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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LTB4DH
Full Name:
Prostaglandin reductase 1
Alias:
15-oxoprostaglandin 13-reductase; Leukotriene B4 12-hydroxydehydrogenase; LTB4D; NADP-dependent leukotriene B4 12-hydroxydehydrogenase; ZADH3; Zinc binding alcohol dehydrogenase domain containing 3
Type:
EC 1.3.1.48; EC 1.3.1.74; Oxidoreductase
Mass (Da):
35870
Number AA:
329
UniProt ID:
Q14914
International Prot ID:
IPI00292657
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0047522
GO:0032440
GO:0004022
PhosphoSite+
KinaseNET
Biological Process:
GO:0006691
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
V
R
T
K
T
W
T
L
K
K
H
F
V
G
Site 2
Y16
L
K
K
H
F
V
G
Y
P
T
N
S
D
F
E
Site 3
T18
K
H
F
V
G
Y
P
T
N
S
D
F
E
L
K
Site 4
S20
F
V
G
Y
P
T
N
S
D
F
E
L
K
T
A
Site 5
T26
N
S
D
F
E
L
K
T
A
E
L
P
P
L
K
Site 6
T62
K
R
L
K
E
G
D
T
M
M
G
Q
Q
V
A
Site 7
S74
Q
V
A
K
V
V
E
S
K
N
V
A
L
P
K
Site 8
S88
K
G
T
I
V
L
A
S
P
G
W
T
T
H
S
Site 9
T92
V
L
A
S
P
G
W
T
T
H
S
I
S
D
G
Site 10
T93
L
A
S
P
G
W
T
T
H
S
I
S
D
G
K
Site 11
S95
S
P
G
W
T
T
H
S
I
S
D
G
K
D
L
Site 12
S97
G
W
T
T
H
S
I
S
D
G
K
D
L
E
K
Site 13
T107
K
D
L
E
K
L
L
T
E
W
P
D
T
I
P
Site 14
Y181
G
S
D
E
K
V
A
Y
L
Q
K
L
G
F
D
Site 15
Y193
G
F
D
V
V
F
N
Y
K
T
V
E
S
L
E
Site 16
T195
D
V
V
F
N
Y
K
T
V
E
S
L
E
E
T
Site 17
S198
F
N
Y
K
T
V
E
S
L
E
E
T
L
K
K
Site 18
T202
T
V
E
S
L
E
E
T
L
K
K
A
S
P
D
Site 19
S207
E
E
T
L
K
K
A
S
P
D
G
Y
D
C
Y
Site 20
Y211
K
K
A
S
P
D
G
Y
D
C
Y
F
D
N
V
Site 21
Y214
S
P
D
G
Y
D
C
Y
F
D
N
V
G
G
E
Site 22
S223
D
N
V
G
G
E
F
S
N
T
V
I
G
Q
M
Site 23
T225
V
G
G
E
F
S
N
T
V
I
G
Q
M
K
K
Site 24
Y262
P
P
P
E
I
V
I
Y
Q
E
L
R
M
E
A
Site 25
Y273
R
M
E
A
F
V
V
Y
R
W
Q
G
D
A
R
Site 26
Y301
G
K
I
Q
Y
K
E
Y
I
I
E
G
F
E
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation