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Updated November 2019
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Protein Info
Short Name:
SETDB1
Full Name:
Histone-lysine N-methyltransferase SETDB1
Alias:
ERG-associated protein with SET domain; ESET; H3-K9-HMTase 4; Histone H3-K9 methyltransferase 4; KG1T; KIAA0067; KMT1E; SET domain bifurcated 1; SET domain, bifurcated 1; SETB1
Type:
Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; Methyltransferase
Mass (Da):
143157
Number AA:
1291
UniProt ID:
Q15047
International Prot ID:
IPI00018321
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005694
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0018024
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0016568
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S86
D
Q
L
F
D
D
A
S
R
A
V
T
N
C
E
Site 2
T90
D
D
A
S
R
A
V
T
N
C
E
S
L
V
K
Site 3
S94
R
A
V
T
N
C
E
S
L
V
K
D
F
Y
S
Site 4
Y100
E
S
L
V
K
D
F
Y
S
K
L
G
L
Q
Y
Site 5
S101
S
L
V
K
D
F
Y
S
K
L
G
L
Q
Y
R
Site 6
Y107
Y
S
K
L
G
L
Q
Y
R
D
S
S
S
E
D
Site 7
S110
L
G
L
Q
Y
R
D
S
S
S
E
D
E
S
S
Site 8
S111
G
L
Q
Y
R
D
S
S
S
E
D
E
S
S
R
Site 9
S112
L
Q
Y
R
D
S
S
S
E
D
E
S
S
R
P
Site 10
S116
D
S
S
S
E
D
E
S
S
R
P
T
E
I
I
Site 11
S117
S
S
S
E
D
E
S
S
R
P
T
E
I
I
E
Site 12
T120
E
D
E
S
S
R
P
T
E
I
I
E
I
P
D
Site 13
S134
D
E
D
D
D
V
L
S
I
D
S
G
D
A
G
Site 14
S137
D
D
V
L
S
I
D
S
G
D
A
G
S
R
T
Site 15
S142
I
D
S
G
D
A
G
S
R
T
P
K
D
Q
K
Site 16
T144
S
G
D
A
G
S
R
T
P
K
D
Q
K
L
R
Site 17
S160
A
M
A
A
L
R
K
S
A
Q
D
V
Q
K
F
Site 18
S175
M
D
A
V
N
K
K
S
S
S
Q
D
L
H
K
Site 19
S177
A
V
N
K
K
S
S
S
Q
D
L
H
K
G
T
Site 20
T184
S
Q
D
L
H
K
G
T
L
S
Q
M
S
G
E
Site 21
S186
D
L
H
K
G
T
L
S
Q
M
S
G
E
L
S
Site 22
S189
K
G
T
L
S
Q
M
S
G
E
L
S
K
D
G
Site 23
S193
S
Q
M
S
G
E
L
S
K
D
G
D
L
I
V
Site 24
S201
K
D
G
D
L
I
V
S
M
R
I
L
G
K
K
Site 25
T212
L
G
K
K
R
T
K
T
W
H
K
G
T
L
I
Site 26
Y230
T
V
G
P
G
K
K
Y
K
V
K
F
D
N
K
Site 27
S240
K
F
D
N
K
G
K
S
L
L
S
G
N
H
I
Site 28
S243
N
K
G
K
S
L
L
S
G
N
H
I
A
Y
D
Site 29
Y249
L
S
G
N
H
I
A
Y
D
Y
H
P
P
A
D
Site 30
Y251
G
N
H
I
A
Y
D
Y
H
P
P
A
D
K
L
Site 31
Y259
H
P
P
A
D
K
L
Y
V
G
S
R
V
V
A
Site 32
Y268
G
S
R
V
V
A
K
Y
K
D
G
N
Q
V
W
Site 33
T284
Y
A
G
I
V
A
E
T
P
N
V
K
N
K
L
Site 34
S303
F
F
D
D
G
Y
A
S
Y
V
T
Q
S
E
L
Site 35
Y304
F
D
D
G
Y
A
S
Y
V
T
Q
S
E
L
Y
Site 36
Y311
Y
V
T
Q
S
E
L
Y
P
I
C
R
P
L
K
Site 37
T320
I
C
R
P
L
K
K
T
W
E
D
I
E
D
I
Site 38
Y336
C
R
D
F
I
E
E
Y
V
T
A
Y
P
N
R
Site 39
T338
D
F
I
E
E
Y
V
T
A
Y
P
N
R
P
M
Site 40
Y340
I
E
E
Y
V
T
A
Y
P
N
R
P
M
V
L
Site 41
S350
R
P
M
V
L
L
K
S
G
Q
L
I
K
T
E
Site 42
Y389
D
K
R
C
E
W
I
Y
R
G
S
T
R
L
E
Site 43
T393
E
W
I
Y
R
G
S
T
R
L
E
P
M
F
S
Site 44
S400
T
R
L
E
P
M
F
S
M
K
T
S
S
A
S
Site 45
T403
E
P
M
F
S
M
K
T
S
S
A
S
A
L
E
Site 46
S404
P
M
F
S
M
K
T
S
S
A
S
A
L
E
K
Site 47
S405
M
F
S
M
K
T
S
S
A
S
A
L
E
K
K
Site 48
S427
P
N
M
G
A
V
R
S
K
G
P
V
V
Q
Y
Site 49
Y434
S
K
G
P
V
V
Q
Y
T
Q
D
L
T
G
T
Site 50
T435
K
G
P
V
V
Q
Y
T
Q
D
L
T
G
T
G
Site 51
T439
V
Q
Y
T
Q
D
L
T
G
T
G
T
Q
F
K
Site 52
T454
P
V
E
P
P
Q
P
T
A
P
P
A
P
P
F
Site 53
S468
F
P
P
A
P
P
L
S
P
Q
A
G
D
S
D
Site 54
S474
L
S
P
Q
A
G
D
S
D
L
E
S
Q
L
A
Site 55
S478
A
G
D
S
D
L
E
S
Q
L
A
Q
S
R
K
Site 56
S491
R
K
Q
V
A
K
K
S
T
S
F
R
P
G
S
Site 57
S493
Q
V
A
K
K
S
T
S
F
R
P
G
S
V
G
Site 58
S498
S
T
S
F
R
P
G
S
V
G
S
G
H
S
S
Site 59
S501
F
R
P
G
S
V
G
S
G
H
S
S
P
T
S
Site 60
S504
G
S
V
G
S
G
H
S
S
P
T
S
P
A
L
Site 61
S505
S
V
G
S
G
H
S
S
P
T
S
P
A
L
S
Site 62
T507
G
S
G
H
S
S
P
T
S
P
A
L
S
E
N
Site 63
S508
S
G
H
S
S
P
T
S
P
A
L
S
E
N
V
Site 64
S512
S
P
T
S
P
A
L
S
E
N
V
S
G
G
K
Site 65
S516
P
A
L
S
E
N
V
S
G
G
K
P
G
I
N
Site 66
T525
G
K
P
G
I
N
Q
T
Y
R
S
P
L
G
S
Site 67
Y526
K
P
G
I
N
Q
T
Y
R
S
P
L
G
S
T
Site 68
S528
G
I
N
Q
T
Y
R
S
P
L
G
S
T
A
S
Site 69
S532
T
Y
R
S
P
L
G
S
T
A
S
A
P
A
P
Site 70
S563
E
R
A
P
A
E
P
S
Y
R
A
P
M
E
K
Site 71
Y564
R
A
P
A
E
P
S
Y
R
A
P
M
E
K
L
Site 72
T612
L
Y
D
F
R
R
M
T
A
R
R
R
V
N
R
Site 73
Y644
T
M
Q
E
I
E
R
Y
L
F
E
T
G
C
D
Site 74
Y673
V
D
R
K
F
Q
P
Y
K
P
F
Y
Y
I
L
Site 75
Y677
F
Q
P
Y
K
P
F
Y
Y
I
L
D
I
T
Y
Site 76
Y678
Q
P
Y
K
P
F
Y
Y
I
L
D
I
T
Y
G
Site 77
T683
F
Y
Y
I
L
D
I
T
Y
G
K
E
D
V
P
Site 78
Y684
Y
Y
I
L
D
I
T
Y
G
K
E
D
V
P
L
Site 79
S692
G
K
E
D
V
P
L
S
C
V
N
E
I
D
T
Site 80
T699
S
C
V
N
E
I
D
T
T
P
P
P
Q
V
A
Site 81
T700
C
V
N
E
I
D
T
T
P
P
P
Q
V
A
Y
Site 82
S708
P
P
P
Q
V
A
Y
S
K
E
R
I
P
G
K
Site 83
T754
T
I
Q
A
T
A
C
T
P
G
G
Q
I
N
P
Site 84
S763
G
G
Q
I
N
P
N
S
G
Y
Q
Y
K
R
L
Site 85
Y767
N
P
N
S
G
Y
Q
Y
K
R
L
E
E
C
L
Site 86
T776
R
L
E
E
C
L
P
T
G
V
Y
E
C
N
K
Site 87
Y779
E
C
L
P
T
G
V
Y
E
C
N
K
R
C
K
Site 88
T810
V
R
L
Q
L
F
K
T
Q
N
K
G
W
G
I
Site 89
T838
I
Y
A
G
K
I
L
T
D
D
F
A
D
K
E
Site 90
Y853
G
L
E
M
G
D
E
Y
F
A
N
L
D
H
I
Site 91
S862
A
N
L
D
H
I
E
S
V
E
N
F
K
E
G
Site 92
Y870
V
E
N
F
K
E
G
Y
E
S
D
A
P
C
S
Site 93
S872
N
F
K
E
G
Y
E
S
D
A
P
C
S
S
D
Site 94
S877
Y
E
S
D
A
P
C
S
S
D
S
S
G
V
D
Site 95
S878
E
S
D
A
P
C
S
S
D
S
S
G
V
D
L
Site 96
S880
D
A
P
C
S
S
D
S
S
G
V
D
L
K
D
Site 97
S881
A
P
C
S
S
D
S
S
G
V
D
L
K
D
Q
Site 98
S893
K
D
Q
E
D
G
N
S
G
T
E
D
P
E
E
Site 99
T895
Q
E
D
G
N
S
G
T
E
D
P
E
E
S
N
Site 100
S901
G
T
E
D
P
E
E
S
N
D
D
S
S
D
D
Site 101
S905
P
E
E
S
N
D
D
S
S
D
D
N
F
C
K
Site 102
S906
E
E
S
N
D
D
S
S
D
D
N
F
C
K
D
Site 103
S917
F
C
K
D
E
D
F
S
T
S
S
V
W
R
S
Site 104
T918
C
K
D
E
D
F
S
T
S
S
V
W
R
S
Y
Site 105
S919
K
D
E
D
F
S
T
S
S
V
W
R
S
Y
A
Site 106
S920
D
E
D
F
S
T
S
S
V
W
R
S
Y
A
T
Site 107
S924
S
T
S
S
V
W
R
S
Y
A
T
R
R
Q
T
Site 108
Y925
T
S
S
V
W
R
S
Y
A
T
R
R
Q
T
R
Site 109
T931
S
Y
A
T
R
R
Q
T
R
G
Q
K
E
N
G
Site 110
S940
G
Q
K
E
N
G
L
S
E
T
T
S
K
D
S
Site 111
T942
K
E
N
G
L
S
E
T
T
S
K
D
S
H
P
Site 112
S944
N
G
L
S
E
T
T
S
K
D
S
H
P
P
D
Site 113
S947
S
E
T
T
S
K
D
S
H
P
P
D
L
G
P
Site 114
S972
V
G
G
C
N
P
P
S
S
E
E
T
P
K
N
Site 115
S973
G
G
C
N
P
P
S
S
E
E
T
P
K
N
K
Site 116
T976
N
P
P
S
S
E
E
T
P
K
N
K
V
A
S
Site 117
S983
T
P
K
N
K
V
A
S
W
L
S
C
N
S
V
Site 118
S986
N
K
V
A
S
W
L
S
C
N
S
V
S
E
G
Site 119
S998
S
E
G
G
F
A
D
S
D
S
H
S
S
F
K
Site 120
S1000
G
G
F
A
D
S
D
S
H
S
S
F
K
T
N
Site 121
S1002
F
A
D
S
D
S
H
S
S
F
K
T
N
E
G
Site 122
S1003
A
D
S
D
S
H
S
S
F
K
T
N
E
G
G
Site 123
T1006
D
S
H
S
S
F
K
T
N
E
G
G
E
G
R
Site 124
S1025
R
M
E
A
E
K
A
S
T
S
G
L
G
I
K
Site 125
T1045
K
Q
A
K
K
E
D
T
D
D
R
N
K
M
S
Site 126
S1052
T
D
D
R
N
K
M
S
V
V
T
E
S
S
R
Site 127
S1057
K
M
S
V
V
T
E
S
S
R
N
Y
G
Y
N
Site 128
Y1061
V
T
E
S
S
R
N
Y
G
Y
N
P
S
P
V
Site 129
S1066
R
N
Y
G
Y
N
P
S
P
V
K
P
E
G
L
Site 130
S1078
E
G
L
R
R
P
P
S
K
T
S
M
H
Q
S
Site 131
T1080
L
R
R
P
P
S
K
T
S
M
H
Q
S
R
R
Site 132
S1081
R
R
P
P
S
K
T
S
M
H
Q
S
R
R
L
Site 133
S1085
S
K
T
S
M
H
Q
S
R
R
L
M
A
S
A
Site 134
S1091
Q
S
R
R
L
M
A
S
A
Q
S
N
P
D
D
Site 135
T1101
S
N
P
D
D
V
L
T
L
S
S
S
T
E
S
Site 136
S1103
P
D
D
V
L
T
L
S
S
S
T
E
S
E
G
Site 137
S1104
D
D
V
L
T
L
S
S
S
T
E
S
E
G
E
Site 138
S1105
D
V
L
T
L
S
S
S
T
E
S
E
G
E
S
Site 139
T1106
V
L
T
L
S
S
S
T
E
S
E
G
E
S
G
Site 140
S1108
T
L
S
S
S
T
E
S
E
G
E
S
G
T
S
Site 141
S1112
S
T
E
S
E
G
E
S
G
T
S
R
K
P
T
Site 142
S1115
S
E
G
E
S
G
T
S
R
K
P
T
A
G
Q
Site 143
T1119
S
G
T
S
R
K
P
T
A
G
Q
T
S
A
T
Site 144
T1123
R
K
P
T
A
G
Q
T
S
A
T
A
V
D
S
Site 145
T1126
T
A
G
Q
T
S
A
T
A
V
D
S
D
D
I
Site 146
S1130
T
S
A
T
A
V
D
S
D
D
I
Q
T
I
S
Site 147
T1135
V
D
S
D
D
I
Q
T
I
S
S
G
S
E
G
Site 148
S1137
S
D
D
I
Q
T
I
S
S
G
S
E
G
D
D
Site 149
S1138
D
D
I
Q
T
I
S
S
G
S
E
G
D
D
F
Site 150
S1140
I
Q
T
I
S
S
G
S
E
G
D
D
F
E
D
Site 151
S1163
K
R
Q
V
A
V
K
S
T
R
G
F
A
L
K
Site 152
S1171
T
R
G
F
A
L
K
S
T
H
G
I
A
I
K
Site 153
S1179
T
H
G
I
A
I
K
S
T
N
M
A
S
V
D
Site 154
T1180
H
G
I
A
I
K
S
T
N
M
A
S
V
D
K
Site 155
S1184
I
K
S
T
N
M
A
S
V
D
K
G
E
S
A
Site 156
S1190
A
S
V
D
K
G
E
S
A
P
V
R
K
N
T
Site 157
T1197
S
A
P
V
R
K
N
T
R
Q
F
Y
D
G
E
Site 158
Y1201
R
K
N
T
R
Q
F
Y
D
G
E
E
S
C
Y
Site 159
Y1208
Y
D
G
E
E
S
C
Y
I
I
D
A
K
L
E
Site 160
Y1221
L
E
G
N
L
G
R
Y
L
N
H
S
C
S
P
Site 161
S1225
L
G
R
Y
L
N
H
S
C
S
P
N
L
F
V
Site 162
S1227
R
Y
L
N
H
S
C
S
P
N
L
F
V
Q
N
Site 163
T1259
S
K
R
I
R
A
G
T
E
L
T
W
D
Y
N
Site 164
Y1265
G
T
E
L
T
W
D
Y
N
Y
E
V
G
S
V
Site 165
Y1267
E
L
T
W
D
Y
N
Y
E
V
G
S
V
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation