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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYBPC3
Full Name:
Myosin-binding protein C, cardiac-type
Alias:
Cardiac MyBP-C; CMH4; C-protein, cardiac muscle; C-protein, cardiac muscle isoform; FHC; MYBP-C; Myosin binding protein C, cardiac; Myosin-binding protein C, cardiac-type; MYPC3
Type:
Contractile protein, myosin binding
Mass (Da):
140606
Number AA:
1273
UniProt ID:
Q14896
International Prot ID:
IPI00292412
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0014705
GO:0005863
Uniprot
OncoNet
Molecular Function:
GO:0001671
GO:0003779
GO:0032036
PhosphoSite+
KinaseNET
Biological Process:
GO:0060048
GO:0007155
GO:0032781
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
E
P
G
K
K
P
V
S
A
F
S
K
K
P
R
Site 2
S13
K
K
P
V
S
A
F
S
K
K
P
R
S
V
E
Site 3
S18
A
F
S
K
K
P
R
S
V
E
V
A
A
G
S
Site 4
S47
V
R
W
Q
R
G
G
S
D
I
S
A
S
N
K
Site 5
S50
Q
R
G
G
S
D
I
S
A
S
N
K
Y
G
L
Site 6
S52
G
G
S
D
I
S
A
S
N
K
Y
G
L
A
T
Site 7
T59
S
N
K
Y
G
L
A
T
E
G
T
R
H
T
L
Site 8
T65
A
T
E
G
T
R
H
T
L
T
V
R
E
V
G
Site 9
T67
E
G
T
R
H
T
L
T
V
R
E
V
G
P
A
Site 10
Y79
G
P
A
D
Q
G
S
Y
A
V
I
A
G
S
S
Site 11
S86
Y
A
V
I
A
G
S
S
K
V
K
F
D
L
K
Site 12
S130
P
A
A
E
L
G
E
S
A
P
S
P
K
G
S
Site 13
S133
E
L
G
E
S
A
P
S
P
K
G
S
S
S
A
Site 14
S137
S
A
P
S
P
K
G
S
S
S
A
A
L
N
G
Site 15
S139
P
S
P
K
G
S
S
S
A
A
L
N
G
P
T
Site 16
T146
S
A
A
L
N
G
P
T
P
G
A
P
D
D
P
Site 17
T167
R
P
Q
D
G
E
V
T
V
G
G
S
I
T
F
Site 18
S200
K
G
K
W
V
D
L
S
S
K
V
G
Q
H
L
Site 19
S201
G
K
W
V
D
L
S
S
K
V
G
Q
H
L
Q
Site 20
S212
Q
H
L
Q
L
H
D
S
Y
D
R
A
S
K
V
Site 21
Y213
H
L
Q
L
H
D
S
Y
D
R
A
S
K
V
Y
Site 22
S217
H
D
S
Y
D
R
A
S
K
V
Y
L
F
E
L
Site 23
Y220
Y
D
R
A
S
K
V
Y
L
F
E
L
H
I
T
Site 24
S236
A
Q
P
A
F
T
G
S
Y
R
C
E
V
S
T
Site 25
T243
S
Y
R
C
E
V
S
T
K
D
K
F
D
C
S
Site 26
S269
T
G
D
L
D
L
L
S
A
F
R
R
T
S
L
Site 27
T274
L
L
S
A
F
R
R
T
S
L
A
G
G
G
R
Site 28
S275
L
S
A
F
R
R
T
S
L
A
G
G
G
R
R
Site 29
S284
A
G
G
G
R
R
I
S
D
S
H
E
D
T
G
Site 30
S286
G
G
R
R
I
S
D
S
H
E
D
T
G
I
L
Site 31
T290
I
S
D
S
H
E
D
T
G
I
L
D
F
S
S
Site 32
S296
D
T
G
I
L
D
F
S
S
L
L
K
K
S
S
Site 33
S297
T
G
I
L
D
F
S
S
L
L
K
K
S
S
S
Site 34
S302
F
S
S
L
L
K
K
S
S
S
F
R
T
P
R
Site 35
S303
S
S
L
L
K
K
S
S
S
F
R
T
P
R
D
Site 36
S304
S
L
L
K
K
S
S
S
F
R
T
P
R
D
S
Site 37
T307
K
K
S
S
S
F
R
T
P
R
D
S
K
L
E
Site 38
S311
S
F
R
T
P
R
D
S
K
L
E
A
P
A
E
Site 39
S331
I
L
R
Q
A
P
P
S
E
Y
E
R
I
A
F
Site 40
Y333
R
Q
A
P
P
S
E
Y
E
R
I
A
F
Q
Y
Site 41
Y340
Y
E
R
I
A
F
Q
Y
G
V
T
D
L
R
G
Site 42
S362
M
R
R
D
E
K
K
S
T
A
F
Q
K
K
L
Site 43
T363
R
R
D
E
K
K
S
T
A
F
Q
K
K
L
E
Site 44
Y373
Q
K
K
L
E
P
A
Y
Q
V
S
K
G
H
K
Site 45
T384
K
G
H
K
I
R
L
T
V
E
L
A
D
H
D
Site 46
S406
N
G
Q
E
I
Q
M
S
G
R
Y
I
F
E
S
Site 47
S413
S
G
R
Y
I
F
E
S
I
G
A
K
R
T
L
Site 48
T419
E
S
I
G
A
K
R
T
L
T
I
S
Q
C
S
Site 49
S423
A
K
R
T
L
T
I
S
Q
C
S
L
A
D
D
Site 50
S426
T
L
T
I
S
Q
C
S
L
A
D
D
A
A
Y
Site 51
T444
V
G
G
E
K
C
S
T
E
L
F
V
K
E
P
Site 52
T456
K
E
P
P
V
L
I
T
R
P
L
E
D
Q
L
Site 53
S477
V
E
F
E
C
E
V
S
E
E
G
A
Q
V
K
Site 54
T497
V
E
L
T
R
E
E
T
F
K
Y
R
F
K
K
Site 55
Y500
T
R
E
E
T
F
K
Y
R
F
K
K
D
G
Q
Site 56
Y547
Q
E
K
K
L
E
V
Y
Q
S
I
A
D
L
M
Site 57
S549
K
K
L
E
V
Y
Q
S
I
A
D
L
M
V
G
Site 58
S568
A
V
F
K
C
E
V
S
D
E
N
V
R
G
V
Site 59
S587
G
K
E
L
V
P
D
S
R
I
K
V
S
H
I
Site 60
S592
P
D
S
R
I
K
V
S
H
I
G
R
V
H
K
Site 61
T606
K
L
T
I
D
D
V
T
P
A
D
E
A
D
Y
Site 62
Y613
T
P
A
D
E
A
D
Y
S
F
V
P
E
G
F
Site 63
S614
P
A
D
E
A
D
Y
S
F
V
P
E
G
F
A
Site 64
S707
A
P
E
D
T
G
D
S
D
E
W
V
F
D
K
Site 65
T728
E
G
R
V
R
V
E
T
T
K
D
R
S
I
F
Site 66
T729
G
R
V
R
V
E
T
T
K
D
R
S
I
F
T
Site 67
T749
K
E
D
E
G
V
Y
T
V
T
V
K
N
P
V
Site 68
T751
D
E
G
V
Y
T
V
T
V
K
N
P
V
G
E
Site 69
T788
N
V
G
E
D
S
C
T
V
Q
W
E
P
P
A
Site 70
Y796
V
Q
W
E
P
P
A
Y
D
G
G
Q
P
I
L
Site 71
Y805
G
G
Q
P
I
L
G
Y
I
L
E
R
K
K
K
Site 72
S814
L
E
R
K
K
K
K
S
Y
R
W
M
R
L
N
Site 73
S829
F
D
L
I
Q
E
L
S
H
E
A
R
R
M
I
Site 74
S857
A
I
G
M
S
R
P
S
P
A
S
Q
P
F
M
Site 75
S860
M
S
R
P
S
P
A
S
Q
P
F
M
P
I
G
Site 76
S881
H
L
A
V
E
D
V
S
D
T
T
V
S
L
K
Site 77
T883
A
V
E
D
V
S
D
T
T
V
S
L
K
W
R
Site 78
T884
V
E
D
V
S
D
T
T
V
S
L
K
W
R
P
Site 79
Y903
G
A
G
G
L
D
G
Y
S
V
E
Y
C
P
E
Site 80
S904
A
G
G
L
D
G
Y
S
V
E
Y
C
P
E
G
Site 81
Y907
L
D
G
Y
S
V
E
Y
C
P
E
G
C
S
E
Site 82
S927
Q
G
L
T
E
H
T
S
I
L
V
K
D
L
P
Site 83
T962
V
T
T
T
E
P
V
T
V
Q
E
I
L
Q
R
Site 84
T981
L
P
R
H
L
R
Q
T
I
Q
K
K
V
G
E
Site 85
T1007
P
R
P
Q
V
T
W
T
K
E
G
Q
P
L
A
Site 86
S1019
P
L
A
G
E
E
V
S
I
R
N
S
P
T
D
Site 87
S1023
E
E
V
S
I
R
N
S
P
T
D
T
I
L
F
Site 88
S1039
R
A
A
R
R
V
H
S
G
T
Y
Q
V
T
V
Site 89
T1041
A
R
R
V
H
S
G
T
Y
Q
V
T
V
R
I
Site 90
Y1042
R
R
V
H
S
G
T
Y
Q
V
T
V
R
I
E
Site 91
T1045
H
S
G
T
Y
Q
V
T
V
R
I
E
N
M
E
Site 92
T1056
E
N
M
E
D
K
A
T
L
V
L
Q
V
V
D
Site 93
S1066
L
Q
V
V
D
K
P
S
P
P
Q
D
L
R
V
Site 94
T1074
P
P
Q
D
L
R
V
T
D
A
W
G
L
N
V
Site 95
Y1099
G
N
T
E
L
W
G
Y
T
V
Q
K
A
D
K
Site 96
T1108
V
Q
K
A
D
K
K
T
M
E
W
F
T
V
L
Site 97
Y1118
W
F
T
V
L
E
H
Y
R
R
T
H
C
V
V
Site 98
T1121
V
L
E
H
Y
R
R
T
H
C
V
V
P
E
L
Site 99
Y1134
E
L
I
I
G
N
G
Y
Y
F
R
V
F
S
Q
Site 100
Y1135
L
I
I
G
N
G
Y
Y
F
R
V
F
S
Q
N
Site 101
S1147
S
Q
N
M
V
G
F
S
D
R
A
A
T
T
K
Site 102
T1152
G
F
S
D
R
A
A
T
T
K
E
P
V
F
I
Site 103
T1165
F
I
P
R
P
G
I
T
Y
E
P
P
N
Y
K
Site 104
Y1166
I
P
R
P
G
I
T
Y
E
P
P
N
Y
K
A
Site 105
Y1171
I
T
Y
E
P
P
N
Y
K
A
L
D
F
S
E
Site 106
S1177
N
Y
K
A
L
D
F
S
E
A
P
S
F
T
Q
Site 107
S1181
L
D
F
S
E
A
P
S
F
T
Q
P
L
V
N
Site 108
S1206
L
C
C
A
V
R
G
S
P
K
P
K
I
S
W
Site 109
S1212
G
S
P
K
P
K
I
S
W
F
K
N
G
L
D
Site 110
S1230
D
A
R
F
R
M
F
S
K
Q
G
V
L
T
L
Site 111
T1236
F
S
K
Q
G
V
L
T
L
E
I
R
K
P
C
Site 112
T1255
G
I
Y
V
C
R
A
T
N
L
Q
G
E
A
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation