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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
EEA1
Full Name:
Early endosome antigen 1
Alias:
Endosome-associated protein p162; ZFYVE2; Zinc finger FYVE domain-containing protein 2
Type:
Vesicle protein
Mass (Da):
162466
Number AA:
1411
UniProt ID:
Q15075
International Prot ID:
IPI00329536
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005769
GO:0019897
Uniprot
OncoNet
Molecular Function:
GO:0030742
GO:0005516
GO:0005545
PhosphoSite+
KinaseNET
Biological Process:
GO:0045022
GO:0016189
GO:0006906
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T9
L
R
R
I
L
Q
R
T
P
G
R
V
G
S
Q
Site 2
S15
R
T
P
G
R
V
G
S
Q
G
S
D
L
D
S
Site 3
S18
G
R
V
G
S
Q
G
S
D
L
D
S
S
A
T
Site 4
S22
S
Q
G
S
D
L
D
S
S
A
T
P
I
N
T
Site 5
S23
Q
G
S
D
L
D
S
S
A
T
P
I
N
T
V
Site 6
T25
S
D
L
D
S
S
A
T
P
I
N
T
V
D
V
Site 7
T29
S
S
A
T
P
I
N
T
V
D
V
N
N
E
S
Site 8
S38
D
V
N
N
E
S
S
S
E
G
F
I
C
P
Q
Site 9
S52
Q
C
M
K
S
L
G
S
A
D
E
L
F
K
H
Site 10
Y60
A
D
E
L
F
K
H
Y
E
A
V
H
D
A
G
Site 11
S70
V
H
D
A
G
N
D
S
G
H
G
G
E
S
N
Site 12
T86
A
L
K
R
D
D
V
T
L
L
R
Q
E
V
Q
Site 13
S98
E
V
Q
D
L
Q
A
S
L
K
E
E
K
W
Y
Site 14
Y105
S
L
K
E
E
K
W
Y
S
E
E
L
K
K
E
Site 15
S106
L
K
E
E
K
W
Y
S
E
E
L
K
K
E
L
Site 16
Y116
L
K
K
E
L
E
K
Y
Q
G
L
Q
Q
Q
E
Site 17
S133
P
D
G
L
V
T
D
S
S
A
E
L
Q
S
L
Site 18
S134
D
G
L
V
T
D
S
S
A
E
L
Q
S
L
E
Site 19
S139
D
S
S
A
E
L
Q
S
L
E
Q
Q
L
E
E
Site 20
T149
Q
Q
L
E
E
A
Q
T
E
N
F
N
I
K
Q
Site 21
S177
T
E
I
A
D
I
K
S
K
Y
D
E
E
R
S
Site 22
Y179
I
A
D
I
K
S
K
Y
D
E
E
R
S
L
R
Site 23
S184
S
K
Y
D
E
E
R
S
L
R
E
A
A
E
Q
Site 24
T197
E
Q
K
V
T
R
L
T
E
E
L
N
K
E
A
Site 25
T212
T
V
I
Q
D
L
K
T
E
L
L
Q
R
P
G
Site 26
T241
Q
T
L
M
D
N
M
T
L
E
R
E
R
E
S
Site 27
S248
T
L
E
R
E
R
E
S
E
K
L
K
D
E
C
Site 28
S260
D
E
C
K
K
L
Q
S
Q
Y
A
S
S
E
A
Site 29
S264
K
L
Q
S
Q
Y
A
S
S
E
A
T
I
S
Q
Site 30
T268
Q
Y
A
S
S
E
A
T
I
S
Q
L
R
S
E
Site 31
S270
A
S
S
E
A
T
I
S
Q
L
R
S
E
L
A
Site 32
S274
A
T
I
S
Q
L
R
S
E
L
A
K
G
P
Q
Site 33
Y286
G
P
Q
E
V
A
V
Y
V
Q
E
L
Q
K
L
Site 34
S295
Q
E
L
Q
K
L
K
S
S
V
N
E
L
T
Q
Site 35
S296
E
L
Q
K
L
K
S
S
V
N
E
L
T
Q
K
Site 36
T301
K
S
S
V
N
E
L
T
Q
K
N
Q
T
L
T
Site 37
Y318
L
L
K
K
E
Q
D
Y
T
K
L
E
E
K
H
Site 38
T319
L
K
K
E
Q
D
Y
T
K
L
E
E
K
H
N
Site 39
S329
E
E
K
H
N
E
E
S
V
S
K
K
N
I
Q
Site 40
S354
Q
Q
L
Q
S
R
L
S
A
S
E
T
S
L
H
Site 41
S356
L
Q
S
R
L
S
A
S
E
T
S
L
H
R
I
Site 42
T358
S
R
L
S
A
S
E
T
S
L
H
R
I
H
V
Site 43
S382
Q
K
L
K
E
E
L
S
E
V
E
T
K
Y
Q
Site 44
Y388
L
S
E
V
E
T
K
Y
Q
H
L
K
A
E
F
Site 45
S414
Q
H
G
L
Q
L
Q
S
E
I
N
Q
L
H
S
Site 46
T426
L
H
S
K
L
L
E
T
E
R
Q
L
G
E
A
Site 47
S444
L
K
E
Q
R
Q
L
S
S
E
K
L
M
D
K
Site 48
S463
A
D
L
Q
L
K
L
S
R
L
E
E
Q
L
K
Site 49
T474
E
Q
L
K
E
K
V
T
N
S
T
E
L
Q
H
Site 50
T486
L
Q
H
Q
L
D
K
T
K
Q
Q
H
Q
E
Q
Site 51
S499
E
Q
Q
A
L
Q
Q
S
T
T
A
K
L
R
E
Site 52
S535
L
E
A
L
L
Q
K
S
K
E
N
I
S
L
L
Site 53
S540
Q
K
S
K
E
N
I
S
L
L
E
K
E
R
E
Site 54
Y550
E
K
E
R
E
D
L
Y
A
K
I
Q
A
G
E
Site 55
T572
Q
L
Q
E
K
N
H
T
L
Q
E
Q
V
T
Q
Site 56
S618
A
A
Q
D
R
V
L
S
L
E
T
S
V
N
E
Site 57
T621
D
R
V
L
S
L
E
T
S
V
N
E
L
N
S
Site 58
S622
R
V
L
S
L
E
T
S
V
N
E
L
N
S
Q
Site 59
S628
T
S
V
N
E
L
N
S
Q
L
N
E
S
K
E
Site 60
S633
L
N
S
Q
L
N
E
S
K
E
K
V
S
Q
L
Site 61
T659
L
S
A
E
A
A
K
T
A
Q
R
A
D
L
Q
Site 62
S705
Q
D
K
Q
E
H
C
S
Q
L
E
S
H
L
K
Site 63
S709
E
H
C
S
Q
L
E
S
H
L
K
E
Y
K
E
Site 64
Y714
L
E
S
H
L
K
E
Y
K
E
K
Y
L
S
L
Site 65
Y718
L
K
E
Y
K
E
K
Y
L
S
L
E
Q
K
T
Site 66
S720
E
Y
K
E
K
Y
L
S
L
E
Q
K
T
E
E
Site 67
S739
I
K
K
L
E
A
D
S
L
E
V
K
A
S
K
Site 68
S745
D
S
L
E
V
K
A
S
K
E
Q
A
L
Q
D
Site 69
T761
Q
Q
Q
R
Q
L
N
T
D
L
E
L
R
A
T
Site 70
T768
T
D
L
E
L
R
A
T
E
L
S
K
Q
L
E
Site 71
S771
E
L
R
A
T
E
L
S
K
Q
L
E
M
E
K
Site 72
S783
M
E
K
E
I
V
S
S
T
R
L
D
L
Q
K
Site 73
S792
R
L
D
L
Q
K
K
S
E
A
L
E
S
I
K
Site 74
S797
K
K
S
E
A
L
E
S
I
K
Q
K
L
T
K
Site 75
T818
I
L
K
Q
D
F
E
T
L
S
Q
E
T
K
I
Site 76
S820
K
Q
D
F
E
T
L
S
Q
E
T
K
I
Q
H
Site 77
T836
E
L
N
N
R
I
Q
T
T
V
T
E
L
Q
K
Site 78
T837
L
N
N
R
I
Q
T
T
V
T
E
L
Q
K
V
Site 79
T839
N
R
I
Q
T
T
V
T
E
L
Q
K
V
K
M
Site 80
T853
M
E
K
E
A
L
M
T
E
L
S
T
V
K
D
Site 81
S856
E
A
L
M
T
E
L
S
T
V
K
D
K
L
S
Site 82
T857
A
L
M
T
E
L
S
T
V
K
D
K
L
S
K
Site 83
S863
S
T
V
K
D
K
L
S
K
V
S
D
S
L
K
Site 84
S866
K
D
K
L
S
K
V
S
D
S
L
K
N
S
K
Site 85
S868
K
L
S
K
V
S
D
S
L
K
N
S
K
S
E
Site 86
S872
V
S
D
S
L
K
N
S
K
S
E
F
E
K
E
Site 87
S874
D
S
L
K
N
S
K
S
E
F
E
K
E
N
Q
Site 88
T893
A
I
L
D
L
E
K
T
C
K
E
L
K
H
Q
Site 89
S918
E
Q
K
E
L
K
K
S
L
E
K
E
K
E
A
Site 90
S926
L
E
K
E
K
E
A
S
H
Q
L
K
L
E
L
Site 91
S967
N
I
N
E
L
K
Q
S
S
E
Q
K
K
K
Q
Site 92
S1024
L
Q
N
N
Y
E
K
S
Q
E
T
F
K
Q
L
Site 93
T1027
N
Y
E
K
S
Q
E
T
F
K
Q
L
Q
S
D
Site 94
S1033
E
T
F
K
Q
L
Q
S
D
F
Y
G
R
E
S
Site 95
Y1036
K
Q
L
Q
S
D
F
Y
G
R
E
S
E
L
L
Site 96
S1040
S
D
F
Y
G
R
E
S
E
L
L
A
T
R
Q
Site 97
T1045
R
E
S
E
L
L
A
T
R
Q
D
L
K
S
V
Site 98
S1051
A
T
R
Q
D
L
K
S
V
E
E
K
L
S
L
Site 99
S1057
K
S
V
E
E
K
L
S
L
A
Q
E
D
L
I
Site 100
S1065
L
A
Q
E
D
L
I
S
N
R
N
Q
I
G
N
Site 101
S1113
Q
D
I
Q
K
E
K
S
L
K
E
K
E
L
V
Site 102
S1124
K
E
L
V
N
E
K
S
K
L
A
E
I
E
E
Site 103
T1141
C
R
Q
E
K
E
I
T
K
L
N
E
E
L
K
Site 104
S1149
K
L
N
E
E
L
K
S
H
K
L
E
S
I
K
Site 105
T1159
L
E
S
I
K
E
I
T
N
L
K
D
A
K
Q
Site 106
S1181
E
L
Q
G
K
A
D
S
L
K
A
A
V
E
Q
Site 107
S1220
E
K
E
A
K
L
H
S
E
I
K
E
K
E
V
Site 108
T1240
E
E
N
E
A
K
L
T
M
Q
I
T
A
L
N
Site 109
T1252
A
L
N
E
N
L
G
T
V
K
K
E
W
Q
S
Site 110
S1259
T
V
K
K
E
W
Q
S
S
Q
R
R
V
S
E
Site 111
S1260
V
K
K
E
W
Q
S
S
Q
R
R
V
S
E
L
Site 112
S1265
Q
S
S
Q
R
R
V
S
E
L
E
K
Q
T
D
Site 113
T1311
G
E
I
E
K
L
Q
T
K
V
L
E
L
Q
R
Site 114
T1323
L
Q
R
K
L
D
N
T
T
A
A
V
Q
E
L
Site 115
T1392
C
S
A
K
N
A
L
T
P
S
S
K
K
P
V
Site 116
S1395
K
N
A
L
T
P
S
S
K
K
P
V
R
V
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation