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Updated November 2019
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Protein Info
Short Name:
KANK1
Full Name:
KN motif and ankyrin repeat domain-containing protein 1
Alias:
ANR15; KANK; Kidney ankyrin repeat-containing protein; KN motif and ankyrin repeat domain-containing protein 1
Type:
Uncharacterized
Mass (Da):
147289
Number AA:
1352
UniProt ID:
Q14678
International Prot ID:
IPI00005635
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005932
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0004835
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
GO:0009987
GO:0045786
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
H
T
T
K
V
N
G
S
A
S
G
K
A
G
D
Site 2
S12
T
K
V
N
G
S
A
S
G
K
A
G
D
I
L
Site 3
S20
G
K
A
G
D
I
L
S
G
D
Q
D
K
E
Q
Site 4
Y31
D
K
E
Q
K
D
P
Y
F
V
E
T
P
Y
G
Site 5
T35
K
D
P
Y
F
V
E
T
P
Y
G
Y
Q
L
D
Site 6
Y48
L
D
L
D
F
L
K
Y
V
D
D
I
Q
K
G
Site 7
S70
I
Q
K
R
R
K
P
S
V
P
C
P
E
P
R
Site 8
T78
V
P
C
P
E
P
R
T
T
S
G
Q
Q
G
I
Site 9
T79
P
C
P
E
P
R
T
T
S
G
Q
Q
G
I
W
Site 10
S80
C
P
E
P
R
T
T
S
G
Q
Q
G
I
W
T
Site 11
T87
S
G
Q
Q
G
I
W
T
S
T
E
S
L
S
S
Site 12
S88
G
Q
Q
G
I
W
T
S
T
E
S
L
S
S
S
Site 13
T89
Q
Q
G
I
W
T
S
T
E
S
L
S
S
S
N
Site 14
S91
G
I
W
T
S
T
E
S
L
S
S
S
N
S
D
Site 15
S93
W
T
S
T
E
S
L
S
S
S
N
S
D
D
N
Site 16
S94
T
S
T
E
S
L
S
S
S
N
S
D
D
N
K
Site 17
S95
S
T
E
S
L
S
S
S
N
S
D
D
N
K
Q
Site 18
S97
E
S
L
S
S
S
N
S
D
D
N
K
Q
C
P
Site 19
S115
I
A
R
S
Q
V
T
S
T
P
I
S
K
P
P
Site 20
T116
A
R
S
Q
V
T
S
T
P
I
S
K
P
P
P
Site 21
S119
Q
V
T
S
T
P
I
S
K
P
P
P
P
L
E
Site 22
T127
K
P
P
P
P
L
E
T
S
L
P
F
L
T
I
Site 23
S128
P
P
P
P
L
E
T
S
L
P
F
L
T
I
P
Site 24
T133
E
T
S
L
P
F
L
T
I
P
E
N
R
Q
L
Site 25
S144
N
R
Q
L
P
P
P
S
P
Q
L
P
K
H
N
Site 26
T157
H
N
L
H
V
T
K
T
L
M
E
T
R
R
R
Site 27
T171
R
L
E
Q
E
R
A
T
M
Q
M
T
P
G
E
Site 28
T175
E
R
A
T
M
Q
M
T
P
G
E
F
R
R
P
Site 29
S186
F
R
R
P
R
L
A
S
F
G
G
M
G
T
T
Site 30
S194
F
G
G
M
G
T
T
S
S
L
P
S
F
V
G
Site 31
S198
G
T
T
S
S
L
P
S
F
V
G
S
G
N
H
Site 32
S202
S
L
P
S
F
V
G
S
G
N
H
N
P
A
K
Site 33
Y216
K
H
Q
L
Q
N
G
Y
Q
G
N
G
D
Y
G
Site 34
Y222
G
Y
Q
G
N
G
D
Y
G
S
Y
A
P
A
A
Site 35
S224
Q
G
N
G
D
Y
G
S
Y
A
P
A
A
P
T
Site 36
T231
S
Y
A
P
A
A
P
T
T
S
S
M
G
S
S
Site 37
T232
Y
A
P
A
A
P
T
T
S
S
M
G
S
S
I
Site 38
S233
A
P
A
A
P
T
T
S
S
M
G
S
S
I
R
Site 39
S234
P
A
A
P
T
T
S
S
M
G
S
S
I
R
H
Site 40
S237
P
T
T
S
S
M
G
S
S
I
R
H
S
P
L
Site 41
S238
T
T
S
S
M
G
S
S
I
R
H
S
P
L
S
Site 42
S242
M
G
S
S
I
R
H
S
P
L
S
S
G
I
S
Site 43
S245
S
I
R
H
S
P
L
S
S
G
I
S
T
P
V
Site 44
S246
I
R
H
S
P
L
S
S
G
I
S
T
P
V
T
Site 45
S249
S
P
L
S
S
G
I
S
T
P
V
T
N
V
S
Site 46
T250
P
L
S
S
G
I
S
T
P
V
T
N
V
S
P
Site 47
S256
S
T
P
V
T
N
V
S
P
M
H
L
Q
H
I
Site 48
T283
E
L
E
E
Q
V
R
T
I
P
V
L
Q
V
K
Site 49
S292
P
V
L
Q
V
K
I
S
V
L
Q
E
E
K
R
Site 50
S312
L
K
N
Q
R
A
A
S
Q
I
N
V
C
G
V
Site 51
S323
V
C
G
V
R
K
R
S
Y
S
A
G
N
A
S
Site 52
Y324
C
G
V
R
K
R
S
Y
S
A
G
N
A
S
Q
Site 53
S325
G
V
R
K
R
S
Y
S
A
G
N
A
S
Q
L
Site 54
S330
S
Y
S
A
G
N
A
S
Q
L
E
Q
L
S
R
Site 55
S336
A
S
Q
L
E
Q
L
S
R
A
R
R
S
G
G
Site 56
S341
Q
L
S
R
A
R
R
S
G
G
E
L
Y
I
D
Site 57
Y346
R
R
S
G
G
E
L
Y
I
D
Y
E
E
E
E
Site 58
Y349
G
G
E
L
Y
I
D
Y
E
E
E
E
M
E
T
Site 59
T356
Y
E
E
E
E
M
E
T
V
E
Q
S
T
Q
R
Site 60
T371
I
K
E
F
R
Q
L
T
A
D
M
Q
A
L
E
Site 61
S384
L
E
Q
K
I
Q
D
S
S
C
E
A
S
S
E
Site 62
S385
E
Q
K
I
Q
D
S
S
C
E
A
S
S
E
L
Site 63
S389
Q
D
S
S
C
E
A
S
S
E
L
R
E
N
G
Site 64
S390
D
S
S
C
E
A
S
S
E
L
R
E
N
G
E
Site 65
S400
R
E
N
G
E
C
R
S
V
A
V
G
A
E
E
Site 66
Y415
N
M
N
D
I
V
V
Y
H
R
G
S
R
S
C
Site 67
S419
I
V
V
Y
H
R
G
S
R
S
C
K
D
A
A
Site 68
T429
C
K
D
A
A
V
G
T
L
V
E
M
R
N
C
Site 69
T479
L
E
V
Q
L
R
E
T
T
H
D
R
E
M
T
Site 70
T480
E
V
Q
L
R
E
T
T
H
D
R
E
M
T
K
Site 71
T486
T
T
H
D
R
E
M
T
K
L
K
Q
E
L
Q
Site 72
T505
R
K
K
V
D
K
A
T
M
A
Q
P
L
V
F
Site 73
S513
M
A
Q
P
L
V
F
S
K
V
V
E
A
V
V
Site 74
T522
V
V
E
A
V
V
Q
T
R
D
Q
M
V
G
S
Site 75
S529
T
R
D
Q
M
V
G
S
H
M
D
L
V
D
T
Site 76
T544
C
V
G
T
S
V
E
T
N
S
V
G
I
S
C
Site 77
S546
G
T
S
V
E
T
N
S
V
G
I
S
C
Q
P
Site 78
S550
E
T
N
S
V
G
I
S
C
Q
P
E
C
K
N
Site 79
S585
H
D
R
C
A
G
R
S
V
E
M
C
D
K
S
Site 80
S592
S
V
E
M
C
D
K
S
V
S
V
E
V
S
V
Site 81
S598
K
S
V
S
V
E
V
S
V
C
E
T
G
S
N
Site 82
T602
V
E
V
S
V
C
E
T
G
S
N
T
E
E
S
Site 83
S604
V
S
V
C
E
T
G
S
N
T
E
E
S
V
N
Site 84
S609
T
G
S
N
T
E
E
S
V
N
D
L
T
L
L
Site 85
T614
E
E
S
V
N
D
L
T
L
L
K
T
N
L
N
Site 86
T618
N
D
L
T
L
L
K
T
N
L
N
L
K
E
V
Site 87
S627
L
N
L
K
E
V
R
S
I
G
C
G
D
C
S
Site 88
T638
G
D
C
S
V
D
V
T
V
C
S
P
K
E
C
Site 89
S641
S
V
D
V
T
V
C
S
P
K
E
C
A
S
R
Site 90
T673
P
R
T
A
D
Q
D
T
S
T
D
L
E
Q
V
Site 91
S674
R
T
A
D
Q
D
T
S
T
D
L
E
Q
V
H
Site 92
T675
T
A
D
Q
D
T
S
T
D
L
E
Q
V
H
Q
Site 93
S701
S
C
T
N
T
C
L
S
T
L
D
K
Q
T
S
Site 94
T716
T
Q
T
V
E
T
R
T
V
A
V
G
E
G
R
Site 95
S729
G
R
V
K
D
I
N
S
S
T
K
T
R
S
I
Site 96
T731
V
K
D
I
N
S
S
T
K
T
R
S
I
G
V
Site 97
T733
D
I
N
S
S
T
K
T
R
S
I
G
V
G
T
Site 98
S735
N
S
S
T
K
T
R
S
I
G
V
G
T
L
L
Site 99
S746
G
T
L
L
S
G
H
S
G
F
D
R
P
S
A
Site 100
S752
H
S
G
F
D
R
P
S
A
V
K
T
K
E
S
Site 101
T756
D
R
P
S
A
V
K
T
K
E
S
G
V
G
Q
Site 102
Y770
Q
I
N
I
N
D
N
Y
L
V
G
L
K
M
R
Site 103
T791
P
Q
L
T
V
G
L
T
A
S
R
R
S
V
G
Site 104
S796
G
L
T
A
S
R
R
S
V
G
V
G
D
D
P
Site 105
Y826
M
M
T
G
L
D
H
Y
I
E
R
I
Q
K
L
Site 106
S857
E
A
F
G
E
P
H
S
Q
M
G
S
L
N
S
Site 107
S861
E
P
H
S
Q
M
G
S
L
N
S
Q
L
I
S
Site 108
S864
S
Q
M
G
S
L
N
S
Q
L
I
S
T
L
S
Site 109
S868
S
L
N
S
Q
L
I
S
T
L
S
S
I
N
S
Site 110
S875
S
T
L
S
S
I
N
S
V
M
K
S
A
S
T
Site 111
S879
S
I
N
S
V
M
K
S
A
S
T
E
E
L
R
Site 112
S881
N
S
V
M
K
S
A
S
T
E
E
L
R
N
P
Site 113
T893
R
N
P
D
F
Q
K
T
S
L
G
K
I
T
G
Site 114
S894
N
P
D
F
Q
K
T
S
L
G
K
I
T
G
N
Site 115
S914
C
K
C
G
G
L
Q
S
G
S
P
L
S
S
Q
Site 116
S916
C
G
G
L
Q
S
G
S
P
L
S
S
Q
T
S
Site 117
S919
L
Q
S
G
S
P
L
S
S
Q
T
S
Q
P
E
Site 118
S920
Q
S
G
S
P
L
S
S
Q
T
S
Q
P
E
Q
Site 119
S923
S
P
L
S
S
Q
T
S
Q
P
E
Q
E
V
G
Site 120
S932
P
E
Q
E
V
G
T
S
E
G
K
P
I
S
S
Site 121
S938
T
S
E
G
K
P
I
S
S
L
D
A
F
P
T
Site 122
S939
S
E
G
K
P
I
S
S
L
D
A
F
P
T
Q
Site 123
T945
S
S
L
D
A
F
P
T
Q
E
G
T
L
S
P
Site 124
T949
A
F
P
T
Q
E
G
T
L
S
P
V
N
L
T
Site 125
S951
P
T
Q
E
G
T
L
S
P
V
N
L
T
D
D
Site 126
T968
A
A
G
L
Y
A
C
T
N
N
E
S
T
L
K
Site 127
S976
N
N
E
S
T
L
K
S
I
M
K
K
K
D
G
Site 128
S987
K
K
D
G
N
K
D
S
N
G
A
K
K
N
L
Site 129
Y1003
F
V
G
I
N
G
G
Y
E
T
T
S
S
D
D
Site 130
S1007
N
G
G
Y
E
T
T
S
S
D
D
S
S
S
D
Site 131
S1008
G
G
Y
E
T
T
S
S
D
D
S
S
S
D
E
Site 132
S1011
E
T
T
S
S
D
D
S
S
S
D
E
S
S
S
Site 133
S1012
T
T
S
S
D
D
S
S
S
D
E
S
S
S
S
Site 134
S1013
T
S
S
D
D
S
S
S
D
E
S
S
S
S
E
Site 135
S1016
D
D
S
S
S
D
E
S
S
S
S
E
S
D
D
Site 136
S1017
D
S
S
S
D
E
S
S
S
S
E
S
D
D
E
Site 137
S1018
S
S
S
D
E
S
S
S
S
E
S
D
D
E
C
Site 138
S1019
S
S
D
E
S
S
S
S
E
S
D
D
E
C
D
Site 139
S1021
D
E
S
S
S
S
E
S
D
D
E
C
D
V
I
Site 140
Y1030
D
E
C
D
V
I
E
Y
P
L
E
E
E
E
E
Site 141
T1043
E
E
E
E
D
E
D
T
R
G
M
A
E
G
H
Site 142
S1060
V
N
I
E
G
L
K
S
A
R
V
E
D
E
M
Site 143
Y1083
K
V
E
I
R
E
R
Y
E
L
S
E
K
M
L
Site 144
S1086
I
R
E
R
Y
E
L
S
E
K
M
L
S
A
C
Site 145
S1091
E
L
S
E
K
M
L
S
A
C
N
L
L
K
N
Site 146
S1126
Q
H
E
W
F
R
V
S
S
Q
K
S
A
I
P
Site 147
S1127
H
E
W
F
R
V
S
S
Q
K
S
A
I
P
A
Site 148
Y1168
N
G
N
T
A
L
H
Y
S
V
S
H
S
N
F
Site 149
S1169
G
N
T
A
L
H
Y
S
V
S
H
S
N
F
E
Site 150
S1173
L
H
Y
S
V
S
H
S
N
F
E
I
V
K
L
Site 151
S1231
G
D
V
N
A
K
A
S
Q
A
G
Q
T
A
L
Site 152
S1302
H
L
E
D
N
D
G
S
T
A
L
S
I
A
L
Site 153
S1306
N
D
G
S
T
A
L
S
I
A
L
E
A
G
H
Site 154
S1331
V
N
F
A
K
A
Q
S
P
G
T
P
R
L
G
Site 155
T1334
A
K
A
Q
S
P
G
T
P
R
L
G
R
K
T
Site 156
T1341
T
P
R
L
G
R
K
T
S
P
G
P
T
H
R
Site 157
S1342
P
R
L
G
R
K
T
S
P
G
P
T
H
R
G
Site 158
T1346
R
K
T
S
P
G
P
T
H
R
G
S
F
D
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation