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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MBTPS1
Full Name:
Membrane-bound transcription factor site-1 protease
Alias:
EC 3.4.21.112; KIAA0091; MBTP1; S1P; S1P endopeptidase; Site-1 protease; SKI1; SKI-1; Subtilisin/kexin-isozyme 1
Type:
Protease
Mass (Da):
117749
Number AA:
1052
UniProt ID:
Q14703
International Prot ID:
IPI00021569
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005788
GO:0016021
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004252
PhosphoSite+
KinaseNET
Biological Process:
GO:0008203
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
G
D
R
L
E
K
K
S
F
E
K
A
P
C
P
Site 2
S49
T
L
K
V
E
F
S
S
T
V
V
E
Y
E
Y
Site 3
S71
F
T
A
K
A
R
N
S
F
I
S
S
A
L
K
Site 4
S74
K
A
R
N
S
F
I
S
S
A
L
K
S
S
E
Site 5
S75
A
R
N
S
F
I
S
S
A
L
K
S
S
E
V
Site 6
S79
F
I
S
S
A
L
K
S
S
E
V
D
N
W
R
Site 7
S95
I
P
R
N
N
P
S
S
D
Y
P
S
D
F
E
Site 8
Y97
R
N
N
P
S
S
D
Y
P
S
D
F
E
V
I
Site 9
S99
N
P
S
S
D
Y
P
S
D
F
E
V
I
Q
I
Site 10
T116
K
Q
K
A
G
L
L
T
L
E
D
H
P
N
I
Site 11
T127
H
P
N
I
K
R
V
T
P
Q
R
K
V
F
R
Site 12
S135
P
Q
R
K
V
F
R
S
L
K
Y
A
E
S
D
Site 13
S141
R
S
L
K
Y
A
E
S
D
P
T
V
P
C
N
Site 14
T144
K
Y
A
E
S
D
P
T
V
P
C
N
E
T
R
Site 15
S158
R
W
S
Q
K
W
Q
S
S
R
P
L
R
R
A
Site 16
S159
W
S
Q
K
W
Q
S
S
R
P
L
R
R
A
S
Site 17
S166
S
R
P
L
R
R
A
S
L
S
L
G
S
G
F
Site 18
S168
P
L
R
R
A
S
L
S
L
G
S
G
F
W
H
Site 19
T177
G
S
G
F
W
H
A
T
G
R
H
S
S
R
R
Site 20
S181
W
H
A
T
G
R
H
S
S
R
R
L
L
R
A
Site 21
S182
H
A
T
G
R
H
S
S
R
R
L
L
R
A
I
Site 22
S222
A
V
F
D
T
G
L
S
E
K
H
P
H
F
K
Site 23
T235
F
K
N
V
K
E
R
T
N
W
T
N
E
R
T
Site 24
T242
T
N
W
T
N
E
R
T
L
D
D
G
L
G
H
Site 25
Y343
I
G
N
D
G
P
L
Y
G
T
L
N
N
P
A
Site 26
S371
E
D
N
I
A
R
F
S
S
R
G
M
T
T
W
Site 27
S372
D
N
I
A
R
F
S
S
R
G
M
T
T
W
E
Site 28
T376
R
F
S
S
R
G
M
T
T
W
E
L
P
G
G
Site 29
Y384
T
W
E
L
P
G
G
Y
G
R
M
K
P
D
I
Site 30
T393
R
M
K
P
D
I
V
T
Y
G
A
G
V
R
G
Site 31
S401
Y
G
A
G
V
R
G
S
G
V
K
G
G
C
R
Site 32
S411
K
G
G
C
R
A
L
S
G
T
S
V
A
S
P
Site 33
S417
L
S
G
T
S
V
A
S
P
V
V
A
G
A
V
Site 34
S429
G
A
V
T
L
L
V
S
T
V
Q
K
R
E
L
Site 35
Y472
K
L
D
L
L
R
A
Y
Q
I
L
N
S
Y
K
Site 36
S477
R
A
Y
Q
I
L
N
S
Y
K
P
Q
A
S
L
Site 37
S483
N
S
Y
K
P
Q
A
S
L
S
P
S
Y
I
D
Site 38
S485
Y
K
P
Q
A
S
L
S
P
S
Y
I
D
L
T
Site 39
S487
P
Q
A
S
L
S
P
S
Y
I
D
L
T
E
C
Site 40
Y506
P
Y
C
S
Q
P
I
Y
Y
G
G
M
P
T
V
Site 41
Y537
D
K
P
D
W
Q
P
Y
L
P
Q
N
G
D
N
Site 42
S574
S
V
T
K
K
A
A
S
W
E
G
I
A
Q
G
Site 43
S589
H
V
M
I
T
V
A
S
P
A
E
T
E
S
K
Site 44
T593
T
V
A
S
P
A
E
T
E
S
K
N
G
A
E
Site 45
T604
N
G
A
E
Q
T
S
T
V
K
L
P
I
K
V
Site 46
T616
I
K
V
K
I
I
P
T
P
P
R
S
K
R
V
Site 47
S620
I
I
P
T
P
P
R
S
K
R
V
L
W
D
Q
Site 48
Y628
K
R
V
L
W
D
Q
Y
H
N
L
R
Y
P
P
Site 49
Y633
D
Q
Y
H
N
L
R
Y
P
P
G
Y
F
P
R
Site 50
Y637
N
L
R
Y
P
P
G
Y
F
P
R
D
N
L
R
Site 51
T659
W
N
G
D
H
I
H
T
N
F
R
D
M
Y
Q
Site 52
Y665
H
T
N
F
R
D
M
Y
Q
H
L
R
S
M
G
Site 53
T692
F
D
A
S
Q
Y
G
T
L
L
M
V
D
S
E
Site 54
S698
G
T
L
L
M
V
D
S
E
E
E
Y
F
P
E
Site 55
Y702
M
V
D
S
E
E
E
Y
F
P
E
E
I
A
K
Site 56
S719
R
D
V
D
N
G
L
S
L
V
I
F
S
D
W
Site 57
Y727
L
V
I
F
S
D
W
Y
N
T
S
V
M
R
K
Site 58
Y738
V
M
R
K
V
K
F
Y
D
E
N
T
R
Q
W
Site 59
S770
S
V
W
N
M
G
F
S
D
G
L
Y
E
G
E
Site 60
Y786
T
L
A
N
H
D
M
Y
Y
A
S
G
C
S
I
Site 61
T806
D
G
V
V
I
T
Q
T
F
K
D
Q
G
L
E
Site 62
Y844
G
G
G
R
I
V
L
Y
G
D
S
N
C
L
D
Site 63
S847
R
I
V
L
Y
G
D
S
N
C
L
D
D
S
H
Site 64
S871
D
A
L
L
Q
Y
T
S
Y
G
V
T
P
P
S
Site 65
T875
Q
Y
T
S
Y
G
V
T
P
P
S
L
S
H
S
Site 66
S878
S
Y
G
V
T
P
P
S
L
S
H
S
G
N
R
Site 67
S880
G
V
T
P
P
S
L
S
H
S
G
N
R
Q
R
Site 68
S882
T
P
P
S
L
S
H
S
G
N
R
Q
R
P
P
Site 69
S890
G
N
R
Q
R
P
P
S
G
A
G
S
V
T
P
Site 70
S894
R
P
P
S
G
A
G
S
V
T
P
E
R
M
E
Site 71
T896
P
S
G
A
G
S
V
T
P
E
R
M
E
G
N
Site 72
Y908
E
G
N
H
L
H
R
Y
S
K
V
L
E
A
H
Site 73
S909
G
N
H
L
H
R
Y
S
K
V
L
E
A
H
L
Site 74
S931
L
P
A
C
P
R
L
S
W
A
K
P
Q
P
L
Site 75
S944
P
L
N
E
T
A
P
S
N
L
W
K
H
Q
K
Site 76
S967
V
V
L
P
N
F
R
S
N
R
P
Q
V
R
P
Site 77
S976
R
P
Q
V
R
P
L
S
P
G
E
S
G
A
W
Site 78
S980
R
P
L
S
P
G
E
S
G
A
W
D
I
P
G
Site 79
Y994
G
G
I
M
P
G
R
Y
N
Q
E
V
G
Q
T
Site 80
S1026
V
Q
I
N
K
A
K
S
R
P
K
R
R
K
P
Site 81
T1049
Q
Q
V
H
P
P
K
T
P
S
V
_
_
_
_
Site 82
S1051
V
H
P
P
K
T
P
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation