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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MVP
Full Name:
Major vault protein
Alias:
LRP; Lung resistance-related protein; VAULT1
Type:
RNA binding protein
Mass (Da):
99327
Number AA:
893
UniProt ID:
Q14764
International Prot ID:
IPI00000105
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005643
GO:0030529
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0051028
GO:0015031
GO:0042493
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
F
I
I
R
I
P
P
Y
H
Y
I
H
V
L
D
Site 2
Y15
I
R
I
P
P
Y
H
Y
I
H
V
L
D
Q
N
Site 3
S23
I
H
V
L
D
Q
N
S
N
V
S
R
V
E
V
Site 4
T34
R
V
E
V
G
P
K
T
Y
I
R
Q
D
N
E
Site 5
T52
F
A
P
M
R
M
V
T
V
P
P
R
H
Y
C
Site 6
Y58
V
T
V
P
P
R
H
Y
C
T
V
A
N
P
V
Site 7
T60
V
P
P
R
H
Y
C
T
V
A
N
P
V
S
R
Site 8
Y100
A
Q
D
P
F
P
L
Y
P
G
E
V
L
E
K
Site 9
T150
W
L
F
E
G
P
G
T
Y
I
P
R
K
E
V
Site 10
T192
R
D
G
K
E
R
V
T
G
E
E
W
L
V
T
Site 11
S242
F
R
D
F
R
G
V
S
R
R
T
G
E
E
W
Site 12
T245
F
R
G
V
S
R
R
T
G
E
E
W
L
V
T
Site 13
T252
T
G
E
E
W
L
V
T
V
Q
D
T
E
A
H
Site 14
S307
R
V
V
K
G
E
K
S
F
F
L
Q
P
G
E
Site 15
Y324
E
Q
G
I
Q
D
V
Y
V
L
S
E
Q
Q
G
Site 16
S350
G
E
D
E
E
K
V
S
H
Q
A
G
D
H
W
Site 17
Y365
L
I
R
G
P
L
E
Y
V
P
S
A
K
V
E
Site 18
Y389
L
D
E
N
E
G
I
Y
V
Q
D
V
K
T
G
Site 19
S404
K
V
R
A
V
I
G
S
T
Y
M
L
T
Q
D
Site 20
T409
I
G
S
T
Y
M
L
T
Q
D
E
V
L
W
E
Site 21
T442
A
D
R
G
E
K
D
T
A
K
S
L
Q
P
L
Site 22
S445
G
E
K
D
T
A
K
S
L
Q
P
L
A
P
R
Site 23
T455
P
L
A
P
R
N
K
T
R
V
V
S
Y
R
V
Site 24
S459
R
N
K
T
R
V
V
S
Y
R
V
P
H
N
A
Site 25
Y460
N
K
T
R
V
V
S
Y
R
V
P
H
N
A
A
Site 26
Y471
H
N
A
A
V
Q
V
Y
D
Y
R
E
K
R
A
Site 27
Y473
A
A
V
Q
V
Y
D
Y
R
E
K
R
A
R
V
Site 28
S499
E
E
Q
F
T
V
L
S
L
S
A
G
R
P
K
Site 29
S501
Q
F
T
V
L
S
L
S
A
G
R
P
K
R
P
Site 30
S563
Q
E
T
A
K
L
F
S
V
P
D
F
V
G
D
Site 31
S585
R
V
R
G
A
V
A
S
V
T
F
D
D
F
H
Site 32
T587
R
G
A
V
A
S
V
T
F
D
D
F
H
K
N
Site 33
S609
A
V
F
G
F
E
T
S
E
A
K
G
P
D
G
Site 34
S642
V
S
S
V
D
V
Q
S
V
E
P
V
D
Q
R
Site 35
S668
A
I
E
I
T
T
N
S
Q
E
A
A
A
K
H
Site 36
S740
A
R
I
E
G
E
G
S
V
L
Q
A
K
L
K
Site 37
Y772
V
R
E
L
E
L
V
Y
A
R
A
Q
L
E
L
Site 38
S782
A
Q
L
E
L
E
V
S
K
A
Q
Q
L
A
E
Site 39
T799
V
K
K
F
K
Q
M
T
E
A
I
G
P
S
T
Site 40
S805
M
T
E
A
I
G
P
S
T
I
R
D
L
A
V
Site 41
T806
T
E
A
I
G
P
S
T
I
R
D
L
A
V
A
Site 42
T830
Q
S
L
G
L
K
S
T
L
I
T
D
G
S
T
Site 43
T833
G
L
K
S
T
L
I
T
D
G
S
T
P
I
N
Site 44
S836
S
T
L
I
T
D
G
S
T
P
I
N
L
F
N
Site 45
S864
P
L
G
R
R
V
A
S
G
P
S
P
G
E
G
Site 46
S867
R
R
V
A
S
G
P
S
P
G
E
G
I
S
P
Site 47
S873
P
S
P
G
E
G
I
S
P
Q
S
A
Q
A
P
Site 48
S876
G
E
G
I
S
P
Q
S
A
Q
A
P
Q
A
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation