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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CLCA4
Full Name:
Calcium-activated chloride channel regulator 4
Alias:
Calcium-activated chloride channel family member 4;Calcium-activated chloride channel protein 2
Type:
Mass (Da):
101283
Number AA:
919
UniProt ID:
Q14CN2
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
L
L
H
Q
S
N
T
S
F
I
K
L
N
N
N
Site 2
T57
E
Q
I
E
D
M
V
T
T
A
S
T
Y
L
F
Site 3
S60
E
D
M
V
T
T
A
S
T
Y
L
F
E
A
T
Site 4
T67
S
T
Y
L
F
E
A
T
E
K
R
F
F
F
K
Site 5
Y90
N
W
K
E
N
P
Q
Y
K
R
P
K
H
E
N
Site 6
T109
D
V
I
V
A
P
P
T
L
P
G
R
D
E
P
Site 7
Y117
L
P
G
R
D
E
P
Y
T
K
Q
F
T
E
C
Site 8
T118
P
G
R
D
E
P
Y
T
K
Q
F
T
E
C
G
Site 9
Y130
E
C
G
E
K
G
E
Y
I
H
F
T
P
D
L
Site 10
T134
K
G
E
Y
I
H
F
T
P
D
L
L
L
G
K
Site 11
Y146
L
G
K
K
Q
N
E
Y
G
P
P
G
K
L
F
Site 12
Y168
R
W
G
V
F
D
E
Y
N
E
D
Q
P
F
Y
Site 13
Y175
Y
N
E
D
Q
P
F
Y
R
A
K
S
K
K
I
Site 14
S179
Q
P
F
Y
R
A
K
S
K
K
I
E
A
T
R
Site 15
S188
K
I
E
A
T
R
C
S
A
G
I
S
G
R
N
Site 16
S192
T
R
C
S
A
G
I
S
G
R
N
R
V
Y
K
Site 17
Y198
I
S
G
R
N
R
V
Y
K
C
Q
G
G
S
C
Site 18
S207
C
Q
G
G
S
C
L
S
R
A
C
R
I
D
S
Site 19
S214
S
R
A
C
R
I
D
S
T
T
K
L
Y
G
K
Site 20
T215
R
A
C
R
I
D
S
T
T
K
L
Y
G
K
D
Site 21
T216
A
C
R
I
D
S
T
T
K
L
Y
G
K
D
C
Site 22
S236
K
V
Q
T
E
K
A
S
I
M
F
M
Q
S
I
Site 23
T272
I
K
C
N
F
R
S
T
W
E
V
I
S
N
S
Site 24
T290
K
N
T
I
P
M
V
T
P
P
P
P
P
V
F
Site 25
S298
P
P
P
P
P
V
F
S
L
L
K
I
S
Q
R
Site 26
S316
L
V
L
D
K
S
G
S
M
G
G
K
D
R
L
Site 27
T337
A
K
H
F
L
L
Q
T
V
E
N
G
S
W
V
Site 28
S364
N
K
L
I
Q
I
K
S
S
D
E
R
N
T
L
Site 29
S365
K
L
I
Q
I
K
S
S
D
E
R
N
T
L
M
Site 30
T370
K
S
S
D
E
R
N
T
L
M
A
G
L
P
T
Site 31
S401
Q
V
I
G
E
L
H
S
Q
L
D
G
S
E
V
Site 32
T418
L
T
D
G
E
D
N
T
A
S
S
C
I
D
E
Site 33
S420
D
G
E
D
N
T
A
S
S
C
I
D
E
V
K
Site 34
S450
D
E
A
V
I
E
M
S
K
I
T
G
G
S
H
Site 35
Y459
I
T
G
G
S
H
F
Y
V
S
D
E
A
Q
N
Site 36
S461
G
G
S
H
F
Y
V
S
D
E
A
Q
N
N
G
Site 37
S478
D
A
F
G
A
L
T
S
G
N
T
D
L
S
Q
Site 38
S484
T
S
G
N
T
D
L
S
Q
K
S
L
Q
L
E
Site 39
S487
N
T
D
L
S
Q
K
S
L
Q
L
E
S
K
G
Site 40
T496
Q
L
E
S
K
G
L
T
L
N
S
N
A
W
M
Site 41
T522
K
D
T
F
F
L
I
T
W
N
S
L
P
P
S
Site 42
S529
T
W
N
S
L
P
P
S
I
S
L
W
D
P
S
Site 43
S531
N
S
L
P
P
S
I
S
L
W
D
P
S
G
T
Site 44
S536
S
I
S
L
W
D
P
S
G
T
I
M
E
N
F
Site 45
Y553
D
A
T
S
K
M
A
Y
L
S
I
P
G
T
A
Site 46
T579
K
A
N
P
E
T
L
T
I
T
V
T
S
R
A
Site 47
T581
N
P
E
T
L
T
I
T
V
T
S
R
A
A
N
Site 48
T583
E
T
L
T
I
T
V
T
S
R
A
A
N
S
S
Site 49
S590
T
S
R
A
A
N
S
S
V
P
P
I
T
V
N
Site 50
T595
N
S
S
V
P
P
I
T
V
N
A
K
M
N
K
Site 51
S606
K
M
N
K
D
V
N
S
F
P
S
P
M
I
V
Site 52
S609
K
D
V
N
S
F
P
S
P
M
I
V
Y
A
E
Site 53
S635
N
V
T
A
F
I
E
S
Q
N
G
H
T
E
V
Site 54
S654
D
N
G
A
G
A
D
S
F
K
N
D
G
V
Y
Site 55
Y661
S
F
K
N
D
G
V
Y
S
R
Y
F
T
A
Y
Site 56
Y664
N
D
G
V
Y
S
R
Y
F
T
A
Y
T
E
N
Site 57
T666
G
V
Y
S
R
Y
F
T
A
Y
T
E
N
G
R
Site 58
Y668
Y
S
R
Y
F
T
A
Y
T
E
N
G
R
Y
S
Site 59
T669
S
R
Y
F
T
A
Y
T
E
N
G
R
Y
S
L
Site 60
Y674
A
Y
T
E
N
G
R
Y
S
L
K
V
R
A
H
Site 61
S675
Y
T
E
N
G
R
Y
S
L
K
V
R
A
H
G
Site 62
T686
R
A
H
G
G
A
N
T
A
R
L
K
L
R
P
Site 63
T723
R
P
E
I
D
E
D
T
Q
T
T
L
E
D
F
Site 64
T725
E
I
D
E
D
T
Q
T
T
L
E
D
F
S
R
Site 65
S731
Q
T
T
L
E
D
F
S
R
T
A
S
G
G
A
Site 66
S735
E
D
F
S
R
T
A
S
G
G
A
F
V
V
S
Site 67
Y753
S
L
P
L
P
D
Q
Y
P
P
S
Q
I
T
D
Site 68
S756
L
P
D
Q
Y
P
P
S
Q
I
T
D
L
D
A
Site 69
T764
Q
I
T
D
L
D
A
T
V
H
E
D
K
I
I
Site 70
Y789
D
V
G
K
V
Q
R
Y
I
I
R
I
S
A
S
Site 71
S803
S
I
L
D
L
R
D
S
F
D
D
A
L
Q
V
Site 72
S816
Q
V
N
T
T
D
L
S
P
K
E
A
N
S
K
Site 73
S822
L
S
P
K
E
A
N
S
K
E
S
F
A
F
K
Site 74
S825
K
E
A
N
S
K
E
S
F
A
F
K
P
E
N
Site 75
S834
A
F
K
P
E
N
I
S
E
E
N
A
T
H
I
Site 76
S851
A
I
K
S
I
D
K
S
N
L
T
S
K
V
S
Site 77
T854
S
I
D
K
S
N
L
T
S
K
V
S
N
I
A
Site 78
S855
I
D
K
S
N
L
T
S
K
V
S
N
I
A
Q
Site 79
S858
S
N
L
T
S
K
V
S
N
I
A
Q
V
T
L
Site 80
T864
V
S
N
I
A
Q
V
T
L
F
I
P
Q
A
N
Site 81
T878
N
P
D
D
I
D
P
T
P
T
P
T
P
T
P
Site 82
T880
D
D
I
D
P
T
P
T
P
T
P
T
P
T
P
Site 83
T882
I
D
P
T
P
T
P
T
P
T
P
T
P
D
K
Site 84
T884
P
T
P
T
P
T
P
T
P
T
P
D
K
S
H
Site 85
T886
P
T
P
T
P
T
P
T
P
D
K
S
H
N
S
Site 86
S890
P
T
P
T
P
D
K
S
H
N
S
G
V
N
I
Site 87
S893
T
P
D
K
S
H
N
S
G
V
N
I
S
T
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation