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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CUL7
Full Name:
Cullin-7
Alias:
CUL-7; Cullin 7; DJ20C7.5; KIAA0076
Type:
Ubiquitin conjugating system
Mass (Da):
191161
Number AA:
1698
UniProt ID:
Q14999
International Prot ID:
IPI00001690
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000151
GO:0000152
GO:0005680
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
GO:0019899
PhosphoSite+
KinaseNET
Biological Process:
GO:0001570
GO:0006508
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y21
L
G
P
G
L
H
A
Y
P
D
E
L
I
R
Q
Site 2
Y38
G
H
D
G
H
P
E
Y
Q
I
R
W
L
I
L
Site 3
S55
G
D
E
G
D
G
G
S
G
Q
V
D
C
K
A
Site 4
S92
D
G
Q
V
I
G
P
S
Q
E
S
A
G
E
V
Site 5
S105
E
V
G
A
L
D
K
S
V
L
E
E
M
E
T
Site 6
T112
S
V
L
E
E
M
E
T
D
V
K
S
L
I
Q
Site 7
S116
E
M
E
T
D
V
K
S
L
I
Q
R
A
L
R
Site 8
T154
Y
A
S
I
E
P
L
T
G
V
F
K
D
P
R
Site 9
S171
D
L
L
M
H
M
L
S
S
P
D
Y
Q
I
R
Site 10
Y175
H
M
L
S
S
P
D
Y
Q
I
R
W
S
A
G
Site 11
S189
G
R
M
I
Q
A
L
S
S
H
D
A
G
T
R
Site 12
S190
R
M
I
Q
A
L
S
S
H
D
A
G
T
R
T
Site 13
T197
S
H
D
A
G
T
R
T
Q
I
L
L
S
L
S
Site 14
S202
T
R
T
Q
I
L
L
S
L
S
Q
Q
E
A
I
Site 15
S204
T
Q
I
L
L
S
L
S
Q
Q
E
A
I
E
K
Site 16
S217
E
K
H
L
D
F
D
S
R
C
A
L
L
A
L
Site 17
S231
L
F
A
Q
A
T
L
S
E
H
P
M
S
F
E
Site 18
S236
T
L
S
E
H
P
M
S
F
E
G
I
Q
L
P
Site 19
T261
V
K
R
Y
L
H
V
T
S
L
L
D
Q
L
N
Site 20
S262
K
R
Y
L
H
V
T
S
L
L
D
Q
L
N
D
Site 21
S270
L
L
D
Q
L
N
D
S
A
A
E
P
G
A
Q
Site 22
S280
E
P
G
A
Q
N
T
S
A
P
E
E
L
S
G
Site 23
S286
T
S
A
P
E
E
L
S
G
E
R
G
Q
L
E
Site 24
S317
A
M
R
W
D
Q
A
S
D
R
P
R
S
S
A
Site 25
S322
Q
A
S
D
R
P
R
S
S
A
R
S
P
G
S
Site 26
S323
A
S
D
R
P
R
S
S
A
R
S
P
G
S
I
Site 27
S326
R
P
R
S
S
A
R
S
P
G
S
I
F
Q
P
Site 28
S329
S
S
A
R
S
P
G
S
I
F
Q
P
Q
L
A
Site 29
S339
Q
P
Q
L
A
D
V
S
P
G
L
P
A
A
Q
Site 30
S350
P
A
A
Q
A
Q
P
S
F
R
R
S
R
R
F
Site 31
S354
A
Q
P
S
F
R
R
S
R
R
F
R
P
R
S
Site 32
S361
S
R
R
F
R
P
R
S
E
F
A
S
G
N
T
Site 33
S365
R
P
R
S
E
F
A
S
G
N
T
Y
A
L
Y
Site 34
Y369
E
F
A
S
G
N
T
Y
A
L
Y
V
R
D
T
Site 35
Y372
S
G
N
T
Y
A
L
Y
V
R
D
T
L
Q
P
Site 36
T376
Y
A
L
Y
V
R
D
T
L
Q
P
G
M
R
V
Site 37
Y389
R
V
R
M
L
D
D
Y
E
E
I
S
A
G
D
Site 38
S393
L
D
D
Y
E
E
I
S
A
G
D
E
G
E
F
Site 39
S403
D
E
G
E
F
R
Q
S
N
N
G
V
P
P
V
Site 40
Y446
D
M
V
E
A
D
E
Y
Q
G
A
V
A
S
R
Site 41
Y475
T
E
L
Y
A
V
P
Y
V
L
P
E
D
E
D
Site 42
T483
V
L
P
E
D
E
D
T
E
E
C
E
H
L
T
Site 43
T546
L
A
Q
D
L
L
L
T
L
P
Q
R
L
N
D
Site 44
S554
L
P
Q
R
L
N
D
S
A
L
R
D
L
I
N
Site 45
Y565
D
L
I
N
C
H
V
Y
K
K
Y
G
P
E
A
Site 46
Y568
N
C
H
V
Y
K
K
Y
G
P
E
A
L
A
G
Site 47
Y579
A
L
A
G
N
Q
A
Y
P
S
L
L
E
A
Q
Site 48
S614
V
E
A
K
E
P
P
S
Q
S
P
N
T
P
L
Site 49
S616
A
K
E
P
P
S
Q
S
P
N
T
P
L
Q
R
Site 50
T619
P
P
S
Q
S
P
N
T
P
L
Q
R
L
V
E
Site 51
S643
L
D
L
E
Q
A
L
S
S
E
G
T
Q
E
N
Site 52
T647
Q
A
L
S
S
E
G
T
Q
E
N
K
V
K
P
Site 53
S672
P
F
L
A
L
M
Q
S
L
D
T
P
E
T
N
Site 54
T675
A
L
M
Q
S
L
D
T
P
E
T
N
R
T
L
Site 55
T678
Q
S
L
D
T
P
E
T
N
R
T
L
H
L
T
Site 56
T681
D
T
P
E
T
N
R
T
L
H
L
T
V
L
R
Site 57
T685
T
N
R
T
L
H
L
T
V
L
R
I
L
K
Q
Site 58
S717
A
C
M
A
C
L
R
S
P
N
T
D
R
E
V
Site 59
T720
A
C
L
R
S
P
N
T
D
R
E
V
L
Q
E
Site 60
S756
L
G
A
R
D
A
I
S
K
A
L
E
K
H
L
Site 61
Y786
C
E
K
H
A
H
L
Y
R
K
L
I
T
N
I
Site 62
T811
Q
I
E
D
H
R
R
T
H
Q
P
I
N
I
P
Site 63
S832
R
Y
L
C
Q
G
S
S
V
E
V
K
E
D
K
Site 64
S854
S
S
N
P
H
R
A
S
K
L
T
D
H
N
P
Site 65
T857
P
H
R
A
S
K
L
T
D
H
N
P
K
T
Y
Site 66
T863
L
T
D
H
N
P
K
T
Y
W
E
S
N
G
S
Site 67
Y864
T
D
H
N
P
K
T
Y
W
E
S
N
G
S
A
Site 68
S867
N
P
K
T
Y
W
E
S
N
G
S
A
G
S
H
Site 69
S873
E
S
N
G
S
A
G
S
H
Y
I
T
L
H
M
Site 70
Y875
N
G
S
A
G
S
H
Y
I
T
L
H
M
R
R
Site 71
T877
S
A
G
S
H
Y
I
T
L
H
M
R
R
G
I
Site 72
S895
Q
L
T
L
L
V
A
S
E
D
S
S
Y
M
P
Site 73
S914
V
C
G
G
D
S
T
S
S
L
H
T
E
L
N
Site 74
S915
C
G
G
D
S
T
S
S
L
H
T
E
L
N
S
Site 75
T918
D
S
T
S
S
L
H
T
E
L
N
S
V
N
V
Site 76
S922
S
L
H
T
E
L
N
S
V
N
V
M
P
S
A
Site 77
T959
C
Q
Q
G
G
I
D
T
R
I
R
G
L
E
I
Site 78
T972
E
I
L
G
P
K
P
T
F
W
P
V
F
R
E
Site 79
S997
M
V
R
A
Q
A
W
S
Q
D
M
A
E
D
R
Site 80
S1006
D
M
A
E
D
R
R
S
L
L
H
L
S
S
R
Site 81
S1011
R
R
S
L
L
H
L
S
S
R
L
N
G
A
L
Site 82
S1012
R
S
L
L
H
L
S
S
R
L
N
G
A
L
R
Site 83
S1056
P
V
V
Q
N
I
T
S
P
D
E
D
G
I
S
Site 84
S1063
S
P
D
E
D
G
I
S
P
L
G
W
L
L
D
Site 85
S1084
E
A
V
F
N
P
Q
S
R
G
P
A
F
F
S
Site 86
S1091
S
R
G
P
A
F
F
S
R
V
R
R
L
T
H
Site 87
T1115
A
P
P
P
V
V
A
T
P
R
P
K
G
R
N
Site 88
S1124
R
P
K
G
R
N
R
S
H
D
W
S
S
L
A
Site 89
S1128
R
N
R
S
H
D
W
S
S
L
A
T
R
G
L
Site 90
S1129
N
R
S
H
D
W
S
S
L
A
T
R
G
L
P
Site 91
T1132
H
D
W
S
S
L
A
T
R
G
L
P
S
S
I
Site 92
S1137
L
A
T
R
G
L
P
S
S
I
M
R
N
L
T
Site 93
S1138
A
T
R
G
L
P
S
S
I
M
R
N
L
T
R
Site 94
T1144
S
S
I
M
R
N
L
T
R
C
W
R
A
V
V
Site 95
Y1172
D
D
D
F
V
P
R
Y
C
E
H
F
N
I
L
Site 96
S1182
H
F
N
I
L
Q
N
S
S
S
E
L
F
G
P
Site 97
S1184
N
I
L
Q
N
S
S
S
E
L
F
G
P
R
A
Site 98
T1263
S
G
L
E
I
A
T
T
F
E
H
Y
Y
Q
H
Site 99
Y1268
A
T
T
F
E
H
Y
Y
Q
H
Y
M
A
D
R
Site 100
Y1271
F
E
H
Y
Y
Q
H
Y
M
A
D
R
L
L
G
Site 101
S1307
L
P
Q
Q
M
L
Q
S
L
S
T
S
K
E
L
Site 102
S1309
Q
Q
M
L
Q
S
L
S
T
S
K
E
L
Q
R
Site 103
S1311
M
L
Q
S
L
S
T
S
K
E
L
Q
R
Q
F
Site 104
Y1321
L
Q
R
Q
F
H
V
Y
Q
L
Q
Q
L
D
Q
Site 105
T1336
E
L
L
K
L
E
D
T
E
K
K
I
Q
V
G
Site 106
S1353
A
S
G
K
E
H
K
S
E
K
E
E
E
A
G
Site 107
Y1381
E
E
E
N
E
D
L
Y
Y
E
G
A
M
P
E
Site 108
Y1382
E
E
N
E
D
L
Y
Y
E
G
A
M
P
E
V
Site 109
T1412
C
H
T
L
N
P
R
T
C
L
P
S
Y
L
R
Site 110
S1416
N
P
R
T
C
L
P
S
Y
L
R
G
T
L
N
Site 111
Y1417
P
R
T
C
L
P
S
Y
L
R
G
T
L
N
R
Site 112
T1421
L
P
S
Y
L
R
G
T
L
N
R
Y
S
N
F
Site 113
S1426
R
G
T
L
N
R
Y
S
N
F
Y
N
K
S
Q
Site 114
Y1429
L
N
R
Y
S
N
F
Y
N
K
S
Q
S
H
P
Site 115
S1432
Y
S
N
F
Y
N
K
S
Q
S
H
P
A
L
E
Site 116
S1434
N
F
Y
N
K
S
Q
S
H
P
A
L
E
R
G
Site 117
S1442
H
P
A
L
E
R
G
S
Q
R
R
L
Q
W
T
Site 118
T1462
E
L
Q
F
G
N
Q
T
L
H
V
S
T
V
Q
Site 119
T1506
N
Q
A
I
G
P
L
T
S
S
R
G
P
L
D
Site 120
S1507
Q
A
I
G
P
L
T
S
S
R
G
P
L
D
L
Site 121
S1508
A
I
G
P
L
T
S
S
R
G
P
L
D
L
H
Site 122
S1531
V
L
K
I
R
D
G
S
K
E
P
R
S
R
W
Site 123
S1536
D
G
S
K
E
P
R
S
R
W
D
I
V
R
L
Site 124
Y1549
R
L
I
P
P
Q
T
Y
L
Q
A
E
G
E
D
Site 125
S1608
C
P
P
R
G
L
V
S
S
L
G
K
G
S
A
Site 126
S1609
P
P
R
G
L
V
S
S
L
G
K
G
S
A
C
Site 127
S1614
V
S
S
L
G
K
G
S
A
C
S
S
T
D
V
Site 128
T1633
L
H
L
L
G
K
G
T
L
R
R
H
D
D
R
Site 129
T1657
V
T
V
M
E
P
H
T
E
S
L
N
P
G
S
Site 130
S1659
V
M
E
P
H
T
E
S
L
N
P
G
S
S
G
Site 131
S1664
T
E
S
L
N
P
G
S
S
G
P
N
P
P
L
Site 132
S1665
E
S
L
N
P
G
S
S
G
P
N
P
P
L
T
Site 133
T1672
S
G
P
N
P
P
L
T
F
H
T
L
Q
I
R
Site 134
T1675
N
P
P
L
T
F
H
T
L
Q
I
R
S
R
G
Site 135
S1687
S
R
G
V
P
Y
A
S
C
T
A
T
Q
S
F
Site 136
T1689
G
V
P
Y
A
S
C
T
A
T
Q
S
F
S
T
Site 137
T1691
P
Y
A
S
C
T
A
T
Q
S
F
S
T
F
R
Site 138
S1693
A
S
C
T
A
T
Q
S
F
S
T
F
R
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation