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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
GRM4
Full Name:
Metabotropic glutamate receptor 4
Alias:
Type:
Mass (Da):
101868
Number AA:
912
UniProt ID:
Q14833
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S29
L
Y
G
P
W
M
P
S
S
L
G
K
P
K
G
Site 2
S30
Y
G
P
W
M
P
S
S
L
G
K
P
K
G
H
Site 3
S62
F
P
V
H
G
R
G
S
E
G
K
P
C
G
E
Site 4
T108
L
G
A
R
I
L
D
T
C
S
R
D
T
H
A
Site 5
S110
A
R
I
L
D
T
C
S
R
D
T
H
A
L
E
Site 6
T113
L
D
T
C
S
R
D
T
H
A
L
E
Q
S
L
Site 7
T132
A
L
I
E
K
D
G
T
E
V
R
C
G
S
G
Site 8
S138
G
T
E
V
R
C
G
S
G
G
P
P
I
I
T
Site 9
T145
S
G
G
P
P
I
I
T
K
P
E
R
V
V
G
Site 10
S178
L
F
K
I
P
Q
I
S
Y
A
S
T
A
P
D
Site 11
S181
I
P
Q
I
S
Y
A
S
T
A
P
D
L
S
D
Site 12
T182
P
Q
I
S
Y
A
S
T
A
P
D
L
S
D
N
Site 13
S187
A
S
T
A
P
D
L
S
D
N
S
R
Y
D
F
Site 14
S190
A
P
D
L
S
D
N
S
R
Y
D
F
F
S
R
Site 15
Y192
D
L
S
D
N
S
R
Y
D
F
F
S
R
V
V
Site 16
S196
N
S
R
Y
D
F
F
S
R
V
V
P
S
D
T
Site 17
Y204
R
V
V
P
S
D
T
Y
Q
A
Q
A
M
V
D
Site 18
Y220
V
R
A
L
K
W
N
Y
V
S
T
V
A
S
E
Site 19
S222
A
L
K
W
N
Y
V
S
T
V
A
S
E
G
S
Site 20
T223
L
K
W
N
Y
V
S
T
V
A
S
E
G
S
Y
Site 21
S226
N
Y
V
S
T
V
A
S
E
G
S
Y
G
E
S
Site 22
S229
S
T
V
A
S
E
G
S
Y
G
E
S
G
V
E
Site 23
Y230
T
V
A
S
E
G
S
Y
G
E
S
G
V
E
A
Site 24
S233
S
E
G
S
Y
G
E
S
G
V
E
A
F
I
Q
Site 25
S242
V
E
A
F
I
Q
K
S
R
E
D
G
G
V
C
Site 26
S340
T
I
L
P
K
R
M
S
V
R
G
F
D
R
Y
Site 27
Y347
S
V
R
G
F
D
R
Y
F
S
S
R
T
L
D
Site 28
S349
R
G
F
D
R
Y
F
S
S
R
T
L
D
N
N
Site 29
T389
G
S
H
V
K
K
C
T
N
R
E
R
I
G
Q
Site 30
S398
R
E
R
I
G
Q
D
S
A
Y
E
Q
E
G
K
Site 31
Y400
R
I
G
Q
D
S
A
Y
E
Q
E
G
K
V
Q
Site 32
Y414
Q
F
V
I
D
A
V
Y
A
M
G
H
A
L
H
Site 33
T444
R
M
D
P
V
D
G
T
Q
L
L
K
Y
I
R
Site 34
Y449
D
G
T
Q
L
L
K
Y
I
R
N
V
N
F
S
Site 35
T464
G
I
A
G
N
P
V
T
F
N
E
N
G
D
A
Site 36
Y475
N
G
D
A
P
G
R
Y
D
I
Y
Q
Y
Q
L
Site 37
Y478
A
P
G
R
Y
D
I
Y
Q
Y
Q
L
R
N
D
Site 38
Y480
G
R
Y
D
I
Y
Q
Y
Q
L
R
N
D
S
A
Site 39
S486
Q
Y
Q
L
R
N
D
S
A
E
Y
K
V
I
G
Site 40
Y489
L
R
N
D
S
A
E
Y
K
V
I
G
S
W
T
Site 41
S511
E
R
M
H
W
P
G
S
G
Q
Q
L
P
R
S
Site 42
S518
S
G
Q
Q
L
P
R
S
I
C
S
L
P
C
Q
Site 43
S521
Q
L
P
R
S
I
C
S
L
P
C
Q
P
G
E
Site 44
T532
Q
P
G
E
R
K
K
T
V
K
G
M
P
C
C
Site 45
Y548
H
C
E
P
C
T
G
Y
Q
Y
Q
V
D
R
Y
Site 46
Y550
E
P
C
T
G
Y
Q
Y
Q
V
D
R
Y
T
C
Site 47
Y555
Y
Q
Y
Q
V
D
R
Y
T
C
K
T
C
P
Y
Site 48
Y562
Y
T
C
K
T
C
P
Y
D
M
R
P
T
E
N
Site 49
T615
T
F
V
R
Y
N
D
T
P
I
V
K
A
S
G
Site 50
S621
D
T
P
I
V
K
A
S
G
R
E
L
S
Y
V
Site 51
S653
E
P
D
L
G
T
C
S
L
R
R
I
F
L
G
Site 52
Y678
L
T
K
T
N
R
I
Y
R
I
F
E
Q
G
K
Site 53
S687
I
F
E
Q
G
K
R
S
V
S
A
P
R
F
I
Site 54
S689
E
Q
G
K
R
S
V
S
A
P
R
F
I
S
P
Site 55
S725
F
V
V
D
P
S
H
S
V
V
D
F
Q
D
Q
Site 56
T734
V
D
F
Q
D
Q
R
T
L
D
P
R
F
A
R
Site 57
T780
K
T
R
G
V
P
E
T
F
N
E
A
K
P
I
Site 58
S811
I
F
F
G
T
S
Q
S
A
D
K
L
Y
I
Q
Site 59
Y816
S
Q
S
A
D
K
L
Y
I
Q
T
T
T
L
T
Site 60
S859
N
V
P
K
R
K
R
S
L
K
A
V
V
T
A
Site 61
T874
A
T
M
S
N
K
F
T
Q
K
G
N
F
R
P
Site 62
S887
R
P
N
G
E
A
K
S
E
L
C
E
N
L
E
Site 63
Y904
A
L
A
T
K
Q
T
Y
V
T
Y
T
N
H
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation