KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
KIAA0182
Full Name:
Genetic suppressor element 1
Alias:
GSE1; K0182; Y182
Type:
Unknown function
Mass (Da):
136164
Number AA:
1217
UniProt ID:
Q14687
International Prot ID:
IPI00215963
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0044464
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
G
M
S
H
E
P
K
S
P
S
L
G
M
L
S
Site 2
S12
S
H
E
P
K
S
P
S
L
G
M
L
S
T
A
Site 3
S17
S
P
S
L
G
M
L
S
T
A
T
R
T
T
A
Site 4
T18
P
S
L
G
M
L
S
T
A
T
R
T
T
A
T
Site 5
T23
L
S
T
A
T
R
T
T
A
T
V
N
P
L
T
Site 6
T25
T
A
T
R
T
T
A
T
V
N
P
L
T
P
S
Site 7
T30
T
A
T
V
N
P
L
T
P
S
P
L
N
G
A
Site 8
S47
P
S
G
S
P
A
T
S
S
A
L
S
A
Q
A
Site 9
S48
S
G
S
P
A
T
S
S
A
L
S
A
Q
A
A
Site 10
S51
P
A
T
S
S
A
L
S
A
Q
A
A
P
S
S
Site 11
S59
A
Q
A
A
P
S
S
S
F
A
A
A
L
R
K
Site 12
S77
Q
A
E
E
P
R
G
S
S
L
S
S
E
S
S
Site 13
S78
A
E
E
P
R
G
S
S
L
S
S
E
S
S
P
Site 14
S80
E
P
R
G
S
S
L
S
S
E
S
S
P
V
S
Site 15
S81
P
R
G
S
S
L
S
S
E
S
S
P
V
S
S
Site 16
S83
G
S
S
L
S
S
E
S
S
P
V
S
S
P
A
Site 17
S84
S
S
L
S
S
E
S
S
P
V
S
S
P
A
T
Site 18
S87
S
S
E
S
S
P
V
S
S
P
A
T
N
H
S
Site 19
S88
S
E
S
S
P
V
S
S
P
A
T
N
H
S
S
Site 20
T91
S
P
V
S
S
P
A
T
N
H
S
S
P
A
S
Site 21
S94
S
S
P
A
T
N
H
S
S
P
A
S
T
P
K
Site 22
S95
S
P
A
T
N
H
S
S
P
A
S
T
P
K
R
Site 23
S98
T
N
H
S
S
P
A
S
T
P
K
R
V
P
M
Site 24
T99
N
H
S
S
P
A
S
T
P
K
R
V
P
M
G
Site 25
T131
V
T
I
A
P
T
K
T
V
N
G
V
W
R
S
Site 26
S138
T
V
N
G
V
W
R
S
E
S
R
Q
D
A
G
Site 27
S140
N
G
V
W
R
S
E
S
R
Q
D
A
G
S
R
Site 28
S146
E
S
R
Q
D
A
G
S
R
S
S
S
G
G
R
Site 29
S148
R
Q
D
A
G
S
R
S
S
S
G
G
R
E
R
Site 30
S149
Q
D
A
G
S
R
S
S
S
G
G
R
E
R
L
Site 31
S150
D
A
G
S
R
S
S
S
G
G
R
E
R
L
I
Site 32
Y181
S
H
L
L
S
T
P
Y
P
F
G
L
S
P
S
Site 33
S186
T
P
Y
P
F
G
L
S
P
S
S
V
V
Q
D
Site 34
S188
Y
P
F
G
L
S
P
S
S
V
V
Q
D
S
R
Site 35
S189
P
F
G
L
S
P
S
S
V
V
Q
D
S
R
F
Site 36
S194
P
S
S
V
V
Q
D
S
R
F
P
P
L
N
L
Site 37
S212
V
H
H
V
V
P
P
S
T
V
T
E
D
Y
L
Site 38
T213
H
H
V
V
P
P
S
T
V
T
E
D
Y
L
R
Site 39
Y218
P
S
T
V
T
E
D
Y
L
R
S
F
R
P
Y
Site 40
S221
V
T
E
D
Y
L
R
S
F
R
P
Y
H
T
T
Site 41
Y225
Y
L
R
S
F
R
P
Y
H
T
T
D
D
L
R
Site 42
T228
S
F
R
P
Y
H
T
T
D
D
L
R
M
S
S
Site 43
S234
T
T
D
D
L
R
M
S
S
L
P
P
L
G
L
Site 44
S235
T
D
D
L
R
M
S
S
L
P
P
L
G
L
D
Site 45
T245
P
L
G
L
D
P
A
T
A
A
A
Y
Y
H
P
Site 46
Y249
D
P
A
T
A
A
A
Y
Y
H
P
S
Y
L
A
Site 47
Y250
P
A
T
A
A
A
Y
Y
H
P
S
Y
L
A
P
Site 48
Y254
A
A
Y
Y
H
P
S
Y
L
A
P
H
P
F
P
Site 49
S270
P
A
F
R
M
D
D
S
Y
C
L
S
A
L
R
Site 50
Y271
A
F
R
M
D
D
S
Y
C
L
S
A
L
R
S
Site 51
S274
M
D
D
S
Y
C
L
S
A
L
R
S
P
F
Y
Site 52
Y281
S
A
L
R
S
P
F
Y
P
I
P
T
P
G
S
Site 53
T285
S
P
F
Y
P
I
P
T
P
G
S
L
P
P
L
Site 54
S288
Y
P
I
P
T
P
G
S
L
P
P
L
H
P
S
Site 55
S295
S
L
P
P
L
H
P
S
A
M
H
L
H
L
S
Site 56
S302
S
A
M
H
L
H
L
S
G
V
R
Y
P
P
E
Site 57
Y306
L
H
L
S
G
V
R
Y
P
P
E
L
S
H
S
Site 58
S311
V
R
Y
P
P
E
L
S
H
S
S
L
A
A
L
Site 59
S313
Y
P
P
E
L
S
H
S
S
L
A
A
L
H
S
Site 60
S314
P
P
E
L
S
H
S
S
L
A
A
L
H
S
E
Site 61
S320
S
S
L
A
A
L
H
S
E
R
M
S
G
L
S
Site 62
S324
A
L
H
S
E
R
M
S
G
L
S
A
E
R
L
Site 63
S327
S
E
R
M
S
G
L
S
A
E
R
L
Q
M
D
Site 64
T422
H
G
L
R
G
H
A
T
E
E
R
G
K
P
S
Site 65
S429
T
E
E
R
G
K
P
S
E
Q
L
T
P
T
R
Site 66
T433
G
K
P
S
E
Q
L
T
P
T
R
A
E
K
L
Site 67
T460
H
P
L
H
P
V
P
T
P
H
H
T
V
P
S
Site 68
T464
P
V
P
T
P
H
H
T
V
P
S
L
I
S
N
Site 69
S467
T
P
H
H
T
V
P
S
L
I
S
N
H
G
I
Site 70
S513
Q
E
K
E
D
R
Q
S
Q
V
S
E
F
R
Q
Site 71
S516
E
D
R
Q
S
Q
V
S
E
F
R
Q
Q
V
L
Site 72
S544
E
A
E
H
R
P
E
S
T
T
R
P
G
P
N
Site 73
T545
A
E
H
R
P
E
S
T
T
R
P
G
P
N
R
Site 74
T546
E
H
R
P
E
S
T
T
R
P
G
P
N
R
H
Site 75
S572
G
G
P
P
P
L
I
S
P
K
P
Q
L
H
A
Site 76
S589
T
A
L
W
N
P
V
S
L
M
D
N
T
L
E
Site 77
T594
P
V
S
L
M
D
N
T
L
E
T
R
R
A
E
Site 78
T597
L
M
D
N
T
L
E
T
R
R
A
E
S
H
S
Site 79
S602
L
E
T
R
R
A
E
S
H
S
L
H
S
H
P
Site 80
S604
T
R
R
A
E
S
H
S
L
H
S
H
P
A
A
Site 81
Y649
E
P
A
P
L
D
K
Y
Q
P
P
P
P
P
P
Site 82
S661
P
P
P
R
E
G
G
S
L
E
H
Q
P
F
L
Site 83
S681
F
L
A
E
L
E
K
S
T
Q
T
I
L
G
Q
Site 84
S703
A
A
T
F
G
E
L
S
G
P
L
K
P
G
S
Site 85
S710
S
G
P
L
K
P
G
S
P
Y
R
P
P
V
P
Site 86
Y712
P
L
K
P
G
S
P
Y
R
P
P
V
P
R
A
Site 87
Y724
P
R
A
P
D
P
A
Y
I
Y
D
E
F
L
Q
Site 88
Y726
A
P
D
P
A
Y
I
Y
D
E
F
L
Q
Q
R
Site 89
S738
Q
Q
R
R
R
L
V
S
K
L
D
L
E
E
R
Site 90
Y755
R
E
A
Q
E
K
G
Y
Y
Y
D
L
D
D
S
Site 91
Y756
E
A
Q
E
K
G
Y
Y
Y
D
L
D
D
S
Y
Site 92
Y757
A
Q
E
K
G
Y
Y
Y
D
L
D
D
S
Y
D
Site 93
S762
Y
Y
Y
D
L
D
D
S
Y
D
E
S
D
E
E
Site 94
Y763
Y
Y
D
L
D
D
S
Y
D
E
S
D
E
E
E
Site 95
S766
L
D
D
S
Y
D
E
S
D
E
E
E
V
R
A
Site 96
T788
Q
P
P
L
K
L
D
T
S
S
E
K
L
E
F
Site 97
S789
P
P
L
K
L
D
T
S
S
E
K
L
E
F
L
Site 98
S790
P
L
K
L
D
T
S
S
E
K
L
E
F
L
Q
Site 99
S826
R
R
M
L
R
E
R
S
P
S
P
P
T
I
Q
Site 100
S828
M
L
R
E
R
S
P
S
P
P
T
I
Q
S
K
Site 101
T831
E
R
S
P
S
P
P
T
I
Q
S
K
R
Q
T
Site 102
S834
P
S
P
P
T
I
Q
S
K
R
Q
T
P
S
P
Site 103
T838
T
I
Q
S
K
R
Q
T
P
S
P
R
L
A
L
Site 104
S840
Q
S
K
R
Q
T
P
S
P
R
L
A
L
S
T
Site 105
S846
P
S
P
R
L
A
L
S
T
R
Y
S
P
D
E
Site 106
T847
S
P
R
L
A
L
S
T
R
Y
S
P
D
E
M
Site 107
S850
L
A
L
S
T
R
Y
S
P
D
E
M
N
N
S
Site 108
S857
S
P
D
E
M
N
N
S
P
N
F
E
E
K
K
Site 109
T868
E
E
K
K
K
F
L
T
I
F
N
L
T
H
I
Site 110
S905
L
S
A
A
V
A
D
S
L
T
N
S
P
R
D
Site 111
T907
A
A
V
A
D
S
L
T
N
S
P
R
D
S
P
Site 112
S909
V
A
D
S
L
T
N
S
P
R
D
S
P
A
V
Site 113
S913
L
T
N
S
P
R
D
S
P
A
V
S
L
S
E
Site 114
S917
P
R
D
S
P
A
V
S
L
S
E
P
A
T
Q
Site 115
S919
D
S
P
A
V
S
L
S
E
P
A
T
Q
Q
A
Site 116
T923
V
S
L
S
E
P
A
T
Q
Q
A
S
L
D
V
Site 117
S961
Q
V
R
P
Q
E
L
S
R
V
Q
E
L
A
P
Site 118
S970
V
Q
E
L
A
P
A
S
G
E
K
A
R
L
S
Site 119
S977
S
G
E
K
A
R
L
S
E
A
P
G
G
K
K
Site 120
S985
E
A
P
G
G
K
K
S
L
S
M
L
H
Y
I
Site 121
S987
P
G
G
K
K
S
L
S
M
L
H
Y
I
R
G
Site 122
Y991
K
S
L
S
M
L
H
Y
I
R
G
A
A
P
K
Site 123
S1005
K
D
I
P
V
P
L
S
H
S
T
N
G
K
S
Site 124
T1008
P
V
P
L
S
H
S
T
N
G
K
S
K
P
W
Site 125
S1012
S
H
S
T
N
G
K
S
K
P
W
E
P
F
V
Site 126
S1030
F
A
H
Q
F
H
E
S
V
L
Q
S
T
Q
K
Site 127
S1034
F
H
E
S
V
L
Q
S
T
Q
K
A
L
Q
K
Site 128
S1045
A
L
Q
K
H
K
G
S
V
A
V
L
S
A
E
Site 129
Y1063
K
V
D
T
S
V
H
Y
N
I
P
E
L
Q
S
Site 130
S1070
Y
N
I
P
E
L
Q
S
S
S
R
A
P
P
P
Site 131
S1071
N
I
P
E
L
Q
S
S
S
R
A
P
P
P
Q
Site 132
S1072
I
P
E
L
Q
S
S
S
R
A
P
P
P
Q
H
Site 133
T1087
N
G
Q
Q
E
P
P
T
A
R
K
G
P
P
T
Site 134
T1094
T
A
R
K
G
P
P
T
Q
E
L
D
R
D
S
Site 135
S1101
T
Q
E
L
D
R
D
S
E
E
E
E
E
E
D
Site 136
T1149
L
E
R
Q
V
L
Q
T
Q
C
R
R
L
E
A
Site 137
Y1159
R
R
L
E
A
R
H
Y
S
L
S
L
T
A
E
Site 138
S1160
R
L
E
A
R
H
Y
S
L
S
L
T
A
E
Q
Site 139
S1162
E
A
R
H
Y
S
L
S
L
T
A
E
Q
L
S
Site 140
T1164
R
H
Y
S
L
S
L
T
A
E
Q
L
S
H
S
Site 141
S1169
S
L
T
A
E
Q
L
S
H
S
V
A
E
L
R
Site 142
S1171
T
A
E
Q
L
S
H
S
V
A
E
L
R
S
Q
Site 143
S1177
H
S
V
A
E
L
R
S
Q
K
Q
K
M
V
S
Site 144
S1184
S
Q
K
Q
K
M
V
S
E
R
E
R
L
Q
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation