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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PCOLCE
Full Name:
Procollagen C-endopeptidase enhancer 1
Alias:
PCOC1; PCPE; PCPE1; Procollagen C-endopeptidase enhancer; Procollagen C-proteinase enhancer 1; Procollagen C-proteinase enhancer protein; Procollagen, type 1, COOH-terminal proteinase enhancer
Type:
Extracellular matrix
Mass (Da):
47972
Number AA:
449
UniProt ID:
Q15113
International Prot ID:
IPI00299738
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005576
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007275
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T27
L
P
F
A
Q
G
Q
T
P
N
Y
T
R
P
V
Site 2
Y30
A
Q
G
Q
T
P
N
Y
T
R
P
V
F
L
C
Site 3
T31
Q
G
Q
T
P
N
Y
T
R
P
V
F
L
C
G
Site 4
S45
G
G
D
V
K
G
E
S
G
Y
V
A
S
E
G
Site 5
Y47
D
V
K
G
E
S
G
Y
V
A
S
E
G
F
P
Site 6
S50
G
E
S
G
Y
V
A
S
E
G
F
P
N
L
Y
Site 7
Y57
S
E
G
F
P
N
L
Y
P
P
N
K
E
C
I
Site 8
T66
P
N
K
E
C
I
W
T
I
T
V
P
E
G
Q
Site 9
S78
E
G
Q
T
V
S
L
S
F
R
V
F
D
L
E
Site 10
T128
V
A
P
G
N
Q
V
T
L
R
M
T
T
D
E
Site 11
T132
N
Q
V
T
L
R
M
T
T
D
E
G
T
G
G
Site 12
T133
Q
V
T
L
R
M
T
T
D
E
G
T
G
G
R
Site 13
T137
R
M
T
T
D
E
G
T
G
G
R
G
F
L
L
Site 14
Y146
G
R
G
F
L
L
W
Y
S
G
R
A
T
S
G
Site 15
S147
R
G
F
L
L
W
Y
S
G
R
A
T
S
G
T
Site 16
T151
L
W
Y
S
G
R
A
T
S
G
T
E
H
Q
F
Site 17
T154
S
G
R
A
T
S
G
T
E
H
Q
F
C
G
G
Site 18
T171
E
K
A
Q
G
T
L
T
T
P
N
W
P
E
S
Site 19
T172
K
A
Q
G
T
L
T
T
P
N
W
P
E
S
D
Site 20
S178
T
T
P
N
W
P
E
S
D
Y
P
P
G
I
S
Site 21
Y180
P
N
W
P
E
S
D
Y
P
P
G
I
S
C
S
Site 22
T201
P
D
Q
V
I
A
L
T
F
E
K
F
D
L
E
Site 23
T211
K
F
D
L
E
P
D
T
Y
C
R
Y
D
S
V
Site 24
Y212
F
D
L
E
P
D
T
Y
C
R
Y
D
S
V
S
Site 25
Y215
E
P
D
T
Y
C
R
Y
D
S
V
S
V
F
N
Site 26
S217
D
T
Y
C
R
Y
D
S
V
S
V
F
N
G
A
Site 27
S219
Y
C
R
Y
D
S
V
S
V
F
N
G
A
V
S
Site 28
S226
S
V
F
N
G
A
V
S
D
D
S
R
R
L
G
Site 29
S229
N
G
A
V
S
D
D
S
R
R
L
G
K
F
C
Site 30
S243
C
G
D
A
V
P
G
S
I
S
S
E
G
N
E
Site 31
S267
S
V
T
A
D
G
F
S
A
S
Y
K
T
L
P
Site 32
S269
T
A
D
G
F
S
A
S
Y
K
T
L
P
R
G
Site 33
T272
G
F
S
A
S
Y
K
T
L
P
R
G
T
A
K
Site 34
T277
Y
K
T
L
P
R
G
T
A
K
E
G
Q
G
P
Site 35
T290
G
P
G
P
K
R
G
T
E
P
K
V
K
L
P
Site 36
S300
K
V
K
L
P
P
K
S
Q
P
P
E
K
T
E
Site 37
T306
K
S
Q
P
P
E
K
T
E
E
S
P
S
A
P
Site 38
S309
P
P
E
K
T
E
E
S
P
S
A
P
D
A
P
Site 39
S311
E
K
T
E
E
S
P
S
A
P
D
A
P
T
C
Site 40
T317
P
S
A
P
D
A
P
T
C
P
K
Q
C
R
R
Site 41
T325
C
P
K
Q
C
R
R
T
G
T
L
Q
S
N
F
Site 42
T327
K
Q
C
R
R
T
G
T
L
Q
S
N
F
C
A
Site 43
S330
R
R
T
G
T
L
Q
S
N
F
C
A
S
S
L
Site 44
S345
V
V
T
A
T
V
K
S
M
V
R
E
P
G
E
Site 45
Y364
T
V
S
L
I
G
A
Y
K
T
G
G
L
D
L
Site 46
S373
T
G
G
L
D
L
P
S
P
P
T
G
A
S
L
Site 47
T376
L
D
L
P
S
P
P
T
G
A
S
L
K
F
Y
Site 48
S379
P
S
P
P
T
G
A
S
L
K
F
Y
V
P
C
Site 49
Y383
T
G
A
S
L
K
F
Y
V
P
C
K
Q
C
P
Site 50
Y398
P
M
K
K
G
V
S
Y
L
L
M
G
Q
V
E
Site 51
S433
D
Q
I
L
T
N
L
S
K
R
K
C
P
S
Q
Site 52
S439
L
S
K
R
K
C
P
S
Q
P
V
R
A
A
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation