KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PLCL1
Full Name:
Inactive phospholipase C-like protein 1
Alias:
Phospholipase C related, but catalytically inactive protein; Phospholipase C-like 1; PLCE; PLCL; PLC-L; PRIP; PRIP-1
Type:
Enzyme, phospholipid phospholipase (inactive)
Mass (Da):
122672
Number AA:
1096
UniProt ID:
Q15111
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0004435
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S47
G
R
M
R
D
R
R
S
G
V
A
L
P
G
A
Site 2
T57
A
L
P
G
A
A
G
T
P
A
D
S
E
A
G
Site 3
T72
L
L
E
A
A
R
A
T
P
R
R
S
S
I
I
Site 4
S76
A
R
A
T
P
R
R
S
S
I
I
K
D
P
S
Site 5
S77
R
A
T
P
R
R
S
S
I
I
K
D
P
S
N
Site 6
S83
S
S
I
I
K
D
P
S
N
Q
K
C
G
G
R
Site 7
T93
K
C
G
G
R
K
K
T
V
S
F
S
S
M
P
Site 8
S95
G
G
R
K
K
T
V
S
F
S
S
M
P
S
E
Site 9
S97
R
K
K
T
V
S
F
S
S
M
P
S
E
K
K
Site 10
S98
K
K
T
V
S
F
S
S
M
P
S
E
K
K
I
Site 11
S101
V
S
F
S
S
M
P
S
E
K
K
I
S
S
A
Site 12
S107
P
S
E
K
K
I
S
S
A
N
D
C
I
S
F
Site 13
S128
L
K
K
V
R
P
N
S
R
I
Y
N
R
F
F
Site 14
Y131
V
R
P
N
S
R
I
Y
N
R
F
F
T
L
D
Site 15
T136
R
I
Y
N
R
F
F
T
L
D
T
D
L
Q
A
Site 16
T139
N
R
F
F
T
L
D
T
D
L
Q
A
L
R
W
Site 17
S149
Q
A
L
R
W
E
P
S
K
K
D
L
E
K
A
Site 18
S161
E
K
A
K
L
D
I
S
A
I
K
E
I
R
L
Site 19
T172
E
I
R
L
G
K
N
T
E
T
F
R
N
N
G
Site 20
T174
R
L
G
K
N
T
E
T
F
R
N
N
G
L
A
Site 21
Y198
S
I
L
H
G
E
N
Y
E
S
L
D
L
V
A
Site 22
S200
L
H
G
E
N
Y
E
S
L
D
L
V
A
N
S
Site 23
Y220
I
W
V
S
G
L
R
Y
L
V
S
R
S
K
Q
Site 24
S223
S
G
L
R
Y
L
V
S
R
S
K
Q
P
L
D
Site 25
S225
L
R
Y
L
V
S
R
S
K
Q
P
L
D
F
M
Site 26
T246
P
R
F
M
W
L
K
T
V
F
E
A
A
D
V
Site 27
T263
N
G
I
M
L
E
D
T
S
V
E
L
I
K
Q
Site 28
S290
K
F
K
E
I
Q
K
S
K
E
K
L
T
T
R
Site 29
T295
Q
K
S
K
E
K
L
T
T
R
V
T
E
E
E
Site 30
T296
K
S
K
E
K
L
T
T
R
V
T
E
E
E
F
Site 31
T299
E
K
L
T
T
R
V
T
E
E
E
F
C
E
A
Site 32
S324
Y
F
L
L
V
Q
I
S
K
N
K
E
Y
L
D
Site 33
T346
L
E
A
E
Q
G
V
T
H
I
T
E
D
I
C
Site 34
Y360
C
L
D
I
I
R
R
Y
E
L
S
E
E
G
R
Site 35
S363
I
I
R
R
Y
E
L
S
E
E
G
R
Q
K
G
Site 36
Y380
A
I
D
G
F
T
Q
Y
L
L
S
S
E
C
D
Site 37
T401
K
K
V
A
Q
D
M
T
Q
P
L
S
H
Y
Y
Site 38
Y407
M
T
Q
P
L
S
H
Y
Y
I
N
A
S
H
N
Site 39
Y408
T
Q
P
L
S
H
Y
Y
I
N
A
S
H
N
T
Site 40
Y416
I
N
A
S
H
N
T
Y
L
I
E
D
Q
F
R
Site 41
Y431
G
P
A
D
I
N
G
Y
I
R
A
L
K
M
G
Site 42
S447
R
S
V
E
L
D
V
S
D
G
S
D
N
E
P
Site 43
S450
E
L
D
V
S
D
G
S
D
N
E
P
I
L
C
Site 44
S467
N
N
M
T
T
H
V
S
F
R
S
V
I
E
V
Site 45
Y516
K
V
F
G
N
K
L
Y
T
E
A
P
L
P
S
Site 46
T517
V
F
G
N
K
L
Y
T
E
A
P
L
P
S
E
Site 47
S523
Y
T
E
A
P
L
P
S
E
S
Y
L
P
S
P
Site 48
S525
E
A
P
L
P
S
E
S
Y
L
P
S
P
E
K
Site 49
S529
P
S
E
S
Y
L
P
S
P
E
K
L
K
R
M
Site 50
S546
V
K
G
K
K
L
P
S
D
P
D
V
L
E
G
Site 51
T556
D
V
L
E
G
E
V
T
D
E
D
E
E
A
E
Site 52
S565
E
D
E
E
A
E
M
S
R
R
M
S
V
D
Y
Site 53
S569
A
E
M
S
R
R
M
S
V
D
Y
N
G
E
Q
Site 54
Y572
S
R
R
M
S
V
D
Y
N
G
E
Q
K
Q
I
Site 55
S590
R
E
L
S
D
L
V
S
I
C
K
S
V
Q
Y
Site 56
S594
D
L
V
S
I
C
K
S
V
Q
Y
R
D
F
E
Site 57
Y597
S
I
C
K
S
V
Q
Y
R
D
F
E
L
S
M
Site 58
Y609
L
S
M
K
S
Q
N
Y
W
E
M
C
S
F
S
Site 59
T618
E
M
C
S
F
S
E
T
E
A
S
R
I
A
N
Site 60
S621
S
F
S
E
T
E
A
S
R
I
A
N
E
Y
P
Site 61
Y627
A
S
R
I
A
N
E
Y
P
E
D
F
V
N
Y
Site 62
Y634
Y
P
E
D
F
V
N
Y
N
K
K
F
L
S
R
Site 63
Y643
K
K
F
L
S
R
I
Y
P
S
A
M
R
I
D
Site 64
S645
F
L
S
R
I
Y
P
S
A
M
R
I
D
S
S
Site 65
S651
P
S
A
M
R
I
D
S
S
N
L
N
P
Q
D
Site 66
S652
S
A
M
R
I
D
S
S
N
L
N
P
Q
D
F
Site 67
S698
C
G
Y
V
L
R
P
S
I
M
R
D
E
V
S
Site 68
S705
S
I
M
R
D
E
V
S
Y
F
S
A
N
T
K
Site 69
Y706
I
M
R
D
E
V
S
Y
F
S
A
N
T
K
G
Site 70
S762
H
G
I
P
A
D
C
S
E
Q
R
T
K
T
V
Site 71
T766
A
D
C
S
E
Q
R
T
K
T
V
Q
Q
N
S
Site 72
T768
C
S
E
Q
R
T
K
T
V
Q
Q
N
S
D
N
Site 73
S773
T
K
T
V
Q
Q
N
S
D
N
P
I
F
D
E
Site 74
T781
D
N
P
I
F
D
E
T
F
E
F
Q
V
N
L
Site 75
Y823
F
E
C
L
Q
P
G
Y
R
H
V
P
L
R
S
Site 76
S830
Y
R
H
V
P
L
R
S
F
V
G
D
I
M
E
Site 77
S860
G
G
K
A
Q
K
R
S
L
S
V
R
M
G
K
Site 78
S862
K
A
Q
K
R
S
L
S
V
R
M
G
K
K
V
Site 79
Y872
M
G
K
K
V
R
E
Y
T
M
L
R
N
I
G
Site 80
T873
G
K
K
V
R
E
Y
T
M
L
R
N
I
G
L
Site 81
T936
T
L
S
S
R
L
I
T
S
D
N
T
P
S
V
Site 82
S937
L
S
S
R
L
I
T
S
D
N
T
P
S
V
S
Site 83
S944
S
D
N
T
P
S
V
S
L
V
M
K
D
S
F
Site 84
Y971
Q
K
K
M
L
T
A
Y
D
L
M
I
Q
E
S
Site 85
S1026
K
L
N
K
A
T
E
S
F
A
W
N
I
T
V
Site 86
T1032
E
S
F
A
W
N
I
T
V
L
K
G
Q
G
D
Site 87
S1069
C
G
L
S
K
A
P
S
S
S
A
E
A
K
S
Site 88
S1070
G
L
S
K
A
P
S
S
S
A
E
A
K
S
K
Site 89
S1071
L
S
K
A
P
S
S
S
A
E
A
K
S
K
R
Site 90
S1076
S
S
S
A
E
A
K
S
K
R
S
L
E
A
I
Site 91
S1079
A
E
A
K
S
K
R
S
L
E
A
I
E
E
K
Site 92
S1088
E
A
I
E
E
K
E
S
S
E
E
N
G
K
L
Site 93
S1089
A
I
E
E
K
E
S
S
E
E
N
G
K
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation