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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
mGluR3
Full Name:
Metabotropic glutamate receptor 3
Alias:
glutamate receptor, metabotropic 3; glutamate receptor, metabotropic, type 3; GPRC1C; GRM3; mGlu3; MGLUR3; MGR3
Type:
G protein-coupled 7TM receptor, glutamate
Mass (Da):
98879
Number AA:
879
UniProt ID:
Q14832
International Prot ID:
IPI00000837
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0008067
PhosphoSite+
KinaseNET
Biological Process:
GO:0007186
GO:0007194
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y84
D
E
I
N
K
D
D
Y
L
L
P
G
V
K
L
Site 2
T103
L
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
Site 3
Y104
D
T
C
S
R
D
T
Y
A
L
E
Q
S
L
E
Site 4
S109
D
T
Y
A
L
E
Q
S
L
E
F
V
R
A
S
Site 5
S116
S
L
E
F
V
R
A
S
L
T
K
V
D
E
A
Site 6
T118
E
F
V
R
A
S
L
T
K
V
D
E
A
E
Y
Site 7
Y125
T
K
V
D
E
A
E
Y
M
C
P
D
G
S
Y
Site 8
Y132
Y
M
C
P
D
G
S
Y
A
I
Q
E
N
I
P
Site 9
S170
L
F
Q
I
P
Q
I
S
Y
A
S
T
S
A
K
Site 10
S173
I
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
Site 11
T174
P
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
Site 12
S175
Q
I
S
Y
A
S
T
S
A
K
L
S
D
K
S
Site 13
S179
A
S
T
S
A
K
L
S
D
K
S
R
Y
D
Y
Site 14
S182
S
A
K
L
S
D
K
S
R
Y
D
Y
F
A
R
Site 15
Y186
S
D
K
S
R
Y
D
Y
F
A
R
T
V
P
P
Site 16
Y196
R
T
V
P
P
D
F
Y
Q
A
K
A
M
A
E
Site 17
T215
F
N
W
T
Y
V
S
T
V
A
S
E
G
D
Y
Site 18
S218
T
Y
V
S
T
V
A
S
E
G
D
Y
G
E
T
Site 19
Y222
T
V
A
S
E
G
D
Y
G
E
T
G
I
E
A
Site 20
S250
T
A
E
K
V
G
R
S
N
I
R
K
S
Y
D
Site 21
S255
G
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
Site 22
Y256
R
S
N
I
R
K
S
Y
D
S
V
I
R
E
L
Site 23
S258
N
I
R
K
S
Y
D
S
V
I
R
E
L
L
Q
Site 24
S289
R
E
L
I
A
A
A
S
R
A
N
A
S
F
T
Site 25
S294
A
A
S
R
A
N
A
S
F
T
W
V
A
S
D
Site 26
T296
S
R
A
N
A
S
F
T
W
V
A
S
D
G
W
Site 27
S308
D
G
W
G
A
Q
E
S
I
I
K
G
S
E
H
Site 28
S327
A
I
T
L
E
L
A
S
Q
P
V
R
Q
F
D
Site 29
Y336
P
V
R
Q
F
D
R
Y
F
Q
S
L
N
P
Y
Site 30
Y343
Y
F
Q
S
L
N
P
Y
N
N
H
R
N
P
W
Site 31
S381
D
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
Site 32
S382
K
H
L
A
I
D
S
S
N
Y
E
Q
E
S
K
Site 33
Y384
L
A
I
D
S
S
N
Y
E
Q
E
S
K
I
M
Site 34
T410
A
L
H
K
M
Q
R
T
L
C
P
N
T
T
K
Site 35
Y431
I
L
D
G
K
K
L
Y
K
D
Y
L
L
K
I
Site 36
Y434
G
K
K
L
Y
K
D
Y
L
L
K
I
N
F
T
Site 37
S452
N
P
N
K
D
A
D
S
I
V
K
F
D
T
F
Site 38
T458
D
S
I
V
K
F
D
T
F
G
D
G
M
G
R
Site 39
Y466
F
G
D
G
M
G
R
Y
N
V
F
N
F
Q
N
Site 40
Y478
F
Q
N
V
G
G
K
Y
S
Y
L
K
V
G
H
Site 41
Y480
N
V
G
G
K
Y
S
Y
L
K
V
G
H
W
A
Site 42
S491
G
H
W
A
E
T
L
S
L
D
V
N
S
I
H
Site 43
S496
T
L
S
L
D
V
N
S
I
H
W
S
R
N
S
Site 44
S500
D
V
N
S
I
H
W
S
R
N
S
V
P
T
S
Site 45
S503
S
I
H
W
S
R
N
S
V
P
T
S
Q
C
S
Site 46
T506
W
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
Site 47
S507
S
R
N
S
V
P
T
S
Q
C
S
D
P
C
A
Site 48
S510
S
V
P
T
S
Q
C
S
D
P
C
A
P
N
E
Site 49
Y539
I
P
C
E
P
Y
E
Y
L
A
D
E
F
T
C
Site 50
T560
Q
W
P
T
A
D
L
T
G
C
Y
D
L
P
E
Site 51
Y563
T
A
D
L
T
G
C
Y
D
L
P
E
D
Y
I
Site 52
Y569
C
Y
D
L
P
E
D
Y
I
R
W
E
D
A
W
Site 53
T604
V
F
I
K
H
N
N
T
P
L
V
K
A
S
G
Site 54
S610
N
T
P
L
V
K
A
S
G
R
E
L
C
Y
I
Site 55
T663
Y
S
A
L
L
T
K
T
N
C
I
A
R
I
F
Site 56
S684
A
Q
R
P
K
F
I
S
P
S
S
Q
V
F
I
Site 57
T714
L
I
L
E
A
P
G
T
R
R
Y
T
L
A
E
Site 58
Y717
E
A
P
G
T
R
R
Y
T
L
A
E
K
R
E
Site 59
T718
A
P
G
T
R
R
Y
T
L
A
E
K
R
E
T
Site 60
S736
K
C
N
V
K
D
S
S
M
L
I
S
L
T
Y
Site 61
Y743
S
M
L
I
S
L
T
Y
D
V
I
L
V
I
L
Site 62
Y754
L
V
I
L
C
T
V
Y
A
F
K
T
R
K
C
Site 63
S794
P
I
F
Y
V
T
S
S
D
Y
R
V
Q
T
T
Site 64
Y796
F
Y
V
T
S
S
D
Y
R
V
Q
T
T
T
M
Site 65
T800
S
S
D
Y
R
V
Q
T
T
T
M
C
I
S
V
Site 66
T836
Q
P
Q
K
N
V
V
T
H
R
L
H
L
N
R
Site 67
S845
R
L
H
L
N
R
F
S
V
S
G
T
G
T
T
Site 68
T849
N
R
F
S
V
S
G
T
G
T
T
Y
S
Q
S
Site 69
T851
F
S
V
S
G
T
G
T
T
Y
S
Q
S
S
A
Site 70
T852
S
V
S
G
T
G
T
T
Y
S
Q
S
S
A
S
Site 71
Y853
V
S
G
T
G
T
T
Y
S
Q
S
S
A
S
T
Site 72
S854
S
G
T
G
T
T
Y
S
Q
S
S
A
S
T
Y
Site 73
S856
T
G
T
T
Y
S
Q
S
S
A
S
T
Y
V
P
Site 74
S859
T
Y
S
Q
S
S
A
S
T
Y
V
P
T
V
C
Site 75
T860
Y
S
Q
S
S
A
S
T
Y
V
P
T
V
C
N
Site 76
Y861
S
Q
S
S
A
S
T
Y
V
P
T
V
C
N
G
Site 77
T864
S
A
S
T
Y
V
P
T
V
C
N
G
R
E
V
Site 78
S874
N
G
R
E
V
L
D
S
T
T
S
S
L
_
_
Site 79
T875
G
R
E
V
L
D
S
T
T
S
S
L
_
_
_
Site 80
S878
V
L
D
S
T
T
S
S
L
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation