PhosphoNET

           
Protein Info 
   
Short Name:  IRF3
Full Name:  Interferon regulatory factor 3
Alias:  IRF-3
Type:  Transcription protein
Mass (Da):  47219
Number AA:  427
UniProt ID:  Q14653
International Prot ID:  IPI00291901
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0005654   Uniprot OncoNet
Molecular Function:  GO:0003702  GO:0003712  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0007249  GO:0044419  GO:0006355 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S14RILPWLVSQLDLGQL
Site 2S30GVAWVNKSRTRFRIP
Site 3Y64WAEATGAYVPGRDKP
Site 4S97LRLAEDRSKDPHDPH
Site 5Y107PHDPHKIYEFVNSGV
Site 6S112KIYEFVNSGVGDFSQ
Site 7S118NSGVGDFSQPDTSPD
Site 8T122GDFSQPDTSPDTNGG
Site 9S123DFSQPDTSPDTNGGG
Site 10T126QPDTSPDTNGGGSTS
Site 11S131PDTNGGGSTSDTQED
Site 12S133TNGGGSTSDTQEDIL
Site 13T135GGGSTSDTQEDILDE
Site 14S159LPDPGPPSLAVAPEP
Site 15S173PCPQPLRSPSLDNPT
Site 16S175PQPLRSPSLDNPTPF
Site 17T180SPSLDNPTPFPNLGP
Site 18S188PFPNLGPSENPLKRL
Site 19S221QVFQQTISCPEGLRL
Site 20S231EGLRLVGSEVGDRTL
Site 21T237GSEVGDRTLPGWPVT
Site 22T244TLPGWPVTLPDPGMS
Site 23S251TLPDPGMSLTDRGVM
Site 24T253PDPGMSLTDRGVMSY
Site 25Y260TDRGVMSYVRHVLSC
Site 26T291QRLGHCHTYWAVSEE
Site 27Y292RLGHCHTYWAVSEEL
Site 28S303SEELLPNSGHGPDGE
Site 29S336LITFTEGSGRSPRYA
Site 30S339FTEGSGRSPRYALWF
Site 31Y342GSGRSPRYALWFCVG
Site 32T370VMVKVVPTCLRALVE
Site 33S385MARVGGASSLENTVD
Site 34S386ARVGGASSLENTVDL
Site 35T390GASSLENTVDLHISN
Site 36S396NTVDLHISNSHPLSL
Site 37S398VDLHISNSHPLSLTS
Site 38S402ISNSHPLSLTSDQYK
Site 39T404NSHPLSLTSDQYKAY
Site 40S405SHPLSLTSDQYKAYL
Site 41Y408LSLTSDQYKAYLQDL
Site 42Y411TSDQYKAYLQDLVEG
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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