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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DIP2A
Full Name:
Disco-interacting protein 2 homolog A
Alias:
C21orf106; DIP2; DIP2 disco-interacting protein 2 A; DIP2-like; Disco-interacting protein 2 homolog A; KIAA0184
Type:
Unknown function
Mass (Da):
170369
Number AA:
1571
UniProt ID:
Q14689
International Prot ID:
IPI00654865
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0008134
PhosphoSite+
KinaseNET
Biological Process:
GO:0008152
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
L
P
A
E
V
R
E
S
L
A
E
L
E
L
E
Site 2
S29
A
E
L
E
L
E
L
S
E
G
D
I
T
Q
K
Site 3
T34
E
L
S
E
G
D
I
T
Q
K
G
Y
E
K
K
Site 4
Y49
R
A
K
L
L
A
R
Y
I
P
L
I
Q
G
I
Site 5
S59
L
I
Q
G
I
D
P
S
L
Q
A
E
N
R
I
Site 6
S70
E
N
R
I
P
G
P
S
Q
T
T
A
A
A
P
Site 7
S82
A
A
P
K
Q
Q
K
S
R
P
T
A
S
R
D
Site 8
T85
K
Q
Q
K
S
R
P
T
A
S
R
D
E
R
F
Site 9
S94
R
F
R
S
D
V
H
T
E
A
V
Q
A
A
L
Site 10
T98
R
F
R
S
D
V
H
T
E
A
V
Q
A
A
L
Site 11
Y108
V
Q
A
A
L
A
K
Y
K
E
R
K
M
P
M
Site 12
S117
E
R
K
M
P
M
P
S
K
R
R
S
V
L
V
Site 13
S121
P
M
P
S
K
R
R
S
V
L
V
H
S
S
V
Site 14
T130
L
V
H
S
S
V
E
T
Y
T
P
P
D
T
S
Site 15
Y131
V
H
S
S
V
E
T
Y
T
P
P
D
T
S
S
Site 16
T132
H
S
S
V
E
T
Y
T
P
P
D
T
S
S
A
Site 17
T136
E
T
Y
T
P
P
D
T
S
S
A
S
E
D
E
Site 18
S137
T
Y
T
P
P
D
T
S
S
A
S
E
D
E
G
Site 19
S138
Y
T
P
P
D
T
S
S
A
S
E
D
E
G
S
Site 20
S140
P
P
D
T
S
S
A
S
E
D
E
G
S
L
R
Site 21
S145
S
A
S
E
D
E
G
S
L
R
R
P
G
R
L
Site 22
T153
L
R
R
P
G
R
L
T
S
T
P
L
Q
S
H
Site 23
S154
R
R
P
G
R
L
T
S
T
P
L
Q
S
H
S
Site 24
T155
R
P
G
R
L
T
S
T
P
L
Q
S
H
S
S
Site 25
S159
L
T
S
T
P
L
Q
S
H
S
S
V
E
P
W
Site 26
S161
S
T
P
L
Q
S
H
S
S
V
E
P
W
L
D
Site 27
S162
T
P
L
Q
S
H
S
S
V
E
P
W
L
D
R
Site 28
S174
L
D
R
V
I
Q
G
S
S
T
S
S
S
A
S
Site 29
S175
D
R
V
I
Q
G
S
S
T
S
S
S
A
S
S
Site 30
T176
R
V
I
Q
G
S
S
T
S
S
S
A
S
S
T
Site 31
S177
V
I
Q
G
S
S
T
S
S
S
A
S
S
T
S
Site 32
S178
I
Q
G
S
S
T
S
S
S
A
S
S
T
S
S
Site 33
S179
Q
G
S
S
T
S
S
S
A
S
S
T
S
S
H
Site 34
S181
S
S
T
S
S
S
A
S
S
T
S
S
H
P
G
Site 35
S182
S
T
S
S
S
A
S
S
T
S
S
H
P
G
G
Site 36
T183
T
S
S
S
A
S
S
T
S
S
H
P
G
G
R
Site 37
S184
S
S
S
A
S
S
T
S
S
H
P
G
G
R
P
Site 38
S185
S
S
A
S
S
T
S
S
H
P
G
G
R
P
T
Site 39
T192
S
H
P
G
G
R
P
T
T
A
P
S
A
A
A
Site 40
T193
H
P
G
G
R
P
T
T
A
P
S
A
A
A
T
Site 41
S196
G
R
P
T
T
A
P
S
A
A
A
T
P
G
A
Site 42
S222
H
T
H
I
D
L
H
S
A
P
P
D
V
T
T
Site 43
T229
S
A
P
P
D
V
T
T
G
L
V
E
H
S
Y
Site 44
Y236
T
G
L
V
E
H
S
Y
F
E
R
P
Q
V
A
Site 45
S244
F
E
R
P
Q
V
A
S
V
R
S
V
P
R
G
Site 46
S247
P
Q
V
A
S
V
R
S
V
P
R
G
C
S
G
Site 47
S253
R
S
V
P
R
G
C
S
G
S
M
L
E
T
A
Site 48
S255
V
P
R
G
C
S
G
S
M
L
E
T
A
D
G
Site 49
S267
A
D
G
V
P
V
N
S
R
V
S
S
K
I
Q
Site 50
S270
V
P
V
N
S
R
V
S
S
K
I
Q
Q
L
L
Site 51
S271
P
V
N
S
R
V
S
S
K
I
Q
Q
L
L
N
Site 52
T279
K
I
Q
Q
L
L
N
T
L
K
R
P
K
R
P
Site 53
S315
N
Q
P
K
P
E
G
S
E
T
S
V
L
R
G
Site 54
T317
P
K
P
E
G
S
E
T
S
V
L
R
G
E
P
Site 55
S318
K
P
E
G
S
E
T
S
V
L
R
G
E
P
L
Site 56
T326
V
L
R
G
E
P
L
T
A
G
V
P
R
P
P
Site 57
S334
A
G
V
P
R
P
P
S
L
L
A
T
L
Q
R
Site 58
T338
R
P
P
S
L
L
A
T
L
Q
R
W
G
T
T
Site 59
T344
A
T
L
Q
R
W
G
T
T
Q
P
K
S
P
C
Site 60
T345
T
L
Q
R
W
G
T
T
Q
P
K
S
P
C
L
Site 61
S349
W
G
T
T
Q
P
K
S
P
C
L
T
A
L
D
Site 62
T353
Q
P
K
S
P
C
L
T
A
L
D
T
T
G
K
Site 63
T366
G
K
A
V
Y
T
L
T
Y
G
K
L
W
S
R
Site 64
S372
L
T
Y
G
K
L
W
S
R
S
L
K
L
A
Y
Site 65
S374
Y
G
K
L
W
S
R
S
L
K
L
A
Y
T
L
Site 66
T380
R
S
L
K
L
A
Y
T
L
L
N
K
L
T
S
Site 67
S387
T
L
L
N
K
L
T
S
K
N
E
P
L
L
K
Site 68
T433
V
P
I
E
V
P
L
T
R
K
D
A
G
S
Q
Site 69
S439
L
T
R
K
D
A
G
S
Q
Q
V
G
F
L
L
Site 70
T469
K
G
L
P
K
A
Q
T
G
E
V
A
A
F
K
Site 71
S482
F
K
G
W
P
P
L
S
W
L
V
I
D
G
K
Site 72
Y511
D
T
G
T
G
T
A
Y
I
E
Y
K
T
S
K
Site 73
Y514
T
G
T
A
Y
I
E
Y
K
T
S
K
E
G
S
Site 74
S517
A
Y
I
E
Y
K
T
S
K
E
G
S
T
V
G
Site 75
S521
Y
K
T
S
K
E
G
S
T
V
G
V
T
V
S
Site 76
T522
K
T
S
K
E
G
S
T
V
G
V
T
V
S
H
Site 77
T540
L
A
Q
C
R
A
L
T
Q
A
C
G
Y
S
E
Site 78
S546
L
T
Q
A
C
G
Y
S
E
A
E
T
L
T
N
Site 79
T550
C
G
Y
S
E
A
E
T
L
T
N
V
L
D
F
Site 80
Y582
M
H
V
V
S
V
P
Y
A
L
M
K
A
N
P
Site 81
S608
A
R
A
A
L
V
K
S
R
D
M
H
W
S
L
Site 82
S614
K
S
R
D
M
H
W
S
L
L
A
Q
R
G
Q
Site 83
S625
Q
R
G
Q
R
D
V
S
L
S
S
L
R
M
L
Site 84
S642
A
D
G
A
N
P
W
S
I
S
S
C
D
A
F
Site 85
S644
G
A
N
P
W
S
I
S
S
C
D
A
F
L
N
Site 86
S655
A
F
L
N
V
F
Q
S
R
G
L
R
P
E
V
Site 87
T674
A
S
S
P
E
A
L
T
V
A
I
R
R
P
P
Site 88
S694
P
P
R
K
A
V
L
S
M
N
G
L
S
Y
G
Site 89
S712
V
D
T
E
E
K
L
S
V
L
T
V
Q
D
V
Site 90
T715
E
E
K
L
S
V
L
T
V
Q
D
V
G
Q
V
Site 91
Y738
V
K
L
E
G
T
P
Y
L
C
K
T
D
E
V
Site 92
T742
G
T
P
Y
L
C
K
T
D
E
V
G
E
I
C
Site 93
S866
A
E
Q
R
P
D
A
S
E
E
D
S
F
Q
W
Site 94
S870
P
D
A
S
E
E
D
S
F
Q
W
M
S
R
V
Site 95
S911
P
L
G
G
I
H
I
S
E
T
K
Q
R
F
L
Site 96
T913
G
G
I
H
I
S
E
T
K
Q
R
F
L
E
G
Site 97
T921
K
Q
R
F
L
E
G
T
L
H
P
C
N
V
L
Site 98
S968
G
K
R
I
A
Q
A
S
G
R
E
L
A
H
L
Site 99
S978
E
L
A
H
L
E
D
S
D
Q
A
R
K
F
L
Site 100
T997
V
L
Q
W
R
A
H
T
T
P
D
H
P
L
F
Site 101
T998
L
Q
W
R
A
H
T
T
P
D
H
P
L
F
L
Site 102
T1071
Y
C
G
C
V
P
V
T
V
R
P
P
H
P
Q
Site 103
T1129
T
W
P
T
I
L
D
T
D
D
I
P
K
K
K
Site 104
S1139
I
P
K
K
K
I
A
S
V
F
R
P
P
S
P
Site 105
S1217
S
V
Y
S
G
H
Q
S
V
L
V
P
P
L
E
Site 106
S1234
S
N
V
S
L
W
L
S
A
V
S
Q
Y
K
A
Site 107
T1244
S
Q
Y
K
A
R
V
T
F
C
S
Y
S
V
M
Site 108
T1291
E
R
P
R
I
A
L
T
Q
S
F
S
K
L
F
Site 109
S1293
P
R
I
A
L
T
Q
S
F
S
K
L
F
K
D
Site 110
T1332
T
A
G
P
D
P
T
T
V
Y
V
D
M
R
A
Site 111
Y1334
G
P
D
P
T
T
V
Y
V
D
M
R
A
L
R
Site 112
S1352
V
R
L
V
E
R
G
S
P
H
S
L
P
L
M
Site 113
S1355
V
E
R
G
S
P
H
S
L
P
L
M
E
S
G
Site 114
S1384
T
K
G
P
L
G
D
S
H
L
G
E
I
W
V
Site 115
S1392
H
L
G
E
I
W
V
S
S
P
H
N
A
T
G
Site 116
S1393
L
G
E
I
W
V
S
S
P
H
N
A
T
G
Y
Site 117
Y1400
S
P
H
N
A
T
G
Y
Y
T
V
Y
G
E
E
Site 118
Y1401
P
H
N
A
T
G
Y
Y
T
V
Y
G
E
E
A
Site 119
T1402
H
N
A
T
G
Y
Y
T
V
Y
G
E
E
A
L
Site 120
Y1404
A
T
G
Y
Y
T
V
Y
G
E
E
A
L
H
A
Site 121
S1415
A
L
H
A
D
H
F
S
A
R
L
S
F
G
D
Site 122
S1419
D
H
F
S
A
R
L
S
F
G
D
T
Q
T
I
Site 123
T1423
A
R
L
S
F
G
D
T
Q
T
I
W
A
R
T
Site 124
T1425
L
S
F
G
D
T
Q
T
I
W
A
R
T
G
Y
Site 125
Y1432
T
I
W
A
R
T
G
Y
L
G
F
L
R
R
T
Site 126
T1439
Y
L
G
F
L
R
R
T
E
L
T
D
A
S
G
Site 127
T1442
F
L
R
R
T
E
L
T
D
A
S
G
G
R
H
Site 128
Y1453
G
G
R
H
D
A
L
Y
V
V
G
S
L
D
E
Site 129
T1461
V
V
G
S
L
D
E
T
L
E
L
R
G
M
R
Site 130
Y1469
L
E
L
R
G
M
R
Y
H
P
I
D
I
E
T
Site 131
T1476
Y
H
P
I
D
I
E
T
S
V
I
R
A
H
R
Site 132
S1477
H
P
I
D
I
E
T
S
V
I
R
A
H
R
S
Site 133
Y1566
A
D
Q
L
D
P
I
Y
V
A
Y
N
M
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation