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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP10
Full Name:
Ubiquitin carboxyl-terminal hydrolase 10
Alias:
Deubiquitinating enzyme 10; KIAA0190; ODE-1; Ubiquitin specific peptidase 10; Ubiquitin thioesterase 10; Ubiquitin thiolesterase 10; Ubiquitin-specific processing protease 10; UBP10; UBPA; UBPO; UCHRP
Type:
EC 3.1.2.15; Protease; Ubiquitin conjugating system
Mass (Da):
87134
Number AA:
798
UniProt ID:
Q14694
International Prot ID:
IPI00291946
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004221
GO:0004843
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S5
_
_
_
M
A
L
H
S
P
Q
Y
I
F
G
D
Site 2
Y8
M
A
L
H
S
P
Q
Y
I
F
G
D
F
S
P
Site 3
S14
Q
Y
I
F
G
D
F
S
P
D
E
F
N
Q
F
Site 4
T24
E
F
N
Q
F
F
V
T
P
R
S
S
V
E
L
Site 5
S27
Q
F
F
V
T
P
R
S
S
V
E
L
P
P
Y
Site 6
S28
F
F
V
T
P
R
S
S
V
E
L
P
P
Y
S
Site 7
T42
S
G
T
V
L
C
G
T
Q
A
V
D
K
L
P
Site 8
Y54
K
L
P
D
G
Q
E
Y
Q
R
I
E
F
G
V
Site 9
S68
V
D
E
V
I
E
P
S
D
T
L
P
R
T
P
Site 10
T70
E
V
I
E
P
S
D
T
L
P
R
T
P
S
Y
Site 11
T74
P
S
D
T
L
P
R
T
P
S
Y
S
I
S
S
Site 12
S76
D
T
L
P
R
T
P
S
Y
S
I
S
S
T
L
Site 13
Y77
T
L
P
R
T
P
S
Y
S
I
S
S
T
L
N
Site 14
S78
L
P
R
T
P
S
Y
S
I
S
S
T
L
N
P
Site 15
S80
R
T
P
S
Y
S
I
S
S
T
L
N
P
Q
A
Site 16
S81
T
P
S
Y
S
I
S
S
T
L
N
P
Q
A
P
Site 17
T82
P
S
Y
S
I
S
S
T
L
N
P
Q
A
P
E
Site 18
T95
P
E
F
I
L
G
C
T
A
S
K
I
T
P
D
Site 19
T100
G
C
T
A
S
K
I
T
P
D
G
I
T
K
E
Site 20
T105
K
I
T
P
D
G
I
T
K
E
A
S
Y
G
S
Site 21
S109
D
G
I
T
K
E
A
S
Y
G
S
I
D
C
Q
Site 22
Y159
K
K
K
R
P
P
G
Y
Y
S
Y
L
K
D
G
Site 23
Y160
K
K
R
P
P
G
Y
Y
S
Y
L
K
D
G
G
Site 24
S161
K
R
P
P
G
Y
Y
S
Y
L
K
D
G
G
D
Site 25
Y162
R
P
P
G
Y
Y
S
Y
L
K
D
G
G
D
D
Site 26
S170
L
K
D
G
G
D
D
S
I
S
T
E
A
L
V
Site 27
S172
D
G
G
D
D
S
I
S
T
E
A
L
V
N
G
Site 28
S183
L
V
N
G
H
A
N
S
A
V
P
N
S
V
S
Site 29
S188
A
N
S
A
V
P
N
S
V
S
A
E
D
A
E
Site 30
S190
S
A
V
P
N
S
V
S
A
E
D
A
E
F
M
Site 31
S203
F
M
G
D
M
P
P
S
V
T
P
R
T
C
N
Site 32
T205
G
D
M
P
P
S
V
T
P
R
T
C
N
S
P
Site 33
T208
P
P
S
V
T
P
R
T
C
N
S
P
Q
N
S
Site 34
S211
V
T
P
R
T
C
N
S
P
Q
N
S
T
D
S
Site 35
S215
T
C
N
S
P
Q
N
S
T
D
S
V
S
D
I
Site 36
T216
C
N
S
P
Q
N
S
T
D
S
V
S
D
I
V
Site 37
S218
S
P
Q
N
S
T
D
S
V
S
D
I
V
P
D
Site 38
S220
Q
N
S
T
D
S
V
S
D
I
V
P
D
S
P
Site 39
S226
V
S
D
I
V
P
D
S
P
F
P
G
A
L
G
Site 40
S234
P
F
P
G
A
L
G
S
D
T
R
T
A
G
Q
Site 41
T236
P
G
A
L
G
S
D
T
R
T
A
G
Q
P
E
Site 42
T238
A
L
G
S
D
T
R
T
A
G
Q
P
E
G
G
Site 43
S253
P
G
A
D
F
G
Q
S
C
F
P
A
E
A
G
Site 44
T263
P
A
E
A
G
R
D
T
L
S
R
T
A
G
A
Site 45
S265
E
A
G
R
D
T
L
S
R
T
A
G
A
Q
P
Site 46
T278
Q
P
C
V
G
T
D
T
T
E
N
L
G
V
A
Site 47
T279
P
C
V
G
T
D
T
T
E
N
L
G
V
A
N
Site 48
S293
N
G
Q
I
L
E
S
S
G
E
G
T
A
T
N
Site 49
T297
L
E
S
S
G
E
G
T
A
T
N
G
V
E
L
Site 50
T299
S
S
G
E
G
T
A
T
N
G
V
E
L
H
T
Site 51
T307
N
G
V
E
L
H
T
T
E
S
I
D
L
D
P
Site 52
T315
E
S
I
D
L
D
P
T
K
P
E
S
A
S
P
Site 53
S319
L
D
P
T
K
P
E
S
A
S
P
P
A
D
G
Site 54
S321
P
T
K
P
E
S
A
S
P
P
A
D
G
T
G
Site 55
T327
A
S
P
P
A
D
G
T
G
S
A
S
G
T
L
Site 56
S329
P
P
A
D
G
T
G
S
A
S
G
T
L
P
V
Site 57
S331
A
D
G
T
G
S
A
S
G
T
L
P
V
S
Q
Site 58
T333
G
T
G
S
A
S
G
T
L
P
V
S
Q
P
K
Site 59
S337
A
S
G
T
L
P
V
S
Q
P
K
S
W
A
S
Site 60
S341
L
P
V
S
Q
P
K
S
W
A
S
L
F
H
D
Site 61
S344
S
Q
P
K
S
W
A
S
L
F
H
D
S
K
P
Site 62
S349
W
A
S
L
F
H
D
S
K
P
S
S
S
S
P
Site 63
S352
L
F
H
D
S
K
P
S
S
S
S
P
V
A
Y
Site 64
S353
F
H
D
S
K
P
S
S
S
S
P
V
A
Y
V
Site 65
S355
D
S
K
P
S
S
S
S
P
V
A
Y
V
E
T
Site 66
Y359
S
S
S
S
P
V
A
Y
V
E
T
K
Y
S
P
Site 67
Y364
S
S
S
S
P
V
A
Y
V
E
T
K
Y
S
P
Site 68
S365
A
Y
V
E
T
K
Y
S
P
P
A
I
S
P
L
Site 69
S370
K
Y
S
P
P
A
I
S
P
L
V
S
E
K
Q
Site 70
S374
P
A
I
S
P
L
V
S
E
K
Q
V
E
V
K
Site 71
S388
K
E
G
L
V
P
V
S
E
D
P
V
A
I
K
Site 72
T457
S
K
V
Q
R
P
C
T
S
T
P
M
I
D
S
Site 73
S458
K
V
Q
R
P
C
T
S
T
P
M
I
D
S
F
Site 74
S464
T
S
T
P
M
I
D
S
F
V
R
L
M
N
E
Site 75
T473
V
R
L
M
N
E
F
T
N
M
P
V
P
P
K
Site 76
T509
T
Y
I
Y
R
L
L
T
V
N
K
S
S
L
S
Site 77
S513
R
L
L
T
V
N
K
S
S
L
S
E
K
G
R
Site 78
S514
L
L
T
V
N
K
S
S
L
S
E
K
G
R
Q
Site 79
S516
T
V
N
K
S
S
L
S
E
K
G
R
Q
E
D
Site 80
Y527
R
Q
E
D
A
E
E
Y
L
G
F
I
L
N
G
Site 81
S547
L
N
L
K
K
L
L
S
P
S
N
E
K
L
T
Site 82
S549
L
K
K
L
L
S
P
S
N
E
K
L
T
I
S
Site 83
T554
S
P
S
N
E
K
L
T
I
S
N
G
P
K
N
Site 84
S556
S
N
E
K
L
T
I
S
N
G
P
K
N
H
S
Site 85
S563
S
N
G
P
K
N
H
S
V
N
E
E
E
Q
E
Site 86
S576
Q
E
E
Q
G
E
G
S
E
D
E
W
E
Q
V
Site 87
T589
Q
V
G
P
R
N
K
T
S
V
T
R
Q
A
D
Site 88
S590
V
G
P
R
N
K
T
S
V
T
R
Q
A
D
F
Site 89
S612
I
F
G
G
H
I
R
S
V
V
Y
Q
Q
S
S
Site 90
Y615
G
H
I
R
S
V
V
Y
Q
Q
S
S
K
E
S
Site 91
S618
R
S
V
V
Y
Q
Q
S
S
K
E
S
A
T
L
Site 92
S619
S
V
V
Y
Q
Q
S
S
K
E
S
A
T
L
Q
Site 93
S622
Y
Q
Q
S
S
K
E
S
A
T
L
Q
P
F
F
Site 94
T624
Q
S
S
K
E
S
A
T
L
Q
P
F
F
T
L
Site 95
S637
T
L
Q
L
D
I
Q
S
D
K
I
R
T
V
Q
Site 96
S655
E
S
L
V
A
R
E
S
V
Q
G
Y
T
T
K
Site 97
Y659
A
R
E
S
V
Q
G
Y
T
T
K
T
K
Q
E
Site 98
S670
T
K
Q
E
V
E
I
S
R
R
V
T
L
E
K
Site 99
T674
V
E
I
S
R
R
V
T
L
E
K
L
P
P
V
Site 100
Y691
L
H
L
K
R
F
V
Y
E
K
T
G
G
C
Q
Site 101
Y706
K
L
I
K
N
I
E
Y
P
V
D
L
E
I
S
Site 102
S713
Y
P
V
D
L
E
I
S
K
E
L
L
S
P
G
Site 103
S718
E
I
S
K
E
L
L
S
P
G
V
K
N
K
N
Site 104
Y732
N
F
K
C
H
R
T
Y
R
L
F
A
V
V
Y
Site 105
Y739
Y
R
L
F
A
V
V
Y
H
H
G
N
S
A
T
Site 106
T751
S
A
T
G
G
H
Y
T
T
D
V
F
Q
I
G
Site 107
Y776
T
V
K
V
I
N
Q
Y
Q
V
V
K
P
T
A
Site 108
Y788
P
T
A
E
R
T
A
Y
L
L
Y
Y
R
R
V
Site 109
Y791
E
R
T
A
Y
L
L
Y
Y
R
R
V
D
L
L
Site 110
Y792
R
T
A
Y
L
L
Y
Y
R
R
V
D
L
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation