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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LysRS
Full Name:
Lysyl-tRNA synthetase
Alias:
KARS2; Lysine tRNA ligase; Lysine--tRNA ligase
Type:
EC 6.1.1.6; Ligase
Mass (Da):
68048
Number AA:
597
UniProt ID:
Q15046
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005759
GO:0005625
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004824
GO:0003676
PhosphoSite+
KinaseNET
Biological Process:
GO:0006430
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
A
E
V
K
V
D
G
S
E
P
K
L
S
K
N
Site 2
S19
D
G
S
E
P
K
L
S
K
N
E
L
K
R
R
Site 3
S44
E
A
K
Q
K
E
L
S
E
K
Q
L
S
Q
A
Site 4
S49
E
L
S
E
K
Q
L
S
Q
A
T
A
A
A
T
Site 5
T52
E
K
Q
L
S
Q
A
T
A
A
A
T
N
H
T
Site 6
S70
G
V
G
P
E
E
E
S
V
D
P
N
Q
Y
Y
Site 7
Y76
E
S
V
D
P
N
Q
Y
Y
K
I
R
S
Q
A
Site 8
Y77
S
V
D
P
N
Q
Y
Y
K
I
R
S
Q
A
I
Site 9
Y95
K
V
N
G
E
D
P
Y
P
H
K
F
H
V
D
Site 10
Y112
L
T
D
F
I
Q
K
Y
S
H
L
Q
P
G
D
Site 11
S138
R
I
H
A
K
R
A
S
G
G
K
L
I
F
Y
Site 12
Y145
S
G
G
K
L
I
F
Y
D
L
R
G
E
G
V
Site 13
Y163
V
M
A
N
S
R
N
Y
K
S
E
E
E
F
I
Site 14
S165
A
N
S
R
N
Y
K
S
E
E
E
F
I
H
I
Site 15
S207
P
Y
E
I
T
L
L
S
P
C
L
H
M
L
P
Site 16
T225
F
G
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
Site 17
Y227
L
K
D
K
E
T
R
Y
R
Q
R
Y
L
D
L
Site 18
Y231
E
T
R
Y
R
Q
R
Y
L
D
L
I
L
N
D
Site 19
T252
I
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
Site 20
Y253
I
R
S
K
I
I
T
Y
I
R
S
F
L
D
E
Site 21
Y295
N
E
L
D
M
N
L
Y
M
R
I
A
P
E
L
Site 22
Y316
V
G
G
I
D
R
V
Y
E
I
G
R
Q
F
R
Site 23
T330
R
N
E
G
I
D
L
T
H
N
P
E
F
T
T
Site 24
Y347
F
Y
M
A
Y
A
D
Y
H
D
L
M
E
I
T
Site 25
T366
S
G
M
V
K
H
I
T
G
S
Y
K
V
T
Y
Site 26
T372
I
T
G
S
Y
K
V
T
Y
H
P
D
G
P
E
Site 27
Y373
T
G
S
Y
K
V
T
Y
H
P
D
G
P
E
G
Site 28
Y383
D
G
P
E
G
Q
A
Y
D
V
D
F
T
P
P
Site 29
T388
Q
A
Y
D
V
D
F
T
P
P
F
R
R
I
N
Site 30
T411
L
G
M
K
L
P
E
T
N
L
F
E
T
E
E
Site 31
T439
V
E
C
P
P
P
R
T
T
A
R
L
L
D
K
Site 32
T440
E
C
P
P
P
R
T
T
A
R
L
L
D
K
L
Site 33
S478
P
L
A
K
W
H
R
S
K
E
G
L
T
E
R
Site 34
T483
H
R
S
K
E
G
L
T
E
R
F
E
L
F
V
Site 35
T584
D
K
K
E
N
V
A
T
T
D
T
L
E
S
T
Site 36
T587
E
N
V
A
T
T
D
T
L
E
S
T
T
V
G
Site 37
S590
A
T
T
D
T
L
E
S
T
T
V
G
T
S
V
Site 38
T591
T
T
D
T
L
E
S
T
T
V
G
T
S
V
_
Site 39
T592
T
D
T
L
E
S
T
T
V
G
T
S
V
_
_
Site 40
S596
E
S
T
T
V
G
T
S
V
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation