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Updated November 2019
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Protein Info
Short Name:
TTLL4
Full Name:
Tubulin polyglutamylase TTLL4
Alias:
EC 6.-.-.-; Tubulin polyglutamylase TTLL4
Type:
Ligase
Mass (Da):
133378
Number AA:
1199
UniProt ID:
Q14679
International Prot ID:
IPI00005635
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005929
GO:0005932
Uniprot
OncoNet
Molecular Function:
GO:0004835
PhosphoSite+
KinaseNET
Biological Process:
GO:0006464
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
A
S
A
G
T
Q
H
Y
S
I
G
L
R
Q
K
Site 2
S18
I
G
L
R
Q
K
N
S
F
K
Q
S
G
P
S
Site 3
S22
Q
K
N
S
F
K
Q
S
G
P
S
G
T
V
P
Site 4
T27
K
Q
S
G
P
S
G
T
V
P
A
T
P
P
E
Site 5
T31
P
S
G
T
V
P
A
T
P
P
E
K
P
S
E
Site 6
S37
A
T
P
P
E
K
P
S
E
G
R
V
W
P
Q
Site 7
S64
K
K
Q
V
E
T
L
S
A
G
L
G
P
G
L
Site 8
Y104
A
G
H
S
S
S
C
Y
L
H
S
L
P
D
L
Site 9
S107
S
S
S
C
Y
L
H
S
L
P
D
L
F
N
S
Site 10
S114
S
L
P
D
L
F
N
S
T
L
L
Y
R
R
S
Site 11
Y118
L
F
N
S
T
L
L
Y
R
R
S
S
Y
R
Q
Site 12
S121
S
T
L
L
Y
R
R
S
S
Y
R
Q
K
P
Y
Site 13
S122
T
L
L
Y
R
R
S
S
Y
R
Q
K
P
Y
Q
Site 14
Y123
L
L
Y
R
R
S
S
Y
R
Q
K
P
Y
Q
Q
Site 15
Y128
S
S
Y
R
Q
K
P
Y
Q
Q
L
E
S
F
C
Site 16
S133
K
P
Y
Q
Q
L
E
S
F
C
L
R
S
S
P
Site 17
S138
L
E
S
F
C
L
R
S
S
P
S
E
K
S
P
Site 18
S139
E
S
F
C
L
R
S
S
P
S
E
K
S
P
F
Site 19
S141
F
C
L
R
S
S
P
S
E
K
S
P
F
S
L
Site 20
S144
R
S
S
P
S
E
K
S
P
F
S
L
P
Q
K
Site 21
S147
P
S
E
K
S
P
F
S
L
P
Q
K
S
L
P
Site 22
S156
P
Q
K
S
L
P
V
S
L
T
A
N
K
A
T
Site 23
T158
K
S
L
P
V
S
L
T
A
N
K
A
T
S
S
Site 24
S165
T
A
N
K
A
T
S
S
M
V
F
S
M
A
Q
Site 25
S176
S
M
A
Q
P
M
A
S
S
S
T
E
P
Y
L
Site 26
S178
A
Q
P
M
A
S
S
S
T
E
P
Y
L
C
L
Site 27
S196
G
E
N
P
S
G
K
S
L
A
S
A
I
S
G
Site 28
S199
P
S
G
K
S
L
A
S
A
I
S
G
K
I
P
Site 29
S207
A
I
S
G
K
I
P
S
P
L
S
S
S
Y
K
Site 30
S210
G
K
I
P
S
P
L
S
S
S
Y
K
P
M
L
Site 31
S211
K
I
P
S
P
L
S
S
S
Y
K
P
M
L
N
Site 32
S212
I
P
S
P
L
S
S
S
Y
K
P
M
L
N
N
Site 33
S227
N
S
F
M
W
P
N
S
T
P
V
P
L
L
Q
Site 34
T228
S
F
M
W
P
N
S
T
P
V
P
L
L
Q
T
Site 35
S243
T
Q
G
L
K
P
V
S
P
P
K
I
Q
P
V
Site 36
S251
P
P
K
I
Q
P
V
S
W
H
H
S
G
G
T
Site 37
S273
V
D
H
K
V
P
K
S
I
G
T
V
P
A
D
Site 38
S288
A
S
A
H
I
A
L
S
T
A
S
S
H
D
T
Site 39
S292
I
A
L
S
T
A
S
S
H
D
T
S
T
T
S
Site 40
T295
S
T
A
S
S
H
D
T
S
T
T
S
V
A
S
Site 41
S296
T
A
S
S
H
D
T
S
T
T
S
V
A
S
S
Site 42
T297
A
S
S
H
D
T
S
T
T
S
V
A
S
S
W
Site 43
T298
S
S
H
D
T
S
T
T
S
V
A
S
S
W
Y
Site 44
S299
S
H
D
T
S
T
T
S
V
A
S
S
W
Y
N
Site 45
S303
S
T
T
S
V
A
S
S
W
Y
N
R
N
N
L
Site 46
Y305
T
S
V
A
S
S
W
Y
N
R
N
N
L
A
M
Site 47
S318
A
M
R
A
E
P
L
S
C
A
L
D
D
S
S
Site 48
S324
L
S
C
A
L
D
D
S
S
D
S
Q
D
P
T
Site 49
S325
S
C
A
L
D
D
S
S
D
S
Q
D
P
T
K
Site 50
S327
A
L
D
D
S
S
D
S
Q
D
P
T
K
E
I
Site 51
T331
S
S
D
S
Q
D
P
T
K
E
I
R
F
T
E
Site 52
T337
P
T
K
E
I
R
F
T
E
A
V
R
K
L
T
Site 53
T344
T
E
A
V
R
K
L
T
A
R
G
F
E
K
M
Site 54
S362
G
C
Q
L
E
Q
S
S
F
L
N
P
S
F
Q
Site 55
S367
Q
S
S
F
L
N
P
S
F
Q
W
N
V
L
N
Site 56
S395
F
P
Q
E
D
A
G
S
V
R
R
V
L
P
G
Site 57
T406
V
L
P
G
A
S
D
T
L
G
L
D
N
T
V
Site 58
T412
D
T
L
G
L
D
N
T
V
F
C
T
K
R
I
Site 59
T416
L
D
N
T
V
F
C
T
K
R
I
S
I
H
L
Site 60
S439
N
H
N
P
A
C
E
S
V
I
D
S
S
A
F
Site 61
S443
A
C
E
S
V
I
D
S
S
A
F
G
E
G
K
Site 62
S470
A
N
V
A
T
R
L
S
S
I
Q
L
G
Q
S
Site 63
S471
N
V
A
T
R
L
S
S
I
Q
L
G
Q
S
E
Site 64
S477
S
S
I
Q
L
G
Q
S
E
K
E
R
P
E
E
Site 65
S490
E
E
A
R
E
L
D
S
S
D
R
D
I
S
S
Site 66
S491
E
A
R
E
L
D
S
S
D
R
D
I
S
S
A
Site 67
S496
D
S
S
D
R
D
I
S
S
A
T
D
L
Q
P
Site 68
S497
S
S
D
R
D
I
S
S
A
T
D
L
Q
P
D
Site 69
T511
D
Q
A
E
T
E
D
T
E
E
E
L
V
D
G
Site 70
S524
D
G
L
E
D
C
C
S
R
D
E
N
E
E
E
Site 71
S535
N
E
E
E
E
G
D
S
E
C
S
S
L
S
A
Site 72
S539
E
G
D
S
E
C
S
S
L
S
A
V
S
P
S
Site 73
S541
D
S
E
C
S
S
L
S
A
V
S
P
S
E
S
Site 74
S548
S
A
V
S
P
S
E
S
V
A
M
I
S
R
S
Site 75
T561
R
S
C
M
E
I
L
T
K
P
L
S
N
H
E
Site 76
S565
E
I
L
T
K
P
L
S
N
H
E
K
V
V
R
Site 77
T586
L
F
P
N
V
P
P
T
I
Y
F
G
T
R
D
Site 78
Y588
P
N
V
P
P
T
I
Y
F
G
T
R
D
E
R
Site 79
T615
R
W
K
M
S
T
V
T
P
N
I
V
K
Q
T
Site 80
S626
V
K
Q
T
I
G
R
S
H
F
K
I
S
K
R
Site 81
S631
G
R
S
H
F
K
I
S
K
R
N
D
D
W
L
Site 82
S649
G
H
H
M
K
S
P
S
F
R
S
I
R
E
H
Site 83
S652
M
K
S
P
S
F
R
S
I
R
E
H
Q
K
L
Site 84
S665
K
L
N
H
F
P
G
S
F
Q
I
G
R
K
D
Site 85
S679
D
R
L
W
R
N
L
S
R
M
Q
S
R
F
G
Site 86
S683
R
N
L
S
R
M
Q
S
R
F
G
K
K
E
F
Site 87
S691
R
F
G
K
K
E
F
S
F
F
P
Q
S
F
I
Site 88
S696
E
F
S
F
F
P
Q
S
F
I
L
P
Q
D
A
Site 89
S712
L
L
R
K
A
W
E
S
S
S
R
Q
K
W
I
Site 90
S713
L
R
K
A
W
E
S
S
S
R
Q
K
W
I
V
Site 91
S714
R
K
A
W
E
S
S
S
R
Q
K
W
I
V
K
Site 92
S738
I
Q
V
I
H
K
W
S
Q
L
P
K
R
R
P
Site 93
Y751
R
P
L
L
V
Q
R
Y
L
H
K
P
Y
L
I
Site 94
Y756
Q
R
Y
L
H
K
P
Y
L
I
S
G
S
K
F
Site 95
S759
L
H
K
P
Y
L
I
S
G
S
K
F
D
L
R
Site 96
S761
K
P
Y
L
I
S
G
S
K
F
D
L
R
I
Y
Site 97
Y768
S
K
F
D
L
R
I
Y
V
Y
V
T
S
Y
D
Site 98
S791
D
G
L
V
R
F
A
S
C
K
Y
S
P
S
M
Site 99
S795
R
F
A
S
C
K
Y
S
P
S
M
K
S
L
G
Site 100
S797
A
S
C
K
Y
S
P
S
M
K
S
L
G
N
K
Site 101
S800
K
Y
S
P
S
M
K
S
L
G
N
K
F
M
H
Site 102
Y811
K
F
M
H
L
T
N
Y
S
V
N
K
K
N
A
Site 103
Y842
A
L
K
A
L
W
N
Y
L
S
Q
K
G
V
N
Site 104
S844
K
A
L
W
N
Y
L
S
Q
K
G
V
N
S
D
Site 105
S850
L
S
Q
K
G
V
N
S
D
A
I
W
E
K
I
Site 106
T864
I
K
D
V
V
V
K
T
I
I
S
S
E
P
Y
Site 107
S867
V
V
V
K
T
I
I
S
S
E
P
Y
V
T
S
Site 108
Y871
T
I
I
S
S
E
P
Y
V
T
S
L
L
K
M
Site 109
S874
S
S
E
P
Y
V
T
S
L
L
K
M
Y
V
R
Site 110
Y879
V
T
S
L
L
K
M
Y
V
R
R
P
Y
S
C
Site 111
Y884
K
M
Y
V
R
R
P
Y
S
C
H
E
L
F
G
Site 112
S910
W
V
L
E
V
N
I
S
P
S
L
H
S
S
S
Site 113
S912
L
E
V
N
I
S
P
S
L
H
S
S
S
P
L
Site 114
S915
N
I
S
P
S
L
H
S
S
S
P
L
D
I
S
Site 115
S917
S
P
S
L
H
S
S
S
P
L
D
I
S
I
K
Site 116
S922
S
S
S
P
L
D
I
S
I
K
G
Q
M
I
R
Site 117
S947
P
N
A
E
D
I
I
S
S
P
S
S
C
S
S
Site 118
S948
N
A
E
D
I
I
S
S
P
S
S
C
S
S
S
Site 119
S950
E
D
I
I
S
S
P
S
S
C
S
S
S
T
T
Site 120
S951
D
I
I
S
S
P
S
S
C
S
S
S
T
T
S
Site 121
S953
I
S
S
P
S
S
C
S
S
S
T
T
S
L
P
Site 122
S954
S
S
P
S
S
C
S
S
S
T
T
S
L
P
T
Site 123
S955
S
P
S
S
C
S
S
S
T
T
S
L
P
T
S
Site 124
T956
P
S
S
C
S
S
S
T
T
S
L
P
T
S
P
Site 125
T957
S
S
C
S
S
S
T
T
S
L
P
T
S
P
G
Site 126
S958
S
C
S
S
S
T
T
S
L
P
T
S
P
G
D
Site 127
S962
S
T
T
S
L
P
T
S
P
G
D
K
C
R
M
Site 128
Y984
Q
K
M
K
K
A
Y
Y
L
T
Q
K
I
P
D
Site 129
S997
P
D
Q
D
F
Y
A
S
V
L
D
V
L
T
P
Site 130
S1018
V
E
M
E
D
E
F
S
R
R
G
Q
F
E
R
Site 131
S1029
Q
F
E
R
I
F
P
S
H
I
S
S
R
Y
L
Site 132
S1032
R
I
F
P
S
H
I
S
S
R
Y
L
R
F
F
Site 133
S1033
I
F
P
S
H
I
S
S
R
Y
L
R
F
F
E
Site 134
Y1035
P
S
H
I
S
S
R
Y
L
R
F
F
E
Q
P
Site 135
Y1044
R
F
F
E
Q
P
R
Y
F
N
I
L
T
T
Q
Site 136
Y1056
T
T
Q
W
E
Q
K
Y
H
G
N
K
L
K
G
Site 137
S1088
S
D
S
A
P
V
W
S
L
P
T
S
L
L
T
Site 138
S1109
I
L
N
A
F
S
K
S
E
T
S
K
L
G
K
Site 139
S1112
A
F
S
K
S
E
T
S
K
L
G
K
Q
S
S
Site 140
S1119
S
K
L
G
K
Q
S
S
C
E
V
S
L
L
L
Site 141
S1123
K
Q
S
S
C
E
V
S
L
L
L
S
E
D
G
Site 142
S1127
C
E
V
S
L
L
L
S
E
D
G
T
T
P
K
Site 143
T1131
L
L
L
S
E
D
G
T
T
P
K
S
K
K
T
Site 144
T1132
L
L
S
E
D
G
T
T
P
K
S
K
K
T
Q
Site 145
S1135
E
D
G
T
T
P
K
S
K
K
T
Q
A
G
L
Site 146
T1138
T
T
P
K
S
K
K
T
Q
A
G
L
S
P
Y
Site 147
S1143
K
K
T
Q
A
G
L
S
P
Y
P
Q
K
P
S
Site 148
Y1145
T
Q
A
G
L
S
P
Y
P
Q
K
P
S
S
S
Site 149
S1150
S
P
Y
P
Q
K
P
S
S
S
K
D
S
E
D
Site 150
S1151
P
Y
P
Q
K
P
S
S
S
K
D
S
E
D
T
Site 151
S1152
Y
P
Q
K
P
S
S
S
K
D
S
E
D
T
S
Site 152
S1155
K
P
S
S
S
K
D
S
E
D
T
S
K
E
P
Site 153
S1159
S
K
D
S
E
D
T
S
K
E
P
S
L
S
T
Site 154
S1163
E
D
T
S
K
E
P
S
L
S
T
Q
T
L
P
Site 155
S1165
T
S
K
E
P
S
L
S
T
Q
T
L
P
V
I
Site 156
T1178
V
I
K
C
S
G
Q
T
S
R
L
S
A
S
S
Site 157
S1179
I
K
C
S
G
Q
T
S
R
L
S
A
S
S
T
Site 158
S1182
S
G
Q
T
S
R
L
S
A
S
S
T
F
Q
S
Site 159
S1184
Q
T
S
R
L
S
A
S
S
T
F
Q
S
I
S
Site 160
S1185
T
S
R
L
S
A
S
S
T
F
Q
S
I
S
D
Site 161
T1186
S
R
L
S
A
S
S
T
F
Q
S
I
S
D
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation