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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SUZ12
Full Name:
Polycomb protein SUZ12
Alias:
JJAZ1; Suppressor of zeste 12 homologue (Drosophila); Suppressor of zeste 12 protein homologue
Type:
Transcription protein
Mass (Da):
83055
Number AA:
739
UniProt ID:
Q15022
International Prot ID:
IPI00299526
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0035098
Uniprot
OncoNet
Molecular Function:
GO:0042054
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
G
G
G
G
G
G
G
S
G
P
S
A
G
S
G
Site 2
S17
G
G
G
G
S
G
P
S
A
G
S
G
G
G
G
Site 3
S20
G
S
G
P
S
A
G
S
G
G
G
G
F
G
G
Site 4
S37
A
V
A
A
A
T
A
S
G
G
K
S
G
G
G
Site 5
S41
A
T
A
S
G
G
K
S
G
G
G
S
C
G
G
Site 6
S45
G
G
K
S
G
G
G
S
C
G
G
G
G
S
Y
Site 7
S51
G
S
C
G
G
G
G
S
Y
S
A
S
S
S
S
Site 8
Y52
S
C
G
G
G
G
S
Y
S
A
S
S
S
S
S
Site 9
S53
C
G
G
G
G
S
Y
S
A
S
S
S
S
S
A
Site 10
S55
G
G
G
S
Y
S
A
S
S
S
S
S
A
A
A
Site 11
S56
G
G
S
Y
S
A
S
S
S
S
S
A
A
A
A
Site 12
S57
G
S
Y
S
A
S
S
S
S
S
A
A
A
A
A
Site 13
T114
A
P
I
F
L
H
R
T
L
T
Y
M
S
H
R
Site 14
T116
I
F
L
H
R
T
L
T
Y
M
S
H
R
N
S
Site 15
Y117
F
L
H
R
T
L
T
Y
M
S
H
R
N
S
R
Site 16
S119
H
R
T
L
T
Y
M
S
H
R
N
S
R
T
N
Site 17
S123
T
Y
M
S
H
R
N
S
R
T
N
I
K
R
K
Site 18
T131
R
T
N
I
K
R
K
T
F
K
V
D
D
M
L
Site 19
S139
F
K
V
D
D
M
L
S
K
V
E
K
M
K
G
Site 20
S150
K
M
K
G
E
Q
E
S
H
S
L
S
A
H
L
Site 21
S152
K
G
E
Q
E
S
H
S
L
S
A
H
L
Q
L
Site 22
S154
E
Q
E
S
H
S
L
S
A
H
L
Q
L
T
F
Site 23
S172
F
H
K
N
D
K
P
S
P
N
S
E
N
E
Q
Site 24
S175
N
D
K
P
S
P
N
S
E
N
E
Q
N
S
V
Site 25
S229
T
K
P
G
N
F
P
S
L
A
V
S
S
N
E
Site 26
S233
N
F
P
S
L
A
V
S
S
N
E
F
E
P
S
Site 27
S234
F
P
S
L
A
V
S
S
N
E
F
E
P
S
N
Site 28
S240
S
S
N
E
F
E
P
S
N
S
H
M
V
K
S
Site 29
S242
N
E
F
E
P
S
N
S
H
M
V
K
S
Y
S
Site 30
S247
S
N
S
H
M
V
K
S
Y
S
L
L
F
R
V
Site 31
S249
S
H
M
V
K
S
Y
S
L
L
F
R
V
T
R
Site 32
T255
Y
S
L
L
F
R
V
T
R
P
G
R
R
E
F
Site 33
T294
N
R
E
D
G
E
K
T
F
V
A
Q
M
T
V
Site 34
T300
K
T
F
V
A
Q
M
T
V
F
D
K
N
R
R
Site 35
Y315
L
Q
L
L
D
G
E
Y
E
V
A
M
Q
E
M
Site 36
T333
P
I
S
K
K
R
A
T
W
E
T
I
L
D
G
Site 37
T336
K
K
R
A
T
W
E
T
I
L
D
G
K
R
L
Site 38
T348
K
R
L
P
P
F
E
T
F
S
Q
G
P
T
L
Site 39
S350
L
P
P
F
E
T
F
S
Q
G
P
T
L
Q
F
Site 40
T354
E
T
F
S
Q
G
P
T
L
Q
F
T
L
R
W
Site 41
T358
Q
G
P
T
L
Q
F
T
L
R
W
T
G
E
T
Site 42
T362
L
Q
F
T
L
R
W
T
G
E
T
N
D
K
S
Site 43
T365
T
L
R
W
T
G
E
T
N
D
K
S
T
A
P
Site 44
S369
T
G
E
T
N
D
K
S
T
A
P
I
A
K
P
Site 45
T379
P
I
A
K
P
L
A
T
R
N
S
E
S
L
H
Site 46
S382
K
P
L
A
T
R
N
S
E
S
L
H
Q
E
N
Site 47
S393
H
Q
E
N
K
P
G
S
V
K
P
T
Q
T
I
Site 48
T397
K
P
G
S
V
K
P
T
Q
T
I
A
V
K
E
Site 49
T399
G
S
V
K
P
T
Q
T
I
A
V
K
E
S
L
Site 50
T412
S
L
T
T
D
L
Q
T
R
K
E
K
D
T
P
Site 51
T418
Q
T
R
K
E
K
D
T
P
N
E
N
R
Q
K
Site 52
Y430
R
Q
K
L
R
I
F
Y
Q
F
L
Y
N
N
N
Site 53
Y434
R
I
F
Y
Q
F
L
Y
N
N
N
T
R
Q
Q
Site 54
T442
N
N
N
T
R
Q
Q
T
E
A
R
D
D
L
H
Site 55
Y461
T
L
N
C
R
K
L
Y
S
L
L
K
H
L
K
Site 56
S462
L
N
C
R
K
L
Y
S
L
L
K
H
L
K
L
Site 57
Y478
H
S
R
F
I
F
N
Y
V
Y
H
P
K
G
A
Site 58
Y480
R
F
I
F
N
Y
V
Y
H
P
K
G
A
R
I
Site 59
S490
K
G
A
R
I
D
V
S
I
N
E
C
Y
D
G
Site 60
Y499
N
E
C
Y
D
G
S
Y
A
G
N
P
Q
D
I
Site 61
S515
R
Q
P
G
F
A
F
S
R
N
G
P
V
K
R
Site 62
T523
R
N
G
P
V
K
R
T
P
I
T
H
I
L
V
Site 63
S539
R
P
K
R
T
K
A
S
M
S
E
F
L
E
S
Site 64
S541
K
R
T
K
A
S
M
S
E
F
L
E
S
E
D
Site 65
S546
S
M
S
E
F
L
E
S
E
D
G
E
V
E
Q
Site 66
T556
G
E
V
E
Q
Q
R
T
Y
S
S
G
H
N
R
Site 67
Y557
E
V
E
Q
Q
R
T
Y
S
S
G
H
N
R
L
Site 68
S558
V
E
Q
Q
R
T
Y
S
S
G
H
N
R
L
Y
Site 69
Y565
S
S
G
H
N
R
L
Y
F
H
S
D
T
C
L
Site 70
S568
H
N
R
L
Y
F
H
S
D
T
C
L
P
L
R
Site 71
T570
R
L
Y
F
H
S
D
T
C
L
P
L
R
P
Q
Site 72
S583
P
Q
E
M
E
V
D
S
E
D
E
K
D
P
E
Site 73
T596
P
E
W
L
R
E
K
T
I
T
Q
I
E
E
F
Site 74
T598
W
L
R
E
K
T
I
T
Q
I
E
E
F
S
D
Site 75
S604
I
T
Q
I
E
E
F
S
D
V
N
E
G
E
K
Site 76
Y643
C
M
L
F
V
E
N
Y
G
Q
K
I
I
K
K
Site 77
S693
Q
K
L
E
K
G
E
S
A
S
P
A
N
E
E
Site 78
S695
L
E
K
G
E
S
A
S
P
A
N
E
E
I
T
Site 79
T708
I
T
E
E
Q
N
G
T
A
N
G
F
S
E
I
Site 80
S713
N
G
T
A
N
G
F
S
E
I
N
S
K
E
K
Site 81
S717
N
G
F
S
E
I
N
S
K
E
K
A
L
E
T
Site 82
T724
S
K
E
K
A
L
E
T
D
S
V
S
G
V
S
Site 83
S726
E
K
A
L
E
T
D
S
V
S
G
V
S
K
Q
Site 84
S728
A
L
E
T
D
S
V
S
G
V
S
K
Q
S
K
Site 85
S734
V
S
G
V
S
K
Q
S
K
K
Q
K
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation