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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PLS1
Full Name:
Plastin-1
Alias:
Intestine-specific plastin; I-plastin
Type:
Actin binding protein
Mass (Da):
70253
Number AA:
629
UniProt ID:
Q14651
International Prot ID:
IPI00032304
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0051015
GO:0005509
GO:0005200
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
E
N
S
T
T
T
I
S
R
E
E
L
Site 2
S9
E
N
S
T
T
T
I
S
R
E
E
L
E
E
L
Site 3
S28
N
K
I
D
I
D
N
S
G
Y
V
S
D
Y
E
Site 4
Y30
I
D
I
D
N
S
G
Y
V
S
D
Y
E
L
Q
Site 5
S32
I
D
N
S
G
Y
V
S
D
Y
E
L
Q
D
L
Site 6
Y34
N
S
G
Y
V
S
D
Y
E
L
Q
D
L
F
K
Site 7
S44
Q
D
L
F
K
E
A
S
L
P
L
P
G
Y
K
Site 8
Y50
A
S
L
P
L
P
G
Y
K
V
R
E
I
V
E
Site 9
S61
E
I
V
E
K
I
L
S
V
A
D
S
N
K
D
Site 10
S65
K
I
L
S
V
A
D
S
N
K
D
G
K
I
S
Site 11
S72
S
N
K
D
G
K
I
S
F
E
E
F
V
S
L
Site 12
S78
I
S
F
E
E
F
V
S
L
M
Q
E
L
K
S
Site 13
S85
S
L
M
Q
E
L
K
S
K
D
I
S
K
T
F
Site 14
S89
E
L
K
S
K
D
I
S
K
T
F
R
K
I
I
Site 15
T91
K
S
K
D
I
S
K
T
F
R
K
I
I
N
K
Site 16
S109
I
T
A
I
G
G
T
S
T
I
S
S
E
G
T
Site 17
S112
I
G
G
T
S
T
I
S
S
E
G
T
Q
H
S
Site 18
S113
G
G
T
S
T
I
S
S
E
G
T
Q
H
S
Y
Site 19
T116
S
T
I
S
S
E
G
T
Q
H
S
Y
S
E
E
Site 20
S119
S
S
E
G
T
Q
H
S
Y
S
E
E
E
K
V
Site 21
Y120
S
E
G
T
Q
H
S
Y
S
E
E
E
K
V
A
Site 22
S121
E
G
T
Q
H
S
Y
S
E
E
E
K
V
A
F
Site 23
S154
P
M
N
P
N
D
D
S
L
F
K
S
L
A
D
Site 24
S172
L
C
K
M
I
N
L
S
E
P
D
T
I
D
E
Site 25
T176
I
N
L
S
E
P
D
T
I
D
E
R
A
I
N
Site 26
T188
A
I
N
K
K
K
L
T
P
F
T
I
S
E
N
Site 27
T191
K
K
K
L
T
P
F
T
I
S
E
N
L
N
L
Site 28
S267
L
E
E
L
M
K
L
S
P
E
E
L
L
L
R
Site 29
Y278
L
L
L
R
W
V
N
Y
H
L
T
N
A
G
W
Site 30
T287
L
T
N
A
G
W
H
T
I
S
N
F
S
Q
D
Site 31
S292
W
H
T
I
S
N
F
S
Q
D
I
K
D
S
R
Site 32
Y301
D
I
K
D
S
R
A
Y
F
H
L
L
N
Q
I
Site 33
S324
P
A
I
A
I
D
L
S
G
I
N
E
T
N
D
Site 34
Y375
V
A
N
L
F
N
T
Y
P
C
L
H
K
P
N
Site 35
T400
G
E
S
K
E
E
R
T
F
R
N
W
M
N
S
Site 36
Y413
N
S
L
G
V
N
P
Y
I
N
H
L
Y
S
D
Site 37
Y431
A
L
V
I
F
Q
L
Y
E
M
I
R
V
P
V
Site 38
Y448
S
H
V
N
K
P
P
Y
P
A
L
G
G
N
M
Site 39
Y463
K
K
I
E
N
C
N
Y
A
V
E
L
G
K
N
Site 40
S475
G
K
N
K
A
K
F
S
L
V
G
I
A
G
Q
Site 41
Y503
V
W
Q
L
M
R
R
Y
T
L
N
V
L
S
D
Site 42
T504
W
Q
L
M
R
R
Y
T
L
N
V
L
S
D
L
Site 43
S509
R
Y
T
L
N
V
L
S
D
L
G
E
G
E
K
Site 44
S532
W
V
N
Q
T
L
K
S
A
N
K
K
T
S
I
Site 45
T537
L
K
S
A
N
K
K
T
S
I
S
S
F
K
D
Site 46
S538
K
S
A
N
K
K
T
S
I
S
S
F
K
D
K
Site 47
S541
N
K
K
T
S
I
S
S
F
K
D
K
S
I
S
Site 48
S546
I
S
S
F
K
D
K
S
I
S
T
S
L
P
V
Site 49
S548
S
F
K
D
K
S
I
S
T
S
L
P
V
L
D
Site 50
S576
M
I
R
R
E
N
L
S
D
E
D
K
L
N
N
Site 51
Y586
D
K
L
N
N
A
K
Y
A
I
S
V
A
R
K
Site 52
S589
N
N
A
K
Y
A
I
S
V
A
R
K
I
G
A
Site 53
Y599
R
K
I
G
A
R
I
Y
A
L
P
D
D
L
V
Site 54
T615
V
K
P
K
M
V
M
T
V
F
A
C
L
M
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation