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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Rab3GAP1
Full Name:
Rab3 GTPase-activating protein catalytic subunit
Alias:
KIAA0066; P130; RAB3 GTPase activating protein 1 (catalytic); RAB3 GTPase activating protein subunit 1 (catalytic); RAB3 GTPase-activating protein 130 kDa; RAB3 GTPase-activating protein 130 kDa subunit; Rab3 GTPase-activating protein catalytic; RAB3GAP; Rab3-GAP; Rab3-GAP p130; RAB3GAP130; RB3GP; WARBM1
Type:
G protein, monomeric, Rab family
Mass (Da):
110524
Number AA:
981
UniProt ID:
Q15042
International Prot ID:
IPI00014235
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005625
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005097
GO:0017137
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0043087
GO:0050790
GO:0051336
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
A
A
D
S
E
P
E
S
E
V
F
E
I
T
D
Site 2
T18
V
F
E
I
T
D
F
T
T
A
S
E
W
E
R
Site 3
S28
S
E
W
E
R
F
I
S
K
V
E
E
V
L
N
Site 4
T57
K
G
I
F
T
S
G
T
W
E
E
K
S
D
E
Site 5
S62
S
G
T
W
E
E
K
S
D
E
I
S
F
A
D
Site 6
S66
E
E
K
S
D
E
I
S
F
A
D
F
K
F
S
Site 7
Y78
K
F
S
V
T
H
H
Y
L
V
Q
E
S
T
D
Site 8
S83
H
H
Y
L
V
Q
E
S
T
D
K
E
G
K
D
Site 9
S141
A
H
S
D
A
V
L
S
E
S
K
C
N
L
L
Site 10
T188
C
Q
G
P
G
V
R
T
D
F
E
M
V
H
L
Site 11
Y202
L
R
K
V
P
N
Q
Y
T
H
L
S
G
L
L
Site 12
T203
R
K
V
P
N
Q
Y
T
H
L
S
G
L
L
D
Site 13
Y234
S
I
A
I
R
F
T
Y
V
L
Q
D
W
Q
Q
Site 14
S277
G
A
C
E
D
P
I
S
E
L
H
L
A
T
T
Site 15
T284
S
E
L
H
L
A
T
T
W
P
H
L
T
E
G
Site 16
Y299
I
I
V
D
N
D
V
Y
S
D
L
D
P
I
Q
Site 17
S300
I
V
D
N
D
V
Y
S
D
L
D
P
I
Q
A
Site 18
S311
P
I
Q
A
P
H
W
S
V
R
V
R
K
A
E
Site 19
S340
K
I
C
R
R
K
E
S
T
D
E
I
L
G
R
Site 20
T341
I
C
R
R
K
E
S
T
D
E
I
L
G
R
S
Site 21
T357
F
E
E
E
G
K
E
T
A
D
I
T
H
A
L
Site 22
T361
G
K
E
T
A
D
I
T
H
A
L
S
K
L
T
Site 23
S365
A
D
I
T
H
A
L
S
K
L
T
E
P
A
S
Site 24
S372
S
K
L
T
E
P
A
S
V
P
I
H
K
L
S
Site 25
S379
S
V
P
I
H
K
L
S
V
S
N
M
V
H
T
Site 26
S381
P
I
H
K
L
S
V
S
N
M
V
H
T
A
K
Site 27
S400
K
H
R
G
V
E
E
S
P
L
N
N
D
V
L
Site 28
S420
F
L
F
P
D
A
V
S
E
K
P
L
D
G
T
Site 29
S429
K
P
L
D
G
T
T
S
T
D
N
N
N
P
P
Site 30
T430
P
L
D
G
T
T
S
T
D
N
N
N
P
P
S
Site 31
S437
T
D
N
N
N
P
P
S
E
S
E
D
Y
N
L
Site 32
Y442
P
P
S
E
S
E
D
Y
N
L
Y
N
Q
F
K
Site 33
Y445
E
S
E
D
Y
N
L
Y
N
Q
F
K
S
A
P
Site 34
S450
N
L
Y
N
Q
F
K
S
A
P
S
D
S
L
T
Site 35
S455
F
K
S
A
P
S
D
S
L
T
Y
K
L
A
L
Site 36
T536
A
R
D
E
G
K
K
T
S
A
S
D
V
T
N
Site 37
S537
R
D
E
G
K
K
T
S
A
S
D
V
T
N
I
Site 38
S539
E
G
K
K
T
S
A
S
D
V
T
N
I
Y
P
Site 39
T542
K
T
S
A
S
D
V
T
N
I
Y
P
G
D
A
Site 40
Y545
A
S
D
V
T
N
I
Y
P
G
D
A
G
K
A
Site 41
S574
E
K
G
E
V
G
K
S
W
D
S
W
S
D
S
Site 42
S577
E
V
G
K
S
W
D
S
W
S
D
S
E
E
E
Site 43
S579
G
K
S
W
D
S
W
S
D
S
E
E
E
F
F
Site 44
S581
S
W
D
S
W
S
D
S
E
E
E
F
F
E
C
Site 45
S590
E
E
F
F
E
C
L
S
D
T
E
E
L
K
G
Site 46
T592
F
F
E
C
L
S
D
T
E
E
L
K
G
N
G
Site 47
S602
L
K
G
N
G
Q
E
S
G
K
K
G
G
P
K
Site 48
Y621
L
R
P
E
G
R
L
Y
Q
H
G
K
L
T
L
Site 49
Y636
L
H
N
G
E
P
L
Y
I
P
V
T
Q
E
P
Site 50
T640
E
P
L
Y
I
P
V
T
Q
E
P
A
P
M
T
Site 51
S655
E
D
L
L
E
E
Q
S
E
V
L
A
K
L
G
Site 52
S664
V
L
A
K
L
G
T
S
A
E
G
A
H
L
R
Site 53
S676
H
L
R
A
R
M
Q
S
A
C
L
L
S
D
M
Site 54
S685
C
L
L
S
D
M
E
S
F
K
A
A
N
P
G
Site 55
S694
K
A
A
N
P
G
C
S
L
E
D
F
V
R
W
Site 56
Y702
L
E
D
F
V
R
W
Y
S
P
R
D
Y
I
E
Site 57
S703
E
D
F
V
R
W
Y
S
P
R
D
Y
I
E
E
Site 58
Y707
R
W
Y
S
P
R
D
Y
I
E
E
E
V
I
D
Site 59
T758
Q
R
R
L
F
D
D
T
R
E
A
E
K
V
L
Site 60
S797
L
K
V
K
E
E
E
S
L
E
N
I
S
S
V
Site 61
S803
E
S
L
E
N
I
S
S
V
K
K
I
I
K
Q
Site 62
S813
K
I
I
K
Q
I
I
S
H
S
S
K
V
L
H
Site 63
S815
I
K
Q
I
I
S
H
S
S
K
V
L
H
F
P
Site 64
S872
E
D
L
E
R
F
V
S
C
L
L
E
Q
P
E
Site 65
T883
E
Q
P
E
V
L
V
T
G
A
G
R
G
H
A
Site 66
T908
A
Q
R
A
A
A
M
T
P
P
E
E
E
L
K
Site 67
S919
E
E
L
K
R
M
G
S
P
E
E
R
R
Q
N
Site 68
S927
P
E
E
R
R
Q
N
S
V
S
D
F
P
P
P
Site 69
S929
E
R
R
Q
N
S
V
S
D
F
P
P
P
A
G
Site 70
T943
G
R
E
F
I
L
R
T
T
V
P
R
P
A
P
Site 71
T944
R
E
F
I
L
R
T
T
V
P
R
P
A
P
Y
Site 72
S952
V
P
R
P
A
P
Y
S
K
A
L
P
Q
R
M
Site 73
Y960
K
A
L
P
Q
R
M
Y
S
V
L
T
K
E
D
Site 74
S961
A
L
P
Q
R
M
Y
S
V
L
T
K
E
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation