KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
GAPVD1
Full Name:
GTPase-activating protein and VPS9 domain-containing protein 1
Alias:
DKFZP434C212; GAPex-5; GTPase activating protein and VPS9 domain-containing protein 1; GTPase activating protein and VPS9 domains 1; KIAA1521; Rab5-activating protein 6
Type:
GTPase activating protein; Guanine nucleotide exchange protein; Intracellular, Membrane, Endosome, Cytosol protein
Mass (Da):
164980
Number AA:
1478
UniProt ID:
Q14C86
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005768
GO:0019898
Uniprot
OncoNet
Molecular Function:
GO:0032794
GO:0005096
GO:0005085
PhosphoSite+
KinaseNET
Biological Process:
GO:0006897
GO:0051223
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
V
K
L
D
I
H
T
L
A
H
H
L
K
Q
Site 2
Y19
H
L
K
Q
E
R
L
Y
V
N
S
E
K
Q
L
Site 3
S22
Q
E
R
L
Y
V
N
S
E
K
Q
L
I
Q
R
Site 4
S66
I
I
T
S
A
E
A
S
P
A
E
C
C
Q
H
Site 5
T80
H
A
K
I
L
E
D
T
Q
F
V
D
G
Y
K
Site 6
Y86
D
T
Q
F
V
D
G
Y
K
Q
L
G
F
Q
E
Site 7
Y96
L
G
F
Q
E
T
A
Y
G
E
F
L
S
R
L
Site 8
S101
T
A
Y
G
E
F
L
S
R
L
R
E
N
P
R
Site 9
T125
E
K
L
N
Q
E
N
T
Q
S
V
I
Y
T
V
Site 10
S147
I
M
Q
E
D
E
S
Y
L
L
Q
V
L
R
Y
Site 11
Y148
I
M
Q
E
D
E
S
Y
L
L
Q
V
L
R
Y
Site 12
S164
I
E
F
E
L
K
E
S
D
N
P
R
R
L
L
Site 13
S227
N
K
L
I
E
R
F
S
P
S
Q
Q
E
K
L
Site 14
S229
L
I
E
R
F
S
P
S
Q
Q
E
K
L
F
G
Site 15
S240
K
L
F
G
E
K
G
S
D
R
F
R
Q
K
V
Site 16
S253
K
V
Q
E
M
V
E
S
N
E
A
K
L
V
A
Site 17
Y268
L
V
N
K
F
I
G
Y
L
K
Q
N
T
Y
C
Site 18
Y274
G
Y
L
K
Q
N
T
Y
C
F
P
H
S
L
R
Site 19
Y288
R
W
I
V
S
Q
M
Y
K
T
L
S
C
V
D
Site 20
S292
S
Q
M
Y
K
T
L
S
C
V
D
R
L
E
V
Site 21
S329
P
E
Q
Y
G
I
I
S
D
A
P
I
N
E
V
Site 22
S356
Q
Q
L
A
M
T
G
S
E
E
G
D
P
R
T
Site 23
T363
S
E
E
G
D
P
R
T
K
S
S
L
G
K
F
Site 24
S365
E
G
D
P
R
T
K
S
S
L
G
K
F
D
K
Site 25
S366
G
D
P
R
T
K
S
S
L
G
K
F
D
K
S
Site 26
T390
I
G
G
R
A
V
E
T
P
P
L
S
S
V
N
Site 27
S452
P
P
A
K
P
G
K
S
S
S
L
E
M
T
P
Site 28
S453
P
A
K
P
G
K
S
S
S
L
E
M
T
P
Y
Site 29
S454
A
K
P
G
K
S
S
S
L
E
M
T
P
Y
N
Site 30
T458
K
S
S
S
L
E
M
T
P
Y
N
T
P
Q
L
Site 31
Y460
S
S
L
E
M
T
P
Y
N
T
P
Q
L
S
P
Site 32
T462
L
E
M
T
P
Y
N
T
P
Q
L
S
P
A
T
Site 33
S466
P
Y
N
T
P
Q
L
S
P
A
T
T
P
A
N
Site 34
T469
T
P
Q
L
S
P
A
T
T
P
A
N
K
K
N
Site 35
T470
P
Q
L
S
P
A
T
T
P
A
N
K
K
N
R
Site 36
T482
K
N
R
L
P
I
A
T
R
S
R
S
R
T
N
Site 37
S484
R
L
P
I
A
T
R
S
R
S
R
T
N
M
L
Site 38
S486
P
I
A
T
R
S
R
S
R
T
N
M
L
M
D
Site 39
T488
A
T
R
S
R
S
R
T
N
M
L
M
D
L
H
Site 40
T526
L
G
T
G
P
Q
L
T
P
G
M
M
S
E
N
Site 41
S541
E
V
L
N
M
Q
L
S
D
G
G
Q
G
D
V
Site 42
T562
L
H
G
K
P
D
K
T
L
R
F
S
L
C
S
Site 43
S566
P
D
K
T
L
R
F
S
L
C
S
D
N
L
E
Site 44
S569
T
L
R
F
S
L
C
S
D
N
L
E
G
I
S
Site 45
S576
S
D
N
L
E
G
I
S
E
G
P
S
N
R
S
Site 46
S580
E
G
I
S
E
G
P
S
N
R
S
N
S
V
S
Site 47
S583
S
E
G
P
S
N
R
S
N
S
V
S
S
L
D
Site 48
S585
G
P
S
N
R
S
N
S
V
S
S
L
D
L
E
Site 49
S587
S
N
R
S
N
S
V
S
S
L
D
L
E
G
E
Site 50
S588
N
R
S
N
S
V
S
S
L
D
L
E
G
E
S
Site 51
S595
S
L
D
L
E
G
E
S
V
S
E
L
G
A
G
Site 52
S604
S
E
L
G
A
G
P
S
G
S
N
G
V
E
A
Site 53
S606
L
G
A
G
P
S
G
S
N
G
V
E
A
L
Q
Site 54
T622
L
E
H
E
Q
A
T
T
Q
D
N
L
D
D
K
Site 55
T642
I
R
D
M
M
G
L
T
D
D
R
D
I
S
E
Site 56
S648
L
T
D
D
R
D
I
S
E
T
V
S
E
T
W
Site 57
T650
D
D
R
D
I
S
E
T
V
S
E
T
W
S
T
Site 58
S652
R
D
I
S
E
T
V
S
E
T
W
S
T
D
V
Site 59
S656
E
T
V
S
E
T
W
S
T
D
V
L
G
S
D
Site 60
T657
T
V
S
E
T
W
S
T
D
V
L
G
S
D
F
Site 61
S705
L
L
D
P
C
T
G
S
T
I
S
E
T
T
S
Site 62
S708
P
C
T
G
S
T
I
S
E
T
T
S
E
A
W
Site 63
S712
S
T
I
S
E
T
T
S
E
A
W
S
V
E
V
Site 64
S716
E
T
T
S
E
A
W
S
V
E
V
L
P
S
D
Site 65
S722
W
S
V
E
V
L
P
S
D
S
E
A
P
D
L
Site 66
S724
V
E
V
L
P
S
D
S
E
A
P
D
L
K
Q
Site 67
S740
E
R
L
Q
E
L
E
S
C
S
G
L
G
S
T
Site 68
S742
L
Q
E
L
E
S
C
S
G
L
G
S
T
S
D
Site 69
S746
E
S
C
S
G
L
G
S
T
S
D
D
T
D
V
Site 70
T747
S
C
S
G
L
G
S
T
S
D
D
T
D
V
R
Site 71
S748
C
S
G
L
G
S
T
S
D
D
T
D
V
R
E
Site 72
T751
L
G
S
T
S
D
D
T
D
V
R
E
V
S
S
Site 73
S757
D
T
D
V
R
E
V
S
S
R
P
S
T
P
G
Site 74
S758
T
D
V
R
E
V
S
S
R
P
S
T
P
G
L
Site 75
S761
R
E
V
S
S
R
P
S
T
P
G
L
S
V
V
Site 76
T762
E
V
S
S
R
P
S
T
P
G
L
S
V
V
S
Site 77
S766
R
P
S
T
P
G
L
S
V
V
S
G
I
S
A
Site 78
S769
T
P
G
L
S
V
V
S
G
I
S
A
T
S
E
Site 79
S787
N
K
I
E
D
L
R
S
E
C
S
S
D
F
G
Site 80
S790
E
D
L
R
S
E
C
S
S
D
F
G
G
K
D
Site 81
S791
D
L
R
S
E
C
S
S
D
F
G
G
K
D
S
Site 82
S798
S
D
F
G
G
K
D
S
V
T
S
P
D
M
D
Site 83
T800
F
G
G
K
D
S
V
T
S
P
D
M
D
E
I
Site 84
S801
G
G
K
D
S
V
T
S
P
D
M
D
E
I
T
Site 85
T808
S
P
D
M
D
E
I
T
H
G
A
H
Q
L
T
Site 86
T815
T
H
G
A
H
Q
L
T
S
P
P
S
Q
S
E
Site 87
S816
H
G
A
H
Q
L
T
S
P
P
S
Q
S
E
S
Site 88
S819
H
Q
L
T
S
P
P
S
Q
S
E
S
L
L
A
Site 89
S823
S
P
P
S
Q
S
E
S
L
L
A
M
F
D
P
Site 90
Y847
V
V
R
P
K
V
H
Y
A
R
P
S
H
P
P
Site 91
S851
K
V
H
Y
A
R
P
S
H
P
P
P
D
P
P
Site 92
S876
A
R
L
P
N
F
G
S
H
V
L
T
P
A
E
Site 93
S892
E
A
F
K
Q
R
H
S
Y
P
E
R
L
V
R
Site 94
Y893
A
F
K
Q
R
H
S
Y
P
E
R
L
V
R
S
Site 95
S900
Y
P
E
R
L
V
R
S
R
S
S
D
I
V
S
Site 96
S902
E
R
L
V
R
S
R
S
S
D
I
V
S
S
V
Site 97
S903
R
L
V
R
S
R
S
S
D
I
V
S
S
V
R
Site 98
S907
S
R
S
S
D
I
V
S
S
V
R
R
P
M
S
Site 99
S908
R
S
S
D
I
V
S
S
V
R
R
P
M
S
D
Site 100
S914
S
S
V
R
R
P
M
S
D
P
S
W
N
R
R
Site 101
S917
R
R
P
M
S
D
P
S
W
N
R
R
P
G
N
Site 102
S939
A
A
A
I
G
A
T
S
L
V
A
A
P
H
S
Site 103
S946
S
L
V
A
A
P
H
S
S
S
S
S
P
S
K
Site 104
S947
L
V
A
A
P
H
S
S
S
S
S
P
S
K
D
Site 105
S948
V
A
A
P
H
S
S
S
S
S
P
S
K
D
S
Site 106
S949
A
A
P
H
S
S
S
S
S
P
S
K
D
S
S
Site 107
S950
A
P
H
S
S
S
S
S
P
S
K
D
S
S
R
Site 108
S952
H
S
S
S
S
S
P
S
K
D
S
S
R
G
E
Site 109
S955
S
S
S
P
S
K
D
S
S
R
G
E
T
E
E
Site 110
S956
S
S
P
S
K
D
S
S
R
G
E
T
E
E
R
Site 111
T960
K
D
S
S
R
G
E
T
E
E
R
K
D
S
D
Site 112
S966
A
A
A
I
G
A
T
S
L
V
A
A
P
H
S
Site 113
S971
K
D
S
D
D
E
K
S
D
R
N
R
P
W
W
Site 114
S1012
D
L
G
P
D
R
F
S
T
L
T
D
D
P
S
Site 115
T1013
L
G
P
D
R
F
S
T
L
T
D
D
P
S
P
Site 116
T1015
P
D
R
F
S
T
L
T
D
D
P
S
P
R
L
Site 117
S1019
S
T
L
T
D
D
P
S
P
R
L
S
A
Q
A
Site 118
S1023
D
D
P
S
P
R
L
S
A
Q
A
Q
V
A
E
Site 119
Y1036
A
E
D
I
L
D
K
Y
R
N
A
I
K
R
T
Site 120
S1044
R
N
A
I
K
R
T
S
P
S
D
G
A
M
A
Site 121
S1046
S
T
L
T
D
D
P
S
P
R
L
S
A
Q
A
Site 122
Y1053
S
D
G
A
M
A
N
Y
E
S
T
G
D
N
H
Site 123
S1065
D
N
H
D
R
D
L
S
S
K
L
L
Y
H
S
Site 124
S1066
N
H
D
R
D
L
S
S
K
L
L
Y
H
S
D
Site 125
Y1070
D
L
S
S
K
L
L
Y
H
S
D
K
E
V
M
Site 126
S1072
S
S
K
L
L
Y
H
S
D
K
E
V
M
G
D
Site 127
S1082
E
V
M
G
D
G
E
S
A
H
D
S
P
R
D
Site 128
S1086
D
G
E
S
A
H
D
S
P
R
D
E
A
L
Q
Site 129
S1096
D
E
A
L
Q
N
I
S
A
D
D
L
P
D
S
Site 130
S1103
S
A
D
D
L
P
D
S
A
S
Q
A
A
H
P
Site 131
S1105
D
E
A
L
Q
N
I
S
A
D
D
L
P
D
S
Site 132
S1116
H
P
Q
D
S
A
F
S
Y
R
D
A
K
K
K
Site 133
Y1117
P
Q
D
S
A
F
S
Y
R
D
A
K
K
K
L
Site 134
S1142
A
F
P
V
L
T
H
S
T
R
N
G
L
P
D
Site 135
T1151
R
N
G
L
P
D
H
T
D
P
E
D
N
E
I
Site 136
T1195
V
C
R
F
D
N
R
T
C
R
K
L
L
A
S
Site 137
S1202
T
C
R
K
L
L
A
S
I
A
E
D
Y
R
K
Site 138
Y1207
L
A
S
I
A
E
D
Y
R
K
R
A
P
Y
I
Site 139
Y1213
D
Y
R
K
R
A
P
Y
I
A
Y
L
T
R
C
Site 140
Y1216
K
R
A
P
Y
I
A
Y
L
T
R
C
R
Q
G
Site 141
T1226
R
C
R
Q
G
L
Q
T
T
Q
A
H
L
E
R
Site 142
T1227
C
R
Q
G
L
Q
T
T
Q
A
H
L
E
R
L
Site 143
Y1248
D
K
E
V
A
N
R
Y
F
T
T
V
C
V
R
Site 144
S1260
C
V
R
L
L
L
E
S
K
E
K
K
I
R
E
Site 145
T1282
L
T
A
A
D
D
K
T
A
Q
V
E
D
F
L
Site 146
S1320
A
Q
L
A
I
E
R
S
V
M
N
R
I
F
K
Site 147
Y1331
R
I
F
K
L
A
F
Y
P
N
Q
D
G
D
I
Site 148
S1352
H
E
H
I
Q
R
L
S
K
V
V
T
A
N
H
Site 149
T1356
Q
R
L
S
K
V
V
T
A
N
H
R
A
L
Q
Site 150
Y1368
A
L
Q
I
P
E
V
Y
L
R
E
A
P
W
P
Site 151
T1383
S
A
Q
S
E
I
R
T
I
S
A
Y
K
T
P
Site 152
S1385
Q
S
E
I
R
T
I
S
A
Y
K
T
P
R
D
Site 153
Y1387
E
I
R
T
I
S
A
Y
K
T
P
R
D
K
V
Site 154
T1389
R
T
I
S
A
Y
K
T
P
R
D
K
V
Q
C
Site 155
S1415
L
S
L
A
N
E
D
S
V
P
G
A
D
D
F
Site 156
S1451
Y
I
S
S
F
Y
A
S
C
L
S
G
E
E
S
Site 157
T1473
A
A
V
E
F
I
K
T
I
D
D
R
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation