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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ITIH4
Full Name:
Inter-alpha-trypsin inhibitor heavy chain H4
Alias:
GP120; H4P; IHRP; Inter-alpha (globulin) inhibitor H4; Inter-alpha-inhibitor heavy chain 4; Inter-alpha-trypsin inhibitor family heavy chain-related protein; ITI heavy chain H4; ITIHL1; PK-120; Plasma kallikrein sensitive glycoprotein 120; Plasma Kallikrein-sensitive glycoprotein
Type:
Mass (Da):
103339
Number AA:
930
UniProt ID:
Q14624
International Prot ID:
IPI00218192
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0004867
PhosphoSite+
KinaseNET
Biological Process:
GO:0006953
GO:0030212
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
K
P
P
R
P
V
R
T
C
S
K
V
L
V
L
Site 2
Y36
E
K
N
G
I
D
I
Y
S
L
T
V
D
S
R
Site 3
S37
K
N
G
I
D
I
Y
S
L
T
V
D
S
R
V
Site 4
S42
I
Y
S
L
T
V
D
S
R
V
S
S
R
F
A
Site 5
S45
L
T
V
D
S
R
V
S
S
R
F
A
H
T
V
Site 6
S46
T
V
D
S
R
V
S
S
R
F
A
H
T
V
V
Site 7
T63
R
V
V
N
R
A
N
T
V
Q
E
A
T
F
Q
Site 8
T68
A
N
T
V
Q
E
A
T
F
Q
M
E
L
P
K
Site 9
S114
A
A
V
A
K
G
K
S
A
G
L
V
K
A
T
Site 10
S131
N
M
E
Q
F
Q
V
S
V
S
V
A
P
N
A
Site 11
S185
I
F
E
P
Q
G
I
S
F
L
E
T
E
S
T
Site 12
T189
Q
G
I
S
F
L
E
T
E
S
T
F
M
T
N
Site 13
T192
S
F
L
E
T
E
S
T
F
M
T
N
Q
L
V
Site 14
T195
E
T
E
S
T
F
M
T
N
Q
L
V
D
A
L
Site 15
T203
N
Q
L
V
D
A
L
T
T
W
Q
N
K
T
K
Site 16
S220
I
R
F
K
P
T
L
S
Q
Q
Q
K
S
P
E
Site 17
S225
T
L
S
Q
Q
Q
K
S
P
E
Q
Q
E
T
V
Site 18
T231
K
S
P
E
Q
Q
E
T
V
L
D
G
N
L
I
Site 19
Y241
D
G
N
L
I
I
R
Y
D
V
D
R
A
I
S
Site 20
S248
Y
D
V
D
R
A
I
S
G
G
S
I
Q
I
E
Site 21
Y262
E
N
G
Y
F
V
H
Y
F
A
P
E
G
L
T
Site 22
S282
V
V
F
V
I
D
K
S
G
S
M
S
G
R
K
Site 23
S284
F
V
I
D
K
S
G
S
M
S
G
R
K
I
Q
Site 24
S286
I
D
K
S
G
S
M
S
G
R
K
I
Q
Q
T
Site 25
T293
S
G
R
K
I
Q
Q
T
R
E
A
L
I
K
I
Site 26
S305
I
K
I
L
D
D
L
S
P
R
D
Q
F
N
L
Site 27
S325
E
A
T
Q
W
R
P
S
L
V
P
A
S
A
E
Site 28
S330
R
P
S
L
V
P
A
S
A
E
N
V
N
K
A
Site 29
S339
E
N
V
N
K
A
R
S
F
A
A
G
I
Q
A
Site 30
S365
M
A
V
Q
L
L
D
S
S
N
Q
E
E
R
L
Site 31
S366
A
V
Q
L
L
D
S
S
N
Q
E
E
R
L
P
Site 32
T389
L
L
T
D
G
D
P
T
V
G
E
T
N
P
R
Site 33
T393
G
D
P
T
V
G
E
T
N
P
R
S
I
Q
N
Site 34
S397
V
G
E
T
N
P
R
S
I
Q
N
N
V
R
E
Site 35
S407
N
N
V
R
E
A
V
S
G
R
Y
S
L
F
C
Site 36
S444
A
R
R
I
H
E
D
S
D
S
A
L
Q
L
Q
Site 37
S446
R
I
H
E
D
S
D
S
A
L
Q
L
Q
D
F
Site 38
Y454
A
L
Q
L
Q
D
F
Y
Q
E
V
A
N
P
L
Site 39
T466
N
P
L
L
T
A
V
T
F
E
Y
P
S
N
A
Site 40
Y469
L
T
A
V
T
F
E
Y
P
S
N
A
V
E
E
Site 41
T506
D
R
G
P
D
V
L
T
A
T
V
S
G
K
L
Site 42
T519
K
L
P
T
Q
N
I
T
F
Q
T
E
S
S
V
Site 43
S525
I
T
F
Q
T
E
S
S
V
A
E
Q
E
A
E
Site 44
S535
E
Q
E
A
E
F
Q
S
P
K
Y
I
F
H
N
Site 45
Y538
A
E
F
Q
S
P
K
Y
I
F
H
N
F
M
E
Site 46
T552
E
R
L
W
A
Y
L
T
I
Q
Q
L
L
E
Q
Site 47
T560
I
Q
Q
L
L
E
Q
T
V
S
A
S
D
A
D
Site 48
S562
Q
L
L
E
Q
T
V
S
A
S
D
A
D
Q
Q
Site 49
S564
L
E
Q
T
V
S
A
S
D
A
D
Q
Q
A
L
Site 50
T594
P
L
T
S
M
V
V
T
K
P
D
D
Q
E
Q
Site 51
S602
K
P
D
D
Q
E
Q
S
Q
V
A
E
K
P
M
Site 52
S613
E
K
P
M
E
G
E
S
R
N
R
N
V
H
S
Site 53
S620
S
R
N
R
N
V
H
S
G
S
T
F
F
K
Y
Site 54
T623
R
N
V
H
S
G
S
T
F
F
K
Y
Y
L
Q
Site 55
Y627
S
G
S
T
F
F
K
Y
Y
L
Q
G
A
K
I
Site 56
Y628
G
S
T
F
F
K
Y
Y
L
Q
G
A
K
I
P
Site 57
S640
K
I
P
K
P
E
A
S
F
S
P
R
R
G
W
Site 58
S642
P
K
P
E
A
S
F
S
P
R
R
G
W
N
R
Site 59
S656
R
Q
A
G
A
A
G
S
R
M
N
F
R
P
G
Site 60
S666
N
F
R
P
G
V
L
S
S
R
Q
L
G
L
P
Site 61
S667
F
R
P
G
V
L
S
S
R
Q
L
G
L
P
G
Site 62
T701
P
A
S
A
P
P
A
T
S
N
P
D
P
A
V
Site 63
T722
K
I
E
E
T
T
M
T
T
Q
T
P
A
P
I
Site 64
T723
I
E
E
T
T
M
T
T
Q
T
P
A
P
I
Q
Site 65
T725
E
T
T
M
T
T
Q
T
P
A
P
I
Q
A
P
Site 66
S761
Q
G
P
V
N
L
L
S
D
P
E
Q
G
V
E
Site 67
Y773
G
V
E
V
T
G
Q
Y
E
R
E
K
A
G
F
Site 68
S809
V
V
T
R
N
R
R
S
S
A
Y
K
W
K
E
Site 69
S810
V
T
R
N
R
R
S
S
A
Y
K
W
K
E
T
Site 70
Y812
R
N
R
R
S
S
A
Y
K
W
K
E
T
L
F
Site 71
T817
S
A
Y
K
W
K
E
T
L
F
S
V
M
P
G
Site 72
T864
L
R
L
L
L
R
D
T
D
R
F
S
S
H
V
Site 73
S868
L
R
D
T
D
R
F
S
S
H
V
G
G
T
L
Site 74
S869
R
D
T
D
R
F
S
S
H
V
G
G
T
L
G
Site 75
Y879
G
G
T
L
G
Q
F
Y
Q
E
V
L
W
G
S
Site 76
S886
Y
Q
E
V
L
W
G
S
P
A
A
S
D
D
G
Site 77
S890
L
W
G
S
P
A
A
S
D
D
G
R
R
T
L
Site 78
T896
A
S
D
D
G
R
R
T
L
R
V
Q
G
N
D
Site 79
S905
R
V
Q
G
N
D
H
S
A
T
R
E
R
R
L
Site 80
T907
Q
G
N
D
H
S
A
T
R
E
R
R
L
D
Y
Site 81
Y914
T
R
E
R
R
L
D
Y
Q
E
G
P
P
G
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation