D
E
V
Q
S
Q
S
S
A
S
S
E
D
Y
I
Site 61
S729
Q
S
Q
S
S
A
S
S
E
D
Y
I
I
I
L
Site 62
T742
I
L
P
E
C
F
D
T
S
R
P
L
G
D
S
Site 63
S743
L
P
E
C
F
D
T
S
R
P
L
G
D
S
M
Site 64
S749
T
S
R
P
L
G
D
S
M
Y
S
S
A
L
S
Site 65
Y751
R
P
L
G
D
S
M
Y
S
S
A
L
S
Q
P
Site 66
S753
L
G
D
S
M
Y
S
S
A
L
S
Q
P
G
L
Site 67
S756
S
M
Y
S
S
A
L
S
Q
P
G
L
E
R
G
Site 68
S796
Q
P
Q
E
H
S
I
S
D
I
L
T
T
S
Q
Site 69
T800
H
S
I
S
D
I
L
T
T
S
Q
T
L
E
T
Site 70
S820
E
V
V
E
L
P
P
S
L
P
R
S
S
P
C
Site 71
S824
L
P
P
S
L
P
R
S
S
P
C
V
H
H
H
Site 72
S825
P
P
S
L
P
R
S
S
P
C
V
H
H
H
G
Site 73
S833
P
C
V
H
H
H
G
S
P
G
V
D
L
P
V
Site 74
S846
P
V
T
I
P
E
V
S
S
V
P
D
Q
I
R
Site 75
S847
V
T
I
P
E
V
S
S
V
P
D
Q
I
R
G
Site 76
S859
I
R
G
E
P
R
G
S
S
G
L
V
N
S
R
Site 77
S860
R
G
E
P
R
G
S
S
G
L
V
N
S
R
Q
Site 78
S865
G
S
S
G
L
V
N
S
R
Q
K
S
Y
D
H
Site 79
S869
L
V
N
S
R
Q
K
S
Y
D
H
S
R
H
H
Site 80
Y870
V
N
S
R
Q
K
S
Y
D
H
S
R
H
H
H
Site 81
S873
R
Q
K
S
Y
D
H
S
R
H
H
H
G
S
S
Site 82
S879
H
S
R
H
H
H
G
S
S
I
A
G
G
L
V
Site 83
S880
S
R
H
H
H
G
S
S
I
A
G
G
L
V
K
Site 84
Y944
R
L
L
K
K
H
N
Y
N
I
L
Q
V
V
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation