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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FRMPD4
Full Name:
FERM and PDZ domain-containing protein 4
Alias:
FERM and PDZ domain containing 4; FRPD4; KIAA0316; PDZ domain containing 10; PDZD10; PDZK10
Type:
Unknown function
Mass (Da):
144379
Number AA:
1322
UniProt ID:
Q14CM0
International Prot ID:
IPI00187159
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0043197
Uniprot
OncoNet
Molecular Function:
GO:0005546
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0051835
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
F
V
K
I
A
K
L
S
S
H
R
T
K
S
S
Site 2
S14
V
K
I
A
K
L
S
S
H
R
T
K
S
S
G
Site 3
T17
A
K
L
S
S
H
R
T
K
S
S
G
W
P
P
Site 4
S19
L
S
S
H
R
T
K
S
S
G
W
P
P
P
S
Site 5
S20
S
S
H
R
T
K
S
S
G
W
P
P
P
S
G
Site 6
S26
S
S
G
W
P
P
P
S
G
T
W
G
L
S
Q
Site 7
T28
G
W
P
P
P
S
G
T
W
G
L
S
Q
V
P
Site 8
S32
P
S
G
T
W
G
L
S
Q
V
P
P
Y
G
W
Site 9
Y37
G
L
S
Q
V
P
P
Y
G
W
E
M
T
A
N
Site 10
Y50
A
N
R
D
G
R
D
Y
F
I
N
H
M
T
Q
Site 11
S68
F
D
D
P
R
L
E
S
C
Q
I
I
P
P
A
Site 12
S103
E
K
P
V
V
V
R
S
V
T
P
G
G
P
S
Site 13
T105
P
V
V
V
R
S
V
T
P
G
G
P
S
E
G
Site 14
S110
S
V
T
P
G
G
P
S
E
G
K
L
I
P
G
Site 15
S129
M
I
N
D
E
P
V
S
A
A
P
R
E
R
V
Site 16
S157
T
V
I
Q
P
Y
P
S
P
K
S
A
F
I
S
Site 17
S160
Q
P
Y
P
S
P
K
S
A
F
I
S
A
A
K
Site 18
S164
S
P
K
S
A
F
I
S
A
A
K
K
A
R
L
Site 19
S173
A
K
K
A
R
L
K
S
N
P
V
K
V
R
F
Site 20
S181
N
P
V
K
V
R
F
S
E
E
V
I
I
N
G
Site 21
T193
I
N
G
Q
V
S
E
T
V
K
D
N
S
L
L
Site 22
S198
S
E
T
V
K
D
N
S
L
L
F
M
P
N
V
Site 23
Y209
M
P
N
V
L
K
V
Y
L
E
N
G
Q
T
K
Site 24
T215
V
Y
L
E
N
G
Q
T
K
S
F
R
F
D
C
Site 25
S217
L
E
N
G
Q
T
K
S
F
R
F
D
C
S
T
Site 26
S223
K
S
F
R
F
D
C
S
T
S
I
K
D
V
I
Site 27
S238
L
T
L
Q
E
K
L
S
I
K
G
I
E
H
F
Site 28
S246
I
K
G
I
E
H
F
S
L
M
L
E
Q
R
T
Site 29
T258
Q
R
T
E
G
A
G
T
K
L
L
L
L
H
E
Site 30
T273
Q
E
T
L
T
Q
V
T
Q
R
P
S
S
H
K
Site 31
S277
T
Q
V
T
Q
R
P
S
S
H
K
M
R
C
L
Site 32
S278
Q
V
T
Q
R
P
S
S
H
K
M
R
C
L
F
Site 33
Y307
R
D
P
V
A
F
E
Y
L
Y
V
Q
S
C
N
Site 34
Y327
R
F
G
P
E
L
K
Y
D
I
A
L
R
L
A
Site 35
T344
Q
M
Y
I
A
T
V
T
T
K
Q
T
Q
K
I
Site 36
T345
M
Y
I
A
T
V
T
T
K
Q
T
Q
K
I
S
Site 37
T348
A
T
V
T
T
K
Q
T
Q
K
I
S
L
K
Y
Site 38
S352
T
K
Q
T
Q
K
I
S
L
K
Y
I
E
K
E
Site 39
Y355
T
Q
K
I
S
L
K
Y
I
E
K
E
W
G
L
Site 40
S401
V
P
P
G
K
K
L
S
A
L
Q
A
K
V
H
Site 41
T427
G
G
R
V
F
K
A
T
L
V
Q
A
E
K
R
Site 42
S474
V
N
R
I
E
M
F
S
E
E
E
S
L
V
R
Site 43
S478
E
M
F
S
E
E
E
S
L
V
R
V
E
L
H
Site 44
S498
P
I
T
L
L
M
E
S
S
D
A
M
N
L
A
Site 45
S499
I
T
L
L
M
E
S
S
D
A
M
N
L
A
C
Site 46
S518
Y
Y
R
L
L
V
D
S
R
R
S
I
F
N
M
Site 47
S521
L
L
V
D
S
R
R
S
I
F
N
M
A
N
K
Site 48
T571
G
E
Q
E
A
Q
I
T
Y
I
D
S
K
Q
K
Site 49
T579
Y
I
D
S
K
Q
K
T
V
E
I
T
D
S
T
Site 50
S585
K
T
V
E
I
T
D
S
T
M
C
P
K
E
H
Site 51
T586
T
V
E
I
T
D
S
T
M
C
P
K
E
H
R
Site 52
Y596
P
K
E
H
R
H
L
Y
I
D
N
A
Y
S
S
Site 53
Y601
H
L
Y
I
D
N
A
Y
S
S
D
G
L
N
Q
Site 54
S602
L
Y
I
D
N
A
Y
S
S
D
G
L
N
Q
Q
Site 55
S603
Y
I
D
N
A
Y
S
S
D
G
L
N
Q
Q
L
Site 56
S611
D
G
L
N
Q
Q
L
S
Q
P
G
E
A
P
C
Site 57
Y622
E
A
P
C
E
A
D
Y
R
S
L
A
Q
R
S
Site 58
S624
P
C
E
A
D
Y
R
S
L
A
Q
R
S
L
L
Site 59
S629
Y
R
S
L
A
Q
R
S
L
L
T
L
S
G
P
Site 60
T632
L
A
Q
R
S
L
L
T
L
S
G
P
E
T
L
Site 61
S634
Q
R
S
L
L
T
L
S
G
P
E
T
L
K
K
Site 62
T638
L
T
L
S
G
P
E
T
L
K
K
A
Q
E
S
Site 63
S645
T
L
K
K
A
Q
E
S
P
R
G
A
K
V
S
Site 64
S665
F
A
L
D
D
G
I
S
P
P
T
L
G
Y
E
Site 65
T668
D
D
G
I
S
P
P
T
L
G
Y
E
T
L
L
Site 66
Y689
L
E
K
Q
R
N
L
Y
I
G
S
A
N
D
M
Site 67
T702
D
M
K
G
L
D
L
T
P
E
A
E
G
I
Q
Site 68
S714
G
I
Q
F
V
E
N
S
V
Y
A
N
I
G
D
Site 69
Y716
Q
F
V
E
N
S
V
Y
A
N
I
G
D
V
K
Site 70
Y741
P
L
L
H
D
I
C
Y
A
E
N
T
D
D
A
Site 71
S755
A
E
D
E
D
E
V
S
C
E
E
D
L
V
V
Site 72
T784
S
D
D
I
I
D
L
T
S
L
P
P
P
E
G
Site 73
S785
D
D
I
I
D
L
T
S
L
P
P
P
E
G
D
Site 74
S817
P
P
P
G
F
R
D
S
S
D
E
E
D
S
Q
Site 75
S818
P
P
G
F
R
D
S
S
D
E
E
D
S
Q
S
Site 76
S823
D
S
S
D
E
E
D
S
Q
S
Q
A
A
S
F
Site 77
S825
S
D
E
E
D
S
Q
S
Q
A
A
S
F
P
E
Site 78
S829
D
S
Q
S
Q
A
A
S
F
P
E
D
K
E
K
Site 79
S839
E
D
K
E
K
G
S
S
L
Q
N
D
E
I
P
Site 80
S848
Q
N
D
E
I
P
V
S
L
I
D
A
V
P
T
Site 81
S856
L
I
D
A
V
P
T
S
A
E
G
K
C
E
K
Site 82
S880
L
G
A
L
E
A
L
S
V
S
E
E
Q
Q
T
Site 83
S882
A
L
E
A
L
S
V
S
E
E
Q
Q
T
S
D
Site 84
T887
S
V
S
E
E
Q
Q
T
S
D
N
S
G
V
A
Site 85
S888
V
S
E
E
Q
Q
T
S
D
N
S
G
V
A
I
Site 86
Y899
G
V
A
I
L
R
A
Y
S
P
E
S
S
S
D
Site 87
S900
V
A
I
L
R
A
Y
S
P
E
S
S
S
D
S
Site 88
S903
L
R
A
Y
S
P
E
S
S
S
D
S
G
N
E
Site 89
S904
R
A
Y
S
P
E
S
S
S
D
S
G
N
E
T
Site 90
S905
A
Y
S
P
E
S
S
S
D
S
G
N
E
T
N
Site 91
S907
S
P
E
S
S
S
D
S
G
N
E
T
N
S
S
Site 92
T911
S
S
D
S
G
N
E
T
N
S
S
E
M
T
E
Site 93
S913
D
S
G
N
E
T
N
S
S
E
M
T
E
S
S
Site 94
S914
S
G
N
E
T
N
S
S
E
M
T
E
S
S
E
Site 95
T917
E
T
N
S
S
E
M
T
E
S
S
E
L
A
T
Site 96
S919
N
S
S
E
M
T
E
S
S
E
L
A
T
A
Q
Site 97
T924
T
E
S
S
E
L
A
T
A
Q
K
Q
S
E
N
Site 98
S933
Q
K
Q
S
E
N
L
S
R
M
F
L
A
T
H
Site 99
T939
L
S
R
M
F
L
A
T
H
E
G
Y
H
P
L
Site 100
S956
E
Q
T
E
F
P
A
S
K
T
P
A
G
G
L
Site 101
T958
T
E
F
P
A
S
K
T
P
A
G
G
L
P
P
Site 102
S967
A
G
G
L
P
P
K
S
S
H
A
L
A
A
R
Site 103
S968
G
G
L
P
P
K
S
S
H
A
L
A
A
R
P
Site 104
S986
L
P
P
K
V
V
P
S
K
Q
L
L
H
S
D
Site 105
S992
P
S
K
Q
L
L
H
S
D
H
M
E
M
E
P
Site 106
T1004
M
E
P
E
T
M
E
T
K
S
V
T
D
Y
F
Site 107
S1006
P
E
T
M
E
T
K
S
V
T
D
Y
F
S
K
Site 108
T1008
T
M
E
T
K
S
V
T
D
Y
F
S
K
L
H
Site 109
Y1010
E
T
K
S
V
T
D
Y
F
S
K
L
H
M
G
Site 110
S1012
K
S
V
T
D
Y
F
S
K
L
H
M
G
S
V
Site 111
S1022
H
M
G
S
V
A
Y
S
C
T
S
K
R
K
S
Site 112
T1024
G
S
V
A
Y
S
C
T
S
K
R
K
S
K
L
Site 113
S1025
S
V
A
Y
S
C
T
S
K
R
K
S
K
L
A
Site 114
S1029
S
C
T
S
K
R
K
S
K
L
A
D
G
E
G
Site 115
S1062
A
E
M
E
E
E
A
S
G
K
F
G
T
V
S
Site 116
T1067
E
A
S
G
K
F
G
T
V
S
S
R
D
S
Q
Site 117
S1069
S
G
K
F
G
T
V
S
S
R
D
S
Q
H
L
Site 118
S1070
G
K
F
G
T
V
S
S
R
D
S
Q
H
L
S
Site 119
S1073
G
T
V
S
S
R
D
S
Q
H
L
S
T
F
N
Site 120
S1077
S
R
D
S
Q
H
L
S
T
F
N
L
E
R
T
Site 121
T1078
R
D
S
Q
H
L
S
T
F
N
L
E
R
T
A
Site 122
T1084
S
T
F
N
L
E
R
T
A
F
R
K
D
S
Q
Site 123
S1090
R
T
A
F
R
K
D
S
Q
R
W
Y
V
A
T
Site 124
Y1094
R
K
D
S
Q
R
W
Y
V
A
T
E
G
G
M
Site 125
T1097
S
Q
R
W
Y
V
A
T
E
G
G
M
A
E
K
Site 126
S1105
E
G
G
M
A
E
K
S
G
L
E
A
A
T
G
Site 127
T1114
L
E
A
A
T
G
K
T
F
P
R
A
S
G
L
Site 128
S1119
G
K
T
F
P
R
A
S
G
L
G
A
R
E
A
Site 129
T1138
E
G
A
P
D
G
E
T
S
D
G
S
G
L
G
Site 130
S1139
G
A
P
D
G
E
T
S
D
G
S
G
L
G
Q
Site 131
S1142
D
G
E
T
S
D
G
S
G
L
G
Q
G
D
R
Site 132
T1152
G
Q
G
D
R
F
L
T
D
V
T
C
A
S
S
Site 133
T1155
D
R
F
L
T
D
V
T
C
A
S
S
A
K
D
Site 134
S1171
D
N
P
E
D
A
D
S
S
T
C
D
H
P
S
Site 135
S1172
N
P
E
D
A
D
S
S
T
C
D
H
P
S
K
Site 136
T1173
P
E
D
A
D
S
S
T
C
D
H
P
S
K
L
Site 137
S1178
S
S
T
C
D
H
P
S
K
L
P
E
A
D
E
Site 138
S1186
K
L
P
E
A
D
E
S
V
A
R
L
C
D
Y
Site 139
Y1193
S
V
A
R
L
C
D
Y
H
L
A
K
R
M
S
Site 140
S1200
Y
H
L
A
K
R
M
S
S
L
Q
S
E
G
H
Site 141
S1201
H
L
A
K
R
M
S
S
L
Q
S
E
G
H
F
Site 142
S1204
K
R
M
S
S
L
Q
S
E
G
H
F
S
L
Q
Site 143
S1209
L
Q
S
E
G
H
F
S
L
Q
S
S
Q
G
S
Site 144
S1212
E
G
H
F
S
L
Q
S
S
Q
G
S
S
V
D
Site 145
S1213
G
H
F
S
L
Q
S
S
Q
G
S
S
V
D
A
Site 146
S1216
S
L
Q
S
S
Q
G
S
S
V
D
A
G
C
G
Site 147
S1217
L
Q
S
S
Q
G
S
S
V
D
A
G
C
G
T
Site 148
S1229
C
G
T
G
S
S
G
S
A
C
A
T
P
V
E
Site 149
S1252
K
H
L
I
P
D
A
S
G
K
G
V
N
Y
I
Site 150
Y1258
A
S
G
K
G
V
N
Y
I
P
S
E
E
R
A
Site 151
S1261
K
G
V
N
Y
I
P
S
E
E
R
A
P
G
L
Site 152
T1306
N
T
E
P
L
F
G
T
L
R
D
G
C
H
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation