PhosphoNET

           
Protein Info 
   
Short Name:  SPCS2
Full Name:  Signal peptidase complex subunit 2
Alias:  Microsomal signal peptidase 25 kDa subunit
Type: 
Mass (Da):  24985
Number AA:  226
UniProt ID:  Q15005
International Prot ID:  IPI00472939
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0000267  GO:0005624  GO:0005626 Uniprot OncoNet
Molecular Function:  GO:0003824  GO:0008233  GO:0016787 PhosphoSite+ KinaseNET
Biological Process:  GO:0006464  GO:0006465  GO:0006518 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S11AAVQGGRSGGSGGCS
Site 2S14QGGRSGGSGGCSGAG
Site 3S18SGGSGGCSGAGGASN
Site 4S24CSGAGGASNCGTGSG
Site 5T28GGASNCGTGSGRSGL
Site 6S30ASNCGTGSGRSGLLD
Site 7S54KIDKWDGSAVKNSLD
Site 8S59DGSAVKNSLDDSAKK
Site 9S63VKNSLDDSAKKVLLE
Site 10Y72KKVLLEKYKYVENFG
Site 11Y131MMGILTIYTSYKEKS
Site 12S138YTSYKEKSIFLVAHR
Site 13T149VAHRKDPTGMDPDDI
Site 14S160PDDIWQLSSSLKRFD
Site 15S162DIWQLSSSLKRFDDK
Site 16Y170LKRFDDKYTLKLTFI
Site 17T171KRFDDKYTLKLTFIS
Site 18T175DKYTLKLTFISGRTK
Site 19S178TLKLTFISGRTKQQR
Site 20T190QQREAEFTKSIAKFF
Site 21S192REAEFTKSIAKFFDH
Site 22Y208GTLVMDAYEPEISRL
Site 23S213DAYEPEISRLHDSLA
Site 24S218EISRLHDSLAIERKI
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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