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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
POLD3
Full Name:
DNA polymerase delta subunit 3
Alias:
DNA polymerase delta subunit p66; DPOD3; KIAA0039; P66; P68; polymerase (DNA-directed) delta 3, accessory subunit
Type:
Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; DNA replication
Mass (Da):
51400
Number AA:
466
UniProt ID:
Q15054
International Prot ID:
IPI00394926
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0043625
GO:0005654
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0003887
GO:0005515
GO:0003824
PhosphoSite+
KinaseNET
Biological Process:
GO:0000731
GO:0006298
GO:0006297
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y42
N
Q
A
K
Q
M
L
Y
D
Y
V
E
R
K
R
Site 2
Y44
A
K
Q
M
L
Y
D
Y
V
E
R
K
R
K
E
Site 3
S53
E
R
K
R
K
E
N
S
G
A
Q
L
H
V
T
Site 4
S90
D
K
L
E
A
V
K
S
K
L
A
V
T
A
S
Site 5
T95
V
K
S
K
L
A
V
T
A
S
I
H
V
Y
S
Site 6
Y101
V
T
A
S
I
H
V
Y
S
I
Q
K
A
M
L
Site 7
S111
Q
K
A
M
L
K
D
S
G
P
L
F
N
T
D
Site 8
T117
D
S
G
P
L
F
N
T
D
Y
D
I
L
K
S
Site 9
Y119
G
P
L
F
N
T
D
Y
D
I
L
K
S
N
L
Site 10
S148
V
P
R
A
P
A
E
S
S
S
S
S
K
K
F
Site 11
S149
P
R
A
P
A
E
S
S
S
S
S
K
K
F
E
Site 12
S150
R
A
P
A
E
S
S
S
S
S
K
K
F
E
Q
Site 13
S151
A
P
A
E
S
S
S
S
S
K
K
F
E
Q
S
Site 14
S152
P
A
E
S
S
S
S
S
K
K
F
E
Q
S
H
Site 15
S158
S
S
K
K
F
E
Q
S
H
L
H
M
S
S
E
Site 16
T173
T
Q
A
N
N
E
L
T
T
N
G
H
G
P
P
Site 17
S182
N
G
H
G
P
P
A
S
K
Q
V
S
Q
Q
P
Site 18
S186
P
P
A
S
K
Q
V
S
Q
Q
P
K
G
I
M
Site 19
T207
A
A
A
K
T
Q
E
T
N
K
E
T
K
T
E
Site 20
S236
P
G
K
G
N
M
M
S
N
F
F
G
K
A
A
Site 21
S253
K
F
K
V
N
L
D
S
E
Q
A
V
K
E
E
Site 22
T267
E
K
I
V
E
Q
P
T
V
S
V
T
E
P
K
Site 23
T277
V
T
E
P
K
L
A
T
P
A
G
L
K
K
S
Site 24
S284
T
P
A
G
L
K
K
S
S
K
K
A
E
P
V
Site 25
S307
R
G
K
R
V
A
L
S
D
D
E
T
K
E
T
Site 26
T311
V
A
L
S
D
D
E
T
K
E
T
E
N
M
R
Site 27
T314
S
D
D
E
T
K
E
T
E
N
M
R
K
K
R
Site 28
S329
R
R
I
K
L
P
E
S
D
S
S
E
D
E
V
Site 29
S331
I
K
L
P
E
S
D
S
S
E
D
E
V
F
P
Site 30
S332
K
L
P
E
S
D
S
S
E
D
E
V
F
P
D
Site 31
S340
E
D
E
V
F
P
D
S
P
G
A
Y
E
A
E
Site 32
Y344
F
P
D
S
P
G
A
Y
E
A
E
S
P
S
P
Site 33
S348
P
G
A
Y
E
A
E
S
P
S
P
P
P
P
P
Site 34
S350
A
Y
E
A
E
S
P
S
P
P
P
P
P
S
P
Site 35
S356
P
S
P
P
P
P
P
S
P
P
L
E
P
V
P
Site 36
T365
P
L
E
P
V
P
K
T
E
P
E
P
P
S
V
Site 37
S371
K
T
E
P
E
P
P
S
V
K
S
S
S
G
E
Site 38
S374
P
E
P
P
S
V
K
S
S
S
G
E
N
K
R
Site 39
S375
E
P
P
S
V
K
S
S
S
G
E
N
K
R
K
Site 40
S376
P
P
S
V
K
S
S
S
G
E
N
K
R
K
R
Site 41
S389
K
R
K
R
V
L
K
S
K
T
Y
L
D
G
E
Site 42
T391
K
R
V
L
K
S
K
T
Y
L
D
G
E
G
C
Site 43
Y392
R
V
L
K
S
K
T
Y
L
D
G
E
G
C
I
Site 44
Y405
C
I
V
T
E
K
V
Y
E
S
E
S
C
T
D
Site 45
S407
V
T
E
K
V
Y
E
S
E
S
C
T
D
S
E
Site 46
S409
E
K
V
Y
E
S
E
S
C
T
D
S
E
E
E
Site 47
T411
V
Y
E
S
E
S
C
T
D
S
E
E
E
L
N
Site 48
S413
E
S
E
S
C
T
D
S
E
E
E
L
N
M
K
Site 49
S422
E
E
L
N
M
K
T
S
S
V
H
R
P
P
A
Site 50
S423
E
L
N
M
K
T
S
S
V
H
R
P
P
A
M
Site 51
T431
V
H
R
P
P
A
M
T
V
K
K
E
P
R
E
Site 52
S458
G
K
A
N
R
Q
V
S
I
T
G
F
F
Q
R
Site 53
T460
A
N
R
Q
V
S
I
T
G
F
F
Q
R
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation