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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NCOA6
Full Name:
Nuclear receptor coactivator 6
Alias:
Amplified in breast cancer protein 3
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
219145
Number AA:
2063
UniProt ID:
Q14686
International Prot ID:
IPI00179071
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0030331
GO:0030374
PhosphoSite+
KinaseNET
Biological Process:
GO:0006310
GO:0006281
GO:0006260
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
L
P
N
L
E
D
I
Y
T
S
L
C
S
S
T
Site 2
T14
P
N
L
E
D
I
Y
T
S
L
C
S
S
T
M
Site 3
S15
N
L
E
D
I
Y
T
S
L
C
S
S
T
M
E
Site 4
S19
I
Y
T
S
L
C
S
S
T
M
E
D
S
E
M
Site 5
T20
Y
T
S
L
C
S
S
T
M
E
D
S
E
M
D
Site 6
S24
C
S
S
T
M
E
D
S
E
M
D
F
D
S
G
Site 7
S30
D
S
E
M
D
F
D
S
G
L
E
D
D
D
T
Site 8
T37
S
G
L
E
D
D
D
T
K
S
D
S
I
L
E
Site 9
S39
L
E
D
D
D
T
K
S
D
S
I
L
E
D
S
Site 10
S41
D
D
D
T
K
S
D
S
I
L
E
D
S
T
I
Site 11
S80
P
N
L
L
H
M
E
S
S
K
L
K
V
Q
K
Site 12
T97
P
W
N
S
V
R
V
T
F
N
I
P
R
E
A
Site 13
S114
R
L
R
I
L
A
Q
S
N
N
Q
Q
L
R
D
Site 14
S144
L
A
L
A
Q
N
R
S
Q
D
V
R
M
N
G
Site 15
S158
G
P
M
G
A
G
N
S
V
R
M
E
A
G
F
Site 16
S191
I
P
P
G
G
N
V
S
S
S
M
M
A
P
G
Site 17
S192
P
P
G
G
N
V
S
S
S
M
M
A
P
G
P
Site 18
S193
P
G
G
N
V
S
S
S
M
M
A
P
G
P
N
Site 19
T207
N
P
E
L
Q
P
R
T
P
R
P
A
S
Q
S
Site 20
S212
P
R
T
P
R
P
A
S
Q
S
D
A
M
D
P
Site 21
S214
T
P
R
P
A
S
Q
S
D
A
M
D
P
L
L
Site 22
S222
D
A
M
D
P
L
L
S
G
L
H
I
Q
Q
Q
Site 23
S230
G
L
H
I
Q
Q
Q
S
H
P
S
G
S
L
A
Site 24
S235
Q
Q
S
H
P
S
G
S
L
A
P
P
H
H
P
Site 25
T310
R
P
Q
F
T
A
P
T
Q
V
P
V
P
P
G
Site 26
S323
P
G
W
N
Q
L
P
S
G
A
L
Q
P
P
P
Site 27
T339
Q
G
S
L
G
T
M
T
A
N
Q
G
W
K
K
Site 28
S362
Q
Q
L
Q
A
R
P
S
L
A
T
V
Q
T
P
Site 29
T365
Q
A
R
P
S
L
A
T
V
Q
T
P
S
H
P
Site 30
T368
P
S
L
A
T
V
Q
T
P
S
H
P
P
P
P
Site 31
S370
L
A
T
V
Q
T
P
S
H
P
P
P
P
Y
P
Site 32
Y376
P
S
H
P
P
P
P
Y
P
F
G
S
Q
Q
A
Site 33
S380
P
P
P
Y
P
F
G
S
Q
Q
A
S
Q
A
H
Site 34
S384
P
F
G
S
Q
Q
A
S
Q
A
H
T
N
F
P
Site 35
T388
Q
Q
A
S
Q
A
H
T
N
F
P
Q
M
S
N
Site 36
S406
F
T
A
P
Q
M
K
S
L
Q
G
G
P
S
R
Site 37
S412
K
S
L
Q
G
G
P
S
R
V
P
T
P
L
Q
Site 38
T416
G
G
P
S
R
V
P
T
P
L
Q
Q
P
H
L
Site 39
T424
P
L
Q
Q
P
H
L
T
N
K
S
P
A
S
S
Site 40
S427
Q
P
H
L
T
N
K
S
P
A
S
S
P
S
S
Site 41
S430
L
T
N
K
S
P
A
S
S
P
S
S
F
Q
Q
Site 42
S431
T
N
K
S
P
A
S
S
P
S
S
F
Q
Q
G
Site 43
S433
K
S
P
A
S
S
P
S
S
F
Q
Q
G
S
P
Site 44
S434
S
P
A
S
S
P
S
S
F
Q
Q
G
S
P
A
Site 45
S439
P
S
S
F
Q
Q
G
S
P
A
S
S
P
T
V
Site 46
S443
Q
Q
G
S
P
A
S
S
P
T
V
N
Q
T
Q
Site 47
T445
G
S
P
A
S
S
P
T
V
N
Q
T
Q
Q
Q
Site 48
S472
Q
G
F
Q
Q
P
V
S
S
P
G
R
N
P
M
Site 49
S473
G
F
Q
Q
P
V
S
S
P
G
R
N
P
M
V
Site 50
S503
P
P
N
Q
G
P
Q
S
L
H
P
G
L
G
G
Site 51
S520
K
R
L
P
P
G
F
S
A
G
Q
A
N
P
N
Site 52
T536
M
Q
G
Q
V
P
S
T
T
A
T
T
P
G
N
Site 53
T539
Q
V
P
S
T
T
A
T
T
P
G
N
S
G
A
Site 54
T540
V
P
S
T
T
A
T
T
P
G
N
S
G
A
P
Site 55
S607
G
V
P
Q
V
N
L
S
N
M
Q
G
Q
P
Q
Site 56
S619
Q
P
Q
Q
G
P
P
S
Q
L
M
G
M
H
Q
Site 57
T641
Q
M
V
Q
Q
Q
G
T
L
N
P
Q
N
P
M
Site 58
S651
P
Q
N
P
M
I
L
S
R
A
Q
L
M
P
Q
Site 59
S667
Q
M
M
V
N
P
P
S
Q
N
L
G
P
S
P
Site 60
S673
P
S
Q
N
L
G
P
S
P
Q
R
M
T
P
P
Site 61
T678
G
P
S
P
Q
R
M
T
P
P
K
Q
M
L
S
Site 62
S685
T
P
P
K
Q
M
L
S
Q
Q
G
P
Q
M
M
Site 63
T748
A
Q
I
M
R
G
P
T
P
N
M
Q
G
N
M
Site 64
S776
Q
Q
G
P
V
N
N
S
P
S
Q
V
M
G
I
Site 65
S778
G
P
V
N
N
S
P
S
Q
V
M
G
I
Q
G
Site 66
S794
V
L
R
P
P
G
P
S
P
H
M
A
Q
Q
H
Site 67
T806
Q
Q
H
G
D
P
A
T
T
A
N
N
D
V
S
Site 68
S813
T
T
A
N
N
D
V
S
L
S
Q
M
M
P
D
Site 69
S815
A
N
N
D
V
S
L
S
Q
M
M
P
D
V
S
Site 70
T826
P
D
V
S
I
Q
Q
T
N
M
V
P
P
H
V
Site 71
S842
A
M
Q
G
N
S
A
S
G
N
H
F
S
G
H
Site 72
S847
S
A
S
G
N
H
F
S
G
H
G
M
S
F
N
Site 73
S852
H
F
S
G
H
G
M
S
F
N
A
P
F
S
G
Site 74
S858
M
S
F
N
A
P
F
S
G
A
P
N
G
N
Q
Site 75
S884
N
K
D
V
T
L
T
S
P
L
L
V
N
L
L
Site 76
S896
N
L
L
Q
S
D
I
S
A
G
H
F
G
V
N
Site 77
S926
P
P
R
K
K
K
N
S
Q
Q
D
L
N
T
P
Site 78
T932
N
S
Q
Q
D
L
N
T
P
D
T
R
P
A
G
Site 79
T935
Q
D
L
N
T
P
D
T
R
P
A
G
L
E
E
Site 80
S959
Q
G
I
N
L
D
N
S
G
P
K
L
P
E
F
Site 81
S967
G
P
K
L
P
E
F
S
N
R
P
P
G
Y
P
Site 82
Y973
F
S
N
R
P
P
G
Y
P
S
Q
P
V
E
Q
Site 83
S975
N
R
P
P
G
Y
P
S
Q
P
V
E
Q
R
P
Site 84
S1019
Q
Q
Q
P
P
P
P
S
Q
P
Q
S
Q
Q
Q
Site 85
S1023
P
P
P
S
Q
P
Q
S
Q
Q
Q
Q
Q
Q
Q
Site 86
S1045
M
M
Q
Q
D
P
K
S
V
R
L
P
V
S
Q
Site 87
S1051
K
S
V
R
L
P
V
S
Q
N
V
H
P
P
R
Site 88
S1065
R
G
P
L
N
P
D
S
Q
R
M
P
M
Q
Q
Site 89
S1073
Q
R
M
P
M
Q
Q
S
G
S
V
P
V
M
V
Site 90
S1087
V
S
L
Q
G
P
A
S
V
P
P
S
P
D
K
Site 91
S1091
G
P
A
S
V
P
P
S
P
D
K
Q
R
M
P
Site 92
T1103
R
M
P
M
P
V
N
T
P
L
G
S
N
S
R
Site 93
S1107
P
V
N
T
P
L
G
S
N
S
R
K
M
V
Y
Site 94
Y1114
S
N
S
R
K
M
V
Y
Q
E
S
P
Q
N
P
Site 95
S1117
R
K
M
V
Y
Q
E
S
P
Q
N
P
S
S
S
Site 96
S1122
Q
E
S
P
Q
N
P
S
S
S
P
L
A
E
M
Site 97
S1123
E
S
P
Q
N
P
S
S
S
P
L
A
E
M
A
Site 98
S1124
S
P
Q
N
P
S
S
S
P
L
A
E
M
A
S
Site 99
S1131
S
P
L
A
E
M
A
S
L
P
E
A
S
G
S
Site 100
S1136
M
A
S
L
P
E
A
S
G
S
E
A
P
S
V
Site 101
S1138
S
L
P
E
A
S
G
S
E
A
P
S
V
P
G
Site 102
S1142
A
S
G
S
E
A
P
S
V
P
G
G
P
N
N
Site 103
S1152
G
G
P
N
N
M
P
S
H
V
V
L
P
Q
N
Site 104
S1171
T
G
P
K
P
G
P
S
P
L
S
A
T
Q
G
Site 105
S1174
K
P
G
P
S
P
L
S
A
T
Q
G
A
T
P
Site 106
T1180
L
S
A
T
Q
G
A
T
P
Q
Q
P
P
V
N
Site 107
S1188
P
Q
Q
P
P
V
N
S
L
P
S
S
H
G
H
Site 108
S1192
P
V
N
S
L
P
S
S
H
G
H
H
F
P
N
Site 109
S1207
V
A
A
P
T
Q
T
S
R
P
K
T
P
N
R
Site 110
T1211
T
Q
T
S
R
P
K
T
P
N
R
A
S
P
R
Site 111
S1216
P
K
T
P
N
R
A
S
P
R
P
Y
Y
P
Q
Site 112
Y1220
N
R
A
S
P
R
P
Y
Y
P
Q
T
P
N
N
Site 113
Y1221
R
A
S
P
R
P
Y
Y
P
Q
T
P
N
N
R
Site 114
T1224
P
R
P
Y
Y
P
Q
T
P
N
N
R
P
P
S
Site 115
S1231
T
P
N
N
R
P
P
S
T
E
P
S
E
I
S
Site 116
T1232
P
N
N
R
P
P
S
T
E
P
S
E
I
S
L
Site 117
S1235
R
P
P
S
T
E
P
S
E
I
S
L
S
P
E
Site 118
S1238
S
T
E
P
S
E
I
S
L
S
P
E
R
L
N
Site 119
S1240
E
P
S
E
I
S
L
S
P
E
R
L
N
A
S
Site 120
S1247
S
P
E
R
L
N
A
S
I
A
G
L
F
P
P
Site 121
T1291
G
Q
A
P
S
N
L
T
M
N
P
S
N
F
A
Site 122
S1295
S
N
L
T
M
N
P
S
N
F
A
T
P
Q
T
Site 123
T1299
M
N
P
S
N
F
A
T
P
Q
T
H
K
L
D
Site 124
T1302
S
N
F
A
T
P
Q
T
H
K
L
D
S
V
V
Site 125
S1307
P
Q
T
H
K
L
D
S
V
V
V
N
S
G
K
Site 126
S1312
L
D
S
V
V
V
N
S
G
K
Q
S
N
S
G
Site 127
S1316
V
V
N
S
G
K
Q
S
N
S
G
A
T
K
R
Site 128
S1318
N
S
G
K
Q
S
N
S
G
A
T
K
R
A
S
Site 129
T1321
K
Q
S
N
S
G
A
T
K
R
A
S
P
S
N
Site 130
S1325
S
G
A
T
K
R
A
S
P
S
N
S
R
R
S
Site 131
S1327
A
T
K
R
A
S
P
S
N
S
R
R
S
S
P
Site 132
S1329
K
R
A
S
P
S
N
S
R
R
S
S
P
G
S
Site 133
S1332
S
P
S
N
S
R
R
S
S
P
G
S
S
R
K
Site 134
S1333
P
S
N
S
R
R
S
S
P
G
S
S
R
K
T
Site 135
S1336
S
R
R
S
S
P
G
S
S
R
K
T
T
P
S
Site 136
S1337
R
R
S
S
P
G
S
S
R
K
T
T
P
S
P
Site 137
T1340
S
P
G
S
S
R
K
T
T
P
S
P
G
R
Q
Site 138
T1341
P
G
S
S
R
K
T
T
P
S
P
G
R
Q
N
Site 139
S1343
S
S
R
K
T
T
P
S
P
G
R
Q
N
S
K
Site 140
S1349
P
S
P
G
R
Q
N
S
K
A
P
K
L
T
L
Site 141
T1355
N
S
K
A
P
K
L
T
L
A
S
Q
T
N
A
Site 142
S1389
A
N
P
P
V
P
G
S
F
P
N
N
S
G
L
Site 143
S1394
P
G
S
F
P
N
N
S
G
L
N
P
Q
N
S
Site 144
S1425
S
L
N
V
P
Q
D
S
D
C
Q
N
S
Q
S
Site 145
S1430
Q
D
S
D
C
Q
N
S
Q
S
R
K
E
Q
V
Site 146
S1465
S
K
K
D
G
Q
P
S
D
P
N
K
L
P
S
Site 147
S1472
S
D
P
N
K
L
P
S
V
E
E
N
K
N
L
Site 148
S1481
E
E
N
K
N
L
V
S
P
A
M
R
E
A
P
Site 149
S1490
A
M
R
E
A
P
T
S
L
S
Q
L
L
D
N
Site 150
S1492
R
E
A
P
T
S
L
S
Q
L
L
D
N
S
G
Site 151
T1516
G
L
T
D
L
E
V
T
P
P
V
V
S
G
E
Site 152
S1529
G
E
D
L
K
K
A
S
V
I
P
T
L
Q
D
Site 153
T1533
K
K
A
S
V
I
P
T
L
Q
D
L
S
S
S
Site 154
S1538
I
P
T
L
Q
D
L
S
S
S
K
E
P
S
N
Site 155
S1539
P
T
L
Q
D
L
S
S
S
K
E
P
S
N
S
Site 156
S1540
T
L
Q
D
L
S
S
S
K
E
P
S
N
S
L
Site 157
S1544
L
S
S
S
K
E
P
S
N
S
L
N
L
P
H
Site 158
S1546
S
S
K
E
P
S
N
S
L
N
L
P
H
S
N
Site 159
S1552
N
S
L
N
L
P
H
S
N
E
L
C
S
S
L
Site 160
S1558
H
S
N
E
L
C
S
S
L
V
H
P
E
L
S
Site 161
S1565
S
L
V
H
P
E
L
S
E
V
S
S
N
V
A
Site 162
S1569
P
E
L
S
E
V
S
S
N
V
A
P
S
I
P
Site 163
S1580
P
S
I
P
P
V
M
S
R
P
V
S
S
S
S
Site 164
S1584
P
V
M
S
R
P
V
S
S
S
S
I
S
T
P
Site 165
S1586
M
S
R
P
V
S
S
S
S
I
S
T
P
L
P
Site 166
S1587
S
R
P
V
S
S
S
S
I
S
T
P
L
P
P
Site 167
S1589
P
V
S
S
S
S
I
S
T
P
L
P
P
N
Q
Site 168
T1590
V
S
S
S
S
I
S
T
P
L
P
P
N
Q
I
Site 169
T1598
P
L
P
P
N
Q
I
T
V
F
V
T
S
N
P
Site 170
T1607
F
V
T
S
N
P
I
T
T
S
A
N
T
S
A
Site 171
S1609
T
S
N
P
I
T
T
S
A
N
T
S
A
A
L
Site 172
S1641
A
G
S
K
V
M
V
S
E
G
Q
S
A
A
Q
Site 173
S1645
V
M
V
S
E
G
Q
S
A
A
Q
S
N
A
R
Site 174
S1649
E
G
Q
S
A
A
Q
S
N
A
R
P
Q
F
I
Site 175
T1657
N
A
R
P
Q
F
I
T
P
V
F
I
N
S
S
Site 176
T1677
M
K
G
S
Q
P
S
T
I
P
A
A
P
L
T
Site 177
S1710
P
Q
N
I
K
F
S
S
A
P
V
P
P
N
A
Site 178
S1719
P
V
P
P
N
A
L
S
S
S
P
A
P
N
I
Site 179
S1720
V
P
P
N
A
L
S
S
S
P
A
P
N
I
Q
Site 180
S1721
P
P
N
A
L
S
S
S
P
A
P
N
I
Q
T
Site 181
T1728
S
P
A
P
N
I
Q
T
G
R
P
L
V
L
S
Site 182
S1735
T
G
R
P
L
V
L
S
S
R
A
T
P
V
Q
Site 183
S1745
A
T
P
V
Q
L
P
S
P
P
C
T
S
S
P
Site 184
T1749
Q
L
P
S
P
P
C
T
S
S
P
V
V
P
S
Site 185
S1750
L
P
S
P
P
C
T
S
S
P
V
V
P
S
H
Site 186
S1751
P
S
P
P
C
T
S
S
P
V
V
P
S
H
P
Site 187
S1756
T
S
S
P
V
V
P
S
H
P
P
V
Q
Q
V
Site 188
S1772
E
L
N
P
D
E
A
S
P
Q
V
N
T
S
A
Site 189
T1783
N
T
S
A
D
Q
N
T
L
P
S
S
Q
S
T
Site 190
S1787
D
Q
N
T
L
P
S
S
Q
S
T
T
M
V
S
Site 191
S1789
N
T
L
P
S
S
Q
S
T
T
M
V
S
P
L
Site 192
S1794
S
Q
S
T
T
M
V
S
P
L
L
T
N
S
P
Site 193
T1798
T
M
V
S
P
L
L
T
N
S
P
G
S
S
G
Site 194
S1800
V
S
P
L
L
T
N
S
P
G
S
S
G
N
R
Site 195
S1804
L
T
N
S
P
G
S
S
G
N
R
R
S
P
V
Site 196
S1809
G
S
S
G
N
R
R
S
P
V
S
S
S
K
G
Site 197
S1812
G
N
R
R
S
P
V
S
S
S
K
G
K
G
K
Site 198
S1813
N
R
R
S
P
V
S
S
S
K
G
K
G
K
V
Site 199
S1814
R
R
S
P
V
S
S
S
K
G
K
G
K
V
D
Site 200
T1859
T
E
G
Q
G
L
D
T
T
A
P
G
L
M
G
Site 201
T1860
E
G
Q
G
L
D
T
T
A
P
G
L
M
G
T
Site 202
S1871
L
M
G
T
E
Q
L
S
T
E
L
D
S
K
T
Site 203
T1872
M
G
T
E
Q
L
S
T
E
L
D
S
K
T
P
Site 204
S1876
Q
L
S
T
E
L
D
S
K
T
P
T
P
P
A
Site 205
T1878
S
T
E
L
D
S
K
T
P
T
P
P
A
P
T
Site 206
T1880
E
L
D
S
K
T
P
T
P
P
A
P
T
L
L
Site 207
S1891
P
T
L
L
K
M
T
S
S
P
V
G
P
G
T
Site 208
T1898
S
S
P
V
G
P
G
T
A
S
A
G
P
S
L
Site 209
S1900
P
V
G
P
G
T
A
S
A
G
P
S
L
P
G
Site 210
S1916
A
L
P
T
S
V
R
S
I
V
T
T
L
V
P
Site 211
T1932
E
L
I
S
A
V
P
T
T
K
S
N
H
G
G
Site 212
S1935
S
A
V
P
T
T
K
S
N
H
G
G
I
A
S
Site 213
S1942
S
N
H
G
G
I
A
S
E
S
L
A
G
G
L
Site 214
S1956
L
V
E
E
K
V
G
S
H
P
E
L
L
P
S
Site 215
S1963
S
H
P
E
L
L
P
S
I
A
P
S
Q
N
L
Site 216
S1967
L
L
P
S
I
A
P
S
Q
N
L
V
S
K
E
Site 217
S1972
A
P
S
Q
N
L
V
S
K
E
T
S
T
T
A
Site 218
S1976
N
L
V
S
K
E
T
S
T
T
A
L
Q
A
S
Site 219
S1983
S
T
T
A
L
Q
A
S
V
A
R
P
E
L
E
Site 220
S1997
E
V
N
A
A
I
V
S
G
Q
S
S
E
P
K
Site 221
S2001
A
I
V
S
G
Q
S
S
E
P
K
E
I
V
E
Site 222
S2010
P
K
E
I
V
E
K
S
K
I
P
G
R
R
N
Site 223
S2018
K
I
P
G
R
R
N
S
R
T
E
E
P
T
V
Site 224
T2020
P
G
R
R
N
S
R
T
E
E
P
T
V
A
S
Site 225
T2024
N
S
R
T
E
E
P
T
V
A
S
E
S
V
E
Site 226
S2029
E
P
T
V
A
S
E
S
V
E
N
G
H
R
K
Site 227
S2038
E
N
G
H
R
K
R
S
S
R
P
A
S
A
S
Site 228
S2039
N
G
H
R
K
R
S
S
R
P
A
S
A
S
S
Site 229
S2043
K
R
S
S
R
P
A
S
A
S
S
S
T
K
D
Site 230
S2045
S
S
R
P
A
S
A
S
S
S
T
K
D
I
T
Site 231
S2046
S
R
P
A
S
A
S
S
S
T
K
D
I
T
S
Site 232
S2047
R
P
A
S
A
S
S
S
T
K
D
I
T
S
A
Site 233
T2048
P
A
S
A
S
S
S
T
K
D
I
T
S
A
V
Site 234
T2052
S
S
S
T
K
D
I
T
S
A
V
Q
S
K
R
Site 235
S2053
S
S
T
K
D
I
T
S
A
V
Q
S
K
R
R
Site 236
S2057
D
I
T
S
A
V
Q
S
K
R
R
K
S
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation