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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACAP2
Full Name:
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Alias:
ARFGAP with coiled-coil, ANK repeat and PH domain-containing protein 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; CEB2; CENB2; Centaurin-beta 2; CENTB2; Cnt-b2; KIAA0041
Type:
GTPase-activating protein for G protein
Mass (Da):
88029
Number AA:
778
UniProt ID:
Q15057
International Prot ID:
IPI00014264
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008060
GO:0008270
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0032312
GO:0032318
GO:0043087
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
F
E
E
C
L
K
D
S
P
R
F
R
A
A
L
Site 2
Y69
G
I
R
D
L
A
Q
Y
S
S
N
D
A
V
V
Site 3
S71
R
D
L
A
Q
Y
S
S
N
D
A
V
V
E
T
Site 4
S79
N
D
A
V
V
E
T
S
L
T
K
F
S
D
S
Site 5
T81
A
V
V
E
T
S
L
T
K
F
S
D
S
L
Q
Site 6
S84
E
T
S
L
T
K
F
S
D
S
L
Q
E
M
I
Site 7
S86
S
L
T
K
F
S
D
S
L
Q
E
M
I
N
F
Site 8
T101
H
T
I
L
F
D
Q
T
Q
R
S
I
K
A
Q
Site 9
S104
L
F
D
Q
T
Q
R
S
I
K
A
Q
L
Q
N
Site 10
S131
K
K
Q
F
E
K
V
S
E
E
K
E
N
A
L
Site 11
S182
L
Q
I
N
V
L
Q
S
K
R
R
S
E
I
L
Site 12
S186
V
L
Q
S
K
R
R
S
E
I
L
K
S
M
L
Site 13
S191
R
R
S
E
I
L
K
S
M
L
S
F
M
Y
A
Site 14
Y197
K
S
M
L
S
F
M
Y
A
H
L
A
F
F
H
Site 15
Y216
L
F
S
E
L
G
P
Y
M
K
D
L
G
A
Q
Site 16
S251
T
I
Q
Q
K
D
F
S
S
D
D
S
K
L
E
Site 17
S252
I
Q
Q
K
D
F
S
S
D
D
S
K
L
E
Y
Site 18
S255
K
D
F
S
S
D
D
S
K
L
E
Y
N
V
D
Site 19
Y259
S
D
D
S
K
L
E
Y
N
V
D
A
A
N
G
Site 20
Y272
N
G
I
V
M
E
G
Y
L
F
K
R
A
S
N
Site 21
Y298
I
Q
N
N
Q
L
V
Y
Q
K
K
F
K
D
N
Site 22
T307
K
K
F
K
D
N
P
T
V
V
V
E
D
L
R
Site 23
T317
V
E
D
L
R
L
C
T
V
K
H
C
E
D
I
Site 24
S338
E
V
V
S
P
T
K
S
C
M
L
Q
A
D
S
Site 25
T358
A
W
I
K
A
V
Q
T
S
I
A
T
A
Y
R
Site 26
S378
S
E
K
L
D
K
K
S
S
P
S
T
G
S
L
Site 27
S379
E
K
L
D
K
K
S
S
P
S
T
G
S
L
D
Site 28
S381
L
D
K
K
S
S
P
S
T
G
S
L
D
S
G
Site 29
T382
D
K
K
S
S
P
S
T
G
S
L
D
S
G
N
Site 30
S384
K
S
S
P
S
T
G
S
L
D
S
G
N
E
S
Site 31
S387
P
S
T
G
S
L
D
S
G
N
E
S
K
E
K
Site 32
S391
S
L
D
S
G
N
E
S
K
E
K
L
L
K
G
Site 33
S443
E
C
S
G
I
H
R
S
L
G
V
H
F
S
K
Site 34
S453
V
H
F
S
K
V
R
S
L
T
L
D
T
W
E
Site 35
T455
F
S
K
V
R
S
L
T
L
D
T
W
E
P
E
Site 36
T458
V
R
S
L
T
L
D
T
W
E
P
E
L
L
K
Site 37
Y479
N
D
V
I
N
R
V
Y
E
A
N
V
E
K
M
Site 38
Y502
Q
R
Q
E
K
E
A
Y
I
R
A
K
Y
V
E
Site 39
Y507
E
A
Y
I
R
A
K
Y
V
E
R
K
F
V
D
Site 40
Y516
E
R
K
F
V
D
K
Y
S
I
S
L
S
P
P
Site 41
S517
R
K
F
V
D
K
Y
S
I
S
L
S
P
P
E
Site 42
S519
F
V
D
K
Y
S
I
S
L
S
P
P
E
Q
Q
Site 43
S521
D
K
Y
S
I
S
L
S
P
P
E
Q
Q
K
K
Site 44
S533
Q
K
K
F
V
S
K
S
S
E
E
K
R
L
S
Site 45
S534
K
K
F
V
S
K
S
S
E
E
K
R
L
S
I
Site 46
S540
S
S
E
E
K
R
L
S
I
S
K
F
G
P
G
Site 47
S553
P
G
D
Q
V
R
A
S
A
Q
S
S
V
R
S
Site 48
S556
Q
V
R
A
S
A
Q
S
S
V
R
S
N
D
S
Site 49
S557
V
R
A
S
A
Q
S
S
V
R
S
N
D
S
G
Site 50
S560
S
A
Q
S
S
V
R
S
N
D
S
G
I
Q
Q
Site 51
S563
S
S
V
R
S
N
D
S
G
I
Q
Q
S
S
D
Site 52
S569
D
S
G
I
Q
Q
S
S
D
D
G
R
E
S
L
Site 53
S575
S
S
D
D
G
R
E
S
L
P
S
T
V
S
A
Site 54
S578
D
G
R
E
S
L
P
S
T
V
S
A
N
S
L
Site 55
T579
G
R
E
S
L
P
S
T
V
S
A
N
S
L
Y
Site 56
S581
E
S
L
P
S
T
V
S
A
N
S
L
Y
E
P
Site 57
S584
P
S
T
V
S
A
N
S
L
Y
E
P
E
G
E
Site 58
Y586
T
V
S
A
N
S
L
Y
E
P
E
G
E
R
Q
Site 59
S595
P
E
G
E
R
Q
D
S
S
M
F
L
D
S
K
Site 60
S596
E
G
E
R
Q
D
S
S
M
F
L
D
S
K
H
Site 61
S601
D
S
S
M
F
L
D
S
K
H
L
N
P
G
L
Site 62
Y611
L
N
P
G
L
Q
L
Y
R
A
S
Y
E
K
N
Site 63
S614
G
L
Q
L
Y
R
A
S
Y
E
K
N
L
P
K
Site 64
Y615
L
Q
L
Y
R
A
S
Y
E
K
N
L
P
K
M
Site 65
T643
N
S
E
E
N
K
A
T
P
L
I
Q
A
V
L
Site 66
T682
R
G
P
L
H
H
A
T
V
L
G
H
T
G
Q
Site 67
S712
E
E
G
K
D
P
L
S
I
A
V
E
A
A
N
Site 68
S738
M
N
E
E
M
R
E
S
E
G
L
Y
G
Q
P
Site 69
Y742
M
R
E
S
E
G
L
Y
G
Q
P
G
D
E
T
Site 70
T749
Y
G
Q
P
G
D
E
T
Y
Q
D
I
F
R
D
Site 71
Y750
G
Q
P
G
D
E
T
Y
Q
D
I
F
R
D
F
Site 72
S758
Q
D
I
F
R
D
F
S
Q
M
A
S
N
N
P
Site 73
S762
R
D
F
S
Q
M
A
S
N
N
P
E
K
L
N
Site 74
S775
L
N
R
F
Q
Q
D
S
Q
K
F
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation