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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SHPRH
Full Name:
E3 ubiquitin-protein ligase SHPRH
Alias:
BA545I5.2; FLJ90837; KIAA2023; SNF2 histone linker PHD RING helicase; SNF2, histone-linker, PHD and RING finger domain-containing helicase
Type:
Ligase; EC 3.6.1.-; Helicase; EC 6.3.2.-; Ubiquitin conjugating system; Ubiquitin ligase
Mass (Da):
193079
Number AA:
1683
UniProt ID:
Q149N8
International Prot ID:
IPI00470627
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000786
GO:0005634
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006259
GO:0006281
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S37
R
N
E
P
I
I
I
S
D
D
D
E
Q
P
C
Site 2
S47
D
E
Q
P
C
P
G
S
D
T
S
S
A
H
Y
Site 3
T49
Q
P
C
P
G
S
D
T
S
S
A
H
Y
I
I
Site 4
S50
P
C
P
G
S
D
T
S
S
A
H
Y
I
I
L
Site 5
S51
C
P
G
S
D
T
S
S
A
H
Y
I
I
L
S
Site 6
Y54
S
D
T
S
S
A
H
Y
I
I
L
S
D
S
L
Site 7
S58
S
A
H
Y
I
I
L
S
D
S
L
K
E
E
V
Site 8
S60
H
Y
I
I
L
S
D
S
L
K
E
E
V
A
H
Site 9
S74
H
R
D
K
K
R
C
S
K
V
V
S
F
S
K
Site 10
S78
K
R
C
S
K
V
V
S
F
S
K
P
I
E
K
Site 11
T88
K
P
I
E
K
E
E
T
V
G
I
F
S
P
L
Site 12
S93
E
E
T
V
G
I
F
S
P
L
S
V
K
L
N
Site 13
S104
V
K
L
N
I
V
I
S
P
Y
H
F
D
N
S
Site 14
Y106
L
N
I
V
I
S
P
Y
H
F
D
N
S
W
K
Site 15
S134
Q
S
L
I
E
N
F
S
E
R
S
I
T
L
M
Site 16
S137
I
E
N
F
S
E
R
S
I
T
L
M
S
S
E
Site 17
T139
N
F
S
E
R
S
I
T
L
M
S
S
E
S
S
Site 18
S142
E
R
S
I
T
L
M
S
S
E
S
S
N
Q
F
Site 19
S143
R
S
I
T
L
M
S
S
E
S
S
N
Q
F
L
Site 20
Y152
S
S
N
Q
F
L
I
Y
V
H
S
K
G
E
D
Site 21
S155
Q
F
L
I
Y
V
H
S
K
G
E
D
V
E
K
Site 22
S169
K
Q
K
K
E
P
M
S
I
C
D
K
G
I
L
Site 23
Y201
K
K
R
R
I
K
L
Y
Q
K
P
E
G
N
H
Site 24
S228
L
A
K
L
D
F
L
S
D
A
N
S
R
M
K
Site 25
S232
D
F
L
S
D
A
N
S
R
M
K
K
F
N
Q
Site 26
S266
E
D
E
D
D
P
E
S
E
P
E
G
Q
D
I
Site 27
Y277
G
Q
D
I
D
E
L
Y
H
F
V
K
Q
T
H
Site 28
Y307
L
I
P
V
L
R
P
Y
Q
R
E
A
V
N
W
Site 29
S323
L
Q
Q
E
C
F
R
S
S
P
A
T
E
S
A
Site 30
S324
Q
Q
E
C
F
R
S
S
P
A
T
E
S
A
L
Site 31
S329
R
S
S
P
A
T
E
S
A
L
H
F
L
W
R
Site 32
S341
L
W
R
E
I
V
T
S
E
G
L
K
L
Y
Y
Site 33
Y347
T
S
E
G
L
K
L
Y
Y
N
P
Y
T
G
C
Site 34
Y348
S
E
G
L
K
L
Y
Y
N
P
Y
T
G
C
I
Site 35
Y359
T
G
C
I
I
R
E
Y
P
N
S
G
P
Q
L
Site 36
S362
I
I
R
E
Y
P
N
S
G
P
Q
L
L
G
G
Site 37
T401
D
V
K
Q
D
A
L
T
L
P
E
G
K
V
V
Site 38
Y410
P
E
G
K
V
V
N
Y
F
I
P
S
H
Y
F
Site 39
Y416
N
Y
F
I
P
S
H
Y
F
G
G
K
L
K
K
Site 40
T424
F
G
G
K
L
K
K
T
E
I
Q
N
I
E
F
Site 41
S463
K
K
G
V
S
I
L
S
I
Y
K
Y
V
S
S
Site 42
Y474
Y
V
S
S
I
Y
R
Y
D
V
Q
R
N
R
S
Site 43
S481
Y
D
V
Q
R
N
R
S
L
L
K
R
M
L
K
Site 44
S505
Q
I
K
G
H
G
F
S
G
T
F
T
L
G
K
Site 45
T507
K
G
H
G
F
S
G
T
F
T
L
G
K
N
Y
Site 46
T509
H
G
F
S
G
T
F
T
L
G
K
N
Y
K
E
Site 47
T523
E
E
D
I
C
D
K
T
K
K
Q
A
V
G
S
Site 48
S530
T
K
K
Q
A
V
G
S
P
R
K
I
Q
K
E
Site 49
S541
I
Q
K
E
T
R
K
S
G
N
K
D
T
D
S
Site 50
T546
R
K
S
G
N
K
D
T
D
S
E
Y
L
P
S
Site 51
S548
S
G
N
K
D
T
D
S
E
Y
L
P
S
D
T
Site 52
Y550
N
K
D
T
D
S
E
Y
L
P
S
D
T
S
D
Site 53
S553
T
D
S
E
Y
L
P
S
D
T
S
D
D
D
D
Site 54
S556
E
Y
L
P
S
D
T
S
D
D
D
D
D
P
Y
Site 55
Y563
S
D
D
D
D
D
P
Y
Y
Y
Y
Y
K
S
R
Site 56
Y564
D
D
D
D
D
P
Y
Y
Y
Y
Y
K
S
R
R
Site 57
Y565
D
D
D
D
P
Y
Y
Y
Y
Y
K
S
R
R
N
Site 58
Y566
D
D
D
P
Y
Y
Y
Y
Y
K
S
R
R
N
R
Site 59
Y567
D
D
P
Y
Y
Y
Y
Y
K
S
R
R
N
R
S
Site 60
S574
Y
K
S
R
R
N
R
S
K
L
R
K
K
L
V
Site 61
T584
R
K
K
L
V
P
S
T
K
K
G
K
S
Q
P
Site 62
S589
P
S
T
K
K
G
K
S
Q
P
F
I
N
P
D
Site 63
S597
Q
P
F
I
N
P
D
S
Q
G
H
C
P
A
T
Site 64
T604
S
Q
G
H
C
P
A
T
S
D
S
G
I
T
D
Site 65
S605
Q
G
H
C
P
A
T
S
D
S
G
I
T
D
V
Site 66
S617
T
D
V
A
M
S
K
S
T
C
I
S
E
F
N
Site 67
S621
M
S
K
S
T
C
I
S
E
F
N
Q
E
H
E
Site 68
S635
E
T
E
D
C
A
E
S
L
N
H
A
D
S
D
Site 69
S641
E
S
L
N
H
A
D
S
D
V
P
P
S
N
T
Site 70
S646
A
D
S
D
V
P
P
S
N
T
M
S
P
F
N
Site 71
T648
S
D
V
P
P
S
N
T
M
S
P
F
N
T
S
Site 72
S650
V
P
P
S
N
T
M
S
P
F
N
T
S
D
Y
Site 73
T654
N
T
M
S
P
F
N
T
S
D
Y
R
F
E
C
Site 74
Y657
S
P
F
N
T
S
D
Y
R
F
E
C
I
C
G
Site 75
T718
E
P
V
S
T
R
A
T
L
I
I
S
P
S
S
Site 76
S741
I
N
R
H
V
R
S
S
S
L
R
V
L
V
Y
Site 77
S742
N
R
H
V
R
S
S
S
L
R
V
L
V
Y
Q
Site 78
Y748
S
S
L
R
V
L
V
Y
Q
G
V
K
K
D
G
Site 79
Y781
V
L
R
S
E
L
N
Y
V
D
I
P
H
S
N
Site 80
S787
N
Y
V
D
I
P
H
S
N
S
E
D
G
R
R
Site 81
S789
V
D
I
P
H
S
N
S
E
D
G
R
R
L
R
Site 82
Y801
R
L
R
N
Q
K
R
Y
M
A
I
P
S
P
L
Site 83
S839
A
E
M
A
Q
R
L
S
G
I
N
R
W
C
I
Site 84
T849
N
R
W
C
I
S
G
T
P
V
Q
R
G
L
E
Site 85
Y884
V
R
L
L
Y
R
P
Y
C
K
K
N
P
Q
H
Site 86
Y934
S
P
V
E
R
H
F
Y
H
R
Q
H
E
V
C
Site 87
S960
S
D
W
A
L
K
L
S
S
L
D
R
R
T
V
Site 88
S961
D
W
A
L
K
L
S
S
L
D
R
R
T
V
T
Site 89
T966
L
S
S
L
D
R
R
T
V
T
S
I
L
Y
P
Site 90
Y972
R
T
V
T
S
I
L
Y
P
L
L
R
L
R
Q
Site 91
S997
E
F
L
P
L
Q
K
S
T
M
T
M
E
E
L
Site 92
T1006
M
T
M
E
E
L
L
T
S
L
Q
K
K
C
G
Site 93
S1007
T
M
E
E
L
L
T
S
L
Q
K
K
C
G
T
Site 94
T1014
S
L
Q
K
K
C
G
T
E
C
E
E
A
H
R
Site 95
Y1047
Y
A
L
A
A
E
L
Y
R
E
V
L
R
S
S
Site 96
S1053
L
Y
R
E
V
L
R
S
S
E
E
H
K
G
K
Site 97
S1054
Y
R
E
V
L
R
S
S
E
E
H
K
G
K
L
Site 98
T1063
E
H
K
G
K
L
K
T
D
S
L
Q
R
L
H
Site 99
S1065
K
G
K
L
K
T
D
S
L
Q
R
L
H
A
T
Site 100
T1089
R
H
P
G
I
P
P
T
L
R
D
G
R
L
E
Site 101
Y1106
A
K
Q
L
R
E
H
Y
M
S
K
C
N
T
E
Site 102
Y1122
A
E
A
Q
Q
A
L
Y
P
V
Q
Q
T
I
H
Site 103
T1153
I
H
R
A
I
E
F
T
I
D
E
E
L
V
Q
Site 104
S1168
R
V
R
N
E
I
T
S
N
Y
K
Q
Q
T
G
Site 105
Y1170
R
N
E
I
T
S
N
Y
K
Q
Q
T
G
K
L
Site 106
S1178
K
Q
Q
T
G
K
L
S
M
S
E
K
F
R
D
Site 107
S1180
Q
T
G
K
L
S
M
S
E
K
F
R
D
C
R
Site 108
T1194
R
G
L
Q
F
L
L
T
T
Q
M
E
E
L
N
Site 109
S1219
K
N
L
E
G
P
P
S
R
N
V
I
E
S
A
Site 110
S1225
P
S
R
N
V
I
E
S
A
T
V
C
H
L
R
Site 111
T1227
R
N
V
I
E
S
A
T
V
C
H
L
R
P
A
Site 112
Y1253
A
D
E
L
F
T
E
Y
E
S
K
L
F
S
N
Site 113
S1259
E
Y
E
S
K
L
F
S
N
T
V
K
G
Q
T
Site 114
T1286
L
V
D
D
R
A
P
T
T
T
R
G
L
W
A
Site 115
T1287
V
D
D
R
A
P
T
T
T
R
G
L
W
A
I
Site 116
S1295
T
R
G
L
W
A
I
S
E
T
E
R
S
M
K
Site 117
S1300
A
I
S
E
T
E
R
S
M
K
A
I
L
S
F
Site 118
S1306
R
S
M
K
A
I
L
S
F
A
K
S
H
R
F
Site 119
S1324
F
V
D
E
G
S
T
S
M
D
L
F
E
A
W
Site 120
Y1341
E
Y
K
L
L
H
E
Y
W
M
A
L
R
N
R
Site 121
Y1412
K
K
L
G
Q
L
L
Y
L
T
N
L
E
K
S
Site 122
T1414
L
G
Q
L
L
Y
L
T
N
L
E
K
S
Q
D
Site 123
S1419
Y
L
T
N
L
E
K
S
Q
D
K
T
S
G
G
Site 124
T1423
L
E
K
S
Q
D
K
T
S
G
G
V
N
P
E
Site 125
Y1464
I
S
I
I
I
E
Q
Y
S
V
G
S
H
R
S
Site 126
S1465
S
I
I
I
E
Q
Y
S
V
G
S
H
R
S
S
Site 127
S1468
I
E
Q
Y
S
V
G
S
H
R
S
S
I
K
C
Site 128
S1472
S
V
G
S
H
R
S
S
I
K
C
A
I
C
R
Site 129
T1481
K
C
A
I
C
R
Q
T
T
S
H
K
E
I
S
Site 130
T1482
C
A
I
C
R
Q
T
T
S
H
K
E
I
S
Y
Site 131
S1488
T
T
S
H
K
E
I
S
Y
V
F
T
S
E
K
Site 132
Y1489
T
S
H
K
E
I
S
Y
V
F
T
S
E
K
A
Site 133
S1493
E
I
S
Y
V
F
T
S
E
K
A
N
Q
E
E
Site 134
T1549
D
I
I
S
K
A
L
T
D
N
N
M
E
F
A
Site 135
T1563
A
Q
I
S
R
V
K
T
F
Q
E
N
L
S
A
Site 136
T1648
R
M
Q
A
M
L
K
T
A
E
R
S
H
T
N
Site 137
S1652
M
L
K
T
A
E
R
S
H
T
N
S
S
A
K
Site 138
T1654
K
T
A
E
R
S
H
T
N
S
S
A
K
H
S
Site 139
S1656
A
E
R
S
H
T
N
S
S
A
K
H
S
E
A
Site 140
S1657
E
R
S
H
T
N
S
S
A
K
H
S
E
A
S
Site 141
S1661
T
N
S
S
A
K
H
S
E
A
S
V
L
T
V
Site 142
T1676
A
D
L
A
D
L
F
T
K
E
T
E
E
L
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation