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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STAT4
Full Name:
Signal transducer and activator of transcription 4
Alias:
Type:
Transcription protein
Mass (Da):
85941
Number AA:
748
UniProt ID:
Q14765
International Prot ID:
IPI00000106
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007259
GO:0006355
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
L
E
Q
V
D
Q
F
Y
D
D
N
F
P
M
E
Site 2
T51
E
A
A
S
N
N
E
T
M
A
T
I
L
L
Q
Site 3
S72
D
E
Q
L
G
R
V
S
K
E
K
N
L
L
L
Site 4
S106
M
H
V
A
V
V
I
S
N
C
L
R
E
E
R
Site 5
S130
V
Q
G
P
L
E
K
S
L
Q
S
S
S
V
S
Site 6
S133
P
L
E
K
S
L
Q
S
S
S
V
S
E
R
Q
Site 7
S134
L
E
K
S
L
Q
S
S
S
V
S
E
R
Q
R
Site 8
S135
E
K
S
L
Q
S
S
S
V
S
E
R
Q
R
N
Site 9
S137
S
L
Q
S
S
S
V
S
E
R
Q
R
N
V
E
Site 10
T157
I
K
N
S
V
Q
M
T
E
Q
D
T
K
Y
L
Site 11
Y163
M
T
E
Q
D
T
K
Y
L
E
D
L
Q
D
E
Site 12
Y173
D
L
Q
D
E
F
D
Y
R
Y
K
T
I
Q
T
Site 13
Y175
Q
D
E
F
D
Y
R
Y
K
T
I
Q
T
M
D
Site 14
T177
E
F
D
Y
R
Y
K
T
I
Q
T
M
D
Q
S
Site 15
S184
T
I
Q
T
M
D
Q
S
D
K
N
S
A
M
V
Site 16
S188
M
D
Q
S
D
K
N
S
A
M
V
N
Q
E
V
Site 17
S204
T
L
Q
E
M
L
N
S
L
D
F
K
R
K
E
Site 18
S214
F
K
R
K
E
A
L
S
K
M
T
Q
I
I
H
Site 19
T284
E
K
L
E
E
Q
S
T
K
M
T
Y
E
G
D
Site 20
T287
E
E
Q
S
T
K
M
T
Y
E
G
D
P
I
P
Site 21
Y288
E
Q
S
T
K
M
T
Y
E
G
D
P
I
P
M
Site 22
T298
D
P
I
P
M
Q
R
T
H
M
L
E
R
V
T
Site 23
S315
I
Y
N
L
F
K
N
S
F
V
V
E
R
Q
P
Site 24
T326
E
R
Q
P
C
M
P
T
H
P
Q
R
P
L
V
Site 25
Y355
I
K
L
P
E
L
N
Y
Q
V
K
V
K
A
S
Site 26
T369
S
I
D
K
N
V
S
T
L
S
N
R
R
F
V
Site 27
S371
D
K
N
V
S
T
L
S
N
R
R
F
V
L
C
Site 28
S386
G
T
N
V
K
A
M
S
I
E
E
S
S
N
G
Site 29
S390
K
A
M
S
I
E
E
S
S
N
G
S
L
S
V
Site 30
S391
A
M
S
I
E
E
S
S
N
G
S
L
S
V
E
Site 31
S394
I
E
E
S
S
N
G
S
L
S
V
E
F
R
H
Site 32
S396
E
S
S
N
G
S
L
S
V
E
F
R
H
L
Q
Site 33
S409
L
Q
P
K
E
M
K
S
S
A
G
G
K
G
N
Site 34
S410
Q
P
K
E
M
K
S
S
A
G
G
K
G
N
E
Site 35
T490
F
N
N
P
P
P
A
T
L
S
Q
L
L
E
V
Site 36
S492
N
P
P
P
A
T
L
S
Q
L
L
E
V
M
S
Site 37
S503
E
V
M
S
W
Q
F
S
S
Y
V
G
R
G
L
Site 38
Y505
M
S
W
Q
F
S
S
Y
V
G
R
G
L
N
S
Site 39
T523
H
M
L
A
E
K
L
T
V
Q
S
S
Y
S
D
Site 40
S527
E
K
L
T
V
Q
S
S
Y
S
D
G
H
L
T
Site 41
S529
L
T
V
Q
S
S
Y
S
D
G
H
L
T
W
A
Site 42
T534
S
Y
S
D
G
H
L
T
W
A
K
F
C
K
E
Site 43
T594
L
K
D
K
M
P
G
T
F
L
L
R
F
S
E
Site 44
T608
E
S
H
L
G
G
I
T
F
T
W
V
D
H
S
Site 45
T610
H
L
G
G
I
T
F
T
W
V
D
H
S
E
S
Site 46
S615
T
F
T
W
V
D
H
S
E
S
G
E
V
R
F
Site 47
S624
S
G
E
V
R
F
H
S
V
E
P
Y
N
K
G
Site 48
Y628
R
F
H
S
V
E
P
Y
N
K
G
R
L
S
A
Site 49
S634
P
Y
N
K
G
R
L
S
A
L
P
F
A
D
I
Site 50
Y645
F
A
D
I
L
R
D
Y
K
V
I
M
A
E
N
Site 51
Y660
I
P
E
N
P
L
K
Y
L
Y
P
D
I
P
K
Site 52
Y662
E
N
P
L
K
Y
L
Y
P
D
I
P
K
D
K
Site 53
S676
K
A
F
G
K
H
Y
S
S
Q
P
C
E
V
S
Site 54
S677
A
F
G
K
H
Y
S
S
Q
P
C
E
V
S
R
Site 55
T686
P
C
E
V
S
R
P
T
E
R
G
D
K
G
Y
Site 56
Y693
T
E
R
G
D
K
G
Y
V
P
S
V
F
I
P
Site 57
T703
S
V
F
I
P
I
S
T
I
R
S
D
S
T
E
Site 58
S706
I
P
I
S
T
I
R
S
D
S
T
E
P
H
S
Site 59
S708
I
S
T
I
R
S
D
S
T
E
P
H
S
P
S
Site 60
T709
S
T
I
R
S
D
S
T
E
P
H
S
P
S
D
Site 61
S713
S
D
S
T
E
P
H
S
P
S
D
L
L
P
M
Site 62
S715
S
T
E
P
H
S
P
S
D
L
L
P
M
S
P
Site 63
S721
P
S
D
L
L
P
M
S
P
S
V
Y
A
V
L
Site 64
S733
A
V
L
R
E
N
L
S
P
T
T
I
E
T
A
Site 65
T739
L
S
P
T
T
I
E
T
A
M
K
S
P
Y
S
Site 66
S743
T
I
E
T
A
M
K
S
P
Y
S
A
E
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation