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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF6
Full Name:
Rho guanine nucleotide exchange factor 6
Alias:
AlphaPIX; Alpha-Pix; ARH6; ARHG6; Cool2; COOL-2; KIAA0006; MRX46; PAK-interacting exchange factor alpha; PAK-interacting exchange factor, alpha; Rac/Cdc42 guanine exchange factor (GEF) 6; Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
87499
Number AA:
776
UniProt ID:
Q15052
International Prot ID:
IPI00014256
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005096
GO:0005089
PhosphoSite+
KinaseNET
Biological Process:
GO:0007254
GO:0006915
GO:0008624
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T23
V
L
E
S
P
K
K
T
I
C
D
P
E
E
F
Site 2
S33
D
P
E
E
F
L
K
S
S
L
K
N
G
V
V
Site 3
S34
P
E
E
F
L
K
S
S
L
K
N
G
V
V
L
Site 4
Y91
I
F
D
P
D
D
L
Y
S
G
V
N
F
S
K
Site 5
S92
F
D
P
D
D
L
Y
S
G
V
N
F
S
K
V
Site 6
S115
K
A
T
E
D
Q
L
S
E
R
P
C
G
R
S
Site 7
S122
S
E
R
P
C
G
R
S
S
S
L
S
A
A
N
Site 8
S123
E
R
P
C
G
R
S
S
S
L
S
A
A
N
T
Site 9
S124
R
P
C
G
R
S
S
S
L
S
A
A
N
T
S
Site 10
S126
C
G
R
S
S
S
L
S
A
A
N
T
S
Q
T
Site 11
T130
S
S
L
S
A
A
N
T
S
Q
T
N
P
Q
G
Site 12
S131
S
L
S
A
A
N
T
S
Q
T
N
P
Q
G
A
Site 13
T133
S
A
A
N
T
S
Q
T
N
P
Q
G
A
V
S
Site 14
S140
T
N
P
Q
G
A
V
S
S
T
V
S
G
L
Q
Site 15
S141
N
P
Q
G
A
V
S
S
T
V
S
G
L
Q
R
Site 16
T142
P
Q
G
A
V
S
S
T
V
S
G
L
Q
R
Q
Site 17
S144
G
A
V
S
S
T
V
S
G
L
Q
R
Q
S
K
Site 18
S150
V
S
G
L
Q
R
Q
S
K
T
V
E
M
T
E
Site 19
T152
G
L
Q
R
Q
S
K
T
V
E
M
T
E
N
G
Site 20
T156
Q
S
K
T
V
E
M
T
E
N
G
S
H
Q
L
Site 21
S180
Q
T
N
E
D
E
L
S
V
C
K
G
D
I
I
Site 22
Y188
V
C
K
G
D
I
I
Y
V
T
R
V
E
E
G
Site 23
T190
K
G
D
I
I
Y
V
T
R
V
E
E
G
G
W
Site 24
Y213
T
G
W
F
P
S
N
Y
V
R
E
I
K
S
S
Site 25
S219
N
Y
V
R
E
I
K
S
S
E
R
P
L
S
P
Site 26
S220
Y
V
R
E
I
K
S
S
E
R
P
L
S
P
K
Site 27
S225
K
S
S
E
R
P
L
S
P
K
A
V
K
G
F
Site 28
T238
G
F
E
T
A
P
L
T
K
N
Y
Y
T
V
V
Site 29
Y241
T
A
P
L
T
K
N
Y
Y
T
V
V
L
Q
N
Site 30
S262
E
Y
A
K
E
L
Q
S
L
L
V
T
Y
L
R
Site 31
S273
T
Y
L
R
P
L
Q
S
N
N
N
L
S
T
V
Site 32
S278
L
Q
S
N
N
N
L
S
T
V
E
V
T
S
L
Site 33
T279
Q
S
N
N
N
L
S
T
V
E
V
T
S
L
L
Site 34
Y334
F
K
S
M
Y
L
A
Y
C
A
N
H
P
S
A
Site 35
S349
V
N
V
L
T
Q
H
S
D
E
L
E
Q
F
M
Site 36
T385
M
R
L
E
K
Y
V
T
L
L
Q
E
L
E
R
Site 37
T397
L
E
R
H
M
E
D
T
H
P
D
H
Q
D
I
Site 38
S433
Q
L
E
L
Q
I
L
S
E
P
I
Q
A
W
E
Site 39
Y470
C
E
E
K
E
E
R
Y
L
M
L
F
S
N
V
Site 40
S482
S
N
V
L
I
M
L
S
A
S
P
R
M
S
G
Site 41
S484
V
L
I
M
L
S
A
S
P
R
M
S
G
F
I
Site 42
S488
L
S
A
S
P
R
M
S
G
F
I
Y
Q
G
K
Site 43
Y492
P
R
M
S
G
F
I
Y
Q
G
K
I
P
I
A
Site 44
T504
P
I
A
G
T
V
V
T
R
L
D
E
I
E
G
Site 45
T515
E
I
E
G
N
D
C
T
F
E
I
T
G
N
T
Site 46
S552
R
L
I
R
G
P
A
S
C
S
S
L
S
K
T
Site 47
S554
I
R
G
P
A
S
C
S
S
L
S
K
T
S
S
Site 48
S555
R
G
P
A
S
C
S
S
L
S
K
T
S
S
S
Site 49
S557
P
A
S
C
S
S
L
S
K
T
S
S
S
S
C
Site 50
T559
S
C
S
S
L
S
K
T
S
S
S
S
C
S
A
Site 51
S560
C
S
S
L
S
K
T
S
S
S
S
C
S
A
H
Site 52
S561
S
S
L
S
K
T
S
S
S
S
C
S
A
H
S
Site 53
S562
S
L
S
K
T
S
S
S
S
C
S
A
H
S
S
Site 54
S563
L
S
K
T
S
S
S
S
C
S
A
H
S
S
F
Site 55
S565
K
T
S
S
S
S
C
S
A
H
S
S
F
S
S
Site 56
S568
S
S
S
C
S
A
H
S
S
F
S
S
T
G
Q
Site 57
S569
S
S
C
S
A
H
S
S
F
S
S
T
G
Q
P
Site 58
S571
C
S
A
H
S
S
F
S
S
T
G
Q
P
R
G
Site 59
S572
S
A
H
S
S
F
S
S
T
G
Q
P
R
G
P
Site 60
T573
A
H
S
S
F
S
S
T
G
Q
P
R
G
P
L
Site 61
S590
P
Q
I
I
K
P
W
S
L
S
C
L
R
P
A
Site 62
S592
I
I
K
P
W
S
L
S
C
L
R
P
A
P
P
Site 63
S603
P
A
P
P
L
R
P
S
A
A
L
G
Y
K
E
Site 64
Y608
R
P
S
A
A
L
G
Y
K
E
R
M
S
Y
I
Site 65
S613
L
G
Y
K
E
R
M
S
Y
I
L
K
E
S
S
Site 66
Y614
G
Y
K
E
R
M
S
Y
I
L
K
E
S
S
K
Site 67
S620
S
Y
I
L
K
E
S
S
K
S
P
K
T
M
K
Site 68
S622
I
L
K
E
S
S
K
S
P
K
T
M
K
K
F
Site 69
T625
E
S
S
K
S
P
K
T
M
K
K
F
L
H
K
Site 70
T635
K
F
L
H
K
R
K
T
E
R
K
P
S
E
E
Site 71
S640
R
K
T
E
R
K
P
S
E
E
E
Y
V
I
R
Site 72
Y644
R
K
P
S
E
E
E
Y
V
I
R
K
S
T
A
Site 73
S649
E
E
Y
V
I
R
K
S
T
A
A
L
E
E
D
Site 74
T650
E
Y
V
I
R
K
S
T
A
A
L
E
E
D
A
Site 75
Y666
I
L
K
V
I
E
A
Y
C
T
S
A
N
F
Q
Site 76
T668
K
V
I
E
A
Y
C
T
S
A
N
F
Q
Q
G
Site 77
S678
N
F
Q
Q
G
H
G
S
S
T
R
K
D
S
I
Site 78
S679
F
Q
Q
G
H
G
S
S
T
R
K
D
S
I
P
Site 79
S684
G
S
S
T
R
K
D
S
I
P
Q
V
L
L
P
Site 80
T701
E
K
L
I
I
E
E
T
R
S
N
G
Q
T
I
Site 81
S703
L
I
I
E
E
T
R
S
N
G
Q
T
I
M
E
Site 82
T707
E
T
R
S
N
G
Q
T
I
M
E
E
K
S
L
Site 83
S713
Q
T
I
M
E
E
K
S
L
V
D
T
V
Y
A
Site 84
T717
E
E
K
S
L
V
D
T
V
Y
A
L
K
D
E
Site 85
Y719
K
S
L
V
D
T
V
Y
A
L
K
D
E
V
R
Site 86
S745
C
L
E
E
E
L
K
S
R
R
D
L
E
K
L
Site 87
T760
V
R
R
L
L
K
Q
T
D
E
C
I
R
G
E
Site 88
S768
D
E
C
I
R
G
E
S
S
S
K
T
S
I
L
Site 89
S769
E
C
I
R
G
E
S
S
S
K
T
S
I
L
P
Site 90
S770
C
I
R
G
E
S
S
S
K
T
S
I
L
P
_
Site 91
T772
R
G
E
S
S
S
K
T
S
I
L
P
_
_
_
Site 92
S773
G
E
S
S
S
K
T
S
I
L
P
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation