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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RASA3
Full Name:
Ras GTPase-activating protein 3
Alias:
GAP1(IP4BP); GAP1IP4BP; GAPIII; Ins P4-binding protein; RAS p21 protein activator 3
Type:
GTPase-activating protein for Ras
Mass (Da):
95699
Number AA:
834
UniProt ID:
Q14644
International Prot ID:
IPI00032267
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0031235
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0015278
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
G
L
R
V
F
Q
S
V
K
I
K
I
G
E
Site 2
S26
G
E
A
K
N
L
P
S
Y
P
G
P
S
K
M
Site 3
Y27
E
A
K
N
L
P
S
Y
P
G
P
S
K
M
R
Site 4
Y37
P
S
K
M
R
D
C
Y
C
T
V
N
L
D
Q
Site 5
T50
D
Q
E
E
V
F
R
T
K
I
V
E
K
S
L
Site 6
S56
R
T
K
I
V
E
K
S
L
C
P
F
Y
G
E
Site 7
Y61
E
K
S
L
C
P
F
Y
G
E
D
F
Y
C
E
Site 8
Y66
P
F
Y
G
E
D
F
Y
C
E
I
P
R
S
F
Site 9
S77
P
R
S
F
R
H
L
S
F
Y
I
F
D
R
D
Site 10
Y79
S
F
R
H
L
S
F
Y
I
F
D
R
D
V
F
Site 11
S90
R
D
V
F
R
R
D
S
I
I
G
K
V
A
I
Site 12
Y105
Q
K
E
D
L
Q
K
Y
H
N
R
D
T
W
F
Site 13
T110
Q
K
Y
H
N
R
D
T
W
F
Q
L
Q
H
V
Site 14
S121
L
Q
H
V
D
A
D
S
E
V
Q
G
K
V
H
Site 15
S178
T
L
A
G
P
F
R
S
E
A
K
K
T
K
V
Site 16
T183
F
R
S
E
A
K
K
T
K
V
K
R
K
T
N
Site 17
T189
K
T
K
V
K
R
K
T
N
N
P
Q
F
D
E
Site 18
Y199
P
Q
F
D
E
V
F
Y
F
E
V
T
R
P
C
Site 19
T203
E
V
F
Y
F
E
V
T
R
P
C
S
Y
S
K
Site 20
S207
F
E
V
T
R
P
C
S
Y
S
K
K
S
H
F
Site 21
Y208
E
V
T
R
P
C
S
Y
S
K
K
S
H
F
D
Site 22
S209
V
T
R
P
C
S
Y
S
K
K
S
H
F
D
F
Site 23
S212
P
C
S
Y
S
K
K
S
H
F
D
F
E
E
E
Site 24
S234
R
V
D
L
W
N
A
S
N
L
K
F
G
D
E
Site 25
S256
P
L
K
V
L
R
Q
S
S
S
Y
E
A
W
Y
Site 26
S257
L
K
V
L
R
Q
S
S
S
Y
E
A
W
Y
F
Site 27
S258
K
V
L
R
Q
S
S
S
Y
E
A
W
Y
F
L
Site 28
Y259
V
L
R
Q
S
S
S
Y
E
A
W
Y
F
L
Q
Site 29
Y263
S
S
S
Y
E
A
W
Y
F
L
Q
P
R
D
N
Site 30
S272
L
Q
P
R
D
N
G
S
K
S
L
K
P
D
D
Site 31
S274
P
R
D
N
G
S
K
S
L
K
P
D
D
L
G
Site 32
S282
L
K
P
D
D
L
G
S
L
R
L
N
V
V
Y
Site 33
Y289
S
L
R
L
N
V
V
Y
T
E
D
H
V
F
S
Site 34
S297
T
E
D
H
V
F
S
S
D
Y
Y
S
P
L
R
Site 35
Y299
D
H
V
F
S
S
D
Y
Y
S
P
L
R
D
L
Site 36
Y300
H
V
F
S
S
D
Y
Y
S
P
L
R
D
L
L
Site 37
Y345
L
V
R
L
F
L
H
Y
G
R
V
V
P
F
I
Site 38
S357
P
F
I
S
A
I
A
S
A
E
V
K
R
T
Q
Site 39
T363
A
S
A
E
V
K
R
T
Q
D
P
N
T
I
F
Site 40
T368
K
R
T
Q
D
P
N
T
I
F
R
G
N
S
L
Site 41
S374
N
T
I
F
R
G
N
S
L
A
S
K
C
I
D
Site 42
T395
G
M
H
Y
L
H
V
T
L
K
P
A
I
E
E
Site 43
Y433
N
M
E
N
L
R
Q
Y
V
D
R
V
F
H
A
Site 44
T442
D
R
V
F
H
A
I
T
E
S
G
V
S
C
P
Site 45
Y475
Q
D
D
P
D
V
R
Y
T
A
V
S
S
F
I
Site 46
T476
D
D
P
D
V
R
Y
T
A
V
S
S
F
I
F
Site 47
T500
S
P
N
L
F
Q
L
T
P
H
H
T
D
P
Q
Site 48
T508
P
H
H
T
D
P
Q
T
S
R
T
L
T
L
I
Site 49
T511
T
D
P
Q
T
S
R
T
L
T
L
I
S
K
T
Site 50
T513
P
Q
T
S
R
T
L
T
L
I
S
K
T
V
Q
Site 51
T518
T
L
T
L
I
S
K
T
V
Q
T
L
G
S
L
Site 52
T521
L
I
S
K
T
V
Q
T
L
G
S
L
S
K
S
Site 53
S524
K
T
V
Q
T
L
G
S
L
S
K
S
K
S
A
Site 54
S526
V
Q
T
L
G
S
L
S
K
S
K
S
A
S
F
Site 55
S528
T
L
G
S
L
S
K
S
K
S
A
S
F
K
E
Site 56
S530
G
S
L
S
K
S
K
S
A
S
F
K
E
S
Y
Site 57
S532
L
S
K
S
K
S
A
S
F
K
E
S
Y
M
A
Site 58
S536
K
S
A
S
F
K
E
S
Y
M
A
T
F
Y
E
Site 59
Y537
S
A
S
F
K
E
S
Y
M
A
T
F
Y
E
F
Site 60
Y542
E
S
Y
M
A
T
F
Y
E
F
F
N
E
Q
K
Site 61
Y550
E
F
F
N
E
Q
K
Y
A
D
A
V
K
N
F
Site 62
S562
K
N
F
L
D
L
I
S
S
S
G
R
R
D
P
Site 63
S563
N
F
L
D
L
I
S
S
S
G
R
R
D
P
K
Site 64
S564
F
L
D
L
I
S
S
S
G
R
R
D
P
K
S
Site 65
S571
S
G
R
R
D
P
K
S
V
E
Q
P
I
V
L
Site 66
Y612
L
T
N
H
E
F
T
Y
H
K
S
K
G
D
Q
Site 67
Y622
S
K
G
D
Q
P
L
Y
S
I
P
I
E
N
I
Site 68
S623
K
G
D
Q
P
L
Y
S
I
P
I
E
N
I
L
Site 69
S639
V
E
K
L
E
E
E
S
F
K
M
K
N
M
F
Site 70
Y656
I
Q
P
E
R
A
L
Y
I
Q
A
N
N
C
V
Site 71
S676
I
D
I
L
T
K
V
S
Q
C
N
Q
K
R
L
Site 72
T684
Q
C
N
Q
K
R
L
T
V
Y
H
P
S
A
Y
Site 73
S703
W
L
C
C
R
A
P
S
D
S
A
P
G
C
S
Site 74
S705
C
C
R
A
P
S
D
S
A
P
G
C
S
P
C
Site 75
S710
S
D
S
A
P
G
C
S
P
C
T
G
G
L
P
Site 76
T730
D
I
D
G
D
R
E
T
E
R
I
Y
S
L
F
Site 77
Y734
D
R
E
T
E
R
I
Y
S
L
F
N
L
Y
M
Site 78
S735
R
E
T
E
R
I
Y
S
L
F
N
L
Y
M
S
Site 79
S753
K
M
Q
E
A
C
G
S
K
S
V
Y
D
G
P
Site 80
S755
Q
E
A
C
G
S
K
S
V
Y
D
G
P
E
Q
Site 81
Y757
A
C
G
S
K
S
V
Y
D
G
P
E
Q
E
E
Site 82
Y765
D
G
P
E
Q
E
E
Y
S
T
F
V
I
D
D
Site 83
T767
P
E
Q
E
E
Y
S
T
F
V
I
D
D
P
Q
Site 84
Y777
I
D
D
P
Q
E
T
Y
K
T
L
K
Q
V
I
Site 85
T779
D
P
Q
E
T
Y
K
T
L
K
Q
V
I
A
G
Site 86
Y797
L
E
Q
E
H
A
Q
Y
K
R
D
K
F
K
K
Site 87
T805
K
R
D
K
F
K
K
T
K
Y
G
S
Q
E
H
Site 88
Y807
D
K
F
K
K
T
K
Y
G
S
Q
E
H
P
I
Site 89
S809
F
K
K
T
K
Y
G
S
Q
E
H
P
I
G
D
Site 90
S818
E
H
P
I
G
D
K
S
F
Q
N
Y
I
R
Q
Site 91
Y822
G
D
K
S
F
Q
N
Y
I
R
Q
Q
S
E
T
Site 92
S827
Q
N
Y
I
R
Q
Q
S
E
T
S
T
H
S
I
Site 93
T829
Y
I
R
Q
Q
S
E
T
S
T
H
S
I
_
_
Site 94
S830
I
R
Q
Q
S
E
T
S
T
H
S
I
_
_
_
Site 95
T831
R
Q
Q
S
E
T
S
T
H
S
I
_
_
_
_
Site 96
S833
Q
S
E
T
S
T
H
S
I
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation