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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LARS2
Full Name:
Probable leucyl-tRNA synthetase, mitochondrial
Alias:
Leucine--tRNA ligase
Type:
Mass (Da):
101958
Number AA:
903
UniProt ID:
Q15031
International Prot ID:
IPI00014213
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005739
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004812
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006139
GO:0006399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
Q
R
L
G
F
Y
A
S
L
L
K
R
Q
L
N
Site 2
S39
V
I
P
G
C
T
R
S
I
Y
S
A
T
G
K
Site 3
Y41
P
G
C
T
R
S
I
Y
S
A
T
G
K
W
T
Site 4
S42
G
C
T
R
S
I
Y
S
A
T
G
K
W
T
K
Site 5
Y51
T
G
K
W
T
K
E
Y
T
L
Q
T
R
K
D
Site 6
S75
K
E
Q
A
S
K
I
S
E
A
D
K
S
K
P
Site 7
S80
K
I
S
E
A
D
K
S
K
P
K
F
Y
V
L
Site 8
Y85
D
K
S
K
P
K
F
Y
V
L
S
M
F
P
Y
Site 9
S88
K
P
K
F
Y
V
L
S
M
F
P
Y
P
S
G
Site 10
S108
H
V
R
V
Y
T
I
S
D
T
I
A
R
F
Q
Site 11
T110
R
V
Y
T
I
S
D
T
I
A
R
F
Q
K
M
Site 12
S148
E
R
N
L
H
P
Q
S
W
T
Q
S
N
I
K
Site 13
S169
D
R
L
G
L
C
F
S
W
D
R
E
I
T
T
Site 14
T176
S
W
D
R
E
I
T
T
C
L
P
D
Y
Y
K
Site 15
Y181
I
T
T
C
L
P
D
Y
Y
K
W
T
Q
Y
L
Site 16
Y187
D
Y
Y
K
W
T
Q
Y
L
F
I
K
L
Y
E
Site 17
T213
N
W
D
P
V
D
Q
T
V
L
A
N
E
Q
V
Site 18
S226
Q
V
D
E
H
G
C
S
W
R
S
G
A
K
V
Site 19
Y237
G
A
K
V
E
Q
K
Y
L
R
Q
W
F
I
K
Site 20
Y299
T
G
E
K
L
T
A
Y
T
A
T
P
E
A
I
Site 21
T300
G
E
K
L
T
A
Y
T
A
T
P
E
A
I
Y
Site 22
T302
K
L
T
A
Y
T
A
T
P
E
A
I
Y
G
T
Site 23
S310
P
E
A
I
Y
G
T
S
H
V
A
I
S
P
S
Site 24
S315
G
T
S
H
V
A
I
S
P
S
H
R
L
L
H
Site 25
S317
S
H
V
A
I
S
P
S
H
R
L
L
H
G
H
Site 26
S325
H
R
L
L
H
G
H
S
S
L
K
E
A
L
R
Site 27
S326
R
L
L
H
G
H
S
S
L
K
E
A
L
R
M
Site 28
S369
A
K
A
D
L
E
G
S
L
D
S
K
I
G
I
Site 29
S372
D
L
E
G
S
L
D
S
K
I
G
I
P
S
T
Site 30
S378
D
S
K
I
G
I
P
S
T
S
S
E
D
T
I
Site 31
T379
S
K
I
G
I
P
S
T
S
S
E
D
T
I
L
Site 32
S380
K
I
G
I
P
S
T
S
S
E
D
T
I
L
A
Site 33
S381
I
G
I
P
S
T
S
S
E
D
T
I
L
A
Q
Site 34
T384
P
S
T
S
S
E
D
T
I
L
A
Q
T
L
G
Site 35
T400
A
Y
S
E
V
I
E
T
L
P
D
G
T
E
R
Site 36
T405
I
E
T
L
P
D
G
T
E
R
L
S
S
S
A
Site 37
S409
P
D
G
T
E
R
L
S
S
S
A
E
F
T
G
Site 38
S410
D
G
T
E
R
L
S
S
S
A
E
F
T
G
M
Site 39
S411
G
T
E
R
L
S
S
S
A
E
F
T
G
M
T
Site 40
T415
L
S
S
S
A
E
F
T
G
M
T
R
Q
D
A
Site 41
S441
R
V
G
G
D
V
T
S
D
K
L
K
D
W
L
Site 42
Y454
W
L
I
S
R
Q
R
Y
W
G
T
P
I
P
I
Site 43
T457
S
R
Q
R
Y
W
G
T
P
I
P
I
V
H
C
Site 44
T517
K
G
A
A
K
R
E
T
D
T
M
D
T
F
V
Site 45
T519
A
A
K
R
E
T
D
T
M
D
T
F
V
D
S
Site 46
T522
R
E
T
D
T
M
D
T
F
V
D
S
A
W
Y
Site 47
S541
T
D
P
H
N
P
H
S
P
F
N
T
A
V
A
Site 48
Y557
Y
W
M
P
V
D
L
Y
I
G
G
K
E
H
A
Site 49
T603
Q
G
L
I
K
G
Q
T
F
R
L
P
S
G
Q
Site 50
S608
G
Q
T
F
R
L
P
S
G
Q
Y
L
Q
R
E
Site 51
Y611
F
R
L
P
S
G
Q
Y
L
Q
R
E
E
V
D
Site 52
T620
Q
R
E
E
V
D
L
T
G
S
V
P
V
H
A
Site 53
S622
E
E
V
D
L
T
G
S
V
P
V
H
A
K
T
Site 54
T636
T
K
E
K
L
E
V
T
W
E
K
M
S
K
S
Site 55
S643
T
W
E
K
M
S
K
S
K
H
N
G
V
D
P
Site 56
T697
R
W
Q
Q
R
L
W
T
L
T
T
R
F
I
E
Site 57
T699
Q
Q
R
L
W
T
L
T
T
R
F
I
E
A
R
Site 58
S708
R
F
I
E
A
R
A
S
G
K
S
P
Q
P
Q
Site 59
S711
E
A
R
A
S
G
K
S
P
Q
P
Q
L
L
S
Site 60
S718
S
P
Q
P
Q
L
L
S
N
K
E
K
A
E
A
Site 61
Y731
E
A
R
K
L
W
E
Y
K
N
S
V
I
S
Q
Site 62
S734
K
L
W
E
Y
K
N
S
V
I
S
Q
V
T
T
Site 63
S737
E
Y
K
N
S
V
I
S
Q
V
T
T
H
F
T
Site 64
T741
S
V
I
S
Q
V
T
T
H
F
T
E
D
F
S
Site 65
T744
S
Q
V
T
T
H
F
T
E
D
F
S
L
N
S
Site 66
S748
T
H
F
T
E
D
F
S
L
N
S
A
I
S
Q
Site 67
S751
T
E
D
F
S
L
N
S
A
I
S
Q
L
M
G
Site 68
S767
S
N
A
L
S
Q
A
S
Q
S
V
I
L
H
S
Site 69
S769
A
L
S
Q
A
S
Q
S
V
I
L
H
S
P
E
Site 70
S774
S
Q
S
V
I
L
H
S
P
E
F
E
D
A
L
Site 71
Y814
P
R
K
L
C
A
H
Y
T
W
D
A
S
V
L
Site 72
S884
V
R
L
L
Q
G
R
S
I
K
K
S
F
L
S
Site 73
S888
Q
G
R
S
I
K
K
S
F
L
S
P
R
T
A
Site 74
S891
S
I
K
K
S
F
L
S
P
R
T
A
L
I
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation