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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSME4
Full Name:
Proteasome activator complex subunit 4
Alias:
KIAA0077; PA200; Proteasome (prosome, macropain) activator subunit 4; Proteasome activator PA200
Type:
Mass (Da):
211334
Number AA:
1843
UniProt ID:
Q14997
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
GO:0000502
Uniprot
OncoNet
Molecular Function:
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0030154
GO:0007275
GO:0007283
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S48
A
E
R
L
D
A
E
S
D
L
Q
L
A
Q
I
Site 2
T81
F
W
T
R
K
L
S
T
Y
I
R
L
Y
G
R
Site 3
Y82
W
T
R
K
L
S
T
Y
I
R
L
Y
G
R
K
Site 4
Y86
L
S
T
Y
I
R
L
Y
G
R
K
F
S
K
E
Site 5
S91
R
L
Y
G
R
K
F
S
K
E
D
H
V
L
F
Site 6
Y146
E
L
P
W
R
P
L
Y
D
M
V
E
R
I
L
Site 7
Y154
D
M
V
E
R
I
L
Y
S
K
T
E
H
L
G
Site 8
T157
E
R
I
L
Y
S
K
T
E
H
L
G
L
N
W
Site 9
S168
G
L
N
W
F
P
N
S
V
E
N
I
L
K
T
Site 10
T175
S
V
E
N
I
L
K
T
L
V
K
S
C
R
P
Site 11
Y183
L
V
K
S
C
R
P
Y
F
P
A
D
A
T
A
Site 12
T189
P
Y
F
P
A
D
A
T
A
E
M
L
E
E
W
Site 13
Y213
T
M
Q
K
A
I
T
Y
F
E
I
F
L
P
T
Site 14
Y269
L
A
T
D
N
I
G
Y
I
D
W
D
P
Y
V
Site 15
Y275
G
Y
I
D
W
D
P
Y
V
P
K
I
F
T
R
Site 16
S336
H
L
A
G
L
F
N
S
I
T
S
F
Y
H
P
Site 17
T338
A
G
L
F
N
S
I
T
S
F
Y
H
P
S
N
Site 18
S339
G
L
F
N
S
I
T
S
F
Y
H
P
S
N
N
Site 19
Y341
F
N
S
I
T
S
F
Y
H
P
S
N
N
G
R
Site 20
S363
L
L
Q
R
L
P
N
S
V
V
R
R
L
H
R
Site 21
Y373
R
R
L
H
R
E
R
Y
K
K
P
S
W
L
T
Site 22
S377
R
E
R
Y
K
K
P
S
W
L
T
P
V
P
D
Site 23
T380
Y
K
K
P
S
W
L
T
P
V
P
D
S
H
K
Site 24
S385
W
L
T
P
V
P
D
S
H
K
L
T
D
Q
D
Site 25
T389
V
P
D
S
H
K
L
T
D
Q
D
V
T
D
F
Site 26
Y441
P
P
V
L
E
R
T
Y
P
A
L
E
T
L
T
Site 27
S521
V
P
L
V
D
C
S
S
V
L
Q
E
R
N
D
Site 28
T530
L
Q
E
R
N
D
L
T
E
V
E
R
E
L
C
Site 29
T562
F
G
L
I
E
S
S
T
L
E
Q
T
R
E
E
Site 30
T570
L
E
Q
T
R
E
E
T
E
T
E
K
M
T
H
Site 31
T572
Q
T
R
E
E
T
E
T
E
K
M
T
H
L
E
Site 32
S580
E
K
M
T
H
L
E
S
L
V
E
L
G
L
S
Site 33
S615
K
V
F
N
F
S
T
S
H
I
F
E
T
R
V
Site 34
S642
V
K
C
C
P
E
E
S
L
K
L
F
V
P
H
Site 35
Y694
D
G
R
K
L
L
L
Y
R
E
Q
L
V
K
I
Site 36
T709
L
Q
R
T
L
H
L
T
C
K
Q
G
Y
T
L
Site 37
T728
L
H
H
L
L
R
S
T
T
L
I
Y
P
T
E
Site 38
T729
H
H
L
L
R
S
T
T
L
I
Y
P
T
E
Y
Site 39
T734
S
T
T
L
I
Y
P
T
E
Y
C
S
V
P
G
Site 40
S748
G
G
F
D
K
P
P
S
E
Y
F
P
I
K
D
Site 41
Y750
F
D
K
P
P
S
E
Y
F
P
I
K
D
W
G
Site 42
S773
G
I
Q
W
H
V
P
S
S
E
E
V
S
F
A
Site 43
S774
I
Q
W
H
V
P
S
S
E
E
V
S
F
A
F
Site 44
S806
G
D
G
K
L
E
M
S
R
D
D
I
L
Q
S
Site 45
S813
S
R
D
D
I
L
Q
S
L
T
I
V
H
N
C
Site 46
S845
N
L
V
P
S
M
V
S
L
E
E
T
K
L
Y
Site 47
T849
S
M
V
S
L
E
E
T
K
L
Y
T
G
L
E
Site 48
Y852
S
L
E
E
T
K
L
Y
T
G
L
E
Y
D
L
Site 49
S860
T
G
L
E
Y
D
L
S
R
E
N
H
R
E
V
Site 50
T870
N
H
R
E
V
I
A
T
V
I
R
K
L
L
N
Site 51
S883
L
N
H
I
L
D
N
S
E
D
D
T
K
S
L
Site 52
T887
L
D
N
S
E
D
D
T
K
S
L
F
L
I
I
Site 53
S889
N
S
E
D
D
T
K
S
L
F
L
I
I
K
I
Site 54
S906
D
L
L
Q
F
Q
G
S
H
K
H
E
F
D
S
Site 55
S917
E
F
D
S
R
W
K
S
F
N
L
V
K
K
S
Site 56
S924
S
F
N
L
V
K
K
S
M
E
N
R
L
H
G
Site 57
T954
Q
H
E
L
R
T
L
T
V
E
G
C
E
Y
K
Site 58
Y960
L
T
V
E
G
C
E
Y
K
K
I
H
Q
D
M
Site 59
S975
I
R
D
L
L
R
L
S
T
S
S
Y
S
Q
V
Site 60
T976
R
D
L
L
R
L
S
T
S
S
Y
S
Q
V
R
Site 61
S977
D
L
L
R
L
S
T
S
S
Y
S
Q
V
R
N
Site 62
S978
L
L
R
L
S
T
S
S
Y
S
Q
V
R
N
K
Site 63
Y979
L
R
L
S
T
S
S
Y
S
Q
V
R
N
K
A
Site 64
S980
R
L
S
T
S
S
Y
S
Q
V
R
N
K
A
Q
Site 65
Y1029
Q
Q
F
K
G
A
L
Y
C
L
L
G
N
H
S
Site 66
Y1087
A
E
K
I
H
R
Q
Y
E
T
I
G
L
D
F
Site 67
S1110
I
A
E
L
L
Q
Q
S
K
N
P
S
I
N
Q
Site 68
S1114
L
Q
Q
S
K
N
P
S
I
N
Q
I
L
L
S
Site 69
S1121
S
I
N
Q
I
L
L
S
P
E
K
I
K
E
G
Site 70
Y1143
N
A
D
A
L
R
N
Y
E
N
L
V
D
T
L
Site 71
T1149
N
Y
E
N
L
V
D
T
L
L
D
G
V
E
Q
Site 72
T1223
K
R
T
H
K
K
L
T
I
N
P
C
E
I
S
Site 73
Y1251
P
D
N
H
W
L
H
Y
D
S
K
T
I
P
R
Site 74
T1255
W
L
H
Y
D
S
K
T
I
P
R
T
K
K
E
Site 75
T1303
G
R
S
R
E
D
M
T
E
A
E
Q
I
I
F
Site 76
S1327
E
Q
L
I
T
F
L
S
L
E
D
R
K
G
K
Site 77
T1375
V
A
D
S
H
E
S
T
Q
R
C
V
A
E
I
Site 78
S1390
I
A
G
L
I
R
G
S
K
H
W
T
F
E
K
Site 79
T1394
I
R
G
S
K
H
W
T
F
E
K
V
E
K
L
Site 80
Y1421
S
N
I
T
V
E
T
Y
N
D
W
G
A
C
I
Site 81
Y1489
L
L
H
R
L
L
K
Y
L
E
P
K
L
T
Q
Site 82
T1495
K
Y
L
E
P
K
L
T
Q
V
Y
K
N
V
R
Site 83
T1522
I
D
V
S
L
P
N
T
T
P
T
I
S
P
H
Site 84
T1523
D
V
S
L
P
N
T
T
P
T
I
S
P
H
V
Site 85
T1525
S
L
P
N
T
T
P
T
I
S
P
H
V
P
E
Site 86
S1527
P
N
T
T
P
T
I
S
P
H
V
P
E
F
T
Site 87
T1534
S
P
H
V
P
E
F
T
A
R
I
L
E
K
L
Site 88
T1568
I
G
E
E
D
E
R
T
Q
G
I
K
L
L
K
Site 89
S1590
A
S
A
G
R
S
F
S
T
A
V
T
E
Q
L
Site 90
T1594
R
S
F
S
T
A
V
T
E
Q
L
Q
L
L
P
Site 91
S1614
A
P
V
E
N
D
N
S
Y
D
E
L
K
R
D
Site 92
Y1615
P
V
E
N
D
N
S
Y
D
E
L
K
R
D
A
Site 93
T1649
V
L
Q
V
L
K
Q
T
A
R
S
S
S
W
H
Site 94
S1652
V
L
K
Q
T
A
R
S
S
S
W
H
A
R
Y
Site 95
S1653
L
K
Q
T
A
R
S
S
S
W
H
A
R
Y
T
Site 96
S1654
K
Q
T
A
R
S
S
S
W
H
A
R
Y
T
V
Site 97
Y1659
S
S
S
W
H
A
R
Y
T
V
L
T
Y
L
Q
Site 98
T1660
S
S
W
H
A
R
Y
T
V
L
T
Y
L
Q
T
Site 99
T1734
H
F
E
Q
L
C
K
T
K
L
P
K
K
R
K
Site 100
S1746
K
R
K
R
D
P
G
S
V
G
D
T
I
P
S
Site 101
T1750
D
P
G
S
V
G
D
T
I
P
S
A
E
L
V
Site 102
S1753
S
V
G
D
T
I
P
S
A
E
L
V
K
R
H
Site 103
T1779
S
S
P
Y
D
V
P
T
W
M
P
Q
L
L
M
Site 104
S1789
P
Q
L
L
M
N
L
S
A
H
L
N
D
P
Q
Site 105
T1801
D
P
Q
P
I
E
M
T
V
K
K
T
L
S
N
Site 106
T1805
I
E
M
T
V
K
K
T
L
S
N
F
R
R
T
Site 107
S1807
M
T
V
K
K
T
L
S
N
F
R
R
T
H
H
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation